Journal
RSC ADVANCES
Volume 4, Issue 9, Pages 4239-4246Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c3ra46268d
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Funding
- MIUR
- University of Salerno
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The tuning of aldol/cyclization cascade reactions of glycine Schiff bases with 2-cyano benzaldehydes provides access to non-natural a-amino acid derivatives substituted alternatively with phthalides or isoindolinones, depending on the strength of the used base. Moreover, a preliminary screening of catalysts and conditions for development of asymmetric versions identified chiral bifunctional phase transfer catalysts as particularly promising, leading to the a-amino esters 3-substituted phthalides in high yields and good diastereo- and enantioselectivity.
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