Correction
Chemistry, Inorganic & Nuclear
Jiahe Li, Zhiyuan Wang, Zhongting Chen, Xingyong Xue, Kejuan Lin, Hailan Chen, Lixia Pan, Yulin Yuan, Zhen Ma
Summary: The correction provides revised information on the crystal structure, photoluminescence, and DNA interactions of silver complexes with substituted terpyridines, which show potential as anticancer metallodrugs.
DALTON TRANSACTIONS
(2023)
Article
Chemistry, Physical
Nimya Ann Mathews, M. R. Prathapachandra Kurup
Summary: In this study, three novel mixed ligand complexes of copper were synthesized and characterized by spectroscopy and X-ray crystallography. The complexes' interaction with CT-DNA, cleavage ability, and cytotoxicity were investigated.
JOURNAL OF MOLECULAR STRUCTURE
(2022)
Article
Chemistry, Inorganic & Nuclear
Pran Gobinda Nandi, Praveen Kumar Jadi, Kanu Das, Siriyara Jagannatha Prathapa, Biman B. Mandal, Akshai Kumar
Summary: The synthesis and characterization of chiral pincer-ruthenium complexes of ((NNN)-N-R2)RuCl2 (PPh3) (R = 3-methylbutyl and 3,3dimethylbutyl) were reported. Cytotoxicity studies showed these complexes inhibited normal and cancer cell growth in a dose-dependent manner. Various assays revealed that the treatment with pincer-ruthenium complexes induced a redox imbalance in cells by upregulating ROS generation and causing necrotic cell death.
INORGANIC CHEMISTRY
(2021)
Article
Biochemistry & Molecular Biology
Tanveer A. A. Wani, Seema Zargar, Hamad M. M. Alkahtani, Nojood Altwaijry, Lamees S. S. Al-Rasheed
Summary: Multiple existing anticancer drugs have limitations in terms of efficacy, solubility, and toxicity, necessitating the continuous search for promising alternatives. This study investigates the anticancer effects of N-ethyl toluene-4-sulphonamide (8a) and 2,5-Dichlorothiophene-3-sulphonamide (8b) on breast and cervical cancer cell lines, as well as their interaction with sperm DNA. 2,5-Dichlorothiophene-3-sulphonamide (8b) is identified as the most promising anticancer drug, exhibiting significant cytotoxicity and similar inhibitory potential to standard drugs like Doxorubicin and cisplatin.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Biochemistry & Molecular Biology
Iogann Tolbatov, Alessandro Marrone, Cecilia Coletti, Nazzareno Re
Summary: Computational chemistry approaches have become crucial for the development of novel anticancer metallodrugs, with inorganic and organometallic complexes of transition metals showing increasing potential in cancer treatment. Among them, Au(I) and Au(III) compounds are promising candidates due to their strong affinity to protein residues. Predicting metal complexes' properties requires QM computations, while MM, MD, and docking approaches can provide valuable information on their interaction with biomolecular targets.
Article
Chemistry, Multidisciplinary
M. K. Gond, Shivendra Kumar Pandey, R. Singh, Manoj K. Bharty, Partha Pratim Manna, V. K. Singh, B. Maiti, L. B. Prasad, R. J. Butcher
Summary: In this study, three new metal complexes based on a specific ligand were synthesized and showed significant anti-tumor potential against cancer cells. These complexes exhibited stronger anti-tumor effects compared to metal salts or free ligands. Molecular docking studies also revealed favorable binding interactions between these complexes and target proteins.
NEW JOURNAL OF CHEMISTRY
(2022)
Article
Biochemistry & Molecular Biology
Yu-Mei Chen, Yu -Can Liu, Jin-Quan Wang, Guang-Chuan Ou, Xiao-Feng Wang, Shu-Qin Gao, Ke-Jie Du, Ying-Wu Lin
Summary: Four copper(II) complexes strongly interact with DNA through partial intercalation and cleave DNA through the generation of singlet oxygen (1O2). In vitro experiments show that these complexes exhibit significant anticancer activity and induce apoptosis in HeLa cells as demonstrated by AO/EB staining.
JOURNAL OF INORGANIC BIOCHEMISTRY
(2023)
Article
Biochemistry & Molecular Biology
Sanam Maikoo, Abir Chakraborty, Nyeleti Vukea, Laura Margaret Kirkpatrick Dingle, William John Samson, Jo-Anne de la Mare, Adrienne Lesley Edkins, Irvin Noel Booysen
Summary: The interactions of ruthenium heterocyclic complexes with DNA and BSA were studied using UV-Vis spectrophotometry, fluorescence emission spectroscopy, and agarose gel electrophoresis. The complexes were found to be groove-binders with high DNA binding constants. Additionally, they exhibited high radical scavenging activities and moderate cytotoxicity against cancer cell lines.
JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS
(2021)
Article
Biochemistry & Molecular Biology
R. Durga Priyadharshini, R. Jeyashree, R. Preethi, K. N. Vennila, Kuppanagounder P. Elango
Summary: The interaction between the anti-cancer drug Palbociclib and calf-thymus DNA was investigated using various biophysical techniques. The results showed that Palbociclib intercalated into the base pairs of DNA, indicating strong binding. Molecular docking studies revealed partial intercalation of the drug between the DNA base pairs, and metadynamics simulation studies confirmed DNA cleavage induced by Palbociclib, which was further validated by gel electrophoresis experiments.
JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS
(2023)
Article
Biochemistry & Molecular Biology
Waddhaah M. Al-Asbahy, Manal Shamsi
Summary: A new copper(II) complex derived from a specific ligand was synthesized and characterized using spectroscopic methods. The complex showed high DNA binding ability, interacted with HSA and SOD targets, and exhibited potential anti-tumor activity and superoxide dismutase mimetic activity. Additionally, molecular docking studies confirmed the specific binding modes with the targets, supporting the spectroscopic results.
JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS
(2021)
Article
Biochemistry & Molecular Biology
Nour E. A. Abd El-Sattar, Khaled El-Adl, Maher A. El-Hashash, Samir A. Salama, Mostafa M. Elhady
Summary: Pyrano[2,3-d]pyrimidine derivatives showed promising antimicrobial and cytotoxic activities against various microbial strains and cell lines, exhibiting strong inhibitory effects on cell wall synthesis and DNA intercalation. The compounds also demonstrated higher anticancer activities than doxorubicin, with some derivatives showing potent Topoisomerase II inhibitory activities. Molecular modeling studies supported the in vitro results, indicating the potential of these derivatives for further development as anti-infective and anticancer agents.
BIOORGANIC CHEMISTRY
(2021)
Article
Multidisciplinary Sciences
Mohammad Javad Taghipour, Hamid Ezzatpanah, Mohammad Ghahderijani
Summary: This study isolated camel milk protein fractions and hydrolyzed them using enzymes, finding peptides with anticancer and antibacterial activities. Two promising peptides, P3 and P5, showed low binding energy and inhibition constant, making them potential drug candidates.
Article
Biochemistry & Molecular Biology
Ashraf Sadat Dorafshan Tabatabai, Effat Dehghanian, Hassan Mansouri-Torshizi
Summary: In this study, a novel Zn(II) complex was synthesized and characterized. The complex exhibited effective antitumor activity and showed interactions with biological macromolecules. Molecular docking simulation confirmed the main interaction as hydrogen bonding.
JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS
(2023)
Article
Chemistry, Physical
Bhagyalalitha Meduri, S. R. Pavan, Ashwini Prabhu, Akshatha Handattu Shankaranarayana, Arun Kumar Sethu, Manisha Singh, Karthik G. Pujar, B. C. Revana Siddappa, Durgesh Bidye, Gurubasavaraj Veeranna Pujar
Summary: In this study, novel LPA1 receptor inhibitors were designed and synthesized, and their anti-cancer activity against breast cancer cells was evaluated through in vitro experiments. Compounds BI-4 and OX-1 showed significant cytotoxicity, reduced cell migration and apoptosis, and decreased the expression of LPA1 and angiogenesis genes.
JOURNAL OF MOLECULAR STRUCTURE
(2024)
Article
Chemistry, Multidisciplinary
Ateyatallah Aljuhani, Meshal A. Almehmadi, Ibrahim O. Barnawi, Nadjet Rezki, Imran Ali, Mouslim Messali, Mohamed Reda Aouad
Summary: This study successfully synthesized a series of click products and evaluated their anticancer activities. Compounds 5d and 5h exhibited high anticancer activities, could interact with DNA, and may serve as potential anticancer candidate compounds.
ARABIAN JOURNAL OF CHEMISTRY
(2021)
Article
Environmental Sciences
Imran Ali, Stoyanova Alyona, Kon'kova Tatiana, Gaydukova Anastasiya, Hassan M. Albishri, Wael Hamad Alshitari
Summary: A sorption-electroflotation method using carbon nanomaterials was developed to remove non-biodegradable and carcinogenic toxic metal ions. Carbon nanotubes (CNTs) and carbon nanoshells (CNSs) were used to remove Ni(II), Co(II), Zn(II), Fe(II), and Cu(II). Surface properties and composition of the nanomaterials were characterized, and different models were applied to analyze the data. The method showed excellent removal efficiency, with the highest percentage removal achieved through simultaneous sorption-electroflotation.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2023)
Article
Biotechnology & Applied Microbiology
Imran Ali, Hokman Mahmudov, Gunel Imanova, Telman Suleymanov, Ahmed M. Hameed, Ahmed Alharbi
Summary: Hydrogen production through water splitting using Al2O3 nanoparticles as a radiation catalyst with gamma rays irradiation was studied. The effects of different particle sizes, surface area, amounts of radiation catalyst, and irradiation time were investigated. It was found that smaller-sized nanoparticles resulted in higher hydrogen production.
JOURNAL OF CHEMICAL TECHNOLOGY AND BIOTECHNOLOGY
(2023)
Article
Engineering, Biomedical
Yi-Ho Hsieh, Yi-Chieh Chu, Jui-Ting Hsiao, Yi-Ting Shu, Ming-Fa Hsieh, Hung-Maan Lee
Summary: This study evaluates the potential use of porcine platelet lysate for the treatment of arthritis in rabbit knee joints. The experimental results show that xenogeneic platelet lysate is a safe and effective method in the treatment of arthritis, which can be used as a research basis for future medical applications.
JOURNAL OF MEDICAL AND BIOLOGICAL ENGINEERING
(2023)
Article
Materials Science, Multidisciplinary
Imran Ali, Teymur Agayev, Gunel T. Imanova, Hokman Mahmudov, Shahla Musayeva, Omar M. L. Alharbi, Mohammad Nahid Siddiqui
Summary: The production of economic green hydrogen fuel is in high demand. In this study, hydrogen generation by water radiolysis of a hexane-water system on ZrO2 surface was investigated at different temperatures. The radiation-catalytic decomposition of hexane-water increased at high temperatures and resulted in an increase in hydrogen production. At a temperature of 673 K, a chain mode conversion of the key products of hexane-water led to molecular hydrogen. The maximum yield of hydrogen achieved was 188.5 molecule/100 eV with the n-ZrO2 + C6H14(ads)-water (0.003 g: 0.0051 g: 0.0015 g) system at 673 K.
Review
Biochemistry & Molecular Biology
Cristian D'Ovidio, Marcello Locatelli, Miryam Perrucci, Luigi Ciriolo, Kenneth G. Furton, Isil Gazioglu, Abuzar Kabir, Giuseppe Maria Merone, Ugo de Grazia, Imran Ali, Antonio Maria Catena, Michele Treglia, Luigi T. Marsella, Fabio Savini
Summary: LC-MS/MS plays a crucial role in screening and tracking pharmacotoxicological and forensic cases due to its advanced features. This review paper focuses on its applications in pharmacotoxicology and highlights its importance in the development of pharmacological and forensic research. It discusses therapeutic drug monitoring and clinical approaches as well as the determination of illicit drugs.
Review
Chemistry, Multidisciplinary
Valentina Greco, Alessandro Giuffrida, Marcello Locatelli, Fabio Savini, Ugo de Grazia, Luigi Ciriolo, Miryam Perrucci, Abuzar Kabir, Halil Ibrahim Ulusoy, Cristian D'Ovidio, Imran Ali
Summary: This review focuses on the sample preparation for forensic analysis, including elimination of interferents, specimen cleanup, and extraction of analytes of interest to reduce matrix effect. The selection of literature provides a general overview of the state-of-the-art in this field. Different biological matrices, such as blood and urine, are commonly used to investigate substances related to death, while other body fluids like bile and oral fluids are still under discussion for their usability. The review also categorizes solid matrices obtained after autopsy into conventional and unconventional matrices for better understanding, considering widely used pretreatment techniques and representative innovative techniques.
APPLIED SCIENCES-BASEL
(2023)
Article
Chemistry, Inorganic & Nuclear
Imran Ali, Gunel T. Imanova, Abdullah Alamri, Sayed Zenab Hasan, Al Arsh Basheer
Summary: Polyhydroquinone graphene oxide nanocomposite was synthesized and used for the removal of cephalexin antibiotic from water. The experimental results showed that the nanocomposite has a high efficiency in removing cephalexin, and the sorption process is spontaneous. Simulation investigation confirmed the physical sorption of cephalexin on the nanocomposite.
INORGANIC CHEMISTRY COMMUNICATIONS
(2023)
Article
Chemistry, Physical
Imran Ali, Yu Pakharukov, F. K. Shabiev, E. Galunin, R. F. Safargaliev, S. A. Vasiljev, B. S. Ezdin, A. E. Burakov, Zeid A. Alothman, Mika Sillanpaa
Summary: In this study, graphene-based nanofluids were synthesized and their viscosities were determined. The molecular interactions of graphene nanoparticles were theoretically analyzed to understand the mechanisms affecting the viscosity of nanofluids. An analytical function describing the dependence of the relative viscosity on the concentration of graphene nanoparticles was obtained based on experimental results. It was found that the viscosity of the nanofluid was influenced by the structure of the graphene sheets, and the self-assembly of the nanoparticles played a crucial role in the viscosity changes.
JOURNAL OF MOLECULAR LIQUIDS
(2023)
Article
Chemistry, Analytical
Syed Dilshad Alam, Mirza Adil Beg, Muralidhararao Bagadi, Marcello Locatelli, Zeid A. Alothman, Mohd Mustaqeem, Imran Ali
Summary: Berberine was extracted from Berberis vulgaris, Berberis aquifolium, and Hydrastis canadensis using ethanol and water (70:30, v/v). The extracted berberine was characterized using UV-visible and Fourier-transform infrared spectroscopy. Thin-layer chromatography and high-performance liquid chromatography (HPLC) methods were both employed for the separation and identification of berberine, and showed different applications. The extracted berberine exhibited better activity in treating Leishmaniosis compared to the standard drug Amphotericin B.
JOURNAL OF SEPARATION SCIENCE
(2023)
Article
Chemistry, Analytical
Khadidja Addadi, Khaled Sekkoum, Nasser Belboukhari, Zeid A. ALOthman, Ahmed M. Aljuwayid, Mika Sillanpaa, Imran Ali
Summary: In this study, the enantio-separation of three chiral sulfoxide drugs was achieved on a Chiralpak AS-3R column using acetonitrile-water as the mobile phase. The chiral separation was validated properly with LOD and LOQ values of 9.70-14.16 and 29.39-42.91 μg/mL, respectively. The enantiomer elution order was confirmed through experimental and theoretical methods. A simple, fast, reliable, and thermodynamically stable HPLC method was developed for the separation and determination of enantiomer elution order of the chiral sulfoxide drugs.
MICROCHEMICAL JOURNAL
(2023)
Article
Biochemistry & Molecular Biology
Imran Ali, Anastasya Gaydukova, Tatiana Kon'kova, Zeid Abdullah ALOthman, Mika Sillanpaa
Summary: This study investigated the acid leaching process of grinding waste from a heat-resistant nickel alloy. Optimal conditions for acid dissolution were established to maximize the extraction of nickel, the main component of the alloy. These results are significant for industry professionals in metal recovery and environmentalists in waste treatment.
Article
Engineering, Chemical
Imran Ali, Aleksandr Shchegolkov, Aleksey Shchegolkov, Maksim Aleksandrovich Chumak, Nashchekin Alexey Viktorovich, Likhachev Kirill Vasilievich, Gunel Imanova, Tonni Agustiono Kurniawan, Mohamed A. Habila
Summary: Multi-walled carbon nanotubes (MWCNTs) synthesized by the microwave method were found to enhance the thermal and electrical conductivity of silicone elastomers. The highest thermal conductivity achieved was 0.48 W/m°C with 8.0 wt% MWCNTs, while the highest electrical conductivity reached 2.4 x 10-5 S/cm. Microwave-synthesized MWCNTs demonstrated high stability in an electrical resistance heater application, making them suitable for household appliances.
POLYMER ENGINEERING AND SCIENCE
(2023)
Review
Energy & Fuels
Muhammad Sarfraz Arshad, Xavier Yangkou Mbianda, Imran Ali, Wanbing Guan, Tariq Kamal, Kimmo Kauhaniemi, Syed Zulqadar Hassan, Ghulam Yasin
Summary: This paper discusses the importance of nanomaterials in solid oxide fuel cells and the enhancement of active sites for electrode reactions through nanoengineering and composite approaches. The use of nanotechnology enables environmentally friendly and sustainable manufacturing processes for SOFCs. Additionally, the paper provides an overview of the applications of SOFCs, notable research institutions and companies, and future challenges and perspectives.
Article
Chemistry, Multidisciplinary
Imran Ali, Aicha Kraimi, Nasser Belboukhari, Khaled Sekkoum, Mouslim Messali
Summary: In order to enhance the anticoagulant activity of acenocoumarol, five new imino derivatives were synthesized and characterized. These derivatives were separated into their stereoisomers using chiral HPLC. The absolute configuration of all 20 stereoisomers was determined and their biological activities were predicted using DFT calculations.
NEW JOURNAL OF CHEMISTRY
(2023)
Article
Biochemical Research Methods
Maha Hasni, Nasser Belboukhari, Khaled Sekkoum, Raluca-Ioana Stefan-van Staden, Zeid A. Alothman, Ersin Demir, Imran Ali
Summary: The essential oil of Heliotropium bacciferum plant has significant medicinal value, and this study extracted and analyzed its essential oil, as well as evaluated its anti-inflammatory and anti-bacterial activities. The results showed that the essential oil displayed effective anti-inflammatory and anti-bacterial properties, indicating its potential as a therapeutic agent.
ANALYTICAL BIOCHEMISTRY
(2023)