Article
Nanoscience & Nanotechnology
Dan Zhao, Xiaoyu Huang, Yanan Tian, Jianhua Zou, Fu Wang, Xiaoyuan Chen
Summary: Ferroptosis is a new type of programmed cell death that plays a crucial role in tumor inhibition. This study introduces a facile fluorescence imaging-incorporated transcriptome strategy to visualize and explore the mechanism of GSH depletion-enhanced ferroptosis. The results demonstrate that TfRA-AuNCs, a multifunctional nanoplatform, can enhance the ferroptosis effect in 4T1 cells and regulate the expression change of ferroptosis-related genes. In vivo results confirm the tumor inhibition effect and long-term biocompatibility after TfRA-AuNC treatment. This study provides new insights into the mechanistic study of nanoagent-induced ferroptosis in tumor treatment.
ACS APPLIED MATERIALS & INTERFACES
(2023)
Article
Materials Science, Biomaterials
Ze Wang, Liang He, Songtian Che, Huiyuan Xing, Lin Guan, Zhe Yang, Xingchen Li, Andrei V. Zvyagin, Quan Lin, Wenrui Qu
Summary: A nano-system has been designed to improve diagnosis and treatment for prostate cancer by combining gold nanoclusters with LHRH analogues. The nano-system enables efficient imaging and targeted therapy.
JOURNAL OF MATERIALS CHEMISTRY B
(2022)
Article
Chemistry, Multidisciplinary
Lianshun Luo, Zhongyu Liu, Xiangsha Du, Rongchao Jin
Summary: The synthesis and photoluminescence of the Au42(PET)32 nanocluster are presented in this work. The nanocluster exhibits dual emission, with fluorescence and phosphorescence at different wavelengths. The emission quantum yield is 11.9% in liquid state and the fluorescence is suppressed while the phosphorescence is enhanced in solid state, which can be explained by interaction-induced transition.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2022)
Article
Chemistry, Multidisciplinary
Zeyang Pang, Weixiao Yan, Jie Yang, Qizhen Li, Yuan Guo, Dejian Zhou, Xingyu Jiang
Summary: Developing effective lymph-node targeting and imaging probes is crucial for the early detection and diagnosis of tumor metastasis. Researchers have developed dualligand-/multiligand-capped gold nanoclusters (GNCs) that can specifically target LN cancer metastasis and provide near-infrared fluorescence imaging, diagnosis, and treatment.
Article
Chemistry, Analytical
Huilin Sun, Yuntai Lv, Jiabao Zhang, Chenyu Zhou, Xingguang Su
Summary: A novel dual-signal sensing system for the determination of beta-galactosidase (β-Gal) activity was established using a dual-emission probe assembled from gold-platinum bimetallic nanoclusters (Au-Pt NCs) and rhodamine B. The detection platform based on Au-Pt NCs and rhodamine B showed the ability to sensitively detect β-Gal activity through ratiometric fluorescent and colorimetric methods. The developed assay method demonstrated good performance in quantitative detection of β-Gal in spiked serum samples.
ANALYTICA CHIMICA ACTA
(2023)
Article
Materials Science, Multidisciplinary
Xiqi Ma, Xiaojuan Wang, Cai Liu, Baosheng Ge, Hua He, Qi Dai, Zhixiong Zhang, Jinyi Yu, Werner M. Nau, Fang Huang
Summary: HBMA is a novel heparanase degradable heparin-based microcarrier developed for specific staining, targeting, and inhibiting tumor cells with high metastatic potential. Results from various assays demonstrate that HBMA effectively suppresses the proliferation and migration of selectively targeted tumor cells, highlighting its potential as a promising cancer theranostic agent to prevent tumor metastasis.
MATERIALS & DESIGN
(2021)
Article
Engineering, Environmental
Wenxing Gao, Qiang Li, Qi- Long Yan, Wencheng Zhong, Xiaomeng Zhou, Li Shang
Summary: The development of reliable sensors for explosive detection is crucial for reducing safety risks and environmental concerns. However, achieving on-site detection of multiple analytes in a simple and efficient way remains highly challenging.
CHEMICAL ENGINEERING JOURNAL
(2023)
Article
Chemistry, Multidisciplinary
Xiaorong Song, Wei Zhu, Xiaoguang Ge, Renfu Li, Shihua Li, Xian Chen, Jibin Song, Jianping Xie, Xueyuan Chen, Huanghao Yang
Summary: The development of bright NIR-II luminescent nanomaterials for efficient protein labelling in vivo without altering their physiological properties is challenging. The synthesized CD-Au NCs can label proteins/antibodies effectively and enable highly efficient in vivo tracking, leading to sensitive tumor-targeted imaging. Additionally, they exhibit good biocompatibility and high renal clearance efficiency in harsh biological environments.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2021)
Article
Chemistry, Analytical
S. S. Evstigneeva, D. S. Chumakov, R. S. Tumskiy, B. N. Khlebtsov, N. G. Khlebtsov
Summary: Bacterial biofilms are a major problem in chronic wounds and medical devices, and there is a need for reliable imaging and detection methods. Fluorescent glutathione-stabilized gold nanoclusters (GSH-AuNCs) were found to specifically interact with extracellular matrix components of bacterial biofilms, resulting in fluorescent staining. Molecular docking studies showed that GSH-AuNCs have affinity for various targets in the extracellular matrix. The developed method using GSH-AuNCs showed improved sensitivity for biofilm detection compared to standard methods.
Article
Chemistry, Physical
Xiaojian Yan, Wencheng Zhong, Shaohua Qu, Ziqian Li, Li Shang
Summary: The design of new fluorescence photoswitches based on photochromic tungsten oxide quantum dots (WO3 QDs) for dual-mode anti-counterfeiting applications was reported in this study. By complexing WO3 QDs with fluorescent gold nanoclusters (AuNCs), a photoswitchable fluorescence system (WO3-AuNCs) was constructed based on fluorescence resonance energy transfer. Photoresponsive and highly reversible switching of both color and fluorescence signals was achieved by alternating irradiation with UV and visible light. The potential utility of the photoswitchable WO3-AuNCs composite for anti-counterfeiting materials was successfully demonstrated, including photoswitchable ink, rewritable paper, and number encryption.
JOURNAL OF COLLOID AND INTERFACE SCIENCE
(2023)
Article
Biochemistry & Molecular Biology
Haoyuan Li, Hongxiang Zhu, Zongyan Quan, Zhiping Chen, Lei Wang, Hui He
Summary: A novel bionic bifunctional cellulose nanocrystal (CNC)-based gold nanocluster probe was successfully constructed by growing gold nanoclusters on CNCs modified with a specific DNA sequence. The probe exhibited excellent fluorescence properties and stability, and could detect different pathological markers in cells.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Biotechnology & Applied Microbiology
Baojuan Wang, Jinxin Fang, Huiliang Tang, Shan Lu, Yan Chen, Xiaoqi Yang, Yuezhen He
Summary: Protein-protected metal nanomaterials, specifically cellulase protected fluorescent gold nanoclusters (Cel-Au NCs), have been developed as a promising tool for biosensing and bioimaging. These nanoclusters exhibit red fluorescence and can be used as a biosensor for specific detection of ascorbic acid (AA) and labeling of bacteria. The Cel-Au NCs show satisfactory linearity and a low detection limit, making them an excellent fluorescent bioprobe for medical diagnosis and human health maintenance.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2023)
Article
Chemistry, Analytical
Jiaojiao Zheng, Jing Zhang, Fengniu Lu, Yi Du, Ding Cao, Shui Hu, Yang Yang, Zhiqin Yuan
Summary: This study successfully visualized the interaction between cationic hyperbranched polyethyleneimine and anionic sodium dodecyl sulfonate surfactant using fluorescence. By measuring the change in fluorescence emission ratio, three inflection points of the polymer-surfactant interaction were obtained and verified through experiments.
Article
Chemistry, Physical
Priya Das, Arun Chattopadhyay
Summary: We report the formation of two-dimensional single crystalline nanosheets of Cu nanoclusters by complexation with Zn metal ion. The so-formed crystals exhibit enhanced prompt photoluminescence and lifetime, as well as delayed photoluminescence with a quantum yield of 83.6 +/- 1.3% and a lifetime of 26.4 +/- 0.7 mu s at room temperature. Surface functionalization of the nanosheets with 8-hydroxyquinoline further increases the delayed photoluminescence lifetime to 145.0 +/- 7.7 mu s. The surface complexation creates a new emitting channel in the crystal, resulting in a single nanocomponent that emits prompt and delayed near-white light.
JOURNAL OF PHYSICAL CHEMISTRY C
(2022)
Article
Chemistry, Analytical
Hui Zhu, Yue Zhou, Yu Wang, Suying Xu, Tony D. James, Leyu Wang
Summary: We developed a new strategy to prepare stable and highly emissive near-infrared gold nanoclusters. These nanoclusters demonstrated bright and stable fluorescence imaging ability in tumors, as well as the capability of fluorine magnetic resonance imaging and computed tomographic imaging. These results indicate the potential of these nanoclusters in the field of biomedical research.
ANALYTICAL CHEMISTRY
(2022)