Article
Oncology
Mengyan Wang, Mingna Zhao, Qiaomei Guo, Jiatao Lou, Lin Wang
Summary: The study revealed that miR-17-5p promotes osteoclastogenesis in lung cancer through the PI3K/Akt pathway and has negative regulatory effects on PTEN.
EXPERIMENTAL CELL RESEARCH
(2021)
Article
Oncology
Wenxiao Yang, Yinan Yin, Ling Bi, Yichao Wang, Jialin Yao, Ling Xu, Lijing Jiao
Summary: miR-182-5p is upregulated in NSCLC tissues and acts as an independent prognostic factor for tumor recurrence in NSCLC patients. It promotes NSCLC progression by targeting EPAS1, which may serve as a potential indicator of tumor recurrence in NSCLC patients.
Article
Oncology
Junhui Ye, Wujun Luo, Lingling Luo, Limin Zhai, Pingping Huang
Summary: This study found that miR-671-5p is downregulated in non-small cell lung cancer (NSCLC) and its low expression is associated with advanced tumor stage and lymph node metastasis. miR-671-5p inhibits the proliferative, migratory, and invasive abilities of NSCLC cells by targeting the MFAP3L gene. Targeting the miR-671-5p/MFAP3L signaling pathway may be a promising therapeutic strategy for NSCLC.
MOLECULAR MEDICINE REPORTS
(2022)
Article
Oncology
Haibo Han, Bo Pan, Fan Liang, Lina Wu, Xijuan Liu, Yue Yang, Jinfeng Chen
Summary: The study demonstrates that miR-224 plays a significant role in lymphatic metastasis of non-small-cell lung cancer and may serve as a potential biomarker for predicting lymphatic metastasis.
Article
Medicine, Research & Experimental
Jinbao Zhou, Hongshu Wang, Qiangling Sun, Xiaomin Liu, Zong Wu, Xianyi Wang, Wentao Fang, Zhongliang Ma
Summary: NSCLC is a common form of cancer, and exosomes enriched with miR-224-5p promote tumor growth and metastasis. miR-224-5p affects NSCLC tumor growth by inhibiting AR and mediating EMT.
MOLECULAR THERAPY-NUCLEIC ACIDS
(2021)
Article
Biotechnology & Applied Microbiology
Dijian Shen, Jianqiang Li, Kaiyi Tao, Youhua Jiang
Summary: MCM3AP-AS1 is overexpressed in NSCLC, promoting cell proliferation, migration, and invasion while also regulating the expression of multiple related genes. It acts as a molecule sponge for miR-195-5p to modulate E2F3 expression, suggesting it as a potential therapeutic target for NSCLC.
Article
Medical Laboratory Technology
Limei Wang, Zhiyong Zhang, Hui Tian
Summary: This study demonstrated the involvement of hsa_circ_0092887 in paclitaxel resistance in non-small cell lung cancer (NSCLC). Silencing hsa_circ_0092887 inhibited cell proliferation and migration, induced apoptosis, and suppressed tumor growth in PTX-treated NSCLC cells in vitro and in vivo. Hsa_circ_0092887 regulated PTX resistance through the miR-490-5p/UBE2T axis.
JOURNAL OF CLINICAL LABORATORY ANALYSIS
(2023)
Article
Nanoscience & Nanotechnology
Guoqing Gu, Chenxi Hu, Kaiyuan Hui, Huiqin Zhang, Ting Chen, Xin Zhang, Xiaodong Jiang
Summary: This study revealed that high levels of plasma exosomal miR-136-5p are associated with poor clinical response to anlotinib. Anlotinib-resistant NSCLC cells transfer functional miR-136-5p to parental NSCLC cells via exosomes, promoting cell proliferation. Furthermore, miR-136-5p confers anlotinib resistance by targeting PPP2R2A and activating the Akt pathway.
INTERNATIONAL JOURNAL OF NANOMEDICINE
(2021)
Article
Cell Biology
Zixu Bao, Ning Zhang, Wanxiang Niu, Maolin Mu, Xiaoming Zhang, Shanshan Hu, Chaoshi Niu
Summary: Exosomes released from glioma stem-like cells (GSCs) containing miR-155-5p can be horizontally transferred to surrounding glioma cells, promoting tumor progression and mesenchymal transition by targeting ACOT12. High expression of miR-155-5p in plasma exosomes is associated with glioma diagnosis and grading, suggesting its potential as a predictive biomarker for glioma.
CELL DEATH & DISEASE
(2022)
Article
Cell Biology
Mengling Ye, Lu Zhao, Lu Zhang, Siyi Wu, Zhao Li, Yi Qin, Fei Lin, Linghui Pan
Summary: Colorectal cancer is a common tumor worldwide, and long non-coding RNAs play important roles in its development. This study reveals that NALT1 promotes the proliferation and migration of colorectal cancer cells by competitively regulating the expression of miRNA-574-5p and PEG10. These findings suggest the potential of NALT1 as a biomarker and therapeutic target for colorectal cancer.
CELL DEATH & DISEASE
(2022)
Article
Medicine, Research & Experimental
Qiang Guo, Haijun Wang, Yanzhao Xu, Mingbo Wang, Ziqiang Tian
Summary: The study indicates that miR-374a-5p acts as a tumor suppressor in NSCLC by targeting NCK1, leading to inhibition of cell proliferation and migration. Lower levels of miR-374a-5p were observed in NSCLC cells compared to normal cells, highlighting the importance of the miR-374a-5p/NCK1 axis in NSCLC.
EXPERIMENTAL AND THERAPEUTIC MEDICINE
(2021)
Article
Cell Biology
Zhe Liu, Liang Ma, Yiming Sun, Wenying Yu, Xue Wang
Summary: The study demonstrated that the STAT3/ZEB1 axis is critical in gefitinib resistance in lung cancer, and a new potential therapeutic strategy targeting STAT3 has been identified with the inhibitor LL1. LL1 was shown to sensitize resistant cells to gefitinib by depleting STAT3 activity and blocking its signaling pathways, with little observed toxicity in animal models, indicating it could be a chemotherapeutic adjuvant for gefitinib resistance in NSCLC.
CELL DEATH & DISEASE
(2021)
Article
Oncology
Zeyong Jiang, Jian Zhao, Hanlin Zou, Kaican Cai
Summary: This study found that circRNA PTPRM (circPTPRM) promotes the progression of non-small-cell lung cancer (NSCLC) by regulating the miR-139-5p/SETD5 axis. The results show that the knockdown of circPTPRM inhibits cell proliferation, migration, and invasion, and this effect can be reversed by a miR-139-5p inhibitor.
TECHNOLOGY IN CANCER RESEARCH & TREATMENT
(2022)
Article
Cell Biology
Ji Nie, Ruian Yang, Ran Zhou, Yi Deng, Dengyuan Li, Deming Gou, Yunhui Zhang
Summary: The study revealed that circFARSA is upregulated in NSCLC and associated with poor prognosis. Knockdown of circFARSA inhibited cell proliferation, migration, and invasion, while overexpression had opposite effects. CircFARSA may promote NSCLC development by modulating miR-15a-5p and B7H3 expression.
Review
Pharmacology & Pharmacy
Jia-Qi Xu, Yan-Li Fu, Jing Zhang, Kai-Yu Zhang, Jie Ma, Jing-Yi Tang, Zhi-Wei Zhang, Zhong-Yan Zhou
Summary: Metabolic disturbance, particularly of glucose metabolism, is a hallmark of tumors such as non-small cell lung cancer (NSCLC). This review focuses on research advances in glycolysis in NSCLC and systematically provides an overview of the key enzymes, biomarkers, non-coding RNAs, and signaling pathways that modulate the glycolysis process and, consequently, tumor growth and metastasis in NSCLC. Current medications, therapeutic approaches, and natural products that affect glycolysis in NSCLC are also summarized. The development of metabolic intervention that targets glycolysis, alone or in combination with current therapy, is a potential therapeutic approach in NSCLC treatment.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Cell Biology
Qingbo Wang, Yongming Huang, Rui Zhou, Ke Wu, Wei Li, Liang Shi, Zefeng Xia, Kaixiong Tao, Guobin Wang, Geng Wang
WOUND REPAIR AND REGENERATION
(2020)
Article
Surgery
Geng Wang, Qingbo Wang, Jie Bai, Ning Zhao, Yu Wang, Rui Zhou, Wen Kong, Tianshu Zeng, Kaixiong Tao, Guobin Wang, Zefeng Xia
Retraction
Oncology
Chun-Hua Wei, Gang Wu, Qian Cai, Xi-Can Gao, Fan Tong, Rui Zhou, Rui-Guang Zhang, Ji-Hua Dong, Yu Hu, Xiao- Rong Dong
JOURNAL OF HEMATOLOGY & ONCOLOGY
(2020)
Article
Biochemistry & Molecular Biology
Xiaohua Jie, William Pat Fong, Rui Zhou, Ye Zhao, Yingchao Zhao, Rui Meng, Sheng Zhang, Xiaorong Dong, Tao Zhang, Kunyu Yang, Gang Wu, Shuangbing Xu
Summary: This study found that overexpression of KDM4C is associated with poor prognosis in lung cancer patients; genetic or pharmacological inhibition of KDM4C can reduce tumorigenesis and radioresistance in lung cancer; USP9X-mediated deubiquitination of KDM4C activates TGF-beta 2/Smad signaling pathway to promote radioresistance in lung cancer.
CELL DEATH AND DIFFERENTIATION
(2021)
Correction
Oncology
Jing Guo, Rui Meng, Zhongyuan Yin, Pengcheng Li, Rui Zhou, Sheng Zhang, Xiaorong Dong, Li Liu, Gang Wu
MOLECULAR MEDICINE REPORTS
(2021)
Article
Surgery
Yu Wang, Geng Wang, Jie Bai, Ning Zhao, Qingbo Wang, Rui Zhou, Gang Li, Chaojie Hu, Xin Li, Kaixiong Tao, Zefeng Xia, Guobin Wang
Summary: The study found that sleeve gastrectomy increased the levels of I3A, which correlated with liver CT values and fat attenuation. In mouse models, surgery increased the percentage of M2 macrophages in the liver. Both oral and in vitro stimulation of I3A promoted M2 differentiation without significantly affecting hepatocytes.
Article
Cell Biology
Xiaoshu Zhou, Rui Zhou, Xinrui Rao, Jiaxin Hong, Qianwen Li, Xiaohua Jie, Jian Wang, Yingzhuo Xu, Kuikui Zhu, Zhenyu Li, Gang Wu
Summary: This study demonstrated that apatinib could reprogram glutamine metabolism in human NSCLC cells through activation of the amino acid response pathway, indicating that targeting ATF4 is a potential therapeutic strategy for relieving apatinib resistance.
CELL DEATH & DISEASE
(2022)
Article
Oncology
Xinrui Rao, Biyuan Xing, Zilong Wu, Yawen Bin, Yunshang Chen, Yingzhuo Xu, Dong Zhou, Xiaoshu Zhou, Chuangyan Wu, Wang Ye, Weibin Chen, Geng Wang, Sheng Zhang, Xiaorong Dong, Rui Meng, Gang Wu, Rui Zhou
Summary: POLQ, an overexpressed DNA polymerase in non-small-cell lung cancer (NSCLC), is correlated with high tumor stage, poor prognosis, increased tumor mutational burden, and ALK and TP5 mutation status. Inhibition of POLQ impairs lung tumorigenesis and enhances radiosensitivity by prolonging the G2/M phase and promoting faster DNA damage repair. Novobiocin (NVB), a specific POLQ inhibitor, targets cancer cells without causing significant toxicity to normal pulmonary epithelial cells. These findings suggest that POLQ is a promising target for improving radiotherapy efficacy in NSCLC.
Article
Endocrinology & Metabolism
Geng Wang, Yu Wang, Jie Bai, Gang Li, Yang Liu, Shichang Deng, Rui Zhou, Kaixiong Tao, Zefeng Xia
Summary: Bariatric surgery can increase plasma genistein levels by altering the gut microbiota, which helps alleviate non-alcoholic fatty liver disease (NAFLD).
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Surgery
Geng Wang, Yuanjue Wu, Yang Cao, Rui Zhou, Kaixiong Tao, Linfang Wang
Summary: This study aims to evaluate potential factors affecting postoperative pain in hemorrhoidectomy patients. The results show that preoperative depression and the amount of excisional hemorrhoids are related to postsurgical pain.
FRONTIERS IN SURGERY
(2023)
Article
Biology
Xinrui Rao, Hongyuan Liu, Yuewen Zhang, Yaqiong Xie, Geng Wang, Sheng Zhang, Gang Wu, Ye Wang, Rui Zhou
Summary: This study aimed to investigate the role of BMI in non-small cell lung cancer patients' radiation treatment, and the results revealed that higher BMI may be associated with setup error, dosimetric parameters, and the incidence of radiation pneumonitis.
INTERNATIONAL JOURNAL OF RADIATION BIOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Michelle L. Swift, Rui Zhou, Aleem Syed, Lisa A. Moreau, Bartlomiej Tomasik, John A. Tainer, Panagiotis A. Konstantinopoulos, Alan D. D'Andrea, Yizhou Joseph He, Dipanjan Chowdhury
Summary: DYNLL1 works with the Shieldin complex to protect DNA ends and limit end resection, while Shieldin localization depends on MRE11 activity and is regulated by the interaction of DYNLL1 with MRE11. The constitutive association of DYNLL1 with MRE11 can resensitize BRCA1-deficient cells to PARP inhibitors.
NATURE STRUCTURAL & MOLECULAR BIOLOGY
(2023)
Article
Respiratory System
Xinrui Rao, Dong Zhou, Huilin Deng, Yunshang Chen, Jian Wang, Xiaoshu Zhou, Xiaohua Jie, Yingzhuo Xu, Zilong Wu, Geng Wang, Xiaorong Dong, Sheng Zhang, Rui Meng, Chuangyan Wu, Shijie Xing, Kai Fan, Gang Wu, Rui Zhou
Summary: This study demonstrates the critical role of NLRP3 inflammasome activation in radiation-induced lung injury. Targeting NLRP3 pathway may be a potential therapeutic strategy for reducing radiation-induced lung injury in clinical settings.
RESPIRATORY RESEARCH
(2023)
Review
Oncology
Xinrui Rao, Weibing Chen, Ji Li, Gang Peng, Gang Wu, Rui Zhou, Qian Ding
Summary: Primary thymic atypical carcinoid (TAC) is an extremely rare neuroendocrine tumor with high malignant potential and poor prognosis. Treatment options for TAC have not been extensively studied in multicenter clinical trials. This case report highlights a patient with multiple axial skeleton metastases from TAC who opted for palliative care and succumbed to the disease within a short timeframe.
MOLECULAR AND CLINICAL ONCOLOGY
(2021)
Article
Medicine, Research & Experimental
Guojun Yao, Jing Tang, Xijie Yang, Ye Zhao, Rui Zhou, Rui Meng, Sheng Zhang, Xiaorong Dong, Tao Zhang, Kunyu Yang, Gang Wu, Shuangbing Xu
