Article
Medicine, General & Internal
Beibei Dong, Jinfang Sun, Mengmeng Zhi, Manman Han, Hao Lin, Hong Yu, Ling Li
Summary: The study found that gestational weight gain in the third trimester was positively correlated with serum leptin concentrations and HOMA-IR indices, but not with adiponectin concentrations. Multivariate analysis revealed that weight gain and leptin concentration were independently associated with HOMA-IR levels, and mediation analysis showed that the association between weight gain and HOMA-IR was mediated by serum leptin concentrations.
ARCHIVES OF MEDICAL SCIENCE
(2021)
Article
Nutrition & Dietetics
Malgorzata Lewandowska
Summary: The study found that maternal pre-pregnancy obesity is associated with an increased risk of low birth weight, fetal growth restriction, and macrosomia in newborns. Additionally, the risk of macrosomia was three times higher for obese mothers, while the risk of low birth weight was 17 times higher, particularly in the subgroup of normal gestational weight gain. The risk profile showed that higher BMI values were associated with a higher risk of these outcomes, with specific threshold BMI values identified.
Article
Psychiatry
Yuying Qiu, Meijuan Li, Yonghui Zhang, Ying Liu, Yongping Zhao, Jing Zhang, Qiong Jia, Jie Li
Summary: Berberine could reduce weight gain in schizophrenia patients, with significant weight loss observed in the berberine group compared to placebo. The effect may be related to the regulation of leptin levels.
ASIAN JOURNAL OF PSYCHIATRY
(2022)
Review
Public, Environmental & Occupational Health
Kara M. Whitaker, Rachel Ryan, Courtney Becker, Heather Healy
Summary: This systematic review included 29 studies and found that excessive gestational weight gain was associated with an increased risk of hypertensive disorders of pregnancy, while inadequate gestational weight gain was associated with lower birthweight, being small for gestational age, and preterm birth in twins. Though gestational weight gain within IOM guidelines appeared to lead to more optimal outcomes, further methodologically rigorous studies are needed to inform evidence-based guidelines.
JOURNAL OF WOMENS HEALTH
(2022)
Article
Endocrinology & Metabolism
Oddrun Kristiansen, Manuela Zucknick, Trine M. Reine, Svein O. Kolset, Thomas Jansson, Theresa L. Powell, Guttorm Haugen, Tore Henriksen, Trond M. Michelsen
Summary: The study suggests that placental weight is the main mediator linking pregestational BMI and gestational weight gain to birthweight and neonatal fat mass percentage. Maternal mediators only partially mediate the effect of pBMI, while placental weight is the main mediator in this association.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2021)
Article
Nutrition & Dietetics
Gilberto Kac, Thais R. B. Carilho, Kathleen M. Rasmussen, Michael E. Reichenheim, Dayana R. Farias, Jennifer A. Hutcheon
Summary: Monitoring gestational weight gain is crucial for a successful pregnancy, and this study aimed to construct GWG charts for Brazilian women based on pre-pregnancy BMI. The charts offer insights into GWG patterns by gestational age and BMI, providing valuable information for monitoring and improving maternal and neonatal health outcomes.
AMERICAN JOURNAL OF CLINICAL NUTRITION
(2021)
Article
Biochemistry & Molecular Biology
M. A. Galindo-Caceres, R. Parra-Unda, J. Murillo-Llanes, F. Morgan-Ortiz, J. G. Rendon-Maldonado, K. Y. Osuna-Espinoza, I. Osuna-Ramirez
Summary: The study explores the relationship between maternal weight, leptin receptor expression in maternal peripheral blood mononuclear cells (PBMC), and placental tissue to analyze its impact on birth outcomes. The results suggest that maternal nutrition status can affect fetal development and birth outcomes through leptin receptor expression.
Article
Public, Environmental & Occupational Health
Sanna Mustaniemi, Hilkka Nikkinen, Aini Bloigu, Anneli Pouta, Risto Kaaja, Johan G. Eriksson, Hannele Laivuori, Mika Gissler, Eero Kajantie, Marja Vaarasmaki
Summary: The study showed that normal gestational weight gain is associated with a lower risk of large-for-gestational-age infants and lower birth weight standard deviation scores in the presence of gestational diabetes and maternal obesity.
FRONTIERS IN PUBLIC HEALTH
(2021)
Article
Nutrition & Dietetics
Thais Rangel Bousquet Carrilho, Jennifer A. Hutcheon, Kathleen M. Rasmussen, Michael E. Reichenheim, Dayana Rodrigues Farias, Nathalia Cristina Freitas-Costa, Gilberto Kac
Summary: This study aimed to determine the ranges of gestational weight gain (GWG) associated with the lowest risks of adverse maternal and infant outcomes using Brazilian GWG charts. The findings showed that GWG z-scores were associated with large-for-gestational-age (LGA) and small-for-gestational-age (SGA) births, indicating the importance of GWG range in affecting maternal and neonatal outcomes.
AMERICAN JOURNAL OF CLINICAL NUTRITION
(2023)
Article
Medicine, General & Internal
Ethan K. Gough, Thaddeus J. Edens, Hyun Min Geum, Iman Baharmand, Sandeep K. Gill, Ruairi C. Robertson, Kuda Mutasa, Robert Ntozini, Laura E. Smith, Bernard Chasekwa, Florence D. Majo, Naume Tavengwa, Batsirai Mutasa, Freddy Francis, Lynnea Carr, Joice Tome, Rebecca J. Stoltzfus, Lawrence H. Moulton, Andrew J. Prendergast, Jean H. Humphrey, Amee R. Manges
Summary: The study in rural Zimbabwe found that the maternal intestinal microbiome composition and functions during pregnancy are closely related to infant birth weight and growth outcomes, with resistant starch-degrading bacteria playing a key role in predicting birth outcomes.
Article
Nutrition & Dietetics
Orianne Dumas, Anna Chen Arroyo, Mohammad Kamal Faridi, Kaitlyn James, Sarah Hsu, Camille Powe, Carlos A. Camargo
Summary: This study investigated the association between maternal gestational weight gain (GWG) and gestational diabetes mellitus (GDM) with childhood asthma. The findings showed no significant association between GWG and asthma, but a positive association between GDM and asthma, particularly among mothers with normal BMI.
Article
Endocrinology & Metabolism
Jessie Nallely Zurita-Cruz, Miguel Angel Villasis-Keever, Leticia Manuel-Apolinar, Leticia Damasio-Santana, Eulalia Garrido-Magana, Aleida de Jesus Rivera-Hernandez
Summary: In girls with central precocious puberty (CPP) undergoing GnRH analogs treatment, leptin levels and higher leptin/adiponectin ratio (LAR) are associated with greater weight gain. This association is particularly evident in girls with BMI < 94th percentile.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Nutrition & Dietetics
Yan Li, Xuezhen Zhou, Yu Zhang, Chunrong Zhong, Li Huang, Xi Chen, Renjuan Chen, Jiangyue Wu, Qian Li, Guoqiang Sun, Heng Yin, Guoping Xiong, Liping Hao, Nianhong Yang, Xuefeng Yang
Summary: This study found that a dietary pattern rich in beans and vegetables is beneficial for effectively controlling maternal weight gain and increasing birth weight.
FRONTIERS IN NUTRITION
(2021)
Article
Pediatrics
Raja Sriswan Mamidi, Santosh Kumar Banjara, Sridevi Manchala, Ch Khadar Babu, J. J. Babu Geddam, Naveen Kumar Boiroju, Bhaskar Varanasi, G. Neeraja, G. Venkat Raji Reddy, B. A. Ramalakshmi, R. Hemalatha, Gargi Meur
Summary: Maternal nutritional status and care during pregnancy play a crucial role in determining birth weight. This study found that low birthweight and small size for gestational age are associated with maternal body weight and composition, as well as preterm delivery and fewer antenatal check-ups.
Article
Pediatrics
Claudia Bohn, Mandy Vogel, Tanja Poulain, Ulrike Spielau, Cornelia Hilbert, Wieland Kiess, Antje Koerner
Summary: The study found that birth order can affect birth weight, with second-born and third-born or later children having significantly higher birth weights than first-born children. Maternal weight gain during pregnancy is associated with birth weight, but maternal weight gain is lower for higher birth orders.
Article
Biology
Marc Ditzhaus, Jon Genuneit, Arnold Janssen, Markus Pauly
Summary: We propose inference procedures for general factorial designs with time-to-event endpoints, which allows working without restrictive model assumptions as proportional hazards and can detect the crossing points of survival or hazard curves.
Review
Pediatrics
Linda P. Siziba, Sebastian Huhn, Elisabeth Puetz, Caroline Baier, Raphael S. Peter, Corinna Gebauer, Samantha Griffin, Sophie Wedekind, Natalie Shenker, Jon Genuneit
Summary: This scoping review provides an overview of the current state and emerging trends in donor human milk banking. The predominant topics identified were milk type and composition, and there is a lack of research on the associations between different milk types and infant outcomes. Further research is needed to explore the appropriateness of different funding sources and to foster collaborations between academics, clinicians, and milk banks in low-income or middle-income countries to improve access to donor human milk.
ARCHIVES OF DISEASE IN CHILDHOOD-FETAL AND NEONATAL EDITION
(2023)
Review
Public, Environmental & Occupational Health
Marko Mandic, Hengjing Li, Fatemeh Safizadeh, Tobias Niedermaier, Michael Hoffmeister, Hermann Brenner
Summary: This study aimed to assess if and to what extent potential bias from prediagnostic weight loss has been considered in available epidemiological evidence on the BMI-CRC association. After searching for systematic reviews and meta-analyses, it was found that none of them thoroughly considered or discussed prediagnostic weight loss as a potential source of bias. Results from individual cohort studies included in the latest review were reported heterogeneously, but effect estimates mostly increased with increasing length of exclusion of initial years of follow-up. The impact of overweight and obesity on CRC risk may be larger than suggested by the existing epidemiological evidence.
EUROPEAN JOURNAL OF EPIDEMIOLOGY
(2023)
Article
Oncology
Xuechen Chen, Thomas Heisser, Rafael Cardoso, Michael Hoffmeister, Hermann Brenner
Summary: Colorectal cancer (CRC) has higher incidence and mortality rates in men compared to women. A study estimated the risk advancement periods (RAPs) for men compared to women to determine at what age men reach comparable levels of risk. The results showed that men had significantly higher CRC risk in the age groups 50-59 and 60-69, with RAPs as high as 8.7 and 6.2 years earlier, respectively. This suggests the need for gender-specific screening starting ages in countries where screening starts above age 50.
INTERNATIONAL JOURNAL OF CANCER
(2023)
Review
Oncology
Daniele Campa, Manuel Gentiluomo, Angelika Stein, Mateus Nobrega Aoki, Martin Oliverius, Ludmila Vodickova, Krzysztof Jamroziak, George Theodoropoulos, Claudio Pasquali, William Greenhalf, Paolo Giorgio Arcidiacono, Faik Uzunoglu, Raffaele Pezzilli, Claudio Luchini, Marta Puzzono, Martin Loos, Matteo Giaccherini, Verena Katzke, Andrea Mambrini, Edita Kiudeliene, Kauffmann Emanuele Federico, Julia Johansen, Tamas Hussein, Beatrice Mohelnikova-Duchonova, Casper H. J. van Eijck, Hermann Brenner, Riccardo Farinella, Juan Sainz Perez, Martin Lovecek, Markus W. Buechler, Viktor Hlavac, Jakob R. Izbicki, Thilo Hackert, Roger Chammas, Alessandro Zerbi, Rita Lawlor, Alessio Felici, Mara Goetz, Gabriele Capurso, Laura Ginocchi, Maria Gazouli, Juozas Kupcinskas, Giulia Martina Cavestro, Pavel Vodicka, Stefania Moz, John P. Neoptolemos, Lumir Kunovsky, Stig E. Bojesen, Silvia Carrara, Domenica Gioffreda, Egidijus Morkunas, Olga Abian, Stefania Bunduc, Daniela Basso, Ugo Boggi, Barbara Wlodarczyk, Andrea Szentesi, Giuseppe Vanella, Inna Chen, Maarten F. Bijlsma, Vytautas Kiudelis, Stefano Landi, Ben Schoettker, Chiara Corradi, Nathalia Giese, Rudolf Kaaks, Giulia Peduzzi, Peter Hegyi, Luca Morelli, Niccolo Furbetta, Pavel Soucek, Anna Latiano, Renata Talar-Wojnarowska, Sidsel C. Lindgaard, Frederik Dijk, Anna Caterina Milanettoj, Francesca Tavano, Klara Cervena, Balint Eross, Sabrina G. Testoni, Judith H. E. Verhagen-Oldenampsen, E. Malecka-Wojciesko, Eithne Costello, Roberto Salvia, Evaristo Maiello, Stefano Ermini, Cosimo Sperti, Bernd Holleczek, Francesco Perri, Jurgita Skieceviciene, Livia Archibugi, Maurizio Lucchesi, Cosmeri Rizzato, Federico Canzian
Summary: Pancreatic cancer is a deadly disease with few known risk factors and susceptibility loci. The rarity of the disease and lack of adequate research power have hindered progress in understanding its genetic mechanisms. However, the PANDoRA consortium, the largest in Europe, has made significant contributions in discovering susceptibility loci, which will be crucial in developing preventive strategies.
CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY
(2023)
Article
Cardiac & Cardiovascular Systems
Lisa Pennells, Stephen Kaptoge, Helena Bleken Ostergaard, Stephanie H. Read, Fabrizio Carinci, Josep Franch-Nadal, Carmen Petitjean, Owen Taylor, Steven H. J. Hageman, Zhe Xu, Fanchao Shi, Sarah Spackman, Stefano Gualdi, Naomi Holman, Rui Bebiano Da Providencia E Costa, Fabrice Bonnet, Hermann Brenner, Richard F. Gillum, Stefan Kiechl, Deborah A. Lawlor, Louis Potier, Ben Schoettker, Reecha Sofat, Henry Voelzke, Johann Willeit, Zane Baltane, Stephen Fava, Sandor Janos, Astrid Lavens, Santa Pildava, Tamara Poljicanin, Ivan Pristas, Peter Rossing, Reiff Sascha, Christa Scheidt-Nave, Iztok Stotl, Gail Tibor, Vilma Urbancic-Rovan, An-Sofie Vanherwegen, Dorte Vistisen, Yong Du, Matthew R. Walker, Peter Willeit, Brian Ference, Dirk De Bacquer, Martin Halle, Radu Huculeci, John William McEvoy, Adam Timmis, Panagiotis Vardas, Jannick A. N. Dorresteijn, Ian Graham, Angela Wood, Bjorn Eliasson, William Herrington, John Danesh, Didac Mauricio, Massimo Massi Benedetti, Naveed Sattar, Frank L. J. Visseren, Sarah Wild, Emanuele Di Angelantonio, Beverley Balkau, Frederic Fumeron, Hannah Stocker, Bernd Holleczek, Sabine Schipf, Carsten Oliver Schmidt, Marcus Doerr, Herbert Tilg, Christoph Leitner, Marlene Notdurfter, Julie Taylor, Caroline Dale, David Prieto-Merino, Richard F. Gillum, Tamara Buble, Pero Ivanko, Bendix Carstensen, Christin Heidemann, Tibor Gall, Janos Sandor, Jana Lepiksone, Caroline J. Magri, Joseph Azzopardi, Jordi Real, Bogdan Vlacho, Manel Mata-Cases
Summary: The study aimed to develop and validate a recalibrated prediction model (SCORE2-Diabetes) for estimating the 10-year risk of cardiovascular disease (CVD) in individuals with type 2 diabetes in Europe. The model showed good discrimination and improvement over previous models, with risk predictions varying based on individuals' diabetes-related factors. SCORE2-Diabetes enhances the identification of individuals at higher risk of CVD in Europe.
EUROPEAN HEART JOURNAL
(2023)
Article
Public, Environmental & Occupational Health
Sha Sha, Tafirenyika Gwenzi, Li-Ju Chen, Hermann Brenner, Ben Schoettker
Summary: This study investigated the interrelationships between vitamin D deficiency, biomarkers of systemic inflammation response (SIR), and mortality. It found that vitamin D deficiency was associated with disadvantageous levels of blood cell count-based SIR biomarkers, but not with C-reactive protein (CRP)-based biomarkers. Vitamin D deficiency and all SIR biomarkers were significantly associated with all-cause mortality and mortality from cancer, cardiovascular, and respiratory disease. The study suggests that clinical interventions targeting both vitamin D deficiency and underlying causes of systemic inflammation may be beneficial.
EUROPEAN JOURNAL OF EPIDEMIOLOGY
(2023)
Article
Multidisciplinary Sciences
Michela C. Massi, Nicola R. Franco, Andrea Manzoni, Anna Maria Paganoni, Hanla A. Park, Michael Hoffmeister, Hermann Brenner, Jenny Chang-Claude, Francesca Ieva, Paolo Zunino
Summary: Within the precision medicine framework, the stratification of individual genetic susceptibility based on inherited DNA variation is crucial. Traditional Polygenic Risk Scores (PRS) approaches face challenges in modeling complex high-order non-linear SNP-SNP interactions and their effect on the phenotype. In this study, we propose a novel approach called High-order Interactions-aware Polygenic Risk Score (hiPRS), which incorporates high-order interactions and provides a simple and interpretable model. Through comprehensive simulations and real data analysis, hiPRS demonstrates superior performance in scoring and interpretability compared to state of the art methods.
Letter
Oncology
Tobias Niedermaier, Elizabeth Alwers, Xuechen Chen, Thomas Heisser, Michael Hoffmeister, Hermann Brenner
CANCER COMMUNICATIONS
(2023)
Letter
Oncology
Megha Bhardwaj, Ben Schoettker, Bernd Holleczek, Hermann Brenner
CANCER COMMUNICATIONS
(2023)
Article
Cell Biology
Jan Moritz Niehues, Philip Quirke, Nicholas P. West, Heike I. Grabsch, Marko van Treeck, Yoni Schirris, Gregory P. Veldhuizen, Gordon G. A. Hutchins, Susan D. Richman, Sebastian Foersch, Titus J. Brinker, Junya Fukuoka, Andrey Bychkov, Wataru Uegami, Daniel Truhn, Hermann Brenner, Alexander Brobeil, Michael Hoffmeister, Jakob Nikolas Kather
Summary: Deep learning can predict microsatellite instability (MSI) from routine histopathology slides of colorectal cancer (CRC). It is unclear whether DL can also predict other biomarkers with high performance and whether DL predictions generalize to external patient populations.
CELL REPORTS MEDICINE
(2023)
Article
Oncology
Zhunzhun Liu, Melissa S. Y. Thong, Daniela Doege, Lena Koch-Gallenkamp, Linda Weisser, Heike Bertram, Andrea Eberle, Bernd Holleczek, Alice Nennecke, Annika Waldmann, Sylke Ruth Zeissig, Ron Pritzkuleit, Hermann Brenner, Volker Arndt
Summary: This study explores the relationship between benefit finding/posttraumatic growth and health-related quality of life in long-term cancer survivors. The results show that lower levels of benefit finding are associated with better quality of life, while posttraumatic growth is associated with role functioning and global health status/quality of life. These findings provide further evidence that benefit finding and posttraumatic growth are two distinct positive psychological concepts.
Review
Computer Science, Artificial Intelligence
Tanwei Yuan, Dominic Edelmann, Ziwen Fan, Elizabeth Alwers, Jakob Nikolas Kather, Hermann Brenner, Michael Hoffmeister
Summary: This systematic review discusses the use of machine learning in epigenome-wide studies for identifying DNA methylation biomarkers associated with cancer prognosis. The study reveals that there is a lack of performance evaluation and methodological flaws in the current approaches.
ARTIFICIAL INTELLIGENCE IN MEDICINE
(2023)
Article
Oncology
Pooja K. Middha, Xiaoliang Wang, Sabine Behrens, Manjeet K. Bolla, Qin Wang, Joe Dennis, Kyriaki Michailidou, Thomas U. Ahearn, Irene L. Andrulis, Hoda Anton-Culver, Volker Arndt, Kristan J. Aronson, Paul L. Auer, Annelie Augustinsson, Thais Baert, Laura E. Beane Freeman, Heiko Becher, Matthias W. Beckmann, Javier Benitez, Stig E. Bojesen, Hiltrud Brauch, Hermann Brenner, Angela Brooks-Wilson, Daniele Campa, Federico Canzian, Angel Carracedo, Jose E. Castelao, Stephen J. Chanock, Georgia Chenevix-Trench, Emilie Cordina-Duverger, Fergus J. Couch, Angela Cox, Simon S. Cross, Kamila Czene, Laure Dossus, Pierre-Antoine Dugue, A. Heather Eliassen, Mikael Eriksson, D. Gareth Evans, Peter A. Fasching, Jonine Figueroa, Olivia Fletcher, Henrik Flyger, Marike Gabrielson, Manuela Gago-Dominguez, Graham G. Giles, Anna Gonzalez-Neira, Felix Grassmann, Anne Grundy, Pascal Guenel, Christopher A. Haiman, Niclas Hakansson, Per Hall, Ute Hamann, Susan E. Hankinson, Elaine F. Harkness, Bernd Holleczek, Reiner Hoppe, John L. Hopper, Richard S. Houlston, Anthony Howell, David J. Hunter, Christian Ingvar, Karolin Isaksson, Helena Jernstroem, Esther M. John, Michael E. Jones, Rudolf Kaaks, Renske Keeman, Cari M. Kitahara, Yon-Dschun Ko, Stella Koutros, Allison W. Kurian, James V. Lacey, Diether Lambrechts, Nicole L. Larson, Susanna Larsson, Loic Le Marchand, Flavio Lejbkowicz, Shuai Li, Martha Linet, Jolanta Lissowska, Maria Elena Martinez, Tabea Maurer, Anna Marie Mulligan, Claire Mulot, Rachel A. Murphy, William G. Newman, Sune F. Nielsen, Borge G. Nordestgaard, Aaron Norman, Katie M. O'Brien, Janet E. Olson, Alpa V. Patel, Ross Prentice, Erika Rees-Punia, Gad Rennert, Valerie Rhenius, Kathryn J. Ruddy, Dale P. Sandler, Christopher G. Scott, Mitul T. Shah, Xiao-Ou Shu, Ann Smeets, Melissa C. Southey, Jennifer Stone, Rulla M. Tamimi, Jack A. Taylor, Lauren R. Teras, Katarzyna Tomczyk, Melissa A. Troester, Therese Truong, Celine M. Vachon, Sophia S. Wang, Clarice R. Weinberg, Hans Wildiers, Walter Willett, Stacey J. Winham, Alicja Wolk, Xiaohong Yang, M. Pilar Zamora, Wei Zheng, Argyrios Ziogas, Alison M. Dunning, Paul D. P. Pharoah, Montserrat Garcia-Closas, Marjanka K. Schmidt, Peter Kraft, Roger L. Milne, Sara Lindstroem, Douglas F. Easton, Jenny Chang-Claude
Summary: A genome-wide study identified two independent SNP-risk factor pairs associated with breast cancer risk and estrogen receptor positive (ER +) breast cancer risk. Overall, gene-environment interactions have a very small contribution to the heritability of breast cancer. At the population level, these interactions do not significantly contribute to risk prediction for breast cancer.
BREAST CANCER RESEARCH
(2023)
Article
Cardiac & Cardiovascular Systems
Julia Karady, Thomas Mayrhofer, James L. Januzzi, James E. Udelson, Jerome L. Fleg, Bela Merkely, Michael T. Lu, William F. Peacock, John T. Nagurney, Wolfgang Koenig, Maros Ferencik, Udo Hoffmann
Summary: This study aimed to determine the concordance of different high-sensitivity cardiac troponin (hs-cTn) assays in risk stratification for cardiovascular disease and compare the differences in patient management, cost, and predicted quality of care.
EUROPEAN HEART JOURNAL-ACUTE CARDIOVASCULAR CARE
(2023)
