Article
Materials Science, Multidisciplinary
Zhenzhen Chen, Liang Shen, Xiong Zhao, Hongqiang Chen, Yaxuan Xiao, Yonghai Zhang, Xiaoping Yang, Jinhua Zhang, Jinjia Wei, Nanjing Hao
Summary: Microfluidics, especially acoustofluidics, offers new opportunities in chemical and biomedical engineering by manipulating fluids at the micrometer or submicrometer scale. This review discusses the utility of acoustofluidic technology, summarizes different types of acoustic micromixers, highlights their applications in various fields, and identifies the practical challenges that need to be addressed. Overall, this review provides valuable insights for both academic research and industrial applications.
APPLIED MATERIALS TODAY
(2022)
Article
Multidisciplinary Sciences
Tyler Sano, Ravipa Losakul, Holger Schmidt
Summary: Integrated optofluidic devices, combining microfluidics and photonic structures, have gained high interest for rapid biosensor devices. Researchers demonstrated a polydimethylsiloxane-based device with two on-chip optofluidic laser cavities, enabling simultaneous detection of multiple fluorescent targets.
SCIENTIFIC REPORTS
(2023)
Article
Engineering, Electrical & Electronic
Dezhao Jiao, Ruirong Zhang, Hantian Zhang, Shuang Ren, Huicheng Feng, Honglong Chang
Summary: This paper proposes a three-dimensional split-and-recombination (SAR) micromixer inspired by the horseshoe transform principle, and reveals the optimal size through computational fluid dynamics simulations and experimental tests. The results show that the SAR micromixer achieves high mixing efficiency and has potential applications in the field of microchip-based biochemical analysis.
JOURNAL OF MICROMECHANICS AND MICROENGINEERING
(2022)
Article
Computer Science, Artificial Intelligence
Yang Yang, Zichang Tan, Prayag Tiwari, Hari Mohan Pandey, Jun Wan, Zhen Lei, Guodong Guo, Stan Z. Li
Summary: The paper introduces a cascaded Split-and-Aggregate Learning (SAL) approach and Feature Recombination (FR) method to enhance the performance of multi-label pedestrian attribute recognition in surveillance tasks.
INTERNATIONAL JOURNAL OF COMPUTER VISION
(2021)
Article
Chemistry, Analytical
Xin Wang, Zhanqiang Liu, Bing Wang, Yukui Cai, Qinghua Song
Summary: This paper provides an overview of the design and applications of micromixers, including the typical designs and mixing mechanisms of passive and active micromixers, and application cases in the chemical, biological, and medical fields. The characteristics, advantages, and restrictions of different micromixers are also discussed, along with a proposed future perspective on micromixer design.
ANALYTICA CHIMICA ACTA
(2023)
Review
Chemistry, Analytical
Federico Sala, Carlotta Ficorella, Roberto Osellame, Josef A. Kaes, Rebeca Martinez Vazquez
Summary: Understanding cell migration is crucial for unraveling physiological phenomena and predicting pathologies like cancer metastasis. Microfluidic devices have been used to investigate cellular migration response by engineering mechanical and spatial stimuli. This review discusses the existing technologies, such as soft lithography and femtosecond laser micromachining, used in microfluidic cellular migration assays. It highlights the different geometrical configurations employed and envisions future developments in in vitro migration studies under spatial confinement in microfluidic devices.
Review
Pharmacology & Pharmacy
Renata Maia, Violeta Carvalho, Rui Lima, Graca Minas, Raquel O. Rodrigues
Summary: This systematic review summarizes the recent progress in the use of microneedles (MNs) in biomedical applications, including drug delivery, biomarker detection, and their potential integration with microfluidic devices. Although MNs have been extensively utilized in lab-on-a-chip platforms, recent studies have also explored their applicability in organ-on-a-chip models. Overall, the presence of MNs in advanced microfluidic devices offers simplified drug delivery, microinjection, and biomarker detection through integrated biosensors, enabling real-time monitoring of various biomarkers in lab- and organ-on-a-chip platforms.
Review
Chemistry, Analytical
Ruth Shinar, Joseph Shinar
Summary: Organic electronics (OE) technology has matured in displays and is advancing in solid-state lighting applications. It also shows great potential in (bio)chemical sensing, imaging, in vitro cell monitoring, and other biomedical diagnostics. OE devices, such as organic LEDs, organic and hybrid perovskite-based photodetectors, and organic thin-film transistors, are utilized in these applications. The integration of compact and sensitive OE devices with microfluidic channels and lab-on-a-chip (LOC) structures is very promising.
Article
Chemistry, Analytical
Melika Haji Mohammadi, Sterre Mulder, Patricia Khashayar, Alireza Kalbasi, Mostafa Azimzadeh, Amir Reza Aref
Summary: Lab-on-a-chip (LOC) devices have revolutionized the field of metabolic detection by combining the advantages of biosensors and microfluidics. Saliva is now being recognized as a non-invasive alternative biofluid for diagnostics, leading to promising applications of LOCs in analyzing saliva for a wide range of medical situations and diseases. Advancements in utilizing LOCs for detecting various bacteria and viruses, cytokines, metabolites, kidney related diseases, prostate cancer, and oral diseases are being explored with the potential to aid in addressing current pandemics.
MICROCHEMICAL JOURNAL
(2021)
Article
Multidisciplinary Sciences
Amina Farooq, Fezan Hayat, Sobia Zafar, Nauman Zafar Butt
Summary: This study explores the design of an impedimetric microfluidic cytometer on a flexible substrate and compares two microfluidic geometries for their sensitivity. The results show that the microelectrode surface area and the geometry of the sensing volume significantly affect the sensor's output response. Reducing the sensing volume improves pulse amplitude and signal-to-noise ratio. The proposed design demonstrates good detection and differentiation of polystyrene beads and leukemia cells. Additionally, the study presents a feasible approach to achieve irreversible and strong bond strength between thin flexible surfaces in a biochip.
SCIENTIFIC REPORTS
(2022)
Article
Chemistry, Analytical
Gianni Antonelli, Arianna Mencattini, Micol Massimiani, Valentina Lacconi, Joanna Filippi, Margherita Losardo, Michele 'Orazio, Paola Casti, Mario Bragaglia, Giorgia Curci, Francesca Nanni, Luisa Campagnolo, Eugenio Martinelli
Summary: Lab-On-Chips (LOCs) offer advantages in studying biological models and evaluating drug efficacy. This research presents a cost-effective technique to integrate optical biosensors into the lab-on-chip and successfully measures pH in human embryonic stem cell cultures, advancing the understanding of cell-scale metabolic mechanisms.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Semra Akgonullu, Adil Denizli
Summary: The innovative technology of a marketable lab-on-a-chip platform for point-of-care (POC) in vitro detection has attracted remarkable attention. The development of a cost-effective, rapid, and efficient method for biomolecule detection is urgently needed. Molecular imprinting polymers (MIPs) have shown promising applications in medical diagnosis, pharmaceutical bioassays, and environmental monitoring.
JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS
(2023)
Article
Optics
Shijie Sun, Yuanhua Che, Yuhang Xie, Qidong Yu, Fei Wang, Xibin Wang, Daming Zhang
Summary: We present a 1x1 multimode optical switch based on cascaded MZI waveguides, capable of switching E11, E21, E12, and E22 modes. The experimental device exhibits high extinction ratios and fast response times, making it suitable for multimode switching in MDM systems.
Review
Chemistry, Multidisciplinary
Adithya Sridhar, Ashish Kapoor, Ponnusamy Senthil Kumar, Muthamilselvi Ponnuchamy, Balasubramanian Sivasamy, Dai-Viet Nguyen Vo
Summary: The advancement of microfluidic systems has revolutionized lab-on-a-chip devices, showing great potential in the food industry. Research focuses on fabrication technologies, materials, pathogen detection methods, and smart packaging technologies for better product identification and traceability.
ENVIRONMENTAL CHEMISTRY LETTERS
(2022)
Article
Food Science & Technology
Fareeha Arshad, Muhammedin Deliorman, Pavithra Sukumar, Mohammad A. Qasaimeh, James Salveo Olarve, Gil Nonato Santos, Vipul Bansal, Minhaz Uddin Ahmed
Summary: Lab-on-a-chip (LOC) devices have attracted scientific attention for their ability to incorporate multiple complex analytical processes onto a single chip. This review discusses the recent developments and applications of nanomaterial-based LOC devices in sustainable food and agricultural industries. Nanomaterial-based LOC devices have considerable potential in identifying nucleic acid, proteinic, and cellular components from complex food and agricultural samples with high specificity and can be applied in the continuous monitoring of multiple agri-food analytes to ensure sustainability and food safety.
TRENDS IN FOOD SCIENCE & TECHNOLOGY
(2023)