Article
Chemistry, Organic
Alessandra Casnati, Dawid Lichosyt, Bruno Lainer, Lukas Veth, Pawel Dydio
Summary: The research presents a multicatalytic method for converting alkenes, unsaturated aliphatic alcohols, and aryl boronic acids into secondary benzylic alcohols with high stereoselectivity. Prochiral allylic alcohols can also be selectively transformed into different stereoisomers of the product.
Article
Chemistry, Multidisciplinary
Hongyan Lin, Ziling Zhou, Xiaopeng Ma, Qingqing Chen, Hongwei Han, Xiaoming Wang, Jinliang Qi, Yonghua Yang
Summary: The study presents a green method for obtaining aryl nitriles from aromatic aldehyde in water, utilizing water as a solvent instead of harmful chemical reagents. Twenty-five aryl nitriles were conveniently synthesized with minimal pollution to the environment. The reaction mechanism was further confirmed by capturing intermediates, aldoximes.
Article
Thermodynamics
Zhonghai Liu, Junwei Liao, Yuying Gong, Jinliang Song, Tiejun Wang
Summary: In this study, phosphotungstic acid loaded on beta-zeolite was used as a catalyst for the direct dehydration-oligomerization of higher alcohols derived from upgraded bioethanol. The results showed that this strategy has great potential for the production of jet fuel.
ENERGY CONVERSION AND MANAGEMENT
(2024)
Article
Chemistry, Multidisciplinary
Lei Zhang, Liming Cao, Maolin Sun, Chaoming Liang, Lei Yang, Yueyue Ma, Ruihua Cheng, Jinxing Ye
Summary: A straightforward synthesis approach to chiral 1-aryl-2-aminoethanols via the one-pot asymmetric hydrogenation catalyzed by Ir catalyst was developed. This tandem process involves the in situ generation of alpha-amino ketones via the nucleophilic substitution of alpha-bromoketones with amines and the Ir-catalyzed asymmetric hydrogenation of ketone intermediates to provide diverse enantiomerically enriched beta-amino alcohols. The excellent yields and enantioselectivities (up to 96 % yield and up to >99 % ee) with a wide substrate scope in this one-pot strategy were obtained.
CHEMISTRY-A EUROPEAN JOURNAL
(2023)
Article
Chemistry, Applied
Rongrong Zhao, Qiao Wei, Yuxin Huang, Qin Qu, Qixing Liu, Haifeng Zhou
Summary: A one-pot synthesis of fluorinated chiral alcohols from alpha-bromoarylketones and fluoroalcohols is described. The fluorinated ketone intermediates were formed from alpha-bromoarylketones with fluoroalcohols as nucleophiles and solvents, which were reduced subsequentially by adding a chiral Ru catalyst and a mixture of formic acid and triethyl amines (FA: TEA=1.1:1) as hydrogen donor to give 27 examples of fluorinated chiral alcohols in 60-93% yields and 85-98% ee values. Notably, K3PO4 acts as a base in nucleophilic substitution and an additive in reductive step to enhance the reactivity and enantioselectivity, which is crucial for constructing compatible conditions for one-pot process. This one-pot process is also applicable to gram-scale synthesis.
ADVANCED SYNTHESIS & CATALYSIS
(2023)
Article
Chemistry, Organic
Nadezhda T. Sevostyanova, Sergey A. Batashev, Anastasiya S. Rodionova, Dar'ya K. Kozlenko
Summary: The aim of this study is to develop a method for the synthesis of esters by combining acid-catalytic alcohols dehydration and resulting alkenes alkoxycarbonylation in one reactor. The target esters were successfully synthesized under different catalytic systems and conditions. Additionally, for the first time, the dehydration processes of secondary linear alcohols were coupled with isomerizing alkoxycarbonylation to yield the isomeric esters as products.
Article
Chemistry, Multidisciplinary
Yu Li, Na Hu, Zefei Xu, Yunfeng Cui, Jinhui Feng, Peiyuan Yao, Qiaqing Wu, Dunming Zhu, Yanhe Ma
Summary: The enzymatic asymmetric reductive amination process can be used to convert simple aldehydes and amines into chiral N-substituted 1,2-amino alcohols, providing an environmentally friendly and economical method.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2022)
Article
Chemistry, Organic
Preethi Dhanapal, S. L. Manju
Summary: Thiazole based Schiff base scaffolds have become an integral part of drug development in recent years, playing a versatile role as building blocks for lead drug molecules. This study presents a facile one pot synthetic method for producing novel 4-aryl thiazoles with high yield, shorter reaction time, and milder conditions, without the need for catalysts or purification techniques.
SYNTHETIC COMMUNICATIONS
(2024)
Article
Chemistry, Physical
Mingming Hao, Zhaohui Li
Summary: Pd@NH2-UiO-66(Zr) composite material, obtained through a double-solvent impregnation and photoreduction process, demonstrates superior activity in visible light initiated reactions. This study provides an efficient and green strategy for the production of secondary amines and highlights the great potential of using M/MOFs nano-composites as multifunctional catalysts for light induced one-pot tandem reactions.
APPLIED CATALYSIS B-ENVIRONMENTAL
(2022)
Article
Chemistry, Applied
Toru Hashimoto, Keisuke Shiota, Kei Funatsu, Yoshitaka Yamaguchi
Summary: A nickel-catalyzed cross-coupling reaction between aryl halides and primary or secondary aliphatic alcohols has been achieved using a bench-stable nickel complex supported by a monoanionic O,N,N-tridentate ligand. The reaction proceeds smoothly without the need for a phosphine ligand, giving moderate to good yields of alkyl aryl ethers.
ADVANCED SYNTHESIS & CATALYSIS
(2021)
Article
Chemistry, Multidisciplinary
Serguei Savilov, Evgeniya Suslova, Vsevolod Epishev, Evgeniya Tveritinova, Yuriy Zhitnev, Alexander Ulyanov, Konstantin Maslakov, Oksana Isaikina
Summary: The study found that through oxidation treatment, despite the decrease in specific surface area, the oxidized samples exhibited enhanced catalytic activity due to an increased number of oxygen radicals. Experimental data demonstrated that the structure of carbon nanomaterials determines the effectiveness of alcohol conversion catalysis.
Article
Chemistry, Multidisciplinary
Lin Guo, Shu-Qing Yang, Kai-Chun Zhao, Xiao-Chao Chen, Yong Lu, Ye Liu
Summary: In this study, a new Pd catalytic system was developed for the synthesis of 2,5-diaryl-1,3,4-oxadiazoles through a one-pot carbonylation-dehydration tandem reaction of aryl iodides with acylhydrazines. The method exhibited advantages of simplified manipulations, high efficiency (yields of 62-93%), and high safety of applied organic substrates.
MONATSHEFTE FUR CHEMIE
(2023)
Article
Chemistry, Multidisciplinary
Qinglin Zhang, Yongbin Duan, Huifeng Guo, Hong Yang, Jiulong Zhai, Tiantian Li, Zhihai Wang, Xiaolei Lu, Yan Wang, Yan Yin
Summary: A Bi(OTf)(3)-catalyzed reaction was investigated for the synthesis of alpha-halo-beta-amino ketones and acyl aziridines, which showed high yields and convenient experimental operations, suitable for large scale production.
CHEMISTRY-AN ASIAN JOURNAL
(2021)
Article
Chemistry, Multidisciplinary
Hitesh B. Jalani, Aneesh Sivaraman, Kyoung Ho Min, Hwa Young Lee, Na Kyoung Oh, Hyeseul Kang, Gyochang Keum, Yongseok Choi, Kyeong Lee
Summary: An expeditious one-pot method for the synthesis of highly substituted 5-aminoimidazoles from glyoxals, anilines, and amidines under metal/catalyst-free conditions operative at room temperature is proposed. The method is environmentally friendly and can be applied to the synthesis of bioactive and medicinal compounds.
Article
Chemistry, Organic
Priti Singh, Santosh Kumar Sahoo, Nerella Sridhar Goud, Baijayantimala Swain, Venkata Madhavi Yaddanapudi, Mohammed Arifuddin
Summary: A protocol has been developed for the synthesis of 2-aryl/heteroaryl-4-quinolones using readily available and affordable starting materials. The reaction, conducted under microwave conditions with a copper catalyst, proceeded with moderate to high yields. The method is characterized by short reaction time, good functional group tolerance, high atom economy, non-toxic byproduct, and no need for special ligands, highlighting its applicability in organic synthesis.
ASIAN JOURNAL OF ORGANIC CHEMISTRY
(2022)
