Review
Oncology
Yeu-Chai Jang, Chi Yan Leung, Hsi -Lan Huang
Summary: Analysis of 11 cohort studies involving 2,712,313 women found no overall association between menopausal hormone therapy (MHT) use and risk of pancreatic cancer. However, subgroup analysis revealed a decreased risk among users of estrogen-only and combined estrogen-progestin therapy. Future studies should focus on investigating MHT formulations.
CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION
(2023)
Review
Oncology
Saverio Caini, Sofia Chioccioli, Elisa Pastore, Miriam Fontana, Katia Tortora, Giovanna Caderni, Giovanna Masala
Summary: This study conducted a meta-analysis to investigate the association between fish consumption and colorectal cancer (CRC) risk, and found that increased fish consumption may protect against CRC development. Preclinical studies also identified multiple mechanisms through which fish components can inhibit colorectal carcinogenesis. These findings have important implications for dietary recommendations for cancer prevention.
Review
Nutrition & Dietetics
Yudi Sun, Xinyi He, Yan Sun
Summary: This meta-analysis examines the relationship between red and processed meat consumption and pancreatic cancer risk. The results indicate that there is no association between the consumption of red and processed meat and the risk of pancreatic cancer.
FRONTIERS IN NUTRITION
(2023)
Review
Nutrition & Dietetics
Long-Gang Zhao, Zhuo-Ying Li, Guo-Shan Feng, Xiao-Wei Ji, Yu-Ting Tan, Hong-Lan Li, Marc J. Gunter, Yong-Bing Xiang
Summary: This comprehensive meta-analysis of tea drinking and cancer risk found inconsistent associations, with weak evidence for certain types of cancer. More well-designed studies are needed to further investigate the relationships between tea intake and cancer risk.
ADVANCES IN NUTRITION
(2021)
Review
Medicine, General & Internal
Ming-Hui Sun, Zhao-Yan Wen, Ran Wang, Chang Gao, Jia-Li Yin, Yu-Jiao Chang, Qi-Jun Wu, Yu-Hong Zhao
Summary: Parity is associated with an increased risk of metabolic syndrome (MetS). Each additional live birth is associated with a 12% higher risk of MetS. More large prospective cohort studies are needed to confirm these findings.
FRONTIERS IN MEDICINE
(2022)
Letter
Gastroenterology & Hepatology
Jong-Myon Bae
Summary: The study found that oral contraceptive use may not be associated with the risk of pancreatic cancer in women.
WORLD JOURNAL OF GASTROENTEROLOGY
(2021)
Review
Nutrition & Dietetics
Xianpeng Qin, Jing Chen, Guiqing Jia, Zhou Yang
Summary: This umbrella review aimed to examine the associations between dietary factors and pancreatic cancer risk. The study found a positive association between fructose intake and pancreatic cancer risk, and a negative association between nuts intake or adherence to the Mediterranean diet and pancreatic cancer incidence. However, weak evidence was found for the associations between red meat or heavy alcohol intake and pancreatic cancer incidence.
ADVANCES IN NUTRITION
(2023)
Article
Pharmacology & Pharmacy
Jie Wang, Jing Gao, Hong-li Xu, Ying Qian, Li Xie, Herbert Yu, Bi-yun Qian
Summary: This study found a negative association between Citrus fruit intake and lung cancer risk. Moreover, there was a nonlinear dose-response relationship between Citrus intake and lung cancer risk within a certain range.
PHARMACOLOGICAL RESEARCH
(2021)
Article
Oncology
Sheng Cheng, Bo Yang, Liwei Xu, Qiming Zheng, Guoqing Ding, Gonghui Li
Summary: This meta-analysis found a significant increase in the risk of prostate cancer among men who underwent vasectomy, with an association also found with the risk of advanced prostate cancer. Further large prospective studies are needed to validate these findings and explore potential underlying molecular mechanisms.
Review
Gastroenterology & Hepatology
Ankit Chhoda, Ziga Vodusek, Kapil Wattamwar, Eric Mukherjee, Craig Gunderson, Alyssa Grimshaw, Anup Sharma, Nita Ahuja, Fay Kastrinos, James J. Farrell
Summary: This study quantified the occurrence of late-stage pancreatic ductal adenocarcinoma (PDAC) during surveillance of high-risk individuals (HRIs) and found that their incidence was not associated with baseline clinicoradiologic features. Further research on stage-based outcomes is needed to improve HRI surveillance.
Review
Gastroenterology & Hepatology
Hongjuan Fu, Jie Zeng, Chang Liu, Yi Gu, Yixin Zou, Hui Chang
Summary: High intake of folate may be associated with a decreased risk of pancreatic cancer, especially in case-control studies. However, this association was not observed in cohort studies. Dose-response meta-analysis showed a marginal association between an increment of folate intake and the risk of pancreatic cancer.
DIGESTIVE DISEASES AND SCIENCES
(2021)
Review
Medicine, Research & Experimental
Monica Butnariu, Cristina Quispe, Jesus Herrera-Bravo, Pawel Helon, Wirginia Kukula-Koch, Victor Lopez, Francisco Les, Cristian Valdes Vergara, Pedro Alarcon-Zapata, Barbara Alarcon-Zapata, Miquel Martorell, Marius Pentea, Aneta Anca Dragunescu, Ionel Samfira, Zura Yessimsiitova, Sevgi Durna Dastan, Carla Marina Salgado Castillo, Thomas H. Roberts, Javad Sharifi-Rad, Wojciech Koch, William C. Cho
Summary: Thymoquinone has multiple biological activities, including anti-inflammatory, antioxidant, and anticancer effects. It has shown potential as an additional therapeutic agent against pancreatic cancer by altering cell cycle progression, inhibiting cell proliferation, and stimulating apoptosis. Clinical trials are needed to further explore its success in human medicine.
BIOMEDICINE & PHARMACOTHERAPY
(2022)
Article
Clinical Neurology
Fangfang Zhang, Kuanhong Wang, Peixin Du, Wei Yang, Yazhou He, Tian Li, Zubing Mei
Summary: This meta-analysis indicates that cancer survivors have a relatively higher risk of stroke compared to cancer-free populations, especially among female survivors, younger individuals, and those with shorter cancer survival duration. Survivors are more prone to ischemic stroke. Due to substantial heterogeneity among the studies, caution is needed in interpreting the results.
Article
Public, Environmental & Occupational Health
Sabine Naudin, Joshua N. Sampson, Steven C. Moore, Demetrius Albanes, Neal D. Freedman, Stephanie J. Weinstein, Rachael Stolzenberg-Solomon
Summary: The study found that abnormal lipid metabolism in prospective studies is associated with pancreatic ductal carcinoma (PDAC). A comprehensive investigation of two prospective studies revealed that 43 lipid species were associated with PDAC.
EUROPEAN JOURNAL OF EPIDEMIOLOGY
(2023)
Article
Gastroenterology & Hepatology
Shuai Xu, Hui-lan Wang, Chao Xia, Jun Lv, Gang Zhang
Summary: The relationship between oral disease and pancreatic cancer (PC) is investigated in this systematic review and meta-analysis. Epidemiological studies have shown inconsistent results on the association of poor oral hygiene, periodontal disease, and tooth loss with the risk of PC. Therefore, this study aims to provide a comprehensive analysis of existing literature on this topic.
Article
Immunology
Jianbo Tian, Ming Zhang, Meng Jin, Fengqin Zhang, Qian Chu, Xiaoyang Wang, Can Chen, Huihui Yue, Li Zhang, Ronghui Du, Dong Zhao, Zhaofu Zeng, Yang Zhao, Kui Liu, Mengmei Wang, Ke Hu, Xiaoping Miao, Huilan Zhang
Summary: This study found that tocilizumab treatment in COVID-19 patients can lower the risk of in-hospital death and acute respiratory distress syndrome. Patients had heightened inflammation and dysregulated immune cells before treatment, but these indicators improved after tocilizumab administration.
JOURNAL OF IMMUNOLOGY
(2021)
Article
Genetics & Heredity
Pei Ji, Jiang Chang, Xiaoyu Wei, Xueyao Song, Hua Yuan, Linnan Gong, Yuancheng Li, Dongsheng Ding, Erbao Zhang, Caiwang Yan, Meng Zhu, Xiaoping Miao, Chen Wu, Guangfu Jin, Zhibin Hu, Hongbing Shen, Hongxia Ma
Summary: This study identified three novel genetic variants associated with SCCHN risk. Functional analysis revealed that one variant could modulate TCF19 expression by regulating the binding affinity of SREBF1 to the promoter of TCF19. These findings suggest that TCF19 may serve as a susceptibility gene for SCCHN.
JOURNAL OF MEDICAL GENETICS
(2022)
Article
Medicine, General & Internal
Ting Ding, Tian Wang, Jinjin Zhang, Pengfei Cui, Zhe Chen, Su Zhou, Suzhen Yuan, Wenqing Ma, Minli Zhang, Yueguang Rong, Jiang Chang, Xiaoping Miao, Xiangyi Ma, Shixuan Wang
Summary: The study revealed that COVID-19 may impact ovarian function in reproductive-aged women, leading to ovarian injury and reproductive endocrine disorders. Extra attention should be paid to the ovarian function of this population during the pandemic.
FRONTIERS IN MEDICINE
(2021)
Article
Oncology
Ying Zhu, Jianbo Tian, Xiating Peng, Xiaoyang Wang, Nan Yang, Pingting Ying, Haoxue Wang, Bin Li, Yue Li, Ming Zhang, Yimin Cai, Zequn Lu, Siyuan Niu, Yao Li, Rong Zhong, Jiang Chang, Xiaoping Miao
Summary: This study aimed to identify functional genes and genetic variants associated with PDAC prognosis, and revealed that CAV2 gene plays an important role in PDAC progression and prognosis through regulating genes involved in focal adhesion and extracellular matrix organization pathways. Overexpression of CAV2 promoted PDAC progression and metastasis, while knockout of CAV2 suppressed PDAC progression.
EUROPEAN JOURNAL OF CANCER
(2021)
Article
Urology & Nephrology
Hui Tang, Can Tu, Fei Xiong, Xin Sun, Jian-Bo Tian, Jun-Wu Dong, Xiao-Hui Wang, Chun-Tao Lei, Jing Liu, Zheng Zhao, Yang Qiu, Xiao-Ping Miao, Chun Zhang
Summary: Maintenance hemodialysis patients are at increased risk of mortality and prolonged virus shedding period in the ongoing COVID-19 pandemic. Advanced age, decreased oxygen saturation, low diastolic blood pressure on admission, and complications like acute cardiac injury are independently associated with poor prognosis.
SEMINARS IN DIALYSIS
(2022)
Article
Biochemistry & Molecular Biology
Hongda Chen, Li Liu, Ming Lu, Yuhan Zhang, Bin Lu, Ying Zhu, Jianbo Tian, Xinying Li, Shaofa Nie, Xiaoping Miao, Min Dai
Summary: The study found that individuals with unfavorable lifestyle and higher genetic risk have a significantly increased risk of developing colorectal neoplasm. For high-risk individuals, the estimated absolute risk of developing colorectal neoplasm is higher. Risk models and risk-adapted screening help in developing effective personalized CRC prevention and screening strategies.
FRONTIERS IN MOLECULAR BIOSCIENCES
(2021)
Article
Oncology
Jianbo Tian, Zequn Lu, Siyuan Niu, Shanshan Zhang, Pingting Ying, Lu Wang, Ming Zhang, Yimin Cai, Tianyi Dong, Ying Zhu, Rong Zhong, Zhihua Wang, Jiang Chang, Xiaoping Miao
Summary: The study identified a germline variant (rs2274110) in the MCM10 gene associated with ESCC prognosis, with individuals carrying the AA genotype having poorer survival outcomes. This variant increased SUMOylation levels of the MCM10 protein, leading to its overexpression and contributing to the proliferation and metastasis abilities of ESCC cells. MCM10 inhibitors, such as Suramin, were shown to effectively block ESCC cell metastasis.
CLINICAL AND TRANSLATIONAL MEDICINE
(2021)
Article
Oncology
Haoxue Wang, Ying Zhu, Hongda Chen, Nan Yang, Xiaoyang Wang, Bin Li, Pingting Ying, Heng He, Yimin Cai, Ming Zhang, Siyuan Niu, Yue Li, Zequn Lu, Xiating Peng, Danyi Zou, Rong Zhong, Jiang Chang, Min Dai, Jianbo Tian, Xiaoping Miao
Summary: This study comprehensively characterized the role of ATF1 in CRC through RNA-seq and ChIP-seq assays, identifying a specific variant, rs7017386, associated with the risk of CRC by affecting the expression of CCAT1 and PVT1 in the Wnt pathway. Mechanistically, the rs7017386 allele was found to enhance ATF1 binding affinity and promote the expressions of PVT1 and CCAT1 by forming a long-range chromatin loop, resulting in the activation of the Wnt pathway in CRC progression.
Article
Environmental Sciences
Heng He, Yao Deng, Hao Wan, Na Shen, Jiaoyuan Li, Qiang Zeng, Jiang Chang, Qing Lu, Xiaoping Miao, Jianbo Tian, Rong Zhong
Summary: The study found that breast cancer patients had significantly higher urinary BPA concentrations than healthy individuals, with a 54% increased risk of breast cancer for every 1-unit increase in log-transformed urinary BPA. Individuals with the CYP19A1 rs1902580 GA + AA genotype had a significantly higher risk of breast cancer than those with the GG genotype. The interaction between BPA and CYP17A1 rs743572 was associated with a higher risk of breast cancer.
Article
Environmental Sciences
Yu Miao, Mao Rong, Min Li, Heng He, Li Zhang, Shanshan Zhang, Chong Liu, Ying Zhu, Yan-Ling Deng, Pan-Pan Chen, Jia-Yue Zeng, Rong Zhong, Su-Rong Mei, Xiao-Ping Miao, Qiang Zeng
Summary: Studies have found a positive association between exposure to organochlorine pesticides (OCPs) and risk of breast cancer, with lipid peroxidation potentially mediating this relationship.
ENVIRONMENTAL POLLUTION
(2021)
Article
Environmental Sciences
Yao Deng, Heng He, Hao Wan, Na Shen, Jiaoyuan Li, Shanshan Zhang, Qiang Zeng, Jiang Chang, Qing Lu, Rong Zhong, Xiaoping Miao
Summary: The study showed significant positive associations between BPA, 8-OHdG, and HNE-MA with colorectal cancer risk. The positive association of BPA with CRC risk might be partly mediated by oxidative stress HNE-MA. Additionally, BPA was found to interact with specific genetic variants to increase CRC risk.
ENVIRONMENTAL POLLUTION
(2021)
Article
Environmental Sciences
Shuang Zhou, Qiuqi Zhu, Huimin Liu, Shunli Jiang, Xu Zhang, Cheng Peng, Guanlin Yang, Jiaoyuan Li, Liming Cheng, Rong Zhong, Qiang Zeng, Xiaoping Miao, Qing Lu
Summary: This study found that urinary metabolites of naphthalene and phenanthrene were positively associated with lung cancer risk, and the genetic polymorphism of X-ray repair cross-complementation 1 gene may modify this association.
ENVIRONMENTAL POLLUTION
(2021)
Article
Peripheral Vascular Disease
Jia He, Zhaoyang Li, Ruixin Wang, Hongli Nie, Fei Wang, Jing Yuan, Xiaoping Miao, Ping Yao, Sheng Wei, Xiaomin Zhang, Huan Guo, Handong Yang, Tangchun Wu, Meian He
Summary: In older individuals, combining abnormal glucose metabolism with different levels of systolic blood pressure is associated with an increased risk of incident CKD. Furthermore, long-term blood pressure changes of more than 5 mmHg are also linked to the risk of developing CKD in individuals with normal glucose metabolism or prediabetes.
JOURNAL OF CLINICAL HYPERTENSION
(2021)
Article
Environmental Sciences
Rong Zhong, Heng He, Meng Jin, Zequn Lu, Yao Deng, Chong Liu, Na Shen, Jiaoyuan Li, Haoxue Wang, Pingting Ying, Bin Li, Qiang Zeng, Qing Lu, Liming Cheng, Ying Zhu, Xiaoping Miao, Jianbo Tian
Summary: This study in a Chinese population found a positive association between bisphenols, triclosan and oxidative stress markers. Significant interactions between genetic variants and endocrine disruptors were identified, indicating that endocrine disruptors may modify the effect of genetic variants on oxidative stress.
SCIENCE OF THE TOTAL ENVIRONMENT
(2022)
Article
Oncology
Bin Li, Xiang Cheng, Ying Zhu, Hao Wan, Zequn Lu, Yimin Cai, Wenhui Li, Pengfei Yi, Li Liu, Jiang Chang, Xiaoping Miao, Jianbo Tian, Rong Zhong
Summary: The study revealed that the regulatory variant rs7160774 was associated with a decreased risk of breast cancer. Biological experiments demonstrated that the rs7160774[A] allele down-regulated FOXA1 expression by affecting transcription factor binding affinity, suggesting a crucial role in breast cancer development.
