High fat diet-induced TGF-β/Gbb signaling provokes insulin resistance through the tribbles expression

Tribbles homologue 3 stimulates canonical TGF-β signalling to regulate fibroblast activation and tissue fibrosis

(2015) Michal Tomcik et al.   ANNALS OF THE RHEUMATIC DISEASES

Strategies for exploring TGF-β signaling in Drosophila

(2014) Aidan J. Peterson et al.   METHODS

Drosophila Tribbles Antagonizes Insulin Signaling-Mediated Growth and Metabolism via Interactions with Akt Kinase

(2014) Rahul Das et al.   PLoS One

Tribbles 3 mediates endoplasmic reticulum stress-induced insulin resistance in skeletal muscle

(2013) Ho-Jin Koh et al.   Nature Communications

A Drosophila Model of High Sugar Diet-Induced Cardiomyopathy

(2013) Jianbo Na et al.   PLoS Genetics

Mechanisms for Insulin Resistance: Common Threads and Missing Links

(2012) Varman T. Samuel et al.   CELL

PTEN Mutations as a Cause of Constitutive Insulin Sensitivity and Obesity

(2012) Aparna Pal et al.   NEW ENGLAND JOURNAL OF MEDICINE

Getting ‘Smad’ about obesity and diabetes

(2012) C K Tan et al.   Nutrition & Diabetes

Minibrain/Dyrk1a Regulates Food Intake through the Sir2-FOXO-sNPF/NPY Pathway in Drosophila and Mammals

(2012) Seung-Hyun Hong et al.   PLoS Genetics

The roles of transforming growth factor-β and Smad3 signaling in adipocyte differentiation and obesity

(2011) Yuya Tsurutani et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Dock/Nck facilitates PTP61F/PTP1B regulation of insulin signalling

(2011) Chia-Lun Wu et al.   BIOCHEMICAL JOURNAL

Protection from Obesity and Diabetes by Blockade of TGF-β/Smad3 Signaling

(2011) Hariom Yadav et al.   Cell Metabolism

Smad3 Deficiency in Mice Protects Against Insulin Resistance and Obesity Induced by a High-Fat Diet

(2011) C. K. Tan et al.   DIABETES

A high-sugar diet produces obesity and insulin resistance in wild-type Drosophila

(2011) L. Palanker Musselman et al.   Disease Models & Mechanisms

Drosophila Genome-wide Obesity Screen Reveals Hedgehog as a Determinant of Brown versus White Adipose Cell Fate

(2010) J. Andrew Pospisilik et al.   CELL

High-Fat-Diet-Induced Obesity and Heart Dysfunction Are Regulated by the TOR Pathway in Drosophila

(2010) Ryan T. Birse et al.   Cell Metabolism

Aberrant hepatic TRIB3 gene expression in insulin-resistant obese humans

(2010) H. Oberkofler et al.   DIABETOLOGIA

Association of serum bone morphogenetic protein 4 levels with obesity and metabolic syndrome in non-diabetic individuals

(2010) Jang-Won Son et al.   ENDOCRINE JOURNAL

Gbb/BMP signaling is required to maintain energy homeostasis in Drosophila

(2009) Shannon L. Ballard et al.   DEVELOPMENTAL BIOLOGY

The Perfect Storm: Obesity, Adipocyte Dysfunction, and Metabolic Consequences

(2008) S. de Ferranti et al.   CLINICAL CHEMISTRY

Drosophila short neuropeptide F signalling regulates growth by ERK-mediated insulin signalling

(2008) Kyu-Sun Lee et al.   NATURE CELL BIOLOGY

Adipocyte dysfunctions linking obesity to insulin resistance and type 2 diabetes

(2008) Adilson Guilherme et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Reduction of DILP2 in Drosophila Triages a Metabolic Phenotype from Lifespan Revealing Redundancy and Compensation among DILPs

(2008) Susan Broughton et al.   PLoS One