Small molecule generators of biologically reactive sulfur species

Light triggered uncaging of hydrogen sulfide (H2S) with real-time monitoring

(2018) Yarra Venkatesh et al.   CHEMICAL COMMUNICATIONS

Cyclic Acyl Disulfides and Acyl Selenylsulfides as the Precursors for Persulfides (RSSH), Selenylsulfides (RSeSH), and Hydrogen Sulfide (H2S)

(2018) Jianming Kang et al.   ORGANIC LETTERS

Ambient sulfur dioxide levels associated with reduced risk of initial outpatient visits for tuberculosis: A population based time series analysis

(2017) Erjia Ge et al.   ENVIRONMENTAL POLLUTION

Blue light-induced oxidative stress in live skin

(2017) Yuya Nakashima et al.   FREE RADICAL BIOLOGY AND MEDICINE

Toward Direct Protein S-Persulfidation: A Prodrug Approach That Directly Delivers Hydrogen Persulfide

(2017) Bingchen Yu et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Kinetic Insights into Hydrogen Sulfide Delivery from Caged-Carbonyl Sulfide Isomeric Donor Platforms

(2017) Yu Zhao et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Click and Release: SO2 Prodrugs with Tunable Release Rates

(2017) Xingyue Ji et al.   ORGANIC LETTERS

Light-Activated COS/H2S Donation from Photocaged Thiocarbamates

(2017) Yu Zhao et al.   ORGANIC LETTERS

Esterase Sensitive Self-Immolative Sulfur Dioxide Donors

(2017) Kundansingh A. Pardeshi et al.   ORGANIC LETTERS

The opposing roles of NO and oxidative stress in cardiovascular disease

(2017) Rebecca H. Ritchie et al.   PHARMACOLOGICAL RESEARCH

“On demand” redox buffering by H2S contributes to antibiotic resistance revealed by a bacteria-specific H2S donor

(2017) Prashant Shukla et al.   Chemical Science

Discovery and Mechanistic Characterization of Selective Inhibitors of H2S-producing Enzyme: 3-Mercaptopyruvate Sulfurtransferase (3MST) Targeting Active-site Cysteine Persulfide

(2017) Kenjiro Hanaoka et al.   Scientific Reports

Benzothiazole Sulfinate: a Water-Soluble and Slow-Releasing Sulfur Dioxide Donor

(2016) Jacob J. Day et al.   ACS Chemical Biology

Hydrogen Sulfide Donors Activated by Reactive Oxygen Species

(2016) Yu Zhao et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Esterase-Sensitive Prodrugs with Tunable Release Rates and Direct Generation of Hydrogen Sulfide

(2016) Yueqin Zheng et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

pH-Controlled Hydrogen Sulfide Release for Myocardial Ischemia-Reperfusion Injury

(2016) Jianming Kang et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Therapeutic Delivery of H2S via COS: Small Molecule and Polymeric Donors with Benign Byproducts

(2016) Chadwick R. Powell et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Self-Immolative Thiocarbamates Provide Access to Triggered H2S Donors and Analyte Replacement Fluorescent Probes

(2016) Andrea K. Steiger et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Esterase Activated Carbonyl Sulfide/Hydrogen Sulfide (H2S) Donors

(2016) Preeti Chauhan et al.   ORGANIC LETTERS

9-Fluorenylmethyl (Fm) Disulfides: Biomimetic Precursors for Persulfides

(2016) Chung-Min Park et al.   ORGANIC LETTERS

“Zipped Synthesis” by Cross-Metathesis Provides a Cystathionine β-Synthase Inhibitor that Attenuates Cellular H2S Levels and Reduces Neuronal Infarction in a Rat Ischemic Stroke Model

(2016) Christopher D. McCune et al.   ACS Central Science

A novel persulfide detection method reveals protein persulfide- and polysulfide-reducing functions of thioredoxin and glutathione systems

(2016) E. Doka et al.   Science Advances

Quantitative Persulfide Site Identification (qPerS-SID) Reveals Protein Targets of H2S Releasing Donors in Mammalian Cells

(2016) Sebastian Longen et al.   Scientific Reports

Signaling of Hydrogen Sulfide and Polysulfides

(2015) Hideo Kimura   ANTIOXIDANTS & REDOX SIGNALING

Thiol activated prodrugs of sulfur dioxide (SO2) as MRSA inhibitors

(2015) Kundansingh A. Pardeshi et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

A diarylethene as the SO2 gas generator upon UV irradiation

(2015) Ryuhei Kodama et al.   CHEMICAL COMMUNICATIONS

Peptide-based hydrogen sulphide-releasing gels

(2015) Jennifer M. Carter et al.   CHEMICAL COMMUNICATIONS

Reactions of isolated persulfides provide insights into the interplay between H 2 S and persulfide reactivity

(2015) T. Spencer Bailey et al.   FREE RADICAL BIOLOGY AND MEDICINE

CO-releasing Metal Carbonyl Compounds as Antimicrobial Agents in the Post-antibiotic Era

(2015) Lauren K. Wareham et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Reaction of Hydrogen Sulfide with Disulfide and Sulfenic Acid to Form the Strongly Nucleophilic Persulfide

(2015) Ernesto Cuevasanta et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Biosynthesis and Reactivity of Cysteine Persulfides in Signaling

(2015) Pramod K. Yadav et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Persulfides: current knowledge and challenges in chemistry and chemical biology

(2015) Chung-Min Park et al.   Molecular BioSystems

Biogenesis of reactive sulfur species for signaling by hydrogen sulfide oxidation pathways

(2015) Tatiana V Mishanina et al.   Nature Chemical Biology

Hydrogen sulfide-based therapeutics: exploiting a unique but ubiquitous gasotransmitter

(2015) John L. Wallace et al.   NATURE REVIEWS DRUG DISCOVERY

Kinetic and thermodynamic studies on the disulfide-bond reducing potential of hydrogen sulfide

(2015) Anita Vasas et al.   NITRIC OXIDE-BIOLOGY AND CHEMISTRY

Benzosulfones as photochemically activated sulfur dioxide (SO2) donors

(2015) Satish R. Malwal et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

The Development and Application of Sulfur Dioxide Surrogates in Synthetic Organic Chemistry

(2015) Edward J. Emmett et al.   Asian Journal of Organic Chemistry

Sulfur as a Signaling Nutrient Through Hydrogen Sulfide

(2014) Omer Kabil et al.   Annual Review of Nutrition

Nitric oxide in cancer metastasis

(2014) Huiwen Cheng et al.   CANCER LETTERS

A Persulfide Analogue of the Nitrosothiol SNAP: Formation, Characterization and Reactivity

(2014) Isabelle Artaud et al.   CHEMBIOCHEM

Hydrogen sulfide (H2S) releasing agents: chemistry and biological applications

(2014) Yu Zhao et al.   CHEMICAL COMMUNICATIONS

Redox chemistry and chemical biology of H2S, hydropersulfides, and derived species: Implications of their possible biological activity and utility

(2014) Katsuhiko Ono et al.   FREE RADICAL BIOLOGY AND MEDICINE

Organization of the Human Mitochondrial Hydrogen Sulfide Oxidation Pathway

(2014) Marouane Libiad et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Substituent Effects on Reactive Oxygen Species (ROS) Generation by Hydroquinones

(2014) Allimuthu T. Dharmaraja et al.   JOURNAL OF ORGANIC CHEMISTRY

Understanding Hydrogen Sulfide Storage: Probing Conditions for Sulfide Release from Hydrodisulfides

(2014) T. Spencer Bailey et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Functionalization of Methacrylate Polymers with Thiooximes: A Robust Postpolymerization Modification Reaction and a Method for the Preparation of H2S-Releasing Polymers

(2014) Jeffrey C. Foster et al.   MACROMOLECULES

Arylboronate Ester Based Diazeniumdiolates (BORO/NO), a Class of Hydrogen Peroxide Inducible Nitric Oxide (NO) Donors

(2014) Allimuthu T. Dharmaraja et al.   ORGANIC LETTERS

Thiol-Activated gem-Dithiols: A New Class of Controllable Hydrogen Sulfide Donors

(2014) Yu Zhao et al.   ORGANIC LETTERS

S-Aroylthiooximes: A Facile Route to Hydrogen Sulfide Releasing Compounds with Structure-Dependent Release Kinetics

(2014) Jeffrey C. Foster et al.   ORGANIC LETTERS

Reactive cysteine persulfides and S-polythiolation regulate oxidative stress and redox signaling

(2014) T. Ida et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Hydrogen sulfide donors in research and drug development

(2014) Zhi Jian Song et al.   MedChemComm

Controllable Hydrogen Sulfide Donors and Their Activity against Myocardial Ischemia-Reperfusion Injury

(2013) Yu Zhao et al.   ACS Chemical Biology

Detection of Protein S-Sulfhydration by a Tag-Switch Technique

(2013) Dehui Zhang et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Nitroreductase-activated nitric oxide (NO) prodrugs

(2013) Kavita Sharma et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

New Biologically Active Hydrogen Sulfide Donors

(2013) Thomas Roger et al.   CHEMBIOCHEM

Synthesis of a photocontrollable hydrogen sulfide donor using ketoprofenate photocages

(2013) Naoki Fukushima et al.   CHEMICAL COMMUNICATIONS

A water-soluble near-infrared probe for colorimetric and ratiometric sensing of SO2derivatives in living cells

(2013) Ming-Yu Wu et al.   CHEMICAL COMMUNICATIONS

Polysulfides are possible H2S-derived signaling molecules in rat brain

(2013) Yuka Kimura et al.   FASEB JOURNAL

Adenosine-5′-phosphosulfate - a multifaceted modulator of bifunctional 3′-phospho-adenosine-5′-phosphosulfate synthases and related enzymes

(2013) Jonathan W. Mueller et al.   FEBS Journal

Carbonyl Sulfide Hydrolase from Thiobacillus thioparus Strain THI115 Is One of the β-Carbonic Anhydrase Family Enzymes

(2013) Takahiro Ogawa et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Benzosultines as Sulfur Dioxide (SO2) Donors

(2013) Satish R. Malwal et al.   ORGANIC LETTERS

INDQ/NO, a Bioreductively Activated Nitric Oxide Prodrug

(2013) Kavita Sharma et al.   ORGANIC LETTERS

A Small Molecule for Controlled Generation of Reactive Oxygen Species (ROS)

(2013) Allimuthu T. Dharmaraja et al.   ORGANIC LETTERS

Light-Induced Hydrogen Sulfide Release from “Caged” gem-Dithiols

(2013) Nelmi O. Devarie-Baez et al.   ORGANIC LETTERS

Arylthioamides as H2S Donors: l-Cysteine-Activated Releasing Properties and Vascular Effects in Vitro and in Vivo

(2013) Alma Martelli et al.   ACS Medicinal Chemistry Letters

Sulfhydration mediates neuroprotective actions of parkin

(2013) M. Scott Vandiver et al.   Nature Communications

The Nitric Oxide Prodrug JS-K and Its Structural Analogues as Cancer Therapeutic Agents

(2012) Anna Maciag et al.   Anti-Cancer Agents in Medicinal Chemistry

Synthesis and antimycobacterial activity of prodrugs of sulfur dioxide (SO2)

(2012) Satish R. Malwal et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Involvement of redox-signalling in endogenous hydrogen sulfide production

(2012) Ferenc Gallyas   BRITISH JOURNAL OF PHARMACOLOGY

Design, synthesis and evaluation of small molecule reactive oxygen species generators as selective Mycobacterium tuberculosis inhibitors

(2012) Allimuthu T. Dharmaraja et al.   CHEMICAL COMMUNICATIONS

Potential biological chemistry of hydrogen sulfide (H2S) with the nitrogen oxides

(2012) S. Bruce King   FREE RADICAL BIOLOGY AND MEDICINE

Is NSAIDs-related gastrointestinal damage preventable?

(2012) Carla J. Gargallo et al.   Journal of Digestive Diseases

Hydrogen Sulfide-Linked Sulfhydration of NF-κB Mediates Its Antiapoptotic Actions

(2012) Nilkantha Sen et al.   MOLECULAR CELL

H2S signalling through protein sulfhydration and beyond

(2012) Bindu D. Paul et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Physiological Implications of Hydrogen Sulfide: A Whiff Exploration That Blossomed

(2012) Rui Wang   PHYSIOLOGICAL REVIEWS

Fifty Years of Diazeniumdiolate Research. From Laboratory Curiosity to Broad-Spectrum Biomedical Advances

(2011) Larry K. Keefer   ACS Chemical Biology

Sulfur signaling: Is the agent sulfide or sulfane?

(2011) John I. Toohey   ANALYTICAL BIOCHEMISTRY

Hydrogen Sulfide and Cell Signaling

(2011) Ling Li et al.   Annual Review of Pharmacology and Toxicology

Nitric oxide and redox mechanisms in the immune response

(2011) David A. Wink et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Design, Synthesis, and Evaluation of Thiol-Activated Sources of Sulfur Dioxide (SO2) as Antimycobacterial Agents

(2011) Satish R. Malwal et al.   JOURNAL OF MEDICINAL CHEMISTRY

DABCO-Bis(sulfur dioxide), DABSO, as a Convenient Source of Sulfur Dioxide for Organic Synthesis: Utility in Sulfonamide and Sulfamide Preparation

(2011) Holly Woolven et al.   ORGANIC LETTERS

The Slow-Releasing Hydrogen Sulfide Donor, GYY4137, Exhibits Novel Anti-Cancer Effects In Vitro and In Vivo

(2011) Zheng Wei Lee et al.   PLoS One

H2S: A Universal Defense Against Antibiotics in Bacteria

(2011) K. Shatalin et al.   SCIENCE

H2S-Induced Sulfhydration of the Phosphatase PTP1B and Its Role in the Endoplasmic Reticulum Stress Response

(2011) N. Krishnan et al.   Science Signaling

Hydrogen Sulfide Improves Neutrophil Migration and Survival in Sepsis via K+ATPChannel Activation

(2010) Fernando Spiller et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Synthesis and Biological Effects of Hydrogen Sulfide (H2S): Development of H2S-Releasing Drugs as Pharmaceuticals

(2010) Giuseppe Caliendo et al.   JOURNAL OF MEDICINAL CHEMISTRY

Cysteine-Activated Hydrogen Sulfide (H2S) Donors

(2010) Yu Zhao et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Hydrogen sulphide: novel opportunity for drug discovery

(2010) Alma Martelli et al.   MEDICINAL RESEARCH REVIEWS

Therapeutic potential of new hydrogen sulfide-releasing hybrids

(2010) Anna Sparatore et al.   Expert Review of Clinical Pharmacology

Chemical Biology of Peroxynitrite: Kinetics, Diffusion, and Radicals

(2009) Gerardo Ferrer-Sueta et al.   ACS Chemical Biology

Factors Controlling the Reactivity of Hydrogen Sulfide with Hemeproteins

(2009) Ruth Pietri et al.   BIOCHEMISTRY

Endogenous and Exogenous Hydrogen Sulfide Promotes Resolution of Colitis in Rats

(2009) John L. Wallace et al.   GASTROENTEROLOGY

Multitargeted prevention and therapy of cancer by diallyl trisulfide and related Allium vegetable-derived organosulfur compounds

(2008) Anna A. Powolny et al.   CANCER LETTERS

Mechanism of sulfite cytotoxicity in isolated rat hepatocytes

(2008) Hossein Niknahad et al.   CHEMICO-BIOLOGICAL INTERACTIONS

Characterization of a Novel, Water-Soluble Hydrogen Sulfide–Releasing Molecule (GYY4137)

(2008) Ling Li et al.   CIRCULATION

Three enzymatic activities catalyze the oxidation of sulfide to thiosulfate in mammalian and invertebrate mitochondria

(2008) Tatjana M. Hildebrandt et al.   FEBS Journal

The chemical biology of nitric oxide: Implications in cellular signaling

(2008) Douglas D. Thomas et al.   FREE RADICAL BIOLOGY AND MEDICINE

The role of sulfur dioxide as an endogenous gaseous vasoactive factor in synergy with nitric oxide

(2008) Junling Li et al.   NITRIC OXIDE-BIOLOGY AND CHEMISTRY

Perspective on Recent Developments on Sulfur-Containing Agents and Hydrogen Sulfide Signaling

(2008) Claus Jacob et al.   PLANTA MEDICA

Possible chemical mechanisms underlying the antitumor activity of S-deoxyleinamycin

(2007) Santhosh Sivaramakrishnan et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS