Rational development of Stafib-2: a selective, nanomolar inhibitor of the transcription factor STAT5b

Integration and global analysis of isothermal titration calorimetry data for studying macromolecular interactions

(2016) Chad A Brautigam et al.   Nature Protocols

Intramolecular hydrophobic interactions are critical mediators of STAT5 dimerization

(2016) Dirk Fahrenkamp et al.   Scientific Reports

Antagonizing STAT5B dimerization with an osmium complex

(2016) Li-Juan Liu et al.   Scientific Reports

Phosphorylation of Capsaicinoid Derivatives Provides Highly Potent and Selective Inhibitors of the Transcription Factor STAT5b

(2015) Nagarajan Elumalai et al.   ACS Chemical Biology

Nanomolar Inhibitors of the Transcription Factor STAT5b with High Selectivity over STAT5a

(2015) Nagarajan Elumalai et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Targeting the Src Homology 2 (SH2) Domain of Signal Transducer and Activator of Transcription 6 (STAT6) with Cell-Permeable, Phosphatase-Stable Phosphopeptide Mimics Potently Inhibits Tyr641 Phosphorylation and Transcriptional Activity

(2015) Pijus K. Mandal et al.   JOURNAL OF MEDICINAL CHEMISTRY

High-precision, automated integration of multiple isothermal titration calorimetric thermograms: New features of NITPIC

(2015) Thomas H. Scheuermann et al.   METHODS

Structure-Based Screen Identifies a Potent Small Molecule Inhibitor of Stat5a/b with Therapeutic Potential for Prostate Cancer and Chronic Myeloid Leukemia

(2015) Z. Liao et al.   MOLECULAR CANCER THERAPEUTICS

BCR-ABL Affects STAT5A and STAT5B Differentially

(2014) Michael Schaller-Schönitz et al.   PLoS One

Nanomolar-Potency Small Molecule Inhibitor of STAT5 Protein

(2014) Abbarna A. Cumaraswamy et al.   ACS Medicinal Chemistry Letters

Differential Contributions of STAT5A and STAT5B to Stress Protection and Tyrosine Kinase Inhibitor Resistance of Chronic Myeloid Leukemia Stem/Progenitor Cells

(2013) L. Casetti et al.   CANCER RESEARCH

Therapeutic modulators of STAT signalling for human diseases

(2013) Gabriella Miklossy et al.   NATURE REVIEWS DRUG DISCOVERY

Synthesis and in Vitro Evaluation of a Peptidomimetic Inhibitor Targeting the Src Homology 2 (SH2) Domain of STAT6

(2013) Pietro Morlacchi et al.   ACS Medicinal Chemistry Letters

High-Precision Isothermal Titration Calorimetry with Automated Peak-Shape Analysis

(2012) Sandro Keller et al.   ANALYTICAL CHEMISTRY

NIH Image to ImageJ: 25 years of image analysis

(2012) Caroline A Schneider et al.   NATURE METHODS

Selective Targeting of Disease-Relevant Protein Binding Domains byO-Phosphorylated Natural Product Derivatives

(2011) Martin Gräber et al.   ACS Chemical Biology

Potent and Selective Phosphopeptide Mimetic Prodrugs Targeted to the Src Homology 2 (SH2) Domain of Signal Transducer and Activator of Transcription 3

(2011) Pijus K. Mandal et al.   JOURNAL OF MEDICINAL CHEMISTRY

Small Molecule STAT5-SH2 Domain Inhibitors Exhibit Potent Antileukemia Activity

(2011) Brent D. G. Page et al.   JOURNAL OF MEDICINAL CHEMISTRY

A Scaffold-Tree-Merging Strategy for Prospective Bioactivity Annotation of γ-Pyrones

(2010) Stefan Wetzel et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Natural product inhibitors of protein–protein interactions mediated by Src-family SH2 domains

(2009) Bianca Sperl et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Synthesis of Phosphatase-Stable, Cell-Permeable Peptidomimetic Prodrugs That Target the SH2 Domain of Stat3

(2009) Pijus K. Mandal et al.   ORGANIC LETTERS

A high-throughput assay for signal transducer and activator of transcription 5b based on fluorescence polarization

(2008) Judith Müller et al.   ANALYTICAL BIOCHEMISTRY

Discovery of Chromone-Based Inhibitors of the Transcription Factor STAT5

(2008) Judith Müller et al.   CHEMBIOCHEM

Signal Transducers and Activators of Transcription as Targets for Small Organic Molecules

(2008) Thorsten Berg   CHEMBIOCHEM

Interpretation of cytokine signaling through the transcription factors STAT5A and STAT5B

(2008) L. Hennighausen et al.   GENES & DEVELOPMENT