4.6 Article

A one-pot process for palladium catalyzed direct C-H acylation of anilines in water using a removable ortho directing group

Journal

RSC ADVANCES
Volume 4, Issue 8, Pages 3883-3886

Publisher

ROYAL SOC CHEMISTRY
DOI: 10.1039/c3ra45160g

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Funding

  1. Hungarian Academy of Sciences
  2. [TET_10-1-2011-0245]

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A new mild, practical method for the synthesis of aminobenzophenone derivatives through a three step one-pot reaction sequence involving acylation of anilines, palladium catalyzed cross-dehydrogenative coupling of the formed anilides and the hydrolytic cleavage is reported. The full reaction sequence was performed under aqueous conditions.

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