Article
Engineering, Biomedical
Martin Karl Schneider, James Wang, Aris Kare, Shaunak S. Adkar, Darren Salmi, Caitlin F. Bell, Tom Alsaigh, Dhananjay Wagh, John Coller, Aaron Mayer, Sarah J. Snyder, Alexander D. Borowsky, Steven R. Long, Maarten G. Lansberg, Gary K. Steinberg, Jeremy J. Heit, Nicholas J. Leeper, Katherine W. Ferrara
Summary: The study demonstrates the potential of near-infrared auto-photoacoustic (NIRAPA) imaging in detecting plaque components and differentiating stable and vulnerable plaques. The researchers also developed a methodology to combine molecular imaging with spatial transcriptomic and proteomic methods for a more comprehensive understanding of plaque characteristics.
Article
Engineering, Electrical & Electronic
Kunhe Zhan, Lei Wang, Zhongjiang Chen, Da Xing
Summary: A dual-modality endoscope probe with a diameter of 1 mm was proposed for simultaneously detecting the lipid core and intraplaque hemorrhage (IPH). The system composed of photoacoustic imaging (PAI) and near-infrared auto-fluorescence imaging (NIRAFI) markers was capable of accurately imaging IPH and lipid core expansion.
IEEE JOURNAL OF SELECTED TOPICS IN QUANTUM ELECTRONICS
(2021)
Article
Chemistry, Multidisciplinary
Yuan Ma, Li Xu, Baoli Yin, Jinhui Shang, Fangfang Chen, Juntao Xu, Zhi-Ling Song, Bin Nan, Guosheng Song, Xiao-bing Zhang
Summary: The developed RSPN nanoparticles in this study can accurately assess the rupture risk of vulnerable plaque caused by acute pneumonia and successfully reflect the oxidative stress level in vulnerable plaque, providing a promising approach to reduce the mortality of atherosclerotic-induced cardiovascular disease.
Article
Acoustics
Yuhao Yuan, Guangju Zhang, Yuqi Chen, Hongli Ni, Mingsheng Li, Michael Sturek, Ji-Xin Cheng
Summary: This work reports an intravascular photoacoustic catheter with mode self-cleaning in a graded-index fiber, which improves the sensitivity and spatial resolution for plaque detection. The lower-order modes generated by the self-cleaning effect in the graded-index fiber greatly enhance the photoacoustic spatial resolution and detection sensitivity compared to the higher-order modes in a step-index multimode fiber. The dominant ringing artifact caused by laser absorption of the ultrasound transducer is further reduced by using stripe suppression. A lipid plaque mimicking phantom was imaged for evaluation, and lipid particles with a small diameter of 75.7 μm were clearly observed.
Article
Acoustics
Yi-Chen Li, Thau-Yun Shen, Chien-Cheng Chen, Wei-Ting Chang, Po-Yang Lee, Chih-Chung Huang
Summary: An end-to-end deep-learning convolutional neural network was developed to automatically detect various structures in IVUS images, and the performance was evaluated for different loss functions.
IEEE TRANSACTIONS ON ULTRASONICS FERROELECTRICS AND FREQUENCY CONTROL
(2021)
Article
Biochemical Research Methods
Jose J. Rico-Jimenez, Javier A. Jo
Summary: Coronary heart disease has the highest rate of death and morbidity in the Western world, primarily caused by atherosclerosis. This study presents a deep learning approach for rapid identification of lipid-laden plaques in vivo, aiming to accelerate screening and guide decision making during percutaneous coronary interventions. The method demonstrated high accuracy, sensitivity, and specificity in plaque identification, with the potential to provide high throughput characterization for in vivo imaging.
JOURNAL OF BIOMEDICAL OPTICS
(2022)
Review
Peripheral Vascular Disease
Karlis Trusinskis, Evija Knoka, Laima Caunite, Mairita Karantajere, Maris Lapsovs, Sandra Paeglite, Ieva Briede, Karlis Grikis, Sanda Jegere, Indulis Kumsars, Inga Narbute, Rudolfs Roze, Dace Sondore, Andrejs Erglis
Summary: This paper reviews the pathology of atherosclerotic plaque, the effects of lipid-lowering therapies on plaque stabilization, and the usage of intravascular imaging modalities. The study evaluated the correlation between iMAP-IVUS and NIRS in diagnosing vulnerable coronary plaques.
CURRENT ATHEROSCLEROSIS REPORTS
(2022)
Article
Cardiac & Cardiovascular Systems
Fuxue Deng, Danni Li, Lei Lei, Qiang Yang, Qing Li, Hongtao Wang, Jie Deng, Qiangsun Zheng, Wei Jiang
Summary: The study found that the Apo B/A1 ratio was higher in ACS patients than CCS patients, and also higher in patients with plaque rupture, erosion, or thrombus. A high Apo B/A1 ratio was associated with a high percentage of vulnerable plaques, and negatively related to fibrous cap thickness in lipid-rich plaques.
CARDIOVASCULAR DIABETOLOGY
(2021)
Review
Cardiac & Cardiovascular Systems
S. Koganti, A. Karanasos, E. Regar, R. D. Rakhit
Summary: Despite advances in management, accurately identifying individuals at high risk of acute cardiovascular events remains challenging in preventive cardiology. Biomarkers hold promise in assessing risk, while imaging tools like OCT can assist in understanding the association between biomarkers and high-risk plaques.
HELLENIC JOURNAL OF CARDIOLOGY
(2021)
Article
Integrative & Complementary Medicine
Yanan Hu, Jie Ding, Zhen Zhao, Hao Du, Zhiyuan Qiu, Shujuan Xu, Yi Zhang
Summary: This retrospective cohort study evaluated clinical outcomes in high-risk patients with symptomatic intracranial atherosclerotic stenosis (sICAS) resulting from plaque enhancement who underwent balloon dilation or stent implantation. The study found that high-resolution magnetic resonance vessel wall imaging (HRMR-VWI) can identify vulnerable plaque features and that intravascular intervention combined with standard drug therapy is safe and effective in these patients. The intervention group had a lower incidence of primary outcome compared to the non-intervention group.
ALTERNATIVE THERAPIES IN HEALTH AND MEDICINE
(2023)
Article
Cardiac & Cardiovascular Systems
Kan Saito, Hideki Kitahara, Takaaki Mastuoka, Naoto Mori, Kazuya Tateishi, Yoshihide Fujimoto, Yoshio Kobayashi
Summary: This study found that patients with myocardial bridge had lower lipid content in atherosclerotic plaques assessed by NIRS-IVUS imaging, suggesting that myocardial bridge may be a predictor of lipid content in atherosclerotic plaques.
Article
Engineering, Multidisciplinary
Zheng Sun, Li-shuang Sun
Summary: This paper introduces a method to improve the image quality of IVPAT by simultaneously recovering the SoS, AOED, and OAC in tissues with variable SoS. The results show that the reconstructed images produced by this method have a decreased normalized mean square absolute distance (NMSAD) of about 15% compared to reconstructions with a fixed SoS.
INVERSE PROBLEMS IN SCIENCE AND ENGINEERING
(2021)
Proceedings Paper
Acoustics
Tianrui Zhao, Mengjie Shi, Sebastien Ourselin, Tom Vercauteren, Wenfeng Xia
Summary: A forward-viewing photoacoustic (PA) endomicroscopy imaging system was developed and its performance was further improved using a deep image prior (DIP) neural network. Laser was focused and scanned through a multimode fibre via wavefront shaping, and ultrasound waves were detected by an ultrasound transducer. The DIP approach improved spatial resolution and achieved high fidelity images. The system could potentially be used for real-time guidance in minimally invasive surgeries.
PHOTONS PLUS ULTRASOUND: IMAGING AND SENSING 2022
(2022)
Proceedings Paper
Optics
Taylor M. Cannon, Martin Villiger, Brett E. Bouma, Nestor Uribe-Patarroyo
Summary: The study presents preliminary results on analyzing coronary artery cross-section data using newly developed methods for quantifying scattering parameters and relating optical results to microstructural tissue features in artery walls.
OPTICAL COHERENCE IMAGING TECHNIQUES AND IMAGING IN SCATTERING MEDIA IV
(2021)
Article
Multidisciplinary Sciences
Yingchun Cao, Ayeeshik Kole, Jie Hui, Yi Zhang, Jieying Mai, Mouhamad Alloosh, Michael Sturek, Ji-Xin Cheng
SCIENTIFIC REPORTS
(2018)
Article
Multidisciplinary Sciences
Jie Hui, Yingchun Cao, Yi Zhang, Ayeeshik Kole, Pu Wang, Guangli Yu, Gregory Eakins, Michael Sturek, Weibiao Chen, Ji-Xin Cheng
SCIENTIFIC REPORTS
(2017)
Article
Cardiac & Cardiovascular Systems
Ayeeshik Kole, Yingchun Cao, Jie Hui, Islam A. Bolad, Mouhamad Alloosh, Ji-Xin Cheng, Michael Sturek
JOURNAL OF CARDIOVASCULAR TRANSLATIONAL RESEARCH
(2019)
Article
Chemistry, Multidisciplinary
Pu-Ting Dong, Haroon Mohammad, Jie Hui, Leon G. Leanse, Junjie Li, Lijia Liang, Tianhong Dai, Mohamed N. Seleem, Ji-Xin Cheng
Article
Chemistry, Physical
Sebastian Jusuf, Jie Hui, Pu-Ting Dong, Ji-Xin Cheng
JOURNAL OF PHYSICAL CHEMISTRY C
(2020)
Article
Multidisciplinary Sciences
Pu-Ting Dong, Cheng Zong, Zeina Dagher, Jie Hui, Junjie Li, Yuewei Zhan, Meng Zhang, Michael K. Mansour, Ji-Xin Cheng
Summary: This study used polarization-sensitive stimulated Raman scattering to visualize the distribution of AmB, ergosterol, and lipid in single fungal cells, revealing intracellular lipid droplet accumulation in response to AmB treatment. AmB was primarily located in the cell membrane and intracellular droplets, supporting the ion channel model.
Article
Biochemistry & Molecular Biology
Sebastian Jusuf, Pu-Ting Dong, Jie Hui, Erlinda R. Ulloa, George Y. Liu, Ji-Xin Cheng
Summary: Group B Streptococcus (GBS) is increasingly recognized as a major cause of soft tissue and invasive diseases in the elderly and diabetic populations. Treatment with antibiotics like penicillin is common, but antimicrobial resistance is rising among GBS strains. Research shows that photobleaching may have dual effects on the virulence and antimicrobial susceptibility of GBS, suggesting a novel approach for GBS infection treatment.
PHOTOCHEMISTRY AND PHOTOBIOLOGY
(2021)
Article
Chemistry, Multidisciplinary
Pu-Ting Dong, Yuewei Zhan, Sebastian Jusuf, Jie Hui, Zeina Dagher, Michael K. Mansour, Ji-Xin Cheng
Summary: This study reveals that blue light can inactivate catalase in fungal cells, making them highly susceptible to reactive oxygen species attack. It is also found that the combination of photoinactivation of catalase and ROS-generating agents effectively eradicates various fungal species. Furthermore, catalase photoinactivation enhances macrophage killing of Candida albicans.
Proceedings Paper
Engineering, Biomedical
Kostas G. Mavrakis, Minghua Zhuge, Putting Dong, Kai-chi Huang, Jie Hui, Ji-Xin Cheng
Summary: Pre-resonance Stimulated Raman Scattering (SRS) offers enhanced sensitivity in the detection of micromolar substances while maintaining Raman spectroscopy specificity. The microscope has been successfully applied to solutions of antibiotics and treated yeast cells.
EMERGING TECHNOLOGIES FOR CELL AND TISSUE CHARACTERIZATION
(2021)
Proceedings Paper
Infectious Diseases
Jie Hui, Pu-Ting Dong, Lijia Liang, Taraknath Mandal, Junjie Li, Erlinda R. Ulloa, Yuewei Zhan, Sebastian Jusuf, Cheng Zong, Mohamed N. Seleem, George Y. Liu, Qiang Cui, Ji-Xin Cheng
PHOTONIC DIAGNOSIS, MONITORING, PREVENTION, AND TREATMENT OF INFECTIONS AND INFLAMMATORY DISEASES 2020
(2020)
Proceedings Paper
Infectious Diseases
Pu-Ting Dong, Haroon Mohammad, Jie Hui, Xiaoyu Wang, Junjie Li, Lijia Liang, Mohamed N. Seleem, Ji-Xin Cheng
LIGHT-BASED DIAGNOSIS AND TREATMENT OF INFECTIOUS DISEASES
(2018)
Article
Acoustics
Yingchun Cao, Ayeeshik Kole, Lu Lan, Pu Wang, Jie Hui, Michael Sturek, Ji-Xin Cheng
Proceedings Paper
Optics
Jie Hui, Yingchun Cao, Yi Zhang, Ayeeshik Kole, Pu Wang, Guangli Yu, Gregory Eakins, Michael Sturek, Weibiao Chen, Ji-Xin Cheng
PHOTONS PLUS ULTRASOUND: IMAGING AND SENSING 2017
(2017)
Proceedings Paper
Engineering, Electrical & Electronic
Yingchun Cao, Jie Hui, Ayeeshik Kole, Pu Wang, Weibiao Chen, Michael Sturek, Ji-Xin Cheng
2016 CONFERENCE ON LASERS AND ELECTRO-OPTICS (CLEO)
(2016)
Review
Acoustics
Jie Hui, Rui Li, Evan H. Phillips, Craig J. Goergen, Michael Sturek, Ji-Xin Cheng
