CMT-linked loss-of-function mutations in GDAP1 impair store-operated Ca2+ entry-stimulated respiration

Enhanced Store-Operated Calcium Entry Leads to Striatal Synaptic Loss in a Huntington's Disease Mouse Model

(2016) J. Wu et al.   JOURNAL OF NEUROSCIENCE

Selective Vulnerability of Cancer Cells by Inhibition of Ca2+ Transfer from Endoplasmic Reticulum to Mitochondria

(2016) César Cárdenas et al.   Cell Reports

Store-operated calcium entry compensates fast ER calcium loss in resting hippocampal neurons

(2015) Samira Samtleben et al.   CELL CALCIUM

CCDC90A (MCUR1) Is a Cytochrome c Oxidase Assembly Factor and Not a Regulator of the Mitochondrial Calcium Uniporter

(2015) Vincent Paupe et al.   Cell Metabolism

The Ins and Outs of Mitochondrial Calcium

(2015) T. Finkel et al.   CIRCULATION RESEARCH

The regulation of neuronal mitochondrial metabolism by calcium

(2015) I. Llorente-Folch et al.   JOURNAL OF PHYSIOLOGY-LONDON

Store-Operated Calcium Channels

(2015) Murali Prakriya et al.   PHYSIOLOGICAL REVIEWS

Stim and Orai proteins in neuronal Ca2+ signaling and excitability

(2015) Francesco Moccia et al.   Frontiers in Cellular Neuroscience

The Mitochondrial Calcium Uniporter Matches Energetic Supply with Cardiac Workload during Stress and Modulates Permeability Transition

(2015) Timothy S. Luongo et al.   Cell Reports

The Mitochondrial Calcium Uniporter Selectively Matches Metabolic Output to Acute Contractile Stress in the Heart

(2015) Jennifer Q. Kwong et al.   Cell Reports

Lack of GDAP1 Induces Neuronal Calcium and Mitochondrial Defects in a Knockout Mouse Model of Charcot-Marie-Tooth Neuropathy

(2015) Manuela Barneo-Muñoz et al.   PLoS Genetics

Ca2+ regulation of mitochondrial function in neurons

(2014) Carlos B. Rueda et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS

The Gdap1 knockout mouse mechanistically links redox control to Charcot–Marie–Tooth disease

(2014) Axel Niemann et al.   BRAIN

Junctophilin-1 is a modifier gene of GDAP1-related Charcot–Marie–Tooth disease

(2014) David Pla-Martín et al.   HUMAN MOLECULAR GENETICS

IP3-mediated STIM1 oligomerization requires intact mitochondrial Ca2+ uptake

(2014) A. T. Deak et al.   JOURNAL OF CELL SCIENCE

STIM1 Controls Neuronal Ca2+ Signaling, mGluR1-Dependent Synaptic Transmission, and Cerebellar Motor Behavior

(2014) Jana Hartmann et al.   NEURON

Mitochondrial Calcium Uniporter MCU Supports Cytoplasmic Ca2+ Oscillations, Store-Operated Ca2+ Entry and Ca2+-Dependent Gene Expression in Response to Receptor Stimulation

(2014) Krishna Samanta et al.   PLoS One

Charcot-Marie-Tooth disease-associated mutants of GDAP1 dissociate its roles in peroxisomal and mitochondrial fission

(2013) Nina Huber et al.   EMBO REPORTS

Calcium-Regulation of Mitochondrial Respiration Maintains ATP Homeostasis and Requires ARALAR/AGC1-Malate Aspartate Shuttle in Intact Cortical Neurons

(2013) I. Llorente-Folch et al.   JOURNAL OF NEUROSCIENCE

Clinical implications of genetic advances in Charcot–Marie–Tooth disease

(2013) Alexander M. Rossor et al.   Nature Reviews Neurology

Silencing of the Charcot–Marie–Tooth disease-associated gene GDAP1 induces abnormal mitochondrial distribution and affects Ca2+ homeostasis by reducing store-operated Ca2+ entry

(2013) David Pla-Martín et al.   NEUROBIOLOGY OF DISEASE

Dominant GDAP1 founder mutation is a common cause of axonal Charcot-Marie-Tooth disease in Finland

(2013) Mari Auranen et al.   NEUROGENETICS

Charcot-Marie-Tooth disease: Genetic and clinical spectrum in a Spanish clinical series

(2013) R. Sivera et al.   NEUROLOGY

Role of Mitochondrial Ca2+ in the Regulation of Cellular Energetics

(2012) Brian Glancy et al.   BIOCHEMISTRY

Mitochondrial dynamics and their impact on T cell function

(2012) Ariel Quintana et al.   CELL CALCIUM

MCUR1 is an essential component of mitochondrial Ca2+ uptake that regulates cellular metabolism

(2012) Karthik Mallilankaraman et al.   NATURE CELL BIOLOGY

Mitochondria as sensors and regulators of calcium signalling

(2012) Rosario Rizzuto et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Assessing mitochondrial dysfunction in cells

(2011) Martin D. Brand et al.   BIOCHEMICAL JOURNAL

Charcot–Marie–Tooth disease CMT4A: GDAP1 increases cellular glutathione and the mitochondrial membrane potential

(2011) Rebecca Noack et al.   HUMAN MOLECULAR GENETICS

Mitofusin 2 Regulates STIM1 Migration from the Ca2+Store to the Plasma Membrane in Cells with Depolarized Mitochondria

(2011) Karthika Singaravelu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Dominant GDAP1 mutations cause predominantly mild CMT phenotypes

(2011) M. Zimon et al.   NEUROLOGY

Essential Regulation of Cell Bioenergetics by Constitutive InsP3 Receptor Ca2+ Transfer to Mitochondria

(2010) César Cárdenas et al.   CELL

Genetic epidemiology of Charcot-Marie-Tooth in the general population

(2010) G. J. Braathen et al.   EUROPEAN JOURNAL OF NEUROLOGY

Mitochondrial dysfunction and pathophysiology of Charcot–Marie–Tooth disease involving GDAP1 mutations

(2010) Julien Cassereau et al.   EXPERIMENTAL NEUROLOGY

Phenotypical features of the p.R120W mutation in the GDAP1 gene causing autosomal dominant Charcot-Marie-Tooth disease

(2010) Rafael Sivera et al.   JOURNAL OF THE PERIPHERAL NERVOUS SYSTEM

Alterations in bioenergetics due to changes in mitochondrial DNA copy number

(2010) Wei Qian et al.   METHODS

GDAP1 mutations differ in their effects on mitochondrial dynamics and apoptosis depending on the mode of inheritance

(2009) Axel Niemann et al.   NEUROBIOLOGY OF DISEASE

Targeting and Function of the Mitochondrial Fission Factor GDAP1 Are Dependent on Its Tail-Anchor

(2009) Konstanze M. Wagner et al.   PLoS One

Mechanisms underlying the loss of mitochondrial membrane potential in glutamate excitotoxicity

(2008) Andrey Y. Abramov et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS

Cell expression of GDAP1 in the nervous system and pathogenesis of Charcot-Marie-Tooth type 4A disease

(2008) Laia Pedrola et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Functional relevance of the de novo coupling between hTRPC1 and type II IP3 receptor in store-operated Ca2+ entry in human platelets

(2007) Isaac Jardín et al.   CELLULAR SIGNALLING