Concise and efficient one-pot copper-catalyzed synthesis of H-pyrazolo[5,1-a]isoquinolines

A new, concise and efficient one-pot copper-catalyzed method for the synthesis of H-pyrazolo[5,1-a]isoquinolines has been developed, and the H-pyrazolo[5,1-a]isoquinolines containing various functional groups were prepared in moderate to good yields. The method should provide a simple and practical strategy for this kind of N-fused heterocycles.