Journal
RSC ADVANCES
Volume 3, Issue 23, Pages 8734-8746Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c3ra40950c
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Funding
- University Grants Commission, New Delhi, India
- DST, New Delhi
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A series of novel cationic fullerene (C-60) derivatives, bearing substituted s-triazine moiety as a side arm, synthesized by using the 1,3 dipolar cycloaddition reaction of C-60 with azomethine ylides generated from the corresponding Schiff bases of substituted s-triazine is reported. All the synthesized compounds were characterized by elemental analysis, FT-IR, H-1 NMR, C-13 NMR and ESI-MS. The compounds 7a, 7d, 7e and 7f cleaved the supercoiled pBR322 DNA into nicked form efficiently upon visible light irradiation in the presence of NADH. The photoinduced superoxide radical and hydroxyl radical generated may act as molecular species causing the DNA scission. Further, the interaction of synthesized molecules with pBR322 plasmid DNA was investigated using computational approaches.
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