Friedelin Synthase from Maytenus ilicifolia: Leucine 482 Plays an Essential Role in the Production of the Most Rearranged Pentacyclic Triterpene

A conserved amino acid residue critical for product and substrate specificity in plant triterpene synthases

(2016) Melissa Salmon et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Pristimerin Inhibits Prostate Cancer Bone Metastasis by Targeting PC-3 Stem Cell Characteristics and VEGF-Induced Vasculogenesis of BM-EPCs

(2015) Shuai Huang et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

β-Amyrin Biosynthesis: The Methyl-30 Group of (3S)-2,3-Oxidosqualene Is More Critical to Its Correct Folding To Generate the Pentacyclic Scaffold than the Methyl-24 Group

(2015) Tsutomu Hoshino et al.   CHEMISTRY-A EUROPEAN JOURNAL

Protective effects of friedelin isolated from Azima tetracantha Lam. against ethanol-induced gastric ulcer in rats and possible underlying mechanisms

(2015) Paulrayer Antonisamy et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Control of the 1,2-rearrangement process by oxidosqualene cyclases during triterpene biosynthesis

(2015) Shohei Takase et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Triterpene Biosynthesis in Plants

(2014) Ramesha Thimmappa et al.   Annual Review of Plant Biology

Pristimerin, a naturally occurring triterpenoid, protects against autoimmune arthritis by modulating the cellular and soluble immune mediators of inflammation and tissue damage

(2014) Li Tong et al.   CLINICAL IMMUNOLOGY

Pristimerin, a natural anti-tumor triterpenoid, inhibits LPS-induced TNF-α and IL-8 production through down-regulation of ROS-related classical NF-κB pathway in THP-1 cells

(2014) Bin Hui et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

A new cinnamoylglycoflavonoid, antimycobacterial and antioxidant constituents fromHeritiera littoralisleaf extracts

(2014) R. Christopher et al.   NATURAL PRODUCT RESEARCH

Anti-Inflammatory Effect of Pristimerin on Lipopolysaccharide-Induced Inflammatory Responses in Murine Macrophages

(2013) Hyeon Jin Kim et al.   ARCHIVES OF PHARMACAL RESEARCH

Antiproliferative Effect and the Isolated Compounds ofPouzolzia indica

(2013) Chanyapat Sangsuwon et al.   Evidence-based Complementary and Alternative Medicine

Antioxidant, free radical scavenging and liver protective effects of friedelin isolated from Azima tetracantha Lam. leaves

(2013) Christudas Sunil et al.   FOOD CHEMISTRY

Protein engineering of oxidosqualene-lanosterol cyclase into triterpene monocyclase

(2013) Cheng-Hsiang Chang et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Antifungal Activity of Maytenin and Pristimerin

(2012) Fernanda P. Gullo et al.   Evidence-based Complementary and Alternative Medicine

Combined experimental powder X-ray diffraction and DFT data to obtain the lowest energy molecular conformation of friedelin

(2012) Djalma Menezes de Oliveira et al.   QUIMICA NOVA

Anti-inflammatory, analgesic and antipyretic effects of friedelin isolated fromAzima tetracanthaLam. in mouse and rat models

(2011) Paulrayer Antonisamy et al.   JOURNAL OF PHARMACY AND PHARMACOLOGY

Divergent evolution of oxidosqualene cyclases in plants

(2011) Zheyong Xue et al.   NEW PHYTOLOGIST

Antifungal activity of triterpenoid isolated from Azima tetracantha leaves.

(2010) V Duraipandiyan et al.   FOLIA HISTOCHEMICA ET CYTOBIOLOGICA

Cloning and Characterization of Oxidosqualene Cyclases fromKalanchoe daigremontiana

(2010) Zhonghua Wang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Evaluation of Antioxidant Capacity and Synergistic Associations of Quinonemethide Triterpenes and Phenolic Substances from Maytenus ilicifolia (Celastraceae)

(2010) Vânia Aparecida de Freitas Formenton Macedo dos Santos et al.   MOLECULES

Two Oxidosqualene Cyclases Responsible for Biosynthesis of Tomato Fruit Cuticular Triterpenoids

(2010) Z. Wang et al.   PLANT PHYSIOLOGY

Variabilidade química de compostos orgânicos voláteis e semivoláteis de populações nativas de Maytenus ilicifolia

(2010) Altemir José Mossi et al.   QUIMICA NOVA

Simple and efficient site-directed mutagenesis using two single-primer reactions in parallel to generate mutants for protein structure-function studies

(2009) Oded Edelheit et al.   BMC BIOTECHNOLOGY

AutoDock4 and AutoDockTools4: Automated docking with selective receptor flexibility

(2009) Garrett M. Morris et al.   JOURNAL OF COMPUTATIONAL CHEMISTRY

Saccharomyces cerevisiaeoxidosqualene-lanosterol cyclase: A chemistry-biology interdisciplinary study of the protein's structure-function-reaction mechanism relationships

(2008) Tung-Kung Wu et al.   CHEMICAL RECORD