Genetically engineered pre-microRNA-34a prodrug suppresses orthotopic osteosarcoma xenograft tumor growth via the induction of apoptosis and cell cycle arrest

Anti-Tumor Necrosis Factor Therapy Inhibits Lung Metastasis in an Osteosarcoma Cell Line

(2017) Hiroaki Kato et al.   ONCOLOGY

Bioengineering of noncoding RNAs for research agents and therapeutics

(2016) Pui Yan Ho et al.   Wiley Interdisciplinary Reviews-RNA

tRNA-Derived Small Non-Coding RNAs in Response to Ischemia Inhibit Angiogenesis

(2016) Qing Li et al.   Scientific Reports

The miR-34a-LDHA axis regulates glucose metabolism and tumor growth in breast cancer

(2016) Xiangsheng Xiao et al.   Scientific Reports

Combination therapy with bioengineered miR-34a prodrug and doxorubicin synergistically suppresses osteosarcoma growth

(2015) Yong Zhao et al.   BIOCHEMICAL PHARMACOLOGY

Endogenous tRNA-Derived Fragments Suppress Breast Cancer Progression via YBX1 Displacement

(2015) Hani Goodarzi et al.   CELL

Combination of Hedgehog inhibitors and standard anticancer agents synergistically prevent osteosarcoma growth

(2015) YOSHINOBU SAITOH et al.   INTERNATIONAL JOURNAL OF ONCOLOGY

Review of microRNA in osteosarcoma and chondrosarcoma

(2015) Le Chang et al.   MEDICAL ONCOLOGY

A general approach to high-yield biosynthesis of chimeric RNAs bearing various types of functional small RNAs for broad applications

(2015) Qiu-Xia Chen et al.   NUCLEIC ACIDS RESEARCH

Bone Sarcomas in Pediatrics: Progress in Our Understanding of Tumor Biology and Implications for Therapy

(2015) Rocio K. Rivera-Valentin et al.   PEDIATRIC DRUGS

Genome wide expression profiling of p53 regulated miRNAs in neuroblastoma

(2015) Ali Rihani et al.   Scientific Reports

Delivery of miR-34a by chitosan/PLGA nanoplexes for the anticancer treatment of multiple myeloma

(2015) Donato Cosco et al.   Scientific Reports

Role of mesenchymal stem cells in osteosarcoma and metabolic reprogramming of tumor cells

(2015) Gloria Bonuccelli et al.   Oncotarget

N-methylnicotinamide and nicotinamide N-methyltransferase are associated with microRNA-1291-altered pancreatic carcinoma cell metabolome and suppressed tumorigenesis

(2014) Hui-Chang Bi et al.   CARCINOGENESIS

CXCR4 antibody treatment suppresses metastatic spread to the lung of intratibial human osteosarcoma xenografts in mice

(2014) Patrick Brennecke et al.   CLINICAL & EXPERIMENTAL METASTASIS

In Vivo Activity of MiR-34a Mimics Delivered by Stable Nucleic Acid Lipid Particles (SNALPs) against Multiple Myeloma

(2014) Maria Teresa Di Martino et al.   PLoS One

p53-Dependent Activation of microRNA-34a in Response to Etoposide-Induced DNA Damage in Osteosarcoma Cell Lines Not Impaired by Dominant Negative p53 Expression

(2014) Chiara Novello et al.   PLoS One

MicroRNA-34a Inhibits Human Osteosarcoma Proliferation by Downregulating Ether à go-go 1 Expression

(2013) Xinyu Wu et al.   International Journal of Medical Sciences

Flavokawain B, a kava chalcone, inhibits growth of human osteosarcoma cells through G2/M cell cycle arrest and apoptosis

(2013) Tao Ji et al.   Molecular Cancer

miR-34a inhibits the metastasis of osteosarcoma cells by repressing the expression of CD44

(2013) HAIEN ZHAO et al.   ONCOLOGY REPORTS

Small RNAs derived from the 5′ end of tRNA can inhibit protein translation in human cells

(2013) Andrew Sobala et al.   RNA Biology

A Review of Targeted Therapies Evaluated by the Pediatric Preclinical Testing Program for Osteosarcoma

(2013) Valerie B. Sampson et al.   Frontiers in Oncology

miRNA-34 Prevents Cancer Initiation and Progression in a Therapeutically Resistant K-ras and p53-Induced Mouse Model of Lung Adenocarcinoma

(2012) A. L. Kasinski et al.   CANCER RESEARCH

Adenovirus-mediated overexpression of BMP-9 inhibits human osteosarcoma cell growth and migration through downregulation of the PI3K/AKT pathway

(2012) BO LI et al.   INTERNATIONAL JOURNAL OF ONCOLOGY

Extensive terminal and asymmetric processing of small RNAs from rRNAs, snoRNAs, snRNAs, and tRNAs

(2012) Zhihua Li et al.   NUCLEIC ACIDS RESEARCH

Children's Oncology Group's 2013 blueprint for research: Bone tumors

(2012) Richard Gorlick et al.   PEDIATRIC BLOOD & CANCER

MicroRNA-34a Inhibits the Proliferation and Metastasis of Osteosarcoma Cells Both In Vitro and In Vivo

(2012) Kang Yan et al.   PLoS One

miR-34 – a microRNA replacement therapy is headed to the clinic

(2012) Andreas G. Bader   Frontiers in Genetics

MiR-34a chemosensitizes bladder cancer cells to cisplatin treatment regardless of p53-Rb pathway status

(2011) Ruth L. Vinall et al.   INTERNATIONAL JOURNAL OF CANCER

Functional characterization of osteosarcoma cell lines provides representative models to study the human disease

(2011) Alexander B Mohseny et al.   LABORATORY INVESTIGATION

The microRNA miR-34a inhibits prostate cancer stem cells and metastasis by directly repressing CD44

(2011) Can Liu et al.   NATURE MEDICINE

Insulin-like growth factor binding protein 5 suppresses tumor growth and metastasis of human osteosarcoma

(2011) Y Su et al.   ONCOGENE

Osteosarcoma incidence and survival rates from 1973 to 2004

(2009) Lisa Mirabello et al.   CANCER

Osteoblastic and Osteolytic Human Osteosarcomas can be Studied With a New Xenograft Mouse Model Producing Spontaneous Metastases

(2009) Jun Yuan et al.   CANCER INVESTIGATION

MicroRNAs: Target Recognition and Regulatory Functions

(2009) David P. Bartel   CELL

A novel class of small RNAs: tRNA-derived RNA fragments (tRFs)

(2009) Yong Sun Lee et al.   GENES & DEVELOPMENT

Downregulation of CCND1 and CDK6 by miR-34a induces cell cycle arrest

(2008) Fang Sun et al.   FEBS LETTERS

High grade osteosarcoma of the extremities with lung metastases at presentation: Treatment with neoadjuvant chemotherapy and simultaneous resection of primary and metastatic lesions

(2008) Gaetano Bacci et al.   JOURNAL OF SURGICAL ONCOLOGY

miR-34a repression of SIRT1 regulates apoptosis

(2008) M. Yamakuchi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA