Review
Oncology
Zhi Wei Tay, Prashant Chandrasekharan, Benjamin D. Fellows, Irati Rodrigo Arrizabalaga, Elaine Yu, Malini Olivo, Steven M. Conolly
Summary: Magnetic Particle Imaging (MPI) is an emerging imaging technique that provides direct imaging of superparamagnetic iron oxide nanoparticles, showing great potential in cancer diagnosis and therapy monitoring. Different from MRI, MPI offers ideal image contrast with zero background tissue signal, enabling clear visualization of cancer. MPI enhances therapeutic precision and accuracy through magnetic means, contributing to the advancement of cancer imaging and guided therapy.
Review
Chemistry, Multidisciplinary
Behnaz Lahooti, Racheal G. Akwii, Fatema Tuz Zahra, Md Sanaullah Sajib, Margarita Lamprou, Ahmed Alobaida, Michail S. Lionakis, George Mattheolabakis, Constantinos M. Mikelis
Summary: The review focuses on the characteristics and regulation of vascular permeability in tumor microenvironment, especially the impact of endothelial cells. It discusses the challenges and approaches of targeting vascular permeability for clinical translation, the effects of immune cells on the tumor vessels and nanomedicine delivery, and desirable nanoparticle design approaches.
JOURNAL OF CONTROLLED RELEASE
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Rikkert Van Durme, Guillaume Crevecoeur, Luc Dupre, Annelies Coene
Summary: In magnetic drug targeting, micro- or nanoparticles are used to deliver therapeutics locally in the human body. However, their movement and targeting efficiency are hindered by various factors. This study proposes optimization methods to overcome these adverse effects and improve targeting performance.
Review
Chemistry, Multidisciplinary
Xue Zhou, Erik Jan Cornel, Shisheng He, Jianzhong Du
Summary: With the increasing global population aging, the incidence of bone-related diseases has significantly increased, making nanomaterials a research hotspot for treating these diseases. This review summarizes the latest advances in bone-targeting nanoparticles, including classification, mechanisms, and applications, providing direction for future research.
MATERIALS CHEMISTRY FRONTIERS
(2021)
Article
Nanoscience & Nanotechnology
Boddu Adilakshmi, Obireddy Sreekanth Reddy, Duddekunta Hemalatha, Kummari S. V. Krishna Rao, Wing-Fu Lai
Summary: Site-specific drug delivery systems using PEG as carriers have been widely adopted due to its favorable features. The development of carriers for hydrophobic anticancer agents remains a challenge. The developed drug conjugate PEGDA-MN-DOX shows anticancer potential, cancer-targeting ability, and ROS-generating capacity for effective drug encapsulation and sustained release in chemotherapy.
INTERNATIONAL JOURNAL OF NANOMEDICINE
(2022)
Article
Chemistry, Multidisciplinary
Luz Helena Camargo Casallas, Diego Julian Rodriguez Patarroyo, Jaime Francisco Pantoja Benavides
Summary: The study found that the targeting efficiency of magnetic nanoparticles is highest within a certain range when using small-sized nanoparticles under a constant magnetic field.
JOURNAL OF NANOPARTICLE RESEARCH
(2023)
Review
Biochemistry & Molecular Biology
Mohammad Mahmoudi Gomari, Shadi Abkhiz, Taha Ghantab Pour, Ehsan Lotfi, Neda Rostami, Fatemeh Nafe Monfared, Babak Ghobari, Mona Mosavi, Behruz Alipour, Nikolay V. Dokholyan
Summary: The low efficiency of cancer treatment strategies is a major obstacle in developing cancer inhibitors. Peptidomimetics, a new class of agents, have been introduced to overcome the limitations of peptides and have shown effectiveness in inhibiting metastasis, angiogenesis, and cancerous cell growth.
MOLECULAR MEDICINE
(2022)
Article
Chemistry, Multidisciplinary
Tianyi Wang, Huali Lei, Xiang Li, Nailin Yang, Cheng Ma, Guangqiang Li, Xiang Gao, Jun Ge, Zhuang Liu, Liang Cheng, Gang Chen
Summary: Intracerebral hemorrhage (ICH) is a significant cause of morbidity and mortality worldwide, and surgery remains the most effective way to remove ICH. However, surgery brings potential risks such as brain tissue damage, post-operative infection, and difficulty in removing deep hematoma, which are the main problems in the surgical treatment of ICH.
Article
Biochemistry & Molecular Biology
Natalia Yudintceva, Ekaterina Lomert, Natalia Mikhailova, Elena Tolkunova, Nikol Agadzhanian, Konstantin Samochernych, Gabriele Multhoff, Grigoriy Timin, Vyacheslav Ryzhov, Vladimir Deriglazov, Anton Mazur, Maxim Shevtsov
Summary: The study demonstrates that MSCs have high migratory capacity towards C6 glioblastoma cells and exhibit tumor-tropism. SPION-labeled MSCs can accumulate in tumor tissues in vivo and enhance the contrast of the tumor through high-field magnetic resonance imaging. Biodistribution studies support the retention of MSCs in glioblastoma.
Article
Computer Science, Interdisciplinary Applications
Max C. Lindemann, Till Luttke, Nadine Nottrodt, Thomas Schmitz-Rode, Ioana Slabu
Summary: The results demonstrate that magnetic targeting effectivity can be up to 32% higher when a magnetic field is present. In the investigated vessel network, the effectiveness of targeting depends on the number of magnetic field maxima with a high gradient that are approached, and is noticeable up to a distance of 200 micrometers from the magnet to the vessel geometry.
COMPUTER METHODS AND PROGRAMS IN BIOMEDICINE
(2021)
Review
Pharmacology & Pharmacy
Tingting Yang, Jingming Zhai, Dong Hu, Ruyue Yang, Guidan Wang, Yuanpei Li, Gaofeng Liang
Summary: This article reviews different targeted delivery strategies based on nanoparticles, focusing on the physical and chemical properties of nanoparticles, ligands, and receptors that affect particle targeting. It emphasizes the need for further studying the biological fate of particles in vivo and their interaction mechanism with tumors.
Review
Materials Science, Multidisciplinary
Abdullah Abdelkawi, Aliyah Slim, Zaineb Zinoune, Yashwant Pathak
Summary: This review focuses on the surface modification of metallic nanoparticles for targeted drug delivery. Various strategies, such as polymer coating, functionalization with specific groups, and bioconjugation with targeting ligands, have been explored to enhance their therapeutic potential. The challenges in clinical translation include scalable fabrication and functionalization of nanoparticles, toxicity concerns, and regulatory hurdles. However, continuous advancements in nanoparticle synthesis and surface modification techniques offer a positive outlook for the future.
Article
Chemistry, Multidisciplinary
Manxiang Wu, Tianxiang Chen, Lianfu Wang, Ozioma Udochukwu Akakuru, Xuehua Ma, Jinshan Xu, Jiapeng Hu, Jia Chen, Qianlan Fang, Aiguo Wu, Qiang Li
Summary: This study developed a core membrane nanoplatform for enhanced treatment of triple-negative breast cancer (TNBC) using biomimetic nanotechnology and tumor microenvironment (TME) responsiveness. The nanoplatform showed precise drug delivery and improved oxygen levels in the tumor, resulting in enhanced chemotherapy/phototherapy. In addition, it exhibited good fluorescence and magnetic resonance imaging performances, enabling image-guided combination tumor therapy.
Review
Biochemistry & Molecular Biology
Yuan Zhang, Juhura G. G. Almazi, Hui Xin Ong, Matt D. D. Johansen, Scott Ledger, Daniela Traini, Philip M. M. Hansbro, Anthony D. D. Kelleher, Chantelle L. L. Ahlenstiel
Summary: This review article introduces the potential and application of RNA-interference-based gene therapy in antiviral treatment of COVID-19 disease, with a focus on the role and challenges of nanoparticles as carriers in siRNA delivery, as well as the application of inhalation devices and animal models.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
V. Manjusha, M. R. Rajeev, T. S. Anirudhan
Summary: Safe delivery of hydrophobic drugs to the tumor site is a challenging task for the scientific community. In this study, iron oxide nanoparticles coated chitosan with [2-(methacryloyloxy) ethyl] trimethyl ammonium chloride (METAC) (CS-IONPs-METAC-PTX) were developed as a drug carrier for hydrophobic drug delivery. The drug carrier exhibited excellent therapeutic efficacy and selectivity when tested in cell lines, demonstrating its potential for PTX delivery.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Engineering, Mechanical
Adityakumar Mishra, Sibnath Kayal
Summary: The study aims to eliminate undesirable microstructure in the steel unit and focuses on the microstructure of hot-rolled medium carbon steel, finding that a fine pearlite and ferrite microstructure is crucial for better strength and uniform properties of the material.
PROCEEDINGS OF THE INSTITUTION OF MECHANICAL ENGINEERS PART E-JOURNAL OF PROCESS MECHANICAL ENGINEERING
(2022)
Article
Chemistry, Physical
X. C. Zhong, Y. C. Wu, S. M. Wu, Y. X. Li, J. H. Huang, C. L. Liu, H. Zhang, Z. W. Liu, M. L. Zhong, Z. C. Zhong, R. Ramanujan
Summary: A series of LaFe11.6Si1.4/xwt%Pr2Co2 (x = 0, 5, 10) composites were successfully fabricated by spark plasma sintering (SPS) and subsequent annealing. The effects of particle size and binder content on the phase constitution, microstructure, thermal, mechanical, magnetic, and magnetocaloric properties were investigated. It was found that adjusting the binder content and particle size allowed for control of the magnetic, magnetocaloric, and mechanical properties of the composites, making them promising candidates for near room temperature magnetic cooling applications.
JOURNAL OF ALLOYS AND COMPOUNDS
(2022)
Article
Nanoscience & Nanotechnology
Ling Qiao, R. V. Ramanujan, Jingchuan Zhu
Summary: In this study, a machine learning (ML) method was used to construct a composition-structure-property model with physical features. The PSO-GRNN model showed the best performance and could be used to search for new alloys with targeted properties. The designed Fe2.5Ni2.5CrAl MPEA exhibited excellent mechanical properties and a narrow melting range, making it a promising choice for high performance applications.
MATERIALS SCIENCE AND ENGINEERING A-STRUCTURAL MATERIALS PROPERTIES MICROSTRUCTURE AND PROCESSING
(2022)
Article
Materials Science, Multidisciplinary
X. C. Zhong, S. M. Wu, X. T. Dong, Y. X. Li, J. H. Huang, C. L. Liu, H. Zhang, Y. L. Huang, H. Y. Yu, W. Q. Qiu, Z. W. Liu, M. L. Zhong, Z. C. Zhong, R. Ramanujan
Summary: In this study, La(Fe,Si)(13) based magnetocaloric composites were prepared by spark plasma sintering and annealing. The microstructure, mechanical and magnetocaloric properties were investigated. By adjusting the SPS temperature, a high content of the desired phase was obtained, and significant improvements were observed.
MATERIALS SCIENCE AND ENGINEERING B-ADVANCED FUNCTIONAL SOLID-STATE MATERIALS
(2022)
Article
Materials Science, Multidisciplinary
Xichun Zhong, Yuanxin Li, Simeng Wu, Yucai Wu, Jiaohong Huang, Cuilan Liu, Hongya Yu, Zhongwu Liu, Minglong Zhong, Zhenchen Zhong, Raju Ramanujan
Summary: The phase composition, microstructure, magnetic, mechanical and thermal properties of LaFe11.6Si1.4/10wt%PrxCo7 magnetocaloric composites were studied. The addition of PrxCo7 binder can be used to adjust the phase fraction and magnetic properties, while Pr2Co7 binder promotes the formation of the 1:13 phase. These composites exhibit excellent mechanical and thermal properties, and can be used for magnetic refrigeration by adjusting the Curie temperature.
JOURNAL OF MATERIALS SCIENCE
(2022)
Article
Multidisciplinary Sciences
Li Ping Tan, V Chaudhary, Z. Tsakadze, R. Ramanujan
Summary: A wide range of high-performance materials are used in electrical, electronic, and mechanical systems, which consume a significant amount of electricity worldwide. Rapid determination of multiple property sets is necessary for the development of next-generation systems that require new materials with improved structural and functional properties. This study successfully synthesized iron-cobalt-nickel ternary alloy composition powders and prepared compositionally graded bulk materials libraries. A comprehensive property set was determined for different compositions, providing valuable insights for identifying new ternary compositions with diverse property sets.
SCIENTIFIC REPORTS
(2022)
Article
Chemistry, Physical
Anirudha Karati, Soumya Ranjan Mishra, Sanyukta Ghosh, Ramesh Chandra Mallik, Rajashekhara Shabadi, R. V. Ramanujan, Satyesh Kumar Yadav, B. S. Murty, U. V. Varadaraju
Summary: A new type of high entropy alloy Ti2NiCoSnSb with half-Heusler structure has been synthesized for the first time. It was found that the desired single-phase HH material can be obtained through dry milling, which exhibited simultaneous enhancement in the Seebeck coefficient and electrical conductivity. Moreover, the band structure calculated by density functional theory was in good agreement with the experimental results, and phase separation strongly influenced the thermoelectric properties.
JOURNAL OF ALLOYS AND COMPOUNDS
(2022)
Article
Materials Science, Multidisciplinary
Ling Qiao, R. Ramanujan, Jingchuan Zhu
Summary: This study implemented a machine learning approach to investigate the relationship between temperature, alloying elements, and yield strength in multi-component alloys. Based on the findings, AlxCrFeNi medium-entropy alloys (MEAs) were developed, which exhibited a two-phase structure formed through spinodal decomposition mechanism. The mechanical properties of the developed MEAs, particularly with high Al content, showed significant improvement at elevated temperatures. The oxidation behavior and mechanism of the AlxCrFeNi MEAs (x > 0.8) at 1000 degrees C were also explored. Overall, this work has identified a promising family of MEAs that offer low density and excellent mechanical properties for high temperature structural applications.
Article
Materials Science, Multidisciplinary
Ling Qiao, R. V. Ramanujan, Jingchuan Zhu
Summary: In this study, the microstructure, hardness, and wear resistance of Fe2Ni2CrAl multi-principal elements alloy were investigated. The alloy showed a dual-phase structure and exhibited good wear resistance. Molecular dynamics simulations were also utilized to analyze the wear behavior at the nanoscale. The findings provided valuable insights into the wear mechanisms of Fe2Ni2CrAl alloys.
JOURNAL OF MATERIALS SCIENCE
(2023)
Article
Nanoscience & Nanotechnology
V. Chaudhary, M. S. K. K. Y. Nartu, S. Dasari, S. M. Varahabhatla, A. Sharma, M. Radhakrishnan, S. A. Mantri, S. Gorsse, N. B. Dahotre, R. V. Ramanujan, R. Banerjee
Summary: Varying the Al content significantly influences the microstructure, magnetic properties, and microhardness of Alx(CoFeNi) (x = 0, 10, 30) complex concentrated alloys. The heat treated Al10(CoFeNi) CCA exhibited improved saturation magnetization, Curie temperature, and microhardness due to its hierarchical FCC/L12+BCC/B2 heterostructure. However, there was no significant change in the properties of heat treated CoFeNi and Al30(CoFeNi) CCA. These findings can be explained by thermodynamic modeling of phase stability.
SCRIPTA MATERIALIA
(2023)
Article
Materials Science, Multidisciplinary
Andras Kovacs, Nithin B. Venkataraman, Varun Chaudhary, Sriswaroop Dasari, Thibaud Denneulin, R. V. Ramanujan, Rajarshi Banerjee, Rafal E. Dunin-Borkowski
Summary: The microstructural features significantly affect the coercivity of magnetic alloys. While the influence of homophase boundaries on magnetic domain wall pinning is well understood, the role of heterophase interfaces on domain wall motion is complex and not well known. This study used advanced electron microscopy techniques to reveal the dramatic changes in the magnetization reversal process in an Al0.3CoFeNi magnetic complex concentrated alloy (CCA) and its impact on coercivity. The heterophase FCC/BCC interfaces were found to have a stronger effect on coercivity compared to isostructural chemically ordered/disordered interfaces, providing valuable insights for the rational design of microstructure in magnetic alloys.
Article
Engineering, Mechanical
Xuesong Xu, Hongsheng Ding, Haitao Huang, He Liang, R. V. Ramanujan, Ruirun Chen, Jingjie Guo, Hengzhi Fu
Summary: The deformation mechanism responsible for the high-cycle rotating bending fatigue of a high-Nb TiAl alloy was studied. Superlattice dislocations [0 1 1] and twinning dominated the fatigue deformation in the gamma phase. Dislocations 11 0 in the B2 phase were induced by twins in the adjacent gamma phase due to the low stacking fault energy caused by the high Nb content. Stress transfer between adjacent phases was achieved through atomic rearrangement of the interface by twinning. Local stresses were accommodated by continuous dislocation slip in the B2 phase, deformation twins, and twin intersections in the gamma phase.
INTERNATIONAL JOURNAL OF FATIGUE
(2023)
Article
Nanoscience & Nanotechnology
M. Radhakrishnan, M. McKinstry, V. Chaudhary, M. S. K. K. Y. Nartu, K. V. Mani Krishna, R. V. Ramanujan, R. Banerjee, Narendra B. Dahotre
Summary: The soft magnetic behavior of CoCrxFeNi alloys deposited by laser directed energy deposition was studied. It was found that the saturation magnetization of these alloys decreased with increasing Cr content and exhibited paramagnetic behavior at room temperature. The Curie temperature of the ferromagnetic CoFeNi alloy linearly decreased with Cr content, while the paramagnetic equiatomic alloy had a ferromagnetic transition temperature of 94 K. The as-deposited alloys showed low coercivity values irrespective of the Cr content. The results suggest that the magnetic behavior of the CoFeNi alloy can be tuned with the addition of antiferromagnetic Cr, and the additive manufacturing route is effective for rapidly processing alloys with desired compositions.
SCRIPTA MATERIALIA
(2023)
Article
Materials Science, Multidisciplinary
V. Sharma, X. Tan, P. S. Sankara Rama Krishnan, Sravya Tekumalla, M. Duchamp, Xuesong Xu, Hongsheng Ding, V. Chaudhary, R. V. Ramanujan
Summary: Bulk Ti-48Al alloy samples were prepared by high energy ball milling and spark plasma sintering, and their microstructure, phase evolution and mechanical properties were studied. The resulting alloy exhibited an equiaxed fine grain structure and higher nanohardness, wear resistance and yield pressure compared to the as-cast counterpart. The combination of powder size reduction during ball milling and microstructural development during sintering resulted in improved properties. Therefore, the HBM+SPS processing approach shows promise for the manufacture of high hardness bulk TiAl alloys.
MATERIALS TODAY COMMUNICATIONS
(2023)
Article
Chemistry, Physical
Soumya Ranjan Mishra, Li Ping Tan, Vikrant Trivedi, Manjusha Battabyal, P. S. Sankara Rama Krishnan, Durga Venkata Maheswar Repaka, Satyesh Kumar Yadav, Raju Vijayaraghavan Ramanujan, Budaraju Srinivasa Murty
Summary: The effect of doping on the thermoelectric properties of HH HEA Ti2NiCoSnSb was studied. Sb doping reduced thermal conductivity. Mass scattering by heavy (Ta, Zr) and light (Al) dopants was studied to further lower thermal conductivity. Zr-doped samples showed high HH phase content and low-lattice thermal conductivity of 1.9 W/(m·K). The poor solubility of Ta enhanced electrical properties. NiAl phase in Al-doped samples improved the power factor value significantly. A maximum ZT of 0.29 was achieved in all doped systems, with an optimum dopant level of Zr (25%), Ta (7.5%), and Al (10%).
ACS APPLIED ENERGY MATERIALS
(2023)
