Journal
RSC ADVANCES
Volume 3, Issue 20, Pages 7486-7494Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c3ra00095h
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Funding
- National Natural Science Foundation of China [50902100, 21073054]
- Natural Science Foundation of Henan Province [102300410180]
- Foundation for University Young Key Teacher by Henan Province [2009GGJS-021]
- Henan University [SBGJ090708]
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Heparin-functionalized hollow hydroxyapatite microspheres were successfully prepared using heparin-entrapped calcium carbonate particles as original materials in a Na2HPO4-containing emulsion system. Heparin plays an important role in the formation of hollow structures. The obtained microspheres exhibit good anticoagulant ability and sustained release of basic fibroblast growth factor (bFGF). The cell viability assays indicate that the microspheres are nearly non-toxic to mouse embryo fibroblasts (MEFs) cells up to a concentration of 200 mu g mL(-1), and the proliferation activity of the bFGF-loaded microspheres could be prolonged to at least 6 days. The simulated body fluid immersion tests reveal that the microspheres have a good in vitro bioactivity. Our results suggest that the obtained microspheres may serve as promising candidates for simultaneous use as bone reconstruction material and growth factors delivery vehicle.
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