Article
Pharmacology & Pharmacy
Saeed Mohammadian Haftcheshmeh, Mahmoud Reza Jaafari, Mohammad Mashreghi, Amin Mehrabian, Seyedeh Hoda Alavizadeh, Parvin Zamani, Javad Zarqi, Mohammad Hasan Darvishi, Fatemeh Gheybi
Summary: Targeting drug delivery vehicles to the mitochondria is a major area of interest for cancer treatment. This study demonstrated that modifying Doxil? with mitochondriotropic SS-02 peptide improved the therapeutic efficacy of liposomal formulation both in vitro and in vivo by targeting the mitochondria of tumor cells.
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
(2021)
Review
Oncology
Margret Schottelius, Ken Herrmann, Constantin Lapa
Summary: This review focuses on the role of CXCR4 in tumor cell growth and metastasis, as well as its involvement in inflammatory responses. It discusses the current status of CXCR4-targeted imaging in cancer and inflammation, highlighting recent advances in imaging tools and theranostic agents. The review also addresses the importance of tailored imaging probes for sensitive and specific CXCR4-targeted immune cell imaging.
Article
Chemistry, Multidisciplinary
Jie Deng, Deqing Lin, Xiangyu Ding, Yuan Wang, YuHan Hu, Hui Shi, Lin Chen, Bingyang Chu, Lei Lei, Chunmei Wen, Jiaqing Wang, Zhiyong Qian, Xingyi Li
Summary: This study combines an antioxidant, a non-steroidal anti-inflammatory drug, and a self-assembled peptide to form a hydrogel that reduces the production of inflammatory mediators. It demonstrates superior therapeutic efficacy in an animal model compared to clinically used drugs.
ADVANCED FUNCTIONAL MATERIALS
(2022)
Article
Pharmacology & Pharmacy
Yaiza Nunez, Annabel Garcia-Leon, Aida Falgas, Naroa Serna, Laura Sanchez-Garcia, Ana Garrido, Jorge Sierra, Alberto Gallardo, Ugutz Unzueta, Esther Vazquez, Antonio Villaverde, Ramon Mangues, Isolda Casanova
Summary: Researchers developed a protein nanoparticle, T22-PE24-H6, which can selectively deliver the exotoxin A to CXCR4(+) leukemic cells, and showed potent antitumor activity without toxicity.
Article
Virology
Maria Fernanda de Castro-Amarante, Samuel Santos Pereira, Lennon Ramos Pereira, Lucas Souza Santos, Alexia Adrianne Venceslau-Carvalho, Eduardo Gimenes Martins, Andrea Balan, Luis Carlos de Souza Ferreira
Summary: This study evaluated the cross-inhibition effect of the DV2 peptide against Zika virus (ZIKV) and found that it efficiently inhibited ZIKV infectivity and reduced mortality in mice. These findings suggest that synthetic stem-based peptides have therapeutic potential against ZIKV infections.
Article
Oncology
Hashem O. Alsaab, Atiah H. Almalki
Summary: In this study, the connection between CXCR4 expression and HSP70 inhibitor activity in colorectal cancer was examined. It was found that inhibiting HSP70 significantly reduced the expression of CXCR4 and inhibited cancer cell proliferation and migration.
Article
Medicine, General & Internal
Fengxia Huang, Wei Tang, Yan Lei
Summary: By constructing a miRNA-mRNA interaction network, it was found that miR-107 promotes apoptosis of AML cells by regulating the expression of RAD51, shedding light on its role in the pathogenesis of AML.
ARCHIVES OF MEDICAL SCIENCE
(2021)
Article
Chemistry, Multidisciplinary
Maja Severic, Guanglong Ma, Sara G. T. Pereira, Amalia Ruiz, Calvin C. L. Cheung, Wafa T. Al-Jamal
Summary: The engineered anti-PSMA peptide-targeted EMs showed increased cellular internalization in PSMA positive PC cell lines and higher tumor targeting ability in vivo, indicating their potential as a promising drug delivery system for advanced prostate cancer.
JOURNAL OF CONTROLLED RELEASE
(2021)
Article
Biochemistry & Molecular Biology
Aifang Yao, Yingxue Ma, Ruize Sun, Wanchen Zou, Xiaoling Chen, Mei Zhou, Chengbang Ma, Tianbao Chen, Chris Shaw, Lei Wang
Summary: Antimicrobial peptides, such as crabrolin, are garnering interest as alternatives to combat antibiotic resistance and cancer. By designing analogs based on crabrolin and enhancing cationicity, researchers have developed derivatives with improved antibacterial and anticancer activities, such as crabrolin-TR, which shows promise as a potential candidate for development.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Pharmacology & Pharmacy
Donghui Gan, Yuwen Chen, Zhengjun Wu, Liping Luo, Shimuye Kalayu Yirga, Na Zhang, Fu Ye, Haijun Chen, Jianda Hu, Yingyu Chen
Summary: DOX-PMs-NPMBP demonstrates significant anti-leukemia potential in resistant ALL cells by enhancing chemosensitivity to DOX and inducing apoptosis. This novel drug delivery system may be valuable for developing new therapeutic strategies against multidrug resistant ALL.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Yuan Liu, Yaqin Tang, Xing Tang, Mengqi Wu, Shengjie Hou, Xiaohua Liu, Jing Li, Meichun Deng, Shuaiqin Huang, Liping Jiang
Summary: The study identified a novel spider peptide, XYP1, with potent anti-Toxoplasma activity both in vitro and in vivo. XYP1 inhibited the viability, invasion, and proliferation of tachyzoites with low cytotoxicity on human host cells and improved the survival rate of mice infected with T. gondii. Further exploration of the mechanism revealed XYP1 causes membrane perforation, swelling, and disruption of tachyzoites, potentially through differential expression of membrane-associated proteins including HSP29. Overall, XYP1 shows promise as a new drug candidate for toxoplasmosis treatment.
Article
Food Science & Technology
Ying Zhu, Yuyang Huang, Meiying Li, Bingyu Sun, Linlin Liu, Mingshou Lv, Min Qu, Huanan Guan, Xiuqing Zhu
Summary: The high Fischer (F) ratio hemp peptide (HFHP) was prepared using activated carbon adsorption, ultrafiltration, and gel filtration chromatography. HFHP showed strong scavenging abilities for DPPH, hydroxyl free radicals, and superoxide. Mouse experiments demonstrated that HFHP increased the activity of superoxide dismutase and glutathione peroxidase, and improved swimming performance by reducing lactic acid, serum urea nitrogen, and malondialdehyde levels while increasing liver glycogen.
FOOD RESEARCH INTERNATIONAL
(2023)
Article
Pharmacology & Pharmacy
Jianrong Yang, Jingtao Zhong, Mi Zhou, Yinghong Zhou, Peng Xiu, Feng Liu, Fuhai Wang, Zelun Li, Yuntian Tang, Yuanyuan Chen, Siyang Yao, Tao Huang, Tianqi Liu, Xiaofeng Dong
Summary: T7 peptide inhibits endothelial cell proliferation, migration, and tube formation, and promotes apoptosis under different oxygen conditions via integrin α3β1 and αvβ3 pathways. The combination of T7 peptide and meloxicam enhances the anti-tumor effect against HCC tumors.
Article
Chemistry, Multidisciplinary
Xiao-He Ren, Chang Xu, Li-Li Li, Yan Zuo, Di Han, Xiao-Yan He, Si-Xue Cheng
Summary: A dual-targeting CRISPR-Cas9 genome editing nanosystem was developed to reverse the malignancy of acute myeloid leukemia (AML) cells. The nanosystem effectively knocked out CXCR4 gene, leading to inhibited cell growth and migration. Moreover, this study provides an effective strategy to evaluate therapeutic efficiency through peripheral blood-based ex vivo studies.
JOURNAL OF CONTROLLED RELEASE
(2022)
Article
Gastroenterology & Hepatology
Alex B. Blair, Jianxin Wang, John Davelaar, Andrew Baker, Keyu Li, Nan Niu, Junke Wang, Yingkuan Shao, Vanessa Funes, Pan Li, Jonathan A. Pachter, Daniel C. Maneval, Felipe Dezem, Jasmine Plummer, Keith Syson Chan, Jun Gong, Andrew E. Hendifar, Stephen J. Pandol, Richard Burkhart, Yuqing Zhang, Lei Zheng, Arsen Osipov
Summary: This study identifies the synergistic effects of targeting both intracellular and extracellular components within the PDAC stroma, and supports the potential of testing anti-CXCR4 antibody in combination with FAKi as a PDAC treatment strategy.
Article
Cell Biology
RongLing He, XiangNing Yuan, Xin Lv, QingXiang Liu, LiJian Tao, Jie Meng
Summary: The study found that Cav-1 levels were significantly reduced in the lungs of silicosis patients and mice, and absence of Cav-1 exacerbated lung damage in silicosis models. Cav-1 plays a protective role in silica-induced lung injury by inhibiting inflammatory responses and oxidative stress.
JOURNAL OF CELLULAR AND MOLECULAR MEDICINE
(2022)
Article
Engineering, Multidisciplinary
Chao Liu, Hui Wang, Yu Huang, Youmin Rong, Jie Meng, Gen Li, Guojun Zhang
Summary: A novel intelligent mobile welding robot with adaptive seam tracking ability has been developed, which can navigate autonomously to different stations for welding operations. The robot utilizes a multi-layer sensing strategy and a composite sensor system to accurately detect and track the welding seam, improving the welding quality and efficiency.
MEASUREMENT SCIENCE AND TECHNOLOGY
(2022)
Article
Chemistry, Multidisciplinary
Sidian Zhang, Xue Zhang, Jie Meng, Ling Lu, Shanda Du, Haiyan Xu, Sizhu Wu
Summary: This study combines experimental characterization and molecular simulation to investigate the solubilization of myricetin by solid dispersion. The effectiveness of poly(vinyl pyrrolidone) > hypromellose > poly(ethylene glycol) as polymer excipients is confirmed through analysis of dispersibility and hydrogen-bond interaction. The reliability of simulation and micromechanism analysis is further confirmed by dissolution, cell viability, and ROS-level detection.
Article
Chemistry, Applied
Tian Wang, Boya Hao, Shilin Xu, Jie Meng, Tao Wen, Jian Liu, Haiyan Xu
Summary: This study established a universal strategy for effective RNA interference in different types of leukemia cells by using PS as an siRNA carrier and DL to promote lysosomal escape. The complex of PS and siRNA could be internalized by leukemia cells and escape from lysosomes with the aid of DL, resulting in effective RNAi against key genes.
CARBOHYDRATE POLYMERS
(2022)
Article
Nanoscience & Nanotechnology
Tao Wang, Xue Zhang, Mengfan Jia, Aiyun Yang, Jian Liu, Tao Wen, Jie Meng, Haiyan Xu
Summary: This study investigates the differentiation-induction effects of lab-developed hydrophilic nanocrystals of As4S4 (ee-As4S4) on acute myeloid leukemia (AML) cells. The results show that ee-As4S4 induces effective and multiple-lineage differentiation and apoptosis of AML cells in mouse models and cell lines. The inhibition of histone deacetylase activity plays an important role in the differentiation-induction effects. Furthermore, ee-As4S4 improves the survival of AML mice without causing acute or chronic toxicity in healthy mice, suggesting its promising potential as a novel inductive agent in differentiation therapy of AML.
INTERNATIONAL JOURNAL OF NANOMEDICINE
(2022)
Article
Engineering, Mechanical
Liquan Jiang, Shuting Wang, Yuanlong Xie, Sheng Quan Xie, Shiqi Zheng, Jie Meng
Summary: This study introduces a novel adaptive fractional robust finite time controller, which achieves the required control accuracy and stability under serious time-varying perturbations by designing constrained prediction and sliding mode mechanisms.
MECHANISM AND MACHINE THEORY
(2022)
Article
Immunology
Ting-Ting Yao, Yan Zhang, Rong-Ling He, Xin Lv, Yi-Jun He, Meng -Yu Li, Yuan-Yuan Han, Ling-Zhi Long, Guo-Liang Jiang, Xiao-Yun Cheng, Gao-Yun Hu, Qian-Bin Li, Li-Jian Tao, Jie Meng
Summary: Mefunidone effectively protects against lipopolysaccharide-induced acute lung injury by inhibiting the MAPK signaling pathway and activating the Nrf2 pathway, thereby alleviating inflammation and oxidative stress.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2022)
Article
Nanoscience & Nanotechnology
Aiyun Yang, Tao Wen, Boya Hao, Yiling Meng, Xue Zhang, Tian Wang, Jie Meng, Jian Liu, Jianhua Wang, Haiyan Xu
Summary: In this study, nanorods composed of ultrasmall platinum nanoparticles were synthesized and their distribution and toxic effects in mice were investigated. The results showed that the nanorods mainly accumulated in the liver and spleen without significant toxic effects on organ function.
INTERNATIONAL JOURNAL OF NANOMEDICINE
(2022)
Article
Nanoscience & Nanotechnology
Xue Zhang, Fei Kong, Tian Wang, Xin Huang, Wanqing Li, Meichen Zhang, Tao Wen, Jian Liu, Yu Zhang, Jie Meng, Haiyan Xu
Summary: In this study, the interaction between three types of iron oxide nanoparticles (IONPs) with vascular endothelial cells was investigated. It was found that certain nanoparticles can induce cell growth inhibition and ferroptosis, and the surface coating and core chemistry of the nanoparticles play a role in these effects.
Article
Pharmacology & Pharmacy
Jiajia Li, Yupeng Jiang, Qin Dai, Yue Yu, Xin Lv, Yan Zhang, Xiaohua Liao, Liyun Ao, Gaoyun Hu, Jie Meng, Zhangzhe Peng, Lijian Tao, Yanyun Xie
Summary: In this study, the protective effect of Mefunidone on ischemia-reperfusion injury-induced acute kidney injury was investigated. The results showed that Mefunidone can protect the kidney by relieving kidney tubular injury, suppressing oxidative stress, and inhibiting cell apoptosis. Furthermore, Mefunidone reduced mitochondrial damage and protected mitochondrial function.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Engineering, Biomedical
Jie Meng, Bo Xiao, Fengxin Wu, Lihong Sun, Bo Li, Wen Guo, Xuechun Hu, Xuegai Xu, Tao Wen, Jian Liu, Haiyan Xu
Summary: The integration of carbon fibers and coaxial fibrous mesh in the scaffold can enhance cardiomyocyte maturation and angiogenesis, promoting myocardial regeneration and functional recovery, thus rescuing heart dysfunction.
MATERIALS TODAY BIO
(2022)
Article
Business
Ying Feng, Jie Meng
Summary: This study examines the impact of physical and psychological distance on individuals' perception of connectedness with the servicescape and their perception of value. It also explores how consumers' techno-psychological differences and interaction modes influence this distance-closeness relationship. Using a quasi-experimental design in three service scenarios, the researchers find that contactless technology can effectively change high self-efficiency customers' perception of closeness to the servicescape and their evaluation of the service in distancing settings. The findings have practical implications for different types of consumers in service encounters during or after the COVID-19 pandemic.
JOURNAL OF INTERACTIVE MARKETING
(2023)
Article
Humanities, Multidisciplinary
Zirui Wang, Jie Meng
Summary: This study investigates the impact of digitalisation on the attractiveness and value perception of cultural heritage displays among younger generations, and proposes an integrated model to reveal the associations between relevant variables.
MUSEUM MANAGEMENT AND CURATORSHIP
(2023)
Article
Nanoscience & Nanotechnology
Shilin Xu, Meichen Zhang, Xiaocui Fang, Xuechun Hu, Haiyan Xing, Yanlian Yang, Jie Meng, Tao Wen, Jian Liu, Jianxiang Wang, Chen Wang, Haiyan Xu
Summary: A novel therapeutic strategy for acute myeloid leukemia (AML) was studied, which involved the fabrication of nanomicelles loaded with a CD123 antagonistic peptide. In vitro and in vivo experiments demonstrated that the nanomicelles, referred to as mPO-6, specifically bound to CD123+ AML cells and effectively inhibited cell viability. Intravenous administration of mPO-6 reduced AML cell infiltration and prolonged the survival of AML mice. Further investigation revealed that mPO-6 interfered with the CD123/IL-3 axis by regulating the activation of STAT5, PI3K/AKT, and NF-Kappa B signaling pathways related to cell proliferation or apoptosis at the mRNA and protein levels.
ACS APPLIED MATERIALS & INTERFACES
(2022)
Retraction
Cell Biology
Jingjing Liu, Liming Cao, Jie Meng, Yuanyuan Li, Pengbo Deng, Pinhua Pan, Chengping Hu, Huaping Yang