Article
Medicine, General & Internal
Nikita Sijapati, Monica Sciturro, Matthew Le, Jesus Lanza, Edgar Mercado, Admir Seferovic
Summary: Exercise-induced urticaria is a rare clinical condition where individuals experience flushing, pruritus, and hives after physical exercise, with some patients developing more severe reactions. Food-dependent exercise-induced urticaria is relatively more common and requires avoidance of certain cofactors. Treatment involves avoidance of exercise and modification of physical activity.
CUREUS JOURNAL OF MEDICAL SCIENCE
(2022)
Article
Multidisciplinary Sciences
Gladymar Perez Chacon, Parveen Fathima, Mark Jones, Rosanne Barnes, Peter C. Richmond, Heather F. Gidding, Hannah C. Moore, Thomas L. Snelling
Summary: Research suggests that early priming of infants with whole-cell pertussis vaccine may lower the risk of subsequent IgE-mediated food allergy. If whole-cell vaccination is protective against food allergy and other atopic diseases, particularly childhood asthma, its population-level effects could justify its preferential recommendation. However, further investigation is needed to explore the potential beneficial effects of whole-cell pertussis vaccination on the prevention of atopic diseases at a population scale.
Article
Allergy
Ralf Baumann, Eva Untersmayr, Ulrich M. Zissler, Stefanie Eyerich, Ian M. Adcock, Knut Brockow, Tilo Biedermann, Markus Ollert, Adam M. Chaker, Oliver Pfaar, Holger Garn, Ryan S. Thwaites, Alkis Togias, Marek L. Kowalski, Trevor T. Hansel, Constanze A. Jakwerth, Carsten B. Schmidt-Weber
Summary: Allergic diseases are increasing, and local sampling methods can improve sensitivity, reduce costs, and aid in prevention and treatment.
Article
Allergy
Kawin Duangmee, Pornwalai Boonmuang, Wichai Santimaleeworagun, Hutsaya Prasitdumrong
Summary: This study described and characterized patients who experienced allergic reactions, including urticaria, angioedema, and type I hypersensitivity, caused by fibrinolytic agents. The study found that both nonfibrinolytic and fibrin-specific agents can cause these reactions.
ASIAN PACIFIC JOURNAL OF ALLERGY AND IMMUNOLOGY
(2022)
Article
Multidisciplinary Sciences
Giulia Costanzo, Annalisa Matolo, Laura Saderi, Maria Rita Messina, Davide Firinu, Maria Pina Barca, Paolo Serra, Nicoletta Corso, Giovanni Sotgiu, Stefano Del Giacco
Summary: The aim of this study was to clarify the impact of cofactors on allergic reactions in patients sensitized to LTP and omega-5-gliadin. The findings showed that exercise was the most common cofactor in FDEIAn and its involvement, along with alcohol and multiple cofactors, was more frequent in males than females. The study also revealed that exercise, pollen counts peaks, and multiple cofactors were more often associated with anaphylaxis than mild reactions.
SCIENTIFIC REPORTS
(2022)
Article
Health Care Sciences & Services
Nikolaos Pyrpyris, Maria Kritikou, Xenofon Aggelidis, Ioanna Manolaraki, Michael Makris, Nikolaos G. Papadopoulos, Paraskevi Xepapadaki
Summary: This study analyzes the characteristics of anaphylaxis in a pediatric cohort in Greece and finds a low rate of adrenaline autoinjector administration by lay people. However, drug prescription and counseling after the reaction could help improve correct acute anaphylaxis management in the future.
JOURNAL OF PERSONALIZED MEDICINE
(2022)
Review
Plant Sciences
Dan Norback, Gunilla Wieslander
Summary: Buckwheat allergy is a neglected but noteworthy allergy, with identified allergenic proteins that cross-react with other foods. The prevalence among populations consuming buckwheat in Japan, Korea, and China is estimated to be around 0.1-0.4%, with severe allergic reactions such as anaphylaxis being relatively rare.
Article
Allergy
Riccardo Asero, Renato Ariano, Arianna Aruanno, Claudio Barzaghi, Paolo Borrelli, Moira Busa, Giorgio Celi, Massimo Cinquini, Gabriele Cortellini, Francesca D'Auria, Marco De Carli, Camilla Di Paolo, Giulia Garzi, Fabio Lodi Rizzini, Monica Magnani, Giuseppina Manzotti, Alessandro Marra, Stefano Miceli Sopo, Francesco Murzilli, Eleonora Nucera, Elena Pinter, Valerio Pravettoni, Federica Rivolta, Angela Rizzi, Nicoletta Saporiti, Enrico Scala, Danilo Villalta, Mona-Rita Yacoub, Giuliana Zisa
Summary: The study found that systemic reactions induced by PR-10 and profilin are facilitated by PPI, ingestion of large amounts of unprocessed foods, and fasting. Soybean beverages represent a risk for PR-10 hypersensitive patients.
Review
Allergy
Joakim S. Dahlin, Marcus Maurer, Dean D. Metcalfe, Gunnar Pejler, Ronit Sagi-Eisenberg, Gunnar Nilsson
Summary: Mast cells play a crucial role in maintaining homeostasis and surveillance of the human body, releasing various mediators that affect both immune and non-immune cells. Research using animal models has contributed to a better understanding of mast cell function in health and disease.
Review
Biochemistry & Molecular Biology
Miguel Angel Galvan Morales, Josaphat Miguel Montero-Vargas, Juan Carlos Vizuet-de-Rueda, Luis M. Teran
Summary: PD-1 and its ligands play a crucial role in allergic diseases by regulating immune responses and balancing the inflammatory process. Targeting this immunomodulatory pathway could lead to the development of novel therapeutic strategies.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Allergy
Margitta Worm, Stefan Vieths, Vera Mahler
Summary: Significant progress has been made in the field of anaphylaxis and urticaria in recent years. Studies have provided insights into the genetic and biomarker aspects of these conditions, as well as their IgE-dependent and non-IgE-dependent mechanisms. The potential triggers of anaphylactic reactions related to COVID-19 vaccination and the impact of the COVID-19 pandemic on chronic urticaria have been reported. Clinical advancements include severity grading and risk factors for anaphylaxis, as well as the distinction of phenotypes and triggers for both conditions. Novel treatment approaches for anaphylaxis and different subtypes of urticaria have been evaluated.
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
(2022)
Article
Allergy
Celia Zubrinich, Robert Puy, Robyn O'Hehir, Mark Hew
Summary: For patients with allergy to the omega-5-gliadin component of gluten (O-5-G allergy), accurate diagnosis and stringent management can reduce the risk of recurrent allergic reactions. However, a significant portion of patients do not adhere to the recommended strict approach.
JOURNAL OF ASTHMA AND ALLERGY
(2021)
Review
Biochemistry & Molecular Biology
Samantha Minh Thy Nguyen, Chase Preston Rupprecht, Aaisha Haque, Debendra Pattanaik, Joseph Yusin, Guha Krishnaswamy
Summary: Anaphylaxis is a severe, acute, life-threatening allergic reaction that can be triggered by medications, foods, latex, etc., causing respiratory, cardiovascular, and skin symptoms. The condition is characterized by a variety of symptoms and can have diverse causes.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Allergy
Hutsaya Prasitdumrong, Kawin Duangmee, Pornwalai Boonmuang, Wichai Santimaleeworagun, Yaowares Oppamayun, Cholticha Sonsupap, Thawatchai Nakkaratniyom
Summary: This study analyzed the incidence of urticaria, angioedema, and type I hypersensitivity reactions from fibrinolytic agents. The results showed that type I hypersensitivity reactions were the most common allergic reactions caused by fibrinolytic agents, emphasizing the importance of considering these reactions when using fibrinolytic therapy.
ASIAN PACIFIC JOURNAL OF ALLERGY AND IMMUNOLOGY
(2023)
Review
Microbiology
Maria Teresa Audicana
Summary: The Anisakidae family parasite has infected humans for over 60 years and has become a highly studied parasite in the past 20 years. It induces immune-mediated reactions, primarily affecting the gastrointestinal tract with occasional involvement of other organs.
Editorial Material
Neurosciences
Christopher W. T. Miller, David A. Ross, Andrew M. Novick
BIOLOGICAL PSYCHIATRY
(2020)
Review
Emergency Medicine
Christopher W. T. Miller, Vedrana Hodzic, Eric Weintraub
WESTERN JOURNAL OF EMERGENCY MEDICINE
(2020)
Review
Cardiac & Cardiovascular Systems
Aamina Shakir, Yurong Wheeler, Guha Krishnaswamy
Summary: Immunoglobulin G4-related disease is a systemic fibroinflammatory disease characterized by multiple organ lymphoplasmacytic infiltration, obliterative phlebitis, and storiform fibrosis. Cardiovascular manifestations of IgG4-RD can lead to serious complications that may be overlooked, mimicking common cardiovascular diseases. While systemic corticosteroids are the main treatment, biologics and disease-modifying agents are increasingly being used in the management of this complex disease.
Review
Critical Care Medicine
Guha Krishnaswamy
Summary: Anaphylaxis is a rapidly progressive life-threatening syndrome that requires familiarity with its diagnosis, evaluation and management. Skilled intervention in ICU settings may be necessary for patients with complicated, severe, or refractory anaphylaxis.
CRITICAL CARE MEDICINE
(2021)
Review
Biochemistry & Molecular Biology
Samantha Minh Thy Nguyen, Chase Preston Rupprecht, Aaisha Haque, Debendra Pattanaik, Joseph Yusin, Guha Krishnaswamy
Summary: Anaphylaxis is a severe, acute, life-threatening allergic reaction that can be triggered by medications, foods, latex, etc., causing respiratory, cardiovascular, and skin symptoms. The condition is characterized by a variety of symptoms and can have diverse causes.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Behavioral Sciences
Stephanie S. Kulaga, Christopher W. T. Miller
Summary: The historical association between respiratory infections and neuropsychiatric symptoms, along with recent research on viral infections and schizophrenia, suggests a link between viral infections and mental illnesses. Maternal influenza during pregnancy and viral infections in newborns, children, and adolescents have been linked to the development of schizophrenia. The neuroinvasive and inflammatory properties of COVID-19, similar to other human coronaviruses, may also play a role in the development of psychotic disorders.
NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS
(2021)
Article
Psychiatry
Christopher W. T. Miller
Summary: Stress and trauma can have significant impacts on human biological systems, potentially leading to long-term physiological and psychological changes. Individuals may be affected by parental stress and early adversities, but these factors could also enhance their ability to adapt to their environment.
HARVARD REVIEW OF PSYCHIATRY
(2021)
Article
Clinical Neurology
Olivia L. Francis, Avni Joshi, Ty Prince, Guha Krishnaswamy, Niraj C. Patel
Summary: SCIgPro20 treatment in patients with Stiff Person Syndrome resulted in mild and local reactions, improvement in spasticity symptoms, and reduced seizure frequency in some patients.
JOURNAL OF NEUROMUSCULAR DISEASES
(2021)
Review
Biochemistry & Molecular Biology
Clayton Webster Jackson, Cristina Marie Pratt, Chase Preston Rupprecht, Debendra Pattanaik, Guha Krishnaswamy
Summary: Mast cells are derived from hematopoietic stem cell precursors and play a crucial role in allergic responses and various disorders. Some disorders are associated with specific genetic mutations, while others may be genetic disorders.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Letter
Allergy
Samantha Minh Thy Nguyen, Merin Anna Reji, Aaisha Haque, Guha Krishnaswamy
ANNALS OF ALLERGY ASTHMA & IMMUNOLOGY
(2022)
Letter
Critical Care Medicine
Guha Krishnaswamy
CRITICAL CARE MEDICINE
(2022)
Article
Psychology, Psychoanalysis
Christopher W. T. Miller, Lindsay L. Clarkson, Donald R. Ross
Summary: The text delves into the connection between individuals and the environment, as well as the impact of one's internal world on their reactions to it. Excessive guilt can hinder recognition of individual responsibility in environmental issues, while a paranoid-schizoid mindset may obstruct constructive environmental actions.
INTERNATIONAL JOURNAL OF PSYCHOANALYSIS
(2022)
Article
Medicine, General & Internal
Merin Anna Reji, Aaisha Haque, Supriya Goyal, Guha Krishnaswamy
Summary: Precision therapies and biological drugs have revolutionised the management of atopic diseases, but the monoclonal antibody dupilumab may cause ocular complications.
Article
Public, Environmental & Occupational Health
Narcisse Elenga, Guha Krishnaswamy
FRONTIERS IN PUBLIC HEALTH
(2023)
Article
Medicine, General & Internal
Hiral Patel, Samantha Minh Thy Nguyen, Aaisha Haque, Guha Krishnaswamy
Summary: This article reports the clinical presentation and treatment process of esophagitis in an immunocompetent young adult male. After the treatment of herpes simplex virus esophagitis (HSE), the patient developed dysphagia again, which was diagnosed as eosinophilic esophagitis (EoE). Extensive literature review suggests that HSE may be a harbinger of EoE.