Article
Chemistry, Multidisciplinary
Yide He, Xige Zhang, Fanhui Meng, Jinjin Wang, Yi Li, Yan Zhang, Wen Song, Tianjie Li, Yumei Zhang
Summary: This study demonstrates that biomimetic chiral nanotopography can promote biomaterial-tissue integration by manipulating macrophage phenotype, bringing a novel strategy for immunomodulation.
ADVANCED FUNCTIONAL MATERIALS
(2023)
Article
Engineering, Biomedical
Nadia Kartikasari, Masahiro Yamada, Jun Watanabe, Watcharaphol Tiskratok, Xindie He, Yuya Kamano, Hiroshi Egusa
Summary: This study shows that titanium nanosurfaces with anisotropically patterned nanospikes can regulate macrophage polarization to inhibit osteoclast differentiation of osteoclast precursors, indicating that nanotopographic cues play a key role in this process rather than other physicochemical properties.
ACTA BIOMATERIALIA
(2022)
Article
Immunology
Huiqin Zhou, Wei Zhang, Danxue Qin, Peiqiang Liu, Wenjun Fan, Hao Lv, Lu Tan, Ziang Gao, Yu Xu
Summary: NLRP3 inflammasome activation plays an important role in allergic rhinitis by inducing macrophage pyroptosis and releasing inflammatory mediators to local tissues.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2022)
Article
Dentistry, Oral Surgery & Medicine
Yun Chen, Jia Li, Jue Shi, Dandan Ning, Jianying Feng, Weiwei Lin, Fuming He, Zhijian Xie
Summary: This study investigates the potential role of ipriflavone in early bone healing process and uncovers its underlying mechanism, showing that ipriflavone has an anti-inflammatory effect on NLRP3 inflammasome activation by improving mitochondrial function. It provides a new strategy for the development of immune-regulated biomaterials and treatment options for NLRP3-related diseases.
JOURNAL OF CLINICAL PERIODONTOLOGY
(2022)
Article
Pharmacology & Pharmacy
Chia-Cheng Su, Shu-Chi Wang, I-Chen Chen, Fang-Yen Chiu, Po-Len Liu, Chi-Han Huang, Kuan-Hua Huang, Shih-Hua Fang, Wei-Chung Cheng, Shu-Pin Huang, Hsin-Chih Yeh, Ching-Chih Liu, Po-Yen Lee, Ming-Yii Huang, Chia-Yang Li
Summary: The study demonstrated that zerumbone effectively attenuates LPS-induced inflammatory response in macrophages both in vitro and ex vivo by suppressing the activation of the ERK-MAPK and NF-kappa B signaling pathways as well as blocking the activation of the NLRP3 inflammasome, suggesting its potential benefits for treating sepsis and inflammasome-related diseases.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Materials Science, Multidisciplinary
Boya Xu, Zhe Li, Qingyuan Ye, Guangwen Li, Min Xu, Yi Li, Lipeng Liu, Wen Song, Yumei Zhang
Summary: The photothermal effect of titania nanotubes array (TiNTs) is investigated for mild photothermal therapy (mPTT). The heat delivered by TiNTs is inversely proportional to their diameters and proportional to the power of near-infrared (NIR) light. In mPTT, macrophages, endothelial progenitor cells, and osteoblasts all exhibit favorable alterations, promoting anti-inflammatory effects and bone regeneration.
MATERIALS & DESIGN
(2022)
Article
Engineering, Multidisciplinary
Lu Zhao, Hao Liu, Yingchao Wang, Shufang Wang, Dejin Xun, Yi Wang, Yiyu Cheng, Boli Zhang
Summary: The pharmacological mechanism of Xuanfeibaidu Formula (XFBD) in the treatment of COVID-19 patients was investigated using network pharmacology, transcriptomics, and bioassays. XFBD contains numerous bioactive substances, including anti-inflammatory compounds. Experimental results showed that XFBD significantly reduced pulmonary inflammation and decreased proinflammatory cytokine levels. Furthermore, XFBD demonstrated inhibitory effects on macrophage activation and migration. Active components from different herbs of XFBD were identified, and their anti-inflammatory effects were elucidated. This study reveals the pharmacological mechanism and effective components of XFBD, providing a biological explanation for its clinical efficacy.
Article
Immunology
Liangfei Niu, Geyang Luo, Rui Liang, Chenli Qiu, Jianwei Yang, Lingling Xie, Kaile Zhang, Yu Tian, Decheng Wang, Shu Song, Howard E. Takiff, Ka-Wing Wong, Xiaoyong Fan, Qian Gao, Bo Yan
Summary: This study reveals the important role of nlrc3-like in the regulation of macrophage homeostasis, early bacterial burden control, and inflammation response. Overexpression or deficiency of nlrc3-like leads to abnormal inflammation response and bacterial burden, highlighting the importance of balanced innate immune response during mycobacterial infection.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Nanoscience & Nanotechnology
Panthihage Ruvini L. Dabare, Akash Bachhuka, Jing Yang Quek, Lluis F. F. Marsal, John Hayball, Krasimir Vasilev
Summary: It has been shown that macrophage polarization can be regulated by modifying the surface features of biomaterials, and this effect can be maintained over a prolonged period. In this study, differentiated THP-1 cells were used to control macrophage polarization on nano-rough surfaces for 7 days. The results demonstrate that regardless of surface roughness, the expression of pro-inflammatory cytokines decreases while the expression of anti-inflammatory cytokines increases, and the predominant cell type on the modified surfaces exhibits an M2 anti-inflammatory phenotype.
Editorial Material
Immunology
Fiona D. R. Henkel, Luke A. J. O'Neill
Summary: PANoptosomes are large complexes that induce cell death called PANoptosis during infection and inflammation. Sundaram and colleagues have identified NLRP12 as a PANoptosome that triggers PANoptosis in response to heme, TNF, and pathogen-associated molecular patterns, indicating its involvement in hemolytic and inflammatory diseases.
TRENDS IN IMMUNOLOGY
(2023)
Article
Engineering, Biomedical
Dainelys Guadarrama Bello, Patricia Moraille, Serine Boughari, Antonella Badia, Antonio Nanci
Summary: This study aims to investigate the biomechanical contribution of filopodia and their nanoprotrusions to the adhesive interaction of cells with nanostructured surfaces. The results show that surface topography can change the adhesive interaction of subcellular structures.
MATERIALS TODAY BIO
(2022)
Article
Immunology
Mingwei Zhang, Hailin Lan, Shaoli Peng, Weitong Zhou, Xuezhen Wang, Meina Jiang, Jinsheng Hong, Qiuyu Zhang
Summary: This study investigated the mechanisms of NLRP3-mediated macrophage pyroptosis and identified the role of miR-223-3p in regulating NLRP3 expression. It was found that miR-223-3p can decrease the expression of NLRP3 and proinflammatory factors, resulting in reduced pyroptosis in irradiated murine macrophages. In vivo experiments further demonstrated the effectiveness of miR-223-3p supplementation in alleviating acute radiation-induced lung injury.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Article
Food Science & Technology
Xusheng Li, Haiwei Li, Dongbao Cai, Ping Li, Jietian Jin, Xinwei Jiang, Zhenhua Li, Lingmin Tian, Guobing Chen, Jianxia Sun, Weibin Bai
Summary: Pubertal mice exposed to low-dose cadmium exhibit liver inflammation and severe injury, including inflammatory hepatocyte infiltration, increased apoptotic cells, and upregulation of cytokine expression.
FOOD AND CHEMICAL TOXICOLOGY
(2021)
Article
Medicine, Research & Experimental
Min-Qi Ma, Si-Si Zheng, Hui-Long Chen, Hong-Bo Xu, Dan-Lu Zhang, Ye-An Zhang, Shu-Yang Xiang, Bi-Huan Cheng, Sheng-Wei Jin, Pan-Han Fu
Summary: PCTR1 inhibits the activation of NLRP3 inflammasome and pyroptosis. It blocks the interaction between NLRP3 and ASC and restricts the formation of NLRP3 inflammasome. PCTR1 also exerts inhibitory effects through the cAMP-PKA signaling pathway and shows potential as a treatment option.
LABORATORY INVESTIGATION
(2023)
Article
Engineering, Environmental
Yiren Li, Jian Liu, Yiheng Wang, Xianjin Tang, Jianming Xu, Xingmei Liu
Summary: Cadmium (Cd) and lead (Pb) are common elements in contaminated sites and their behavior in the soil can be influenced by competition for adsorption sites. This study used adsorption experiments, multi-surface models, and advanced spectroscopy technology to explain the adsorption mechanisms of Cd and Pb and determine the contribution of each component in the competitive system. The results showed that pH is a key factor influencing the adsorption contribution of soil components, with soil organic matter being the dominant adsorbent for both Cd and Pb. Clay minerals play a role at low pH, while Fe/Al oxides primarily adsorb metals at high pH. Additionally, the competitive effect of Pb on Cd was mainly observed on soil organic matter rather than clay minerals, emphasizing the importance of considering this competition in soils with high organic matter content.
JOURNAL OF HAZARDOUS MATERIALS
(2023)
Review
Chemistry, Multidisciplinary
Sruthi Venugopal Oopath, Avinash Baji, Mojtaba Abtahi, Trong Quan Luu, Krasimir Vasilev, Vi Khanh Truong
Summary: Researchers are extensively studying antibacterial and antifouling materials to combat the growing risk of bacterial infections and drug-resistant bacteria. This article reviews the role of nanostructures found on the surfaces of natural antibacterial and antifouling materials, such as lotus leaf, cicadas and dragonflies wings, shark skin, and rose petals. It also discusses novel fabrication techniques for biomimetic micro- and nano-structures on synthetic material surfaces.
ADVANCED MATERIALS INTERFACES
(2023)
Article
Chemistry, Physical
Pawel Mierczynski, Agnieszka Mierczynska-Vasilev, Krasimir Vasilev, Malgorzata I. Szynkowska-Jozwik
Summary: This study presents a mechanistic investigation of methane oxy-steam reforming and LNG (OSR-LNG) processes using Fourier transform infrared (FTIR) spectroscopy for the first time. FTIR measurements were conducted in the temperature range of 200-600 degrees Celsius to propose the reaction mechanisms of oxy-steam reforming of CH4 or LNG. It was discovered that the dissociation of methane into carbon-containing molecules and/or onto the catalyst surface is a crucial step in determining the reaction rate. These findings can be applied to the design of catalytic systems for natural gas reforming.
REACTION KINETICS MECHANISMS AND CATALYSIS
(2023)
Article
Biotechnology & Applied Microbiology
Yang Yu, Houyi Sun, Qunshan Lu, Junyuan Sun, Pengfei Zhang, Linran Zeng, Krasimir Vasilev, Yunpeng Zhao, Yu Chen, Peilai Liu
Summary: CaO2-loaded 2D titanium carbide nanosheets (CaO2-TiOx@Ti3C2, C-T@Ti3C2) with sonodynamic and chemodynamic features were developed. These nanosheets exhibited ideal antibacterial effects and promoted osteogenic transformation, which are crucial for the treatment of bacterial infections and wound healing.
JOURNAL OF NANOBIOTECHNOLOGY
(2023)
Article
Chemistry, Physical
Pawel Mierczynski, Agnieszka Mierczynska-Vasilev, Waldemar Maniukiewicz, Krasimir Vasilev, Malgorzata Szynkowska-Jozwik
Summary: In this study, multi-walled carbon nanotubes (MWCNTs) were prepared by chemical vapour deposition (CVD) using acetylene as a carbon source over an iron catalyst. The feasibility of MWCNTs supported monometallic and bimetallic catalysts for hydrogen production during steam reforming of methanol (SRM) and methanol decomposition (DM) was investigated. SEM and XRD methods were used to evaluate the structural characteristics of MWCNTs. TPR and XRD methods were used to analyze the physicochemical properties of the catalysts. The promotion effect of palladium on methanol conversion rate and H2 productivity in the case of the copper catalysts was demonstrated, which was attributed to the formation of Pd-Cu alloy compound.
Editorial Material
Chemistry, Multidisciplinary
Krasimir Vasilev
Article
Chemistry, Multidisciplinary
Evelyn Osehontue Uroro, Richard Bright, Jing Yang Quek, Krasimir Vasilev
Summary: A novel approach for drug administration using stimulus-responsive carriers is introduced in this study to minimize drug dosage and frequency, thereby reducing cytotoxicity levels. Nanocomposites loaded with rifampicin (RFP) were prepared using lipases-sensitive polycaprolactone (PCL) and showed responsive behavior and improved biocompatibility compared to the free drug.
Article
Engineering, Biomedical
Junyuan Sun, Fei Yang, Lianlei Wang, Haichao Yu, Zhijie Yang, Jingjing Wei, Krasimir Vasilev, Xuesong Zhang, Xinyu Liu, Yunpeng Zhao
Summary: Stem cell transplantation is a promising therapeutic method for intervertebral disc degeneration. However, oxidative stress in the degenerated region impairs the efficiency of the treatment. In this study, Coenzyme Q10 was encapsulated in lecithin micelles and successfully delivered to stem cells in vitro and in animal models, providing a potential therapeutic agent for intervertebral disc degeneration.
BIOACTIVE MATERIALS
(2023)
Article
Chemistry, Multidisciplinary
E. O. Uroro, R. Bright, P. R. Lakshika Dabare, J. Y. Quek, N. Goswami, K. Vasilev
Summary: This study developed an enzyme-responsive antibacterial nanomaterial that selectively releases antibacterial agents in the presence of bacterial lipase. It showed minimal toxicity to human fibroblast cells, indicating potential applications in healthcare products and devices for infection prevention and treatment.
MATERIALS TODAY CHEMISTRY
(2023)
Article
Food Science & Technology
Agnieszka M. Mierczynska-Vasilev, Allie C. Kulcsar, Panthihage Ruvini L. Dabare, Krasimir A. Vasilev, Marlize Z. Bekker
Summary: Volatile sulfur compounds (VSCs), including hydrogen sulfide, methanethiol, and ethanethiol, are responsible for "reductive" aromas in wine and contribute to approximately 30% of all wine faults. These compounds have a significant impact on wine aroma and perceived quality, ultimately affecting consumer preference. A new method using nanoengineered surfaces with immobilized gold nanoparticles is reported for the removal of VSC compounds.
NPJ SCIENCE OF FOOD
(2023)
Article
Chemistry, Multidisciplinary
Tuyet Pham, Tien Thanh Nguyen, Ngoc Huu Nguyen, Andrew Hayles, Wenshao Li, Duy Quang Pham, Chung Kim Nguyen, Trung Nguyen, Jitraporn Vongsvivut, Neethu Ninan, Ylias Sabri, Wei Zhang, Krasimir Vasilev, Vi Khanh Truong
Summary: This study presents a novel sustainable technology, using argon atmospheric plasma jet, to transform microalgae into bioactive coatings with excellent antibacterial activity and biological compatibility. This technology has the potential to combat wound infections and advance wound care research.
Review
Pharmacology & Pharmacy
Yanping He, Krasimir Vasilev, Peter Zilm
Summary: Dental caries is a multifactorial biofilm disease caused by cariogenic bacteria that ferment carbohydrates to lactic acid, leading to a loss of minerals in teeth. Developments in pH-responsive delivery systems that release antibacterial agents in response to low pH have shown promise as a targeted therapy for dental caries.
Article
Nanoscience & Nanotechnology
Panthihage Ruvini L. Dabare, Akash Bachhuka, Jing Yang Quek, Lluis F. F. Marsal, John Hayball, Krasimir Vasilev
Summary: It has been shown that macrophage polarization can be regulated by modifying the surface features of biomaterials, and this effect can be maintained over a prolonged period. In this study, differentiated THP-1 cells were used to control macrophage polarization on nano-rough surfaces for 7 days. The results demonstrate that regardless of surface roughness, the expression of pro-inflammatory cytokines decreases while the expression of anti-inflammatory cytokines increases, and the predominant cell type on the modified surfaces exhibits an M2 anti-inflammatory phenotype.
Article
Biotechnology & Applied Microbiology
Andrew Hayles, Richard Bright, Ngoc Huu Nguyen, Vi Khanh Truong, Jonathan Wood, Dennis Palms, Jitraporn Vongsvivut, Dan Barker, Krasimir Vasilev
Summary: This study demonstrates the enhanced susceptibility of pathogenic bacteria to antibiotics by modifying the surface of implantable biomaterials with sharp nanospikes. The presence of nanospikes rejuvenates the activity of antibiotics, resulting in increased bacterial cell death. Differential gene expression and biochemical analysis provide evidence of the mechanism behind the modification of cell surface charge.
NPJ BIOFILMS AND MICROBIOMES
(2023)
