A combination of NMDA and AMPA receptor antagonists retards granule cell dispersion and epileptogenesis in a model of acquired epilepsy

Blockade of the IL-1R1/TLR4 pathway mediates disease-modification therapeutic effects in a model of acquired epilepsy

(2017) Valentina Iori et al.   NEUROBIOLOGY OF DISEASE

Significant effects of sex, strain, and anesthesia in the intrahippocampal kainate mouse model of mesial temporal lobe epilepsy

(2016) Friederike Twele et al.   EPILEPSY & BEHAVIOR

Fit for purpose application of currently existing animal models in the discovery of novel epilepsy therapies

(2016) Wolfgang Löscher   EPILEPSY RESEARCH

Brain inflammation, neurodegeneration and seizure development following picornavirus infection markedly differ among virus and mouse strains and substrains

(2016) Sonja Bröer et al.   EXPERIMENTAL NEUROLOGY

Chemically-induced TLE models: Topical application

(2016) John Jefferys et al.   JOURNAL OF NEUROSCIENCE METHODS

Animal models of temporal lobe epilepsy following systemic chemoconvulsant administration

(2016) Maxime Lévesque et al.   JOURNAL OF NEUROSCIENCE METHODS

Infections, inflammation and epilepsy

(2015) Annamaria Vezzani et al.   ACTA NEUROPATHOLOGICA

Astrocyte uncoupling as a cause of human temporal lobe epilepsy

(2015) Peter Bedner et al.   BRAIN

Network pharmacology for antiepileptogenesis: Tolerability of multitargeted drug combinations in nonepileptic vs. post-status epilepticus mice

(2015) Rebecca Klee et al.   EPILEPSY RESEARCH

Activation of mTOR signaling pathway is secondary to neuronal excitability in a mouse model of mesio-temporal lobe epilepsy

(2015) Ayako Shima et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

The AMPA receptor antagonist NBQX exerts anti-seizure but not antiepileptogenic effects in the intrahippocampal kainate mouse model of mesial temporal lobe epilepsy

(2015) Friederike Twele et al.   NEUROPHARMACOLOGY

Glutamatergic Mechanisms Associated with Seizures and Epilepsy

(2015) Melissa Barker-Haliski et al.   Cold Spring Harbor Perspectives in Medicine

Searching for the Ideal Antiepileptogenic Agent in Experimental Models: Single Treatment Versus Combinatorial Treatment Strategies

(2014) H. Steve White et al.   Neurotherapeutics

Anti-epileptogenic Clinical Trial Designs in Epilepsy: Issues and Options

(2014) Dieter Schmidt et al.   Neurotherapeutics

AMPA receptors as a molecular target in epilepsy therapy

(2013) M. A. Rogawski   ACTA NEUROLOGICA SCANDINAVICA

AMPA Receptor antagonist NBQX attenuates later-life epileptic seizures and autistic-like social deficits following neonatal seizures

(2013) Jocelyn J. Lippman-Bell et al.   EPILEPSIA

Metabolism studies of ifenprodil, a potent GluN2B receptor antagonist

(2013) Evamaria Falck et al.   JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS

New avenues for anti-epileptic drug discovery and development

(2013) Wolfgang Löscher et al.   NATURE REVIEWS DRUG DISCOVERY

Pharmacological blockade of IL-1β/IL-1 receptor type 1 axis during epileptogenesis provides neuroprotection in two rat models of temporal lobe epilepsy

(2013) F.M. Noe et al.   NEUROBIOLOGY OF DISEASE

The kainic acid model of temporal lobe epilepsy

(2013) Maxime Lévesque et al.   NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS

Inflammatory activation enhances NMDA-triggered Ca2+ signalling and IL-1β secretion in primary cultures of rat astrocytes

(2012) Franck Gérard et al.   BRAIN RESEARCH

Perampanel—new promise for refractory epilepsy?

(2012) Wolfgang Löscher et al.   Nature Reviews Neurology

Thiol oxidation and altered NR2B/NMDA receptor functions in in vitro and in vivo pilocarpine models: Implications for epileptogenesis

(2012) Roberto Di Maio et al.   NEUROBIOLOGY OF DISEASE

The role of inflammation in epileptogenesis

(2012) Annamaria Vezzani et al.   NEUROPHARMACOLOGY

Inflammatory changes during epileptogenesis and spontaneous seizures in a mouse model of mesiotemporal lobe epilepsy

(2011) Fabien Pernot et al.   EPILEPSIA

Brain Infiltration of Leukocytes Contributes to the Pathophysiology of Temporal Lobe Epilepsy

(2011) M. Zattoni et al.   JOURNAL OF NEUROSCIENCE

Misplaced NMDA receptors in epileptogenesis contribute to excitotoxicity

(2011) Angelisa Frasca et al.   NEUROBIOLOGY OF DISEASE

Interleukin-1β Biosynthesis Inhibition Reduces Acute Seizures and Drug Resistant Chronic Epileptic Activity in Mice

(2011) Mattia Maroso et al.   Neurotherapeutics

The COX-2 inhibitor parecoxib is neuroprotective but not antiepileptogenic in the pilocarpine model of temporal lobe epilepsy

(2010) Nadine Polascheck et al.   EXPERIMENTAL NEUROLOGY

Disease-Modifying Effects of Phenobarbital and the NKCC1 Inhibitor Bumetanide in the Pilocarpine Model of Temporal Lobe Epilepsy

(2010) C. Brandt et al.   JOURNAL OF NEUROSCIENCE

Toll-like receptor 4 and high-mobility group box-1 are involved in ictogenesis and can be targeted to reduce seizures

(2010) Mattia Maroso et al.   NATURE MEDICINE

Prevention or Modification of Epileptogenesis after Brain Insults: Experimental Approaches and Translational Research

(2010) W. Loscher et al.   PHARMACOLOGICAL REVIEWS

Hippocampal injury, atrophy, synaptic reorganization, and epileptogenesis after perforant pathway stimulation-induced status epilepticus in the mouse

(2009) Friederike Kienzler et al.   JOURNAL OF COMPARATIVE NEUROLOGY

Increased Reelin Promoter Methylation Is Associated With Granule Cell Dispersion in Human Temporal Lobe Epilepsy

(2009) Katja Kobow et al.   JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY

Recommended tests for association in 2×2 tables

(2009) Stian Lydersen et al.   STATISTICS IN MEDICINE

A novel non-transcriptional pathway mediates the proconvulsive effects of interleukin-1 

(2008) S. Balosso et al.   BRAIN

Behavioral alterations in a mouse model of temporal lobe epilepsy induced by intrahippocampal injection of kainate

(2008) Ina Gröticke et al.   EXPERIMENTAL NEUROLOGY