Article
Engineering, Environmental
Haihui Wang, Yifan Jiang, Yichang Liu, Xiaohui Zhu, Yongfei Liu, Minle Chen, Tao Zeng, Zhaowei Chen, Jinyu Li, Chunhua Lu, Huanghao Yang
Summary: This study proposes a straightforward approach for preparing multifunctional DNA-based nanospheres through the direct self-assembly of 2'-fluoro-substituted single-stranded DNA (2'F-DNA) with various small molecules. Molecular dynamics simulation reveals that 2'F substitution in DNA can cause repulsion of adjacent PO(4)(3-) groups, leading to local stretching of the DNA structure. Additionally, the 2'F substituent induces the regular polarization of H2O nearby F to form a hydration layer, which disrupts inherent interactions among bases. This approach allows for the construction of engineering hybrid nanospheres using DNA and other small molecules, holding great potential for further biological applications.
CHEMICAL ENGINEERING JOURNAL
(2023)
Article
Chemistry, Organic
David Leparfait, Feng Xiao, Delphine Coupri, Sabrina Gueulle, Florie Desriac, Aurelie Budin-Verneuil, Nicolas Verneuil, Axel Hartke, Emmanuel Pfund, Thierry Lequeux
Summary: Tri- and tetra-substituted alkenes, including fluoroalkenes, were obtained via selective ring-opening reaction of functionalized oxetanes. By introducing adenine nucleic base, alkenyl and fluoroalkenyl derivatives were synthesized as potential nucleoside mimics and evaluated for their activity against DltA enzyme.
EUROPEAN JOURNAL OF ORGANIC CHEMISTRY
(2023)
Article
Engineering, Environmental
Yanhong Duo, Quan Liu, Daoming Zhu, Bin Zhang, Guanghong Luo, Fu-Bing Wang, Chen Jinghua, Yihai Cao
Summary: Nano-radiosensitization is a new concept for cancer therapy that enhances radiosensitization using nanomaterials. In this study, a novel strategy was described, which involved the release of anticancer nitric oxide (NO) by irradiation-triggered switching of a nanoprodrug. This strategy improved tumor hypoxia and generated reactive oxygen species (ROS) to effectively kill cancer cells.
CHEMICAL ENGINEERING JOURNAL
(2022)
Review
Oncology
Casey W. Williamson, Michael V. Sherer, Dmitriy Zamarin, Andrew B. Sharabi, Brandon A. Dyer, Loren K. Mell, Jyoti S. Mayadev
Summary: This article discusses the relationship between radiation therapy and immune checkpoint blockade, exploring the potential synergies between the two and the optimization of treatment sequencing. Safety considerations and future directions are also reviewed.
Review
Chemistry, Multidisciplinary
Yu Chong, Jiayu Ning, Shengyi Min, Jiaquan Ye, Cuicui Ge
Summary: Radiotherapy is an important treatment for malignant tumors, but tumor resistance and damage to healthy tissues limit its efficacy. Developing novel radioenhancers and radioprotectants is crucial for improving clinical radiotherapy. Nanozymes have shown great potential in radiation medicine due to their multi-enzyme activities and microenvironment-responsive feature. This review systematically illustrates the progress of nanozymes in potentiating radiotherapy and radiation protection, including promoting reactive oxygen species generation, relieving tumor hypoxia, and preventing radiation-induced damage.
CHINESE CHEMICAL LETTERS
(2022)
Review
Chemistry, Multidisciplinary
Phillip T. Lowe, David O'Hagan
Summary: This review discusses the history and development of 4'-fluoro-nucleosides, tracing their origin from the discovery of the rare fluorine-containing natural product nucleocidin. Nucleocidin, which contains a fluorine atom at the 4'-position of its ribose ring, has played an important role in inspiring the exploration of 4'-fluoro-nucleosides as a privileged motif for nucleoside-based therapeutics.
CHEMICAL SOCIETY REVIEWS
(2023)
Article
Chemistry, Medicinal
Alberto Boretti
Summary: Curcumin, an agent with antineoplastic properties, can serve as both a radiosensitizer for cancer cells and a radioprotector for normal cells during radiation therapy. Although the evidence is limited to in vivo and in vitro experiences without clinical trials, promoting supplementation with curcumin during RT is reasonable due to its low risk of adverse effects, aiming to reduce side effects through anti-inflammatory mechanisms.
PHYTOTHERAPY RESEARCH
(2023)
Review
Oncology
Nhu Hanh To, Hoang Quy Nguyen, Allan Thiolat, Bisheng Liu, Jose Cohen, Nina Radosevic-Robin, Yazid Belkacemi
Summary: miRNAs have emerged as important biomarkers and radiosensitizers in triple-negative breast cancer, with potential predictive and prognostic value for response to radiation therapy.
BREAST CANCER RESEARCH AND TREATMENT
(2022)
Article
Nanoscience & Nanotechnology
Dandan Zhou, Yun Gao, Zhe Yang, Ning Wang, Jianxian Ge, Xiaoyi Cao, Dandan Kou, Yuan Gu, Cang Li, Mohammad Javad Afshari, Ruru Zhang, Can Chen, Ling Wen, Shuwang Wu, Jianfeng Zeng, Mingyuan Gao
Summary: To overcome the drawbacks of monomodal strategies, a combination therapy using lanthanide-doped upconversion nanoparticles (UCNPs) integrated with chlorin e6 (Ce6)-imbedded RBC membrane vesicles as a near-infrared-induced photodynamic therapy (PDT) agent is developed. The nanoagent not only acts as a light transductor for PDT but also as a radiosensitizer for enhanced low-dose radiotherapy (RT). The combination of PDT and RT shows potential for synergistic tumor growth inhibition and cancer metastasis arrest.
ACS APPLIED MATERIALS & INTERFACES
(2023)
Article
Biochemistry & Molecular Biology
Martin Holan, Kathryn Tucker, Natalia Dyatkina, Hong Liu, April Kinkade, Guangyi Wang, Zhinan Jin, Marija Prhavc
Summary: Nucleoside analogues have shown excellent efficacy as anti-HBV drugs, but long-term administration may lead to drug resistance. Thus, it is of high importance to search for nucleosides with novel scaffolds.
Article
Engineering, Biomedical
Zi Fu, Zhuang Liu, Jiaxing Wang, Lianfu Deng, Han Wang, Wei Tang, Dalong Ni
Summary: Researchers have developed hafnium-based nanoscale metal-organic frameworks (Hf-nMOFs) loaded with 3-bromopyruvate (3-BrPA) to overcome resistance to radiation therapy and improve its effectiveness. The Hf-nMOFs enhance the deposition of X-rays, leading to stronger DNA damage, while the loaded 3-BrPA reduces energy supply and interferes with protein biosynthesis, decreasing DNA damage repair. This strategy enhances the curative effect of radiation therapy and provides new perspectives on cancer treatment by reducing radiation doses.
Review
Medicine, Research & Experimental
Sijia Li, Lihong Shao, Tiankai Xu, Xin Jiang, Guozi Yang, Lihua Dong
Summary: Radiotherapy is a significant treatment for tumors, but it can cause radiation damage to normal tissues. Exosomes, nanoscale vesicles containing complex miRNAs and proteins, have shown potential as biomarkers for diseases and in treatment of radiation damage by regulating inflammatory response and promoting tissue repair.
BIOMEDICINE & PHARMACOTHERAPY
(2021)
Article
Cell Biology
Changjiang Qin, Zhiyu Ji, Ertao Zhai, Kaiwu Xu, Yijie Zhang, Quanying Li, Hong Jing, Xiaoliang Wang, Xinming Song
Summary: XRCC2-deficient colorectal cancer (CRC) shows increased sensitivity to PARP inhibitors after radiotherapy, supporting the clinical application of olaparib as a radiosensitizer for treating XRCC2-deficient CRC.
CELL DEATH & DISEASE
(2022)
Review
Polymer Science
Jinfeng Lin, Mingming Yin, Xiaoming Liu, Fanling Meng, Liang Luo
Summary: This review provides an overview of functional polymer-based nanomaterials for radiosensitization in recent years. Different types of polymer nanomaterials, including polymeric micelles, dendrimers, polymeric nanospheres, nanoscale coordination polymers, polymersomes, and nanogels, are discussed in terms of their action mechanisms, drug loading methods, targeting efficiencies, impact on therapeutic effects, and biocompatibility. Polymeric nano-radiosensitizers have the potential to improve the efficacy of radiotherapy and minimize damage to healthy tissues.
MACROMOLECULAR RAPID COMMUNICATIONS
(2022)
Article
Chemistry, Multidisciplinary
Yinuo Li, Yoshitaka Matsumoto, Lili Chen, Yu Sugawara, Emiho Oe, Nanami Fujisawa, Mitsuhiro Ebara, Hideyuki Sakurai
Summary: This study proposes a new treatment model for glioblastoma (GBM) using a safe and non-toxic drug-releasing composite Nanofiber mesh (NFM). The NFM combines chemotherapy, molecular targeted therapy, and radiotherapy in a highly simultaneous manner. The combination of temozolomide (TMZ) and 17-allylamino-17-demethoxygeldanamycin (17AAG) in the NFM showed synergistic cytotoxicity and radiation-sensitization effects. The NFM has the potential to address the challenge of high recurrence of GBM post-operatively due to its sustained drug release.
Review
Biochemical Research Methods
Sofia Julin, Adrian Keller, Veikko Linko
Summary: Hierarchical assembly of programmable DNA frameworks, such as DNA origami, has paved the way for versatile nanometer-precise parallel nanopatterning up to macroscopic scales. However, the dynamics of large-scale lattice assembly of such modules is still poorly understood. This article focuses on the dynamics of two-dimensional surface-assisted DNA origami lattice assembly and prospective three-dimensional assemblies, and summarizes their potential applications.
BIOCONJUGATE CHEMISTRY
(2023)
Article
Chemistry, Multidisciplinary
Nabarun Polley, Samim Sardar, Peter Werner, Ingo Gersonde, Yuya Kanehira, Ilko Bald, Daniel Repp, Thomas Pertsch, Claudia Pacholski
Summary: In this research, optical fibers equipped with plasmonic flow sensors were fabricated as photothermomechanical nanopumps for active transport of target analytes. The nanopumps were prepared by stacking a thermoresponsive polymer monolayer and a plasmonic nanohole array on an optical fiber tip. The pump mechanism relied on the temperature-dependent collapse and swelling of the polymer, while the required heat was generated by the photo thermal effect in the plasmonic nanohole array. Simultaneous detection of analytes was achieved by monitoring changes in the plasmonic sensor's optical response. The active mass transport through the nanohole array was visualized using particle imaging velocimetry. The presence of the pump mechanism led to a 4-fold increase in sensitivity compared to the purely photothermal effect, demonstrating the potential of these photothermomechanical nanopumps for sensing applications.
Article
Chemistry, Multidisciplinary
Cui Wang, Kenny Ebel, Katja Heinze, Ute Resch-Genger, Ilko Bald
Summary: Photodynamic therapy (PDT) for cancer treatment relies on the generation of highly reactive oxygen species by light-induced excitation of a photosensitizer in the presence of molecular oxygen, causing DNA damage. Recently, the potential of photoactive complexes of non-noble metals as photosensitizers has been discovered.
CHEMISTRY-A EUROPEAN JOURNAL
(2023)
Article
Materials Science, Multidisciplinary
Ruth Fabiola Balderas-Valadez, Alessandro Nagel, Yuya Kanehira, Ilko Bald, Claudia Pacholski
Summary: The homogeneous and ordered coverage of substrate surfaces with nanostructures is achieved by using colloidal arrays, which allows for the fabrication of highly ordered nanostructure arrays on large areas.
ADVANCED MATERIALS TECHNOLOGIES
(2023)
Article
Biochemistry & Molecular Biology
Marcel Hanke, Emilia Tomm, Guido Grundmeier, Adrian Keller
Summary: The stability of DNA origami nanostructures in aqueous media is affected by the presence of cations, which can screen electrostatic inter-helix repulsion. This study examines the thermal melting behavior of different DNA origami nanostructures under varying concentrations of Mg2+ and compares it to the calculated ensemble melting temperatures of the staple strands used in DNA origami folding. The results show significant deviations between the measured and calculated melting temperatures, particularly at high ionic strength where the melting temperature saturates and becomes independent of ionic strength. The degree of deviation also depends on the superstructure and mechanical properties of the DNA origami nanostructures, suggesting that mechanical strain plays a more dominant role in thermal stability at high ionic strength.
Article
Chemistry, Physical
Kosti Tapio, Charlotte Kielar, Johannes M. Parikka, Adrian Keller, Heini Jarvinen, Karim Fahmy, J. Jussi Toppari
Summary: In recent years, DNA has been used as a promising material for fabricating hierarchical nanostructures due to its self-assembly properties and functionalization schemes. This study demonstrates the assembly of a two-dimensional fishnet-type lattice on a silicon substrate using cross-shaped DNA origami. The effects of environmental and structural factors on lattice assembly are investigated, and a methodology for producing closely-spaced DNA origami lattices on silicon substrate is developed.
CHEMISTRY OF MATERIALS
(2023)
Article
Chemistry, Physical
Radwan M. M. Sarhan, Sergio Kogikoski Jr, Robin M. M. Schuermann, Yuhang Zhao, Andreas Krause, Bernd Schmidt, Ilko Bald, Yan Lu
Summary: This study presents a facile and environmentally friendly method to synthesize black gold nanoparticles via a one-step green synthesis at room temperature using commonly known precursors. The self-assembly of in situ-formed small nanoparticles followed by a fusion step creates extensive networks of nanowires, resulting in strong photothermal and surface-enhanced Raman scattering (SERS) effects. The black gold nanoparticles show potential for applications in solar energy conversion and photothermal therapy.
JOURNAL OF PHYSICAL CHEMISTRY C
(2023)
Article
Virology
Georg Tscheuschner, Marco Ponader, Christopher Raab, Prisca S. Weider, Reni Hartfiel, Jan Ole Kaufmann, Jule L. Voelzke, Gaby Bosc-Bierne, Carsten Prinz, Timm Schwaar, Paul Andrle, Henriette Baessler, Khoa Nguyen, Yanchen Zhu, Antonia S. J. S. Mey, Amr Mostafa, Ilko Bald, Michael G. Weller
Summary: An advanced purification method for the plant virus CCMV was developed, involving precipitation with PEG 8000 and affinity extraction using a novel peptide aptamer. The protocol was validated using multiple methods and demonstrated exceptional purity. This improved method enables the large-scale production and application of plant viruses as nanotechnological platforms.
Review
Engineering, Biomedical
Bhanu Kiran Pothineni, Adrian Keller
Summary: The occurrence and spreading of multidrug resistance in bacterial pathogens is a major challenge in the 21st century. This article reviews the promising developments in the synthesis of nanoparticle-based formulations of glycopeptide antibiotics to overcome antibiotic resistance. Different formulation concepts, synthesis and conjugation strategies are discussed, along with their effects on the antibacterial activity of the nanoparticle formulations.
ADVANCED NANOBIOMED RESEARCH
(2023)
Article
Polymer Science
Ahmad Alsawaf, Yuya Kanehira, Alain M. Bapolisi, Ilko Bald, Matthias Hartlieb
Summary: Designing supramolecular structures with well-defined dimensions and diverse morphologies through the self-assembly of block copolymers is highly regarded. This study focuses on the development of amphiphilic diblock copolymers and the self-assembly of these copolymers to form nanofibers with specific dimensions. The nanofibers have potential applications in various fields, such as microelectronics, photonics, and biomedical research, particularly in the development of antimicrobial nanomaterials.
MACROMOLECULAR CHEMISTRY AND PHYSICS
(2023)
Article
Biochemistry & Molecular Biology
Jingyuan Huang, Yunshu Qiu, Felix Luecke, Jiangling Su, Guido Grundmeier, Adrian Keller
Summary: This study investigates the multiprotein adsorption from diluted human serum at gold and oxidized iron surfaces, revealing stronger protein adsorption at pH 6. The changes in surface topography and the total amount of adsorbed proteins are quantified by atomic force microscopy and polarization-modulation infrared reflection absorption spectroscopy. Qualitative insights into the pH-dependent alterations in the composition of the adsorbed multiprotein films are provided by PM-IRRAS, suggesting a change in protein film composition at pH 6 accompanied by increased adsorption.
Article
Nanoscience & Nanotechnology
Zunhao Wang, Zhe Liu, Wibke Dempwolf, Julia Molle, Yuya Kanehira, Sergio Kogikoski Jr, Markus Etzkorn, Ilko Bald, Rainer Stosch, Stefan Wundrack
Summary: This paper presents a method for highly adjustable surface adsorption of single plasmonic nanostructures using polar surface arrays. The plasmonic nanostructures, made from DNA origami and functionalized with gold nanoparticles, allow for surface-enhanced spectroscopic techniques. The authors describe the fabrication process of the polar surface array and discuss how the concentration of DNA origami structures and the duration of incubation affect the number of adsorbed nanostructures. Density functional theory simulation explains the selective adsorption of plasmonic nanostructures based on substrate surface properties, preventing false identification resulting from agglomeration.
ACS APPLIED NANO MATERIALS
(2023)
Article
Chemistry, Multidisciplinary
Marcel Hanke, Daniel Dornbusch, Emilia Tomm, Guido Grundmeier, Karim Fahmy, Adrian Keller
Summary: The stability of 2D and 3D DNA origami nanostructures in the presence of chaotropic salts is investigated. It is found that the stability depends on the superstructure of DNA origami, with less rigid designs showing higher stability. Melting temperature measurements may overestimate the stability of certain DNA origami nanostructures in certain chemical environments.
Article
Biochemistry & Molecular Biology
Bhanu K. Pothineni, Sabrina Kollmann, Xinyang Li, Guido Grundmeier, Denise J. Erb, Adrian Keller
Summary: The influence of nanoscale surface topography on protein adsorption is studied using atomic force microscopy and X-ray photoelectron spectroscopy. The results show that ferritin adsorption at nanofaceted surfaces is suppressed compared to flat surfaces, attributed to the lower adsorption affinities of the newly formed facets. The adsorption is restricted to pattern grooves, but this effect depends on the protein concentration.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Chemistry, Multidisciplinary
Bhanu Kiran Pothineni, Guido Grundmeier, Adrian Keller
Summary: DNA origami nanostructures are functional materials with potential applications in nanoelectronics and nanophotonics. This study investigates the assembly of hexagonal DNA lattices on oxidized silicon surfaces using atomic force microscopy. The assembly is achieved through a competition of monovalent and divalent cations, with Ca2+ promoting ordered lattices better than Mg2+. The presence of Mg2+ leads to aggregation and multilayer formation of DNA origami at high Na+ concentrations. The formed DNA origami lattices have a lower degree of order compared to those assembled on mica due to a higher desorption rate of the nanostructures.
