Functional metabolic interactions of human neuron-astrocyte 3D in vitro networks

Zika virus impairs growth in human neurospheres and brain organoids

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Prevention of the degeneration of human dopaminergic neurons in an astrocyte co-culture system allowing endogenous drug metabolism

(2015) Liudmila Efremova et al.   BRITISH JOURNAL OF PHARMACOLOGY

A low-cost, high-quality new drug discovery process using patient-derived induced pluripotent stem cells

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Novel scalable 3D cell based model for in vitro neurotoxicity testing: Combining human differentiated neurospheres with gene expression and functional endpoints

(2015) Ana Paula Terrasso et al.   JOURNAL OF BIOTECHNOLOGY

Functional cortical neurons and astrocytes from human pluripotent stem cells in 3D culture

(2015) Anca M Paşca et al.   NATURE METHODS

What does it take to produce a breakthrough drug?

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A Predictive In Vitro Model of the Impact of Drugs with Anticholinergic Properties on Human Neuronal and Astrocytic Systems

(2015) Elizabeth K. Woehrling et al.   PLoS One

Modeling Human Neural FunctionalityIn Vitro: Three-Dimensional Culture for Dopaminergic Differentiation

(2015) Daniel Simão et al.   TISSUE ENGINEERING PART A

Direct neuronal glucose uptake heralds activity-dependent increases in cerebral metabolism

(2015) Iben Lundgaard et al.   Nature Communications

The Pentose Phosphate Pathway and Pyruvate Carboxylation after Neonatal Hypoxic-Ischemic Brain Injury

(2014) Eva MF Brekke et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

A three-dimensional human neural cell culture model of Alzheimer’s disease

(2014) Se Hoon Choi et al.   NATURE

Generation of cerebral organoids from human pluripotent stem cells

(2014) Madeline A Lancaster et al.   Nature Protocols

2013 FDA drug approvals

(2014) Asher Mullard   NATURE REVIEWS DRUG DISCOVERY

Acrylamide alters neurotransmitter induced calcium responses in murine ESC-derived and primary neurons

(2014) Julia Sisnaiske et al.   NEUROTOXICOLOGY

Imaging of human differentiated 3D neural aggregates using light sheet fluorescence microscopy

(2014) Emilio J. Gualda et al.   Frontiers in Cellular Neuroscience

Metabolomics in toxicology and preclinical research

(2014) Tzutzuy Ramirez   ALTEX-Alternatives to Animal Experimentation

Human Ntera2 cells as a predictive in vitro test system for developmental neurotoxicity

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A human pluripotent carcinoma stem cell-based model for in vitro developmental neurotoxicity testing: Effects of methylmercury, lead and aluminum evaluated by gene expression studies

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Functional Astrocyte-Neuron Lactate Shuttle in a Human Stem Cell-Derived Neuronal Network

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OpenSpinMicroscopy: an open-source integrated microscopy platform

(2013) Emilio J Gualda et al.   NATURE METHODS

Distribution of the branched chain aminotransferase proteins in the human brain and their role in glutamate regulation

(2012) Jonathon Hull et al.   JOURNAL OF NEUROCHEMISTRY

Raise standards for preclinical cancer research

(2012) C. Glenn Begley et al.   NATURE

Fiji: an open-source platform for biological-image analysis

(2012) Johannes Schindelin et al.   NATURE METHODS

Metabolism, Compartmentation, Transport and Production of Acetate in the Cortical Brain Tissue Slice

(2012) Caroline Rae et al.   NEUROCHEMICAL RESEARCH

Direct measurement of backflux between oxaloacetate and fumarate following pyruvate carboxylation

(2011) Eva Brekke et al.   GLIA

Characterization of NTera2/D1 cells as a model system for the investigation of cannabinoid function in human neurons and astrocytes

(2011) Catherine E. Goodfellow et al.   JOURNAL OF NEUROSCIENCE RESEARCH

The role of glia in neuronal recovery following anoxia: In vitro evidence of neuronal adaptation

(2011) Sónia Sá Santos et al.   NEUROCHEMISTRY INTERNATIONAL

13C MRS studies of neuroenergetics and neurotransmitter cycling in humans

(2011) Douglas L. Rothman et al.   NMR IN BIOMEDICINE

Regional Differentiation of Retinoic Acid-Induced Human Pluripotent Embryonic Carcinoma Stem Cell Neurons

(2011) Dennis E. Coyle et al.   PLoS One

Synapse microarray identification of small molecules that enhance synaptogenesis

(2011) Peng Shi et al.   Nature Communications

Metabolic alterations induced by ischemia in primary cultures of astrocytes: merging13C NMR spectroscopy and metabolic flux analysis

(2010) Ana I. Amaral et al.   JOURNAL OF NEUROCHEMISTRY

The benefits and limitations of animal models for translational research in neurodegenerative diseases

(2010) Mathias Jucker   NATURE MEDICINE

Can cellular models revolutionize drug discovery in Parkinson's disease?

(2009) Birgitt Schüle et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Integrating human stem cell expansion and neuronal differentiation in bioreactors

(2009) Margarida Serra et al.   BMC BIOTECHNOLOGY

Human Neurospheres as Three-Dimensional Cellular Systems for Developmental Neurotoxicity Testing

(2009) Michaela Moors et al.   ENVIRONMENTAL HEALTH PERSPECTIVES

Improving baculovirus production at high cell density through manipulation of energy metabolism

(2009) Nuno Carinhas et al.   METABOLIC ENGINEERING

Evaluation of the Importance of Astrocytes When Screening for Acute Toxicity in Neuronal Cell Systems

(2009) E. K. Woehrling et al.   NEUROTOXICITY RESEARCH

Differentiating human NT2/D1 neurospheres as a versatile in vitro 3D model system for developmental neurotoxicity testing

(2008) E.J. Hill et al.   TOXICOLOGY

Biomimetic material systems for neural progenitor cell-based therapy

(2007) Wyatt Potter   Frontiers in Bioscience-Landmark