Rational improvement of gp41-targeting HIV-1 fusion inhibitors: an innovatively designed Ile-Asp-Leu tail with alternative conformations

Improved Pharmacological and Structural Properties of HIV Fusion Inhibitor AP3 over Enfuvirtide: Highlighting Advantages of Artificial Peptide Strategy

(2015) Xiaojie Zhu et al.   Scientific Reports

The M-T hook structure increases the potency of HIV-1 fusion inhibitor sifuvirtide and overcomes drug resistance

(2014) Huihui Chong et al.   JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY

Probing the paramyxovirus fusion (F) protein-refolding event from pre- to postfusion by oxidative footprinting

(2014) T. A. Poor et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Structure-based discovery of Middle East respiratory syndrome coronavirus fusion inhibitor

(2014) Lu Lu et al.   Nature Communications

An engineered HIV-1 gp41 trimeric coiled coil with increased stability and anti-HIV-1 activity: implication for developing anti-HIV microbicides

(2013) P. Tong et al.   JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY

HIV-1 variants with a single-point mutation in the gp41 pocket region exhibiting different susceptibility to HIV fusion inhibitors with pocket- or membrane-binding domain

(2012) Lu Lu et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

The M-T Hook Structure Is Critical for Design of HIV-1 Fusion Inhibitors

(2012) Huihui Chong et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Mutations of Gln64 in the HIV-1 gp41 N-Terminal Heptad Repeat Render Viruses Resistant to Peptide HIV Fusion Inhibitors Targeting the gp41 Pocket

(2011) X. Yu et al.   JOURNAL OF VIROLOGY

PHENIX: a comprehensive Python-based system for macromolecular structure solution

(2010) Paul D. Adams et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

Addition of a cholesterol group to an HIV-1 peptide fusion inhibitor dramatically increases its antiviral potency

(2009) P. Ingallinella et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

SC29EK, a Peptide Fusion Inhibitor with Enhanced  -Helicity, Inhibits Replication of Human Immunodeficiency Virus Type 1 Mutants Resistant to Enfuvirtide

(2008) T. Naito et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Rationally Designed Anti-HIV Peptides Containing Multifunctional Domains as Molecule Probes for Studying the Mechanisms of Action of the First and Second Generation HIV Fusion Inhibitors

(2008) Zhi Qi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Design and Evaluation of Sifuvirtide, a Novel HIV-1 Fusion Inhibitor

(2008) Yuxian He et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Albumin-conjugated C34 Peptide HIV-1 Fusion Inhibitor

(2008) Cheryl A. Stoddart et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Identification of a Critical Motif for the Human Immunodeficiency Virus Type 1 (HIV-1) gp41 Core Structure: Implications for Designing Novel Anti-HIV Fusion Inhibitors

(2008) Y. He et al.   JOURNAL OF VIROLOGY