Article
Biology
Chaoying Zhan, Kai Liu, Yuxin Zhang, Yingbo Zhang, Mengqiao He, Rongrong Wu, Cheng Bi, Bairong Shen
Summary: This study proposed a novel bioinformatics model based on multivariate biomolecular network analysis to identify putative key miRNAs of myocardial infarction (MI). The model combined TRS, TFP, and AGP features and successfully screened 31 potential MI-related miRNAs, identifying genes associated with key MI pathways. These findings warrant further experimental and clinical validation for translational applications.
COMPUTERS IN BIOLOGY AND MEDICINE
(2023)
Article
Plant Sciences
Jingjing Zhan, Yangyang Diao, Guo Yin, Muhammad Sajjad, Xi Wei, Zhengying Lu, Ye Wang
Summary: This study identified a total of 312 cotton miRNAs, including 80 known and 232 novel miRNAs, in response to salt stress. 155 miRNAs showed significant differential expression under salt stress, with 72 targets of 25 miRNAs verified by degradome sequencing data. The newly identified miRNAs and mRNA pairs could be beneficial for genetic engineering and understanding the mechanisms responding to salt stress in cotton.
FRONTIERS IN PLANT SCIENCE
(2021)
Review
Biochemistry & Molecular Biology
Ying Yang, Jiu Huang, Qiumin Sun, Jingqi Wang, Lichao Huang, Siyi Fu, Sini Qin, Xiaoting Xie, Sisi Ge, Xiang Li, Zhuo Cheng, Xiaofei Wang, Houming Chen, Bingsong Zheng, Yi He
Summary: Environmental metal pollution is a common problem that poses a threat to sustainable and safe crop production. Plants counteract the toxicity of heavy metals by enhancing defense responses and regulating metal intake through transporters and antioxidant mechanisms. MicroRNAs (miRNAs) have emerged as central regulators in plant responses to heavy metal stress. This article reviews the research progress of miRNAs in plant stress responses to the accumulation of heavy metals and their toxicity.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Biology
Anais N. Bauer, Niska Majumdar, Frank Williams, Smit Rajput, Lok R. Pokhrel, Paul P. Cook, Shaw M. Akula
Summary: Viral outbreaks pose obstacles to human health, and understanding viral pathology is crucial for developing methods to combat infection. The relatively new field of miRNA research in virology has shown that miRNAs play important roles in gene expression regulation. Changes in miRNA expression can either help the host fight infections or be exploited by viruses to enhance infection. Uncovering these interactions and their implications can guide therapeutic and diagnostic advancements. miRNA technology has market potential and is already being used in commercial biopharmaceuticals. Further research into the functions of miRNAs during infection and their therapeutic potential can contribute to strategies against current and future viral pathogens.
Article
Oncology
Magy Sallam, Mohamed Mysara, Sarah Baatout, Pieter-Jan Guns, Raghda Ramadan, Mohammed Abderrafi Benotmane
Summary: Glioblastoma is a grade IV glioma with heterogeneous nature. This meta-analysis identified differentially expressed lncRNAs, PCGs, and miRNAs in glioblastoma through RNA-seq and small RNA-seq. Analysis of co-expression correlation networks revealed a functionally relevant sub-cluster involving two novel lncRNAs and two novel PCGs. Pathway analysis showed an association with the novel cell death pathway, ferroptosis, and several glioblastoma-linked pathways. This research confirms the involvement of ferroptosis in glioblastoma pathophysiology and provides potential candidates for further studies.
Review
Immunology
Kun Li, Ziqiang Wang
Summary: This review focuses on the roles and underlying mechanisms of microRNAs and long non-coding RNAs in regulating T cell exhaustion during chronic viral infections and tumorigenesis. The identification of these molecular targets can provide guidance for the development of more precise and effective immunotherapies.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Oncology
Bai Xue, Shupeng Li, Xianyu Jin, Lifeng Liu
Summary: The study identified key signaling pathways and cellular activities related to cisplatin-resistant ovarian cancer through analyzing differentially expressed genes and miRNAs, and established a miRNA-mRNA regulatory pair (mir-454-UBB) as a potential therapeutic target for drug resistance in ovarian cancer.
Article
Biochemistry & Molecular Biology
Feng Wang, Chaolai Man, Xiaoqiu Wang, Jack Odle, Christian Maltecca, Xi Lin
Summary: Maternal undernutrition during pregnancy can lead to severe fetal impairments, but the exact mechanisms are not fully understood. This study investigated the potential impacts of restricted nutrition on metabolic pathways in fetal pigs. The results revealed differential expression of mRNA and miRNA, as well as alterations in metabolic and signaling pathways. These findings provide valuable insights into the negative effects of maternal malnutrition on hepatic metabolism in full-term fetal pigs via miRNA-mRNA interactions.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2023)
Article
Biochemistry & Molecular Biology
Rim Nefissi Ouertani, Dhivya Arasappan, Ghassen Abid, Mariem Ben Chikha, Rahma Jardak, Henda Mahmoudi, Samiha Mejri, Abdelwahed Ghorbel, Tracey A. Ruhlman, Robert K. Jansen
Summary: Barley, with its rich genetic diversity, serves as an important model for studying salt tolerance response. The response to salt stress mainly involves sensing and signaling pathways, transcriptional reprogramming, hormone and ion homeostasis regulation, reactive oxygen scavenging, as well as activation of transport and photosynthesis systems. This study identifies key genes involved in salt tolerance and highlights the complexity of gene regulation in roots under salt stress.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Endocrinology & Metabolism
Haroon Latif Khan, Shahzad Bhatti, Sana Abbas, Celal Kaloglu, Ahmed M. Isa, Hooria Younas, Rachel Ziders, Yousaf Latif Khan, Zahira Hassan, Bilgun Ozturk Turhan, Aysegul Yildiz, Hikmet Hakan Aydin, Ender Yalcinkaya Kalyan
Summary: The study demonstrated the differential expression of miR-7-5p, miR-378-3p, miR-224, and miR-212-3p in normo-androgenic PCOS patients compared to NOR patients, while miRNA-320a showed significance in predicting embryo quality.
REPRODUCTIVE BIOLOGY AND ENDOCRINOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Giulia Dal Santo, Marco Frasca, Gloria Bertoli, Isabella Castiglioni, Claudia Cava
Summary: This study analyzed miRNA-mRNA interactions and constructed networks for the onset and progression of prostate cancer, identifying potential biomarkers for differential diagnosis. The selected miRNAs showed better performance in predicting the occurrence and progression of prostate cancer compared to the miRNAs selected by the Boruta algorithm.
COMPUTATIONAL AND STRUCTURAL BIOTECHNOLOGY JOURNAL
(2022)
Article
Plant Sciences
Maria Jose Almira Casellas, Laura Perez-Martin, Silvia Busoms, Rene Boesten, Merce Llugany, Mark G. M. Aarts, Charlotte Poschenrieder
Summary: By evaluating the growth condition variation of 270 natural accessions of Arabidopsis thaliana on a natural saline-carbonated soil, significant natural variation in leaf sodium and iron concentrations was discovered. The diversity in leaf sodium concentration was associated with allelic variation in the NINJA and YUC8 genes, while leaf iron concentration diversity was associated with allelic variation in the ALA3 gene. The allelic variation in these genes leads to changes in mRNA expression and correlates with plant differential growth performance under alkaline salinity treatment.
Article
Plant Sciences
Emma Sevilla, Pilar Andreu, Maria F. Fillat, M. Luisa Peleato, Juan A. Marin, Arancha Arbeloa
Summary: Excised root cultures can serve as an excellent experimental approach to study stress physiology and assess tolerance. The study demonstrates that protein changes in excised root cultures of Prunus cerasus under salt stress can be representative of changes in whole plants. Proteomic analysis revealed 16 relevant proteins expressed differentially in response to salt stress.
Article
Plant Sciences
Jing Zhou, Jiang-Ting Wu
Summary: This study analyzed the expression profiles of miRNAs and their targets in poplar roots treated with different forms of nitrogen. Differentially expressed miRNAs and their targets were found to play an important role in regulating the root system architecture in poplar plants.
Article
Biotechnology & Applied Microbiology
Gang Chen, Hong-Mei Qian, Jing Chen, Jie Wang, Ji-Tian Guan, Zai-Long Chi
Summary: The study systematically screened key non-coding RNAs in retinal neurogenesis through whole-transcriptome sequencing. The validated non-coding RNAs and their circular RNA/long non-coding RNA-microRNA-messenger RNA network involve neurotransmitter transport and multicellular organism growth during retinal development.
Article
Agriculture, Multidisciplinary
Xun-lan Li, Shi-lai Yi, Shao-lan He, Qiang Lv, Rang-jin Xie, Yong-qiang Zheng, Lie Deng
PRECISION AGRICULTURE
(2016)
Article
Plant Sciences
Yongqiang Zheng, Xue-mei Jia, Qiong Yang, Yan-mei Liu, Rang-jin Xie, Yan-yan Ma, Shao-lan He, Lie Deng
ACTA PHYSIOLOGIAE PLANTARUM
(2016)
Article
Genetics & Heredity
Rangjin Xie, Xiaoting Pan, Jing Zhang, Yanyan Ma, Shaolan He, Yongqiang Zheng, Yingtao Ma
FUNCTIONAL & INTEGRATIVE GENOMICS
(2018)
Article
Agriculture, Multidisciplinary
Zheng Yong-qiang, Yang Qiong, Jia Xue-mei, Liu Yan-mei, He Shan-ian, Deng Lie, Xie Rang-jin, Yi Shi-lai, Lu Qiang
JOURNAL OF INTEGRATIVE AGRICULTURE
(2017)
Article
Plant Sciences
Rangjin Xie, Ting Ge, Jing Zhang, Xiaoting Pan, Yanyan Ma, Shilai Yi, Yongqiang Zheng
PLANT PHYSIOLOGY AND BIOCHEMISTRY
(2018)
Article
Horticulture
Yongqiang Zheng, Ya Wang, Qiong Yang, Yanmei Liu, Rangjin Xie, Shaolan He, Lie Deng, Shilai Yi, Qiang Lv, Yanyan Ma
SCIENTIA HORTICULTURAE
(2018)
Article
Horticulture
Yongqiang Zheng, Neveen Kumar, Pedro Gonzalez, Ed. Etxeberria
SCIENTIA HORTICULTURAE
(2018)
Article
Horticulture
Qiong Yang, Ya Wang, Xue-mei Jia, Yong-qiang Zheng, Shao-lan He, Lie Deng, Yan-yan Ma, Rang-jin Xie, Shi-lai Yi, Qiang Lv
SCIENTIA HORTICULTURAE
(2018)
Article
Agricultural Engineering
Kejian Wang, Wentao Li, Lie Deng, Qiang Lyu, Yongqiang Zheng, Shilai Yi, Rangjin Xie, Yanyan Ma, Shaolan He
INTERNATIONAL JOURNAL OF AGRICULTURAL AND BIOLOGICAL ENGINEERING
(2018)
Article
Horticulture
Jing Zhang, Xiaoting Pan, Ting Ge, Shilai Yi, Qiang Lv, Yongqiang Zheng, Yanyan Ma, Xiaogang Liu, Rangjin Xie
JOURNAL OF HORTICULTURAL SCIENCE & BIOTECHNOLOGY
(2019)
Article
Horticulture
Yanyan Ma, Tianli Wu, Guangyan Zhong, Yongqiang Zheng
SCIENTIA HORTICULTURAE
(2020)
Article
Agronomy
Renjie Huang, Tingshan Yao, Cheng Zhan, Geng Zhang, Yongqiang Zheng
Summary: This study proposes a monitoring scheme based on automatic e-traps and novel recognition algorithms to address the inefficiency and unreliability of current e-traps for citrus fly detection. By designing a motor-driven e-trap prototype and introducing various detection and recognition algorithms, the study successfully improves the detection and recognition of citrus flies in images.
Article
Agronomy
Lian-Jie Wan, Yang Tian, Man He, Yong-Qiang Zheng, Qiang Lyu, Rang-Jin Xie, Yan-Yan Ma, Lie Deng, Shi-Lai Yi
Summary: Excessive use of chemical fertilizer in citrus orchards around the world, especially in China, has led to soil deterioration, while the use of organic fertilizer has been shown to be a promising solution. Data from a 'Ponkan' orchard revealed that both organic and bioorganic fertilizers can improve soil fertility, growth physiology, and yield of citrus, with bioorganic fertilizer proving to be more effective than organic fertilizer.
Article
Agronomy
Kejian Wang, Dongmei Guo, Yao Zhang, Lie Deng, Rangjin Xie, Qiang Lv, Shilai Yi, Yongqiang Zheng, Yanyan Ma, Shaolan He
FRONTIERS OF AGRICULTURAL SCIENCE AND ENGINEERING
(2019)