Inhibition of PHD3 by salidroside promotes neovascularization through cell–cell communications mediated by muscle-secreted angiogenic factors

Prostacyclin-producing human mesenchymal cells target H19 lncRNA to augment endogenous progenitor function in hindlimb ischaemia

(2016) Yuxiao Deng et al.   Nature Communications

Discovery of a specific inhibitor of human GLUT5 by virtual screening and in vitro transport evaluation

(2016) Alayna M. George Thompson et al.   Scientific Reports

A Lactate-Induced Response to Hypoxia

(2015) Dong Chul Lee et al.   CELL

Prolyl Hydroxylase Domain-2 Silencing Induced by Hydrodynamic Limb Vein Injection Enhances Vascular Regeneration in Critical Limb Ischemia Mice through Activation of Multiple Genes

(2015) Shourong Wu et al.   CURRENT GENE THERAPY

Evodiamine Attenuates PDGF-BB-Induced Migration of Rat Vascular Smooth Muscle Cells through Activating PPARγ

(2015) Xie Ge et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Depletion of PHD3 protects heart from ischemia/reperfusion injury by inhibiting cardiomyocyte apoptosis

(2015) Liang Xie et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Deletion of prolyl hydroxylase domain proteins (PHD1, PHD3) stabilizes hypoxia inducible factor-1 alpha, promotes neovascularization, and improves perfusion in a murine model of hind-limb ischemia

(2015) Muhammad T. Rishi et al.   MICROVASCULAR RESEARCH

Preventing and treating foot complications associated with diabetes mellitus

(2015) Frank L. Bowling et al.   Nature Reviews Endocrinology

Improved Vascular Survival and Growth in the Mouse Model of Hindlimb Ischemia by a Remote Signaling Mechanism

(2014) Kotaro Takeda et al.   AMERICAN JOURNAL OF PATHOLOGY

PHD3-mediated prolyl hydroxylation of nonmuscle actin impairs polymerization and cell motility

(2014) Weibo Luo et al.   MOLECULAR BIOLOGY OF THE CELL

Therapeutic angiogenesis for critical limb ischemia

(2014) Sae Hee Ko et al.   Seminars in Vascular Surgery

ERα upregulates Phd3 to ameliorate HIF-1 induced fibrosis and inflammation in adipose tissue

(2014) Min Kim et al.   Molecular Metabolism

Transcription Factor YY1 Contributes to Tumor Growth by Stabilizing Hypoxia Factor HIF-1  in a p53-Independent Manner

(2013) S. Wu et al.   CANCER RESEARCH

Cell Therapy for Heart Failure

(2013) Santosh K. Sanganalmath et al.   CIRCULATION RESEARCH

Inhibition of MicroRNA-92a Prevents Endothelial Dysfunction and Atherosclerosis in Mice

(2013) Xavier Loyer et al.   CIRCULATION RESEARCH

Cross-talk between hypoxia and insulin signaling through Phd3 regulates hepatic glucose and lipid metabolism and ameliorates diabetes

(2013) Cullen M Taniguchi et al.   NATURE MEDICINE

Therapeutic angiogenesis for critical limb ischaemia

(2013) Brian H. Annex   Nature Reviews Cardiology

Salidroside stimulates the accumulation of HIF-1α protein resulted in the induction of EPO expression: A signaling via blocking the degradation pathway in kidney and liver cells

(2012) Ken Yu-Zhong Zheng et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Salidroside Protects Human Erythrocytes against Hydrogen Peroxide-Induced Apoptosis

(2012) Erin Wei Qian et al.   JOURNAL OF NATURAL PRODUCTS

Update on clinical trials evaluating the effect of biologic therapy in patients with critical limb ischemia

(2012) Richard J. Powell   JOURNAL OF VASCULAR SURGERY

Structural basis for a molecular allosteric control mechanism of cofactor binding to nuclear receptors

(2012) J. Osz et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Effect of Hypoxia-Inducible Factor-1α Gene Therapy on Walking Performance in Patients With Intermittent Claudication

(2011) Mark A. Creager et al.   CIRCULATION

Beyond VEGF: Inhibition of the Fibroblast Growth Factor Pathway and Antiangiogenesis

(2011) C. Lieu et al.   CLINICAL CANCER RESEARCH

Macrophage skewing by Phd2 haplodeficiency prevents ischaemia by inducing arteriogenesis

(2011) Yukiji Takeda et al.   NATURE

PDGF-BB modulates hematopoiesis and tumor angiogenesis by inducing erythropoietin production in stromal cells

(2011) Yuan Xue et al.   NATURE MEDICINE

Endogenous 2-oxoglutarate levels impact potencies of competitive HIF prolyl hydroxylase inhibitors

(2011) Kenneth Thirstrup et al.   PHARMACOLOGICAL RESEARCH

Dipeptidyl-Quinolone Derivatives Inhibit Hypoxia Inducible Factor-1α Prolyl Hydroxylases-1, -2, and -3 with Altered Selectivity

(2010) Justin K. Murray et al.   JOURNAL OF COMBINATORIAL CHEMISTRY

Neuroprotective effects of salidroside against beta-amyloid-induced oxidative stress in SH-SY5Y human neuroblastoma cells

(2010) Li Zhang et al.   NEUROCHEMISTRY INTERNATIONAL

Inhibition of Prolyl Hydroxylase Domain Proteins Promotes Therapeutic Revascularization

(2009) Céline Loinard et al.   CIRCULATION

Coadministration of Adenoviral Vascular Endothelial Growth Factor and Angiopoietin-1 Enhances Vascularization and Reduces Ventricular Remodeling in the Infarcted Myocardium of Type 1 Diabetic Rats

(2009) S. M. Samuel et al.   DIABETES

Peripheral arterial disease in diabetes-a review

(2009) E. B. Jude et al.   DIABETIC MEDICINE

Salidroside protects cardiomyocyte against hypoxia-induced death: A HIF-1α-activated and VEGF-mediated pathway

(2009) Jinping Zhang et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

The transcriptional coactivator PGC-1α mediates exercise-induced angiogenesis in skeletal muscle

(2009) Jessica Chinsomboon et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Short Hairpin RNA Interference Therapy for Ischemic Heart Disease

(2008) M. Huang et al.   CIRCULATION

Prolyl Hydroxylase PHD3 Activates Oxygen-dependent Protein Aggregation

(2008) Krista Rantanen et al.   MOLECULAR BIOLOGY OF THE CELL

Enhancement of Angiogenesis Through Stabilization of Hypoxia-inducible Factor-1 by Silencing Prolyl Hydroxylase Domain-2 Gene

(2008) Shourong Wu et al.   MOLECULAR THERAPY

PHDs overactivation during chronic hypoxia "desensitizes" HIF  and protects cells from necrosis

(2008) A. Ginouves et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA