Journal
RSC ADVANCES
Volume 4, Issue 44, Pages 22964-22970Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c4ra02050b
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Funding
- National Natural Science Foundation of China [30900377, 81271634]
- Fundamental Research Funds for the Central Universities
- Doctoral Station of Ministry of Education of China [20120162110070]
- Hunan Provincial Natural Science Foundation of China [12JJ1012]
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A novel dansyl derivative (1) was designed and synthesized with high yield. It is highly selective for Cu2+ over other competing metal ions such as Ca2+, Co2+, Cr3+, Cu+, Fe2+, Ga3+, Hg2+, Mg2+, Na+, Ni2+ and Pb2+. Zn2+ and Fe3+ only slightly changed the fluorescence of probe 1. The linear relationship between fluorescence intensity and Cu2+ concentration indicates that 1 can be used for quantification. The binding ratio of probe 1 to Cu2+ was found to be 1 : 1 according to Job's plot experiments. Probe 1 can be used in a broad pH value window ranging from 5 to 11. The limit of detection ( LOD) based on 3 x delta(blank)/k was calculated with a value as low as 1.6 x 10(-6) M for Cu2+. Additionally, the association constant of probe 1 - Cu2+ complexes was found to be 5.08 x 104 M-1. Moreover, fluorescence microscopy experiments showed that 1 can be used as a fluorescent probe for evaluating the presence of exogenous Cu2+ in living cells.
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