Article
Allergy
Charles F. Schuler, Sofija Volertas, Dilawar Khokhar, Huseyin Yuce, Lu Chen, Onur Baser, Jenny M. Montejo, Cem Akin
Summary: Using an insurance claims database and a retrospective study at the University of Michigan, it was found that the prevalence of HVA in the US is lower than previously reported, while the prevalence of mastocytosis in patients with HVA is higher but still lower than previously reported. There was no correlation between tryptase level and reaction severity in patients undergoing VIT.
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
(2021)
Review
Allergy
Hans C. Oettgen
Summary: Mast cells throughout the gastrointestinal tract play a crucial role in IgE-mediated allergic reactions to foods. Aside from immediate reactions, recent evidence suggests that mast cells are also important regulators of adaptive immunity to foods. They provide cytokines that initiate and consolidate immune responses to allergens in the gastrointestinal mucosa, as well as molecules that recruit leukocytes causing tissue inflammation. By counteracting the activating effects of IgE antibodies, food-specific IgG antibodies suppress both immediate allergic reactions and mast cell-mediated immune responses.
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
(2023)
Article
Pharmacology & Pharmacy
Gyeongseo Suk, Do Hoon Kwon, Axel Roers, Soman N. Abraham, Hae Woong Choi
Summary: The pharmacological intervention of ORAI1 channel inhibition in mast cells shows promise as a therapeutic avenue for preventing peanut-induced anaphylaxis and acute diarrhea. ORAI1 inhibitors effectively suppress mast cell responses and ameliorate allergic reactions.
PHARMACOLOGICAL RESEARCH
(2023)
Review
Biology
Aurelie Gouel-Cheron, Alice Dejoux, Emma Lamanna, Pierre Bruhns
Summary: Anaphylaxis is a severe form of allergic reaction that can be life-threatening. Human studies on anaphylaxis are difficult due to their rarity and lethality, so animal models, primarily mice and rats, have been established. These models have provided valuable insights into the mechanisms of anaphylaxis in humans.
Article
Allergy
Dinah Foer, Matthew Wien, Elizabeth W. Karlson, Wenyu Song, Joshua A. Boyce, Patrick J. Brennan
Summary: This study aimed to investigate patient-specific and laboratory characteristics associated with reactions to Mrgprx2-activating drugs. The study found that female sex, white race, asthma, chronic urticaria, and mastocytosis were associated with increased odds of a reaction. Patients with allergic disease had a higher rate of adverse drug reactions compared to patients without allergic disease, and elevated absolute eosinophil count was inversely associated with reactions, while elevated total IgE was not associated.
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY-IN PRACTICE
(2023)
Article
Immunology
Tiago Azenha Rama, Diana Martins, Nuno Gomes, Jorge Pinheiro, Ana Nogueira, Luis Delgado, Jose Luis Placido, Alice Coimbra
Summary: Mastocytosis is a rare and heterogeneous group of disorders characterized by expansion and accumulation of clonal mast cells, presenting mainly with cutaneous lesions and anaphylaxis. Due to its unusual features, the diagnosis of mastocytosis may be delayed for several years.
FRONTIERS IN IMMUNOLOGY
(2021)
Review
Biotechnology & Applied Microbiology
Ghalya H. Banafea, Sherin Bakhashab, Huda F. Alshaibi, Peter Natesan Pushparaj, Mahmood Rasool
Summary: Mast cells play a crucial role in inflammatory diseases of the airway tract, releasing various mediators that contribute to immune cell accumulation and tissue remodeling.
Review
Hematology
Melody C. Carter, Dean D. Metcalfe
Summary: Historically, understanding of human mast cells has lagged behind other cell lineages, and there is currently no identified pharmacological agent that can completely and selectively inhibit human MC function. Mast cell diseases are categorized as intrinsic or extrinsic to the MC compartment, with mediators playing a key role in MC activation disorders.
BRITISH JOURNAL OF HAEMATOLOGY
(2022)
Article
Cell Biology
Kasalina N. Kiwanuka, E. Motunrayo Kolawole, Jamie Josephine Avila Mcleod, Bianca Baker, Patrick A. Paez, Matthew P. Zellner, Tamara T. Haque, Anuya Paranjape, Kaitlyn Jackson, Sydney A. Kee, Jordan Dailey, Rebecca K. Martin, John J. Ryan
Summary: The lack of Stat5B in mice results in reduced responses to IgE-mediated anaphylaxis and diminished IgE-induced degranulation and cytokine secretion in mast cells. These findings suggest that the Stat5B isoform is crucial for normal mast cell function and may play a role in limiting IgE production in vivo.
CELLULAR IMMUNOLOGY
(2021)
Article
Immunology
Tongqian Wu, Lan Ma, Xiaoqian Jin, Jingjing He, Ke Chen, Dingshan Zhang, Rui Yuan, Jun Yang, Qin Zhong, Haiyan Zhou, Zou Xiang, Yu Fang
Summary: The study demonstrated that S100A4 plays a critical role in regulating mast cell activation and allergic responses. S100A4(-/-) mice showed reduced symptoms in allergic models, indicating that S100A4 is required for mast cell activation and may be involved in the regulation of allergic diseases through this mechanism.
FRONTIERS IN IMMUNOLOGY
(2021)
Review
Medicine, General & Internal
Roberta Zanotti, Ilaria Tanasi, Andrea Bernardelli, Giovanni Orsolini, Patrizia Bonadonna
Summary: Bone marrow mastocytosis (BMM) is a provisional, indolent subvariant of systemic mastocytosis (SM) characterized by a male sex prevalence, a slight increase of serum tryptase levels, low bone marrow mast cell burden, and an indolent clinical course.
JOURNAL OF CLINICAL MEDICINE
(2021)
Review
Immunology
Zhongwei Zhang, Peter B. Ernst, Hiroshi Kiyono, Yosuke Kurashima
Summary: Mast cells are widely distributed immune cells with diverse phenotypes and functions. They exhibit high functional heterogeneity and plasticity due to their unique maturation mechanism. Mast cells can adapt to different microenvironments and regulate allergy and inflammation under the peripheral immune education system. This review focuses on the mechanism and heterogeneity of mast cell migration to mucosal tissues, such as the gastrointestinal tract. The immunosuppressive properties of mast cells suggest a potential new approach for treating inflammatory and allergic disorders.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Knut Brockow, Katarzyna Plata-Nazar, Magdalena Lange, Boguslaw Nedoszytko, Marek Niedoszytko, Peter Valent
Summary: Mastocytosis is a rare disease characterized by the pathological accumulation of mast cells in various organs. Symptoms include skin lesions, itching, flushing, and possible blistering, with pediatric patients possibly also experiencing gastrointestinal, respiratory, and neurological symptoms.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Cell Biology
Jane Seymour Woodrow, M. Katie Sheats, Bethanie Cooper, Rosemary Bayless
Summary: Asthma is a chronic lower airway inflammation that leads to airway remodeling and permanent decrease in lung function. Animal models have played a crucial role in discovering molecular pathways and new therapeutic approaches for asthma. These models can be induced or naturally occurring, and various species such as mice, rats, guinea pigs, cats, dogs, sheep, horses, and nonhuman primates have been used. Factors to consider when evaluating asthma models include cost, labor, reagent availability, regulatory burden, relevance to human disease, type of inflammation, available biological samples, and ability to answer research questions. This review focuses on discussing the most commonly used animal models for asthma research, with emphasis on the antigen/allergen, inflammatory response, and translation to human asthma.
Review
Allergy
Antonella Cianferoni
Summary: Anaphylaxis is not only IgE-mediated, but also involves non-IgE pathways; mast cells and basophils can be activated by various substances, leading to reactions similar to anaphylaxis.
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
(2021)
Article
Communication
Marcus Maurer, Pablo Jost, Marlene Schaaf, Michael Suelflow, Simon Kruschinski
Summary: The rise of right-wing populist parties in Western democracies is often attributed to their ability to provoke news media deliberately, which generates media coverage and public awareness. This study examines the rise of German right-wing populist party AfD and confirms the role of deliberate provocations in influencing media coverage and public awareness.
INTERNATIONAL JOURNAL OF PRESS-POLITICS
(2023)
Letter
Allergy
Huichun Su, Pavel Kolkhir, Joerg Scheffel, Yi-Kui Xiang, Xu Yao, Marcus Maurer, Sabine Altrichter
Review
Allergy
Jean Bousquet, Mohamed H. Shamji, Josep M. Anto, Holger J. Schuenemann, G. Walter Canonica, Marek Jutel, Stefano Del Giacco, Torsten Zuberbier, Oliver Pfaar, Joao A. Fonseca, Bernardo Sousa-Pinto, Ludger Klimek, Wienczyslawa Czarlewski, Anna Bedbrook, Rita Amaral, Ignacio J. Ansotegui, Sinthia Bosnic-Anticevich, Fulvio Braido, Claudia Chaves Loureiro, Bilun Gemicioglu, Tari Haahtela, Marek Kulus, Piotr Kuna, Maciej Kupczyk, Paolo M. Matricardi, Frederico S. Regateiro, Boleslaw Samolinski, Mikhail Sofiev, Sanna Toppila-Salmi, Arunas Valiulis, Maria Teresa Ventura, Cristina Barbara, Karl C. Bergmann, Michael Bewick, Hubert Blain, Matteo Bonini, Louis-Philippe Boulet, Rodolphe Bourret, Guy Brusselle, Luisa Brussino, Roland Buhl, Victoria Cardona, Thomas Casale, Lorenzo Cecchi, Denis Charpin, Ivan Cherrez-Ojeda, Derek K. Chu, Cemal Cingi, Elisio M. Costa, Alvaro A. Cruz, Philippe Devillier, Stephanie Dramburg, Wytske J. Fokkens, Maia Gotua, Enrico Heffler, Zhanat Ispayeva, Juan Carlos Ivancevich, Guy Joos, Igor Kaidashev, Helga Kraxner, Violeta Kvedariene, Desiree E. Larenas-Linnemann, Daniel Laune, Olga Lourenco, Renaud Louis, Mika Makela, Michael Makris, Marcus Maurer, Erik Melen, Yann Micheli, Mario Morais-Almeida, Joaquim Mullol, Marek Niedoszytko, Robyn O'Hehir, Yoshitaka Okamoto, Heidi Olze, Nikolaos G. Papadopoulos, Alberto Papi, Vincenzo Patella, Benoit Petre, Nhan Pham-Thi, Francesca Puggioni, Santiago Quirce, Nicolas Roche, Philip W. Rouadi, Ana Sa-Sousa, Hironori Sagara, Joaquin Sastre, Nicola Scichilone, Aziz Sheikh, Milan Sova, Charlotte Suppli Ulrik, Luis Taborda-Barata, Ana Todo-Bom, Maria J. Torres, Ioanna Tsiligianni, Omar S. Usmani, Erkka Valovirta, Tuula Vasankari, Rafael Jose Vieira, Dana Wallace, Susan Waserman, Mihaela Zidarn, Arzu Yorgancioglu, Luo Zhang, Tomas Chivato, Markus Ollert
Summary: Biomarkers, especially digital biomarkers, are urgently needed in the diagnosis, treatment and follow-up of patients with rhinitis and/or asthma. The lack of validated biomarkers in primary care poses a challenge, but the digital transformation of health care holds potential in improving allergy management. The Allergic Rhinitis and its Impact on Asthma (ARIA) and the European Academy of Allergy and Clinical Immunology (EAACI) have developed patient-reported outcome measures (PROMs) as digital biomarkers for rhinitis and asthma, including control biomarkers and quality-of-life biomarkers.
Article
Immunology
Yana Hackler, Frank Siebenhaar, Marcus Maurer, Melba Munoz
Summary: This study found that mast cells can directly activate virus-specific CD8(+) T cells and promote their antiviral response during viral infections. Mast cells cluster with virus-specific CD8(+) T cells and induce their activation and production of antiviral cytokines through direct cellular interaction. This finding contributes to a better understanding of the antiviral functions of mast cells and may provide new strategies for treating viral infections.
SCANDINAVIAN JOURNAL OF IMMUNOLOGY
(2023)
Article
Multidisciplinary Sciences
Georg Richtig, Marina Berger, Max Koeller, Markus Richtig, Erika Richtig, Joerg Scheffel, Marcus Maurer, Frank Siebenhaar
Summary: Beall's list is widely used for identifying predatory journals. This study investigates the impact of Beall's list on the perception, publication, and citation behavior of the scientific community. Comprehensive bibliometric analyses were performed using data from various databases. The study found that the number of articles published by journals on Beall's list increased over time but decreased in 2018. Journals on Beall's list were more likely to be cited when indexed by Web of Science and PMC. The importance of Beall's list seems to be overestimated, as journals indexed by reputable databases are more likely to be selected for publication or citation.
Article
Immunology
Axel Rosell, Cecilia Karlstrom, Joakim S. Dahlin, Daryl Boey, Monika Klimkowska, Kajsa Ax, Charlotte Thalin, Johanna Ungerstedt
Summary: There is no evidence of global increase in neutrophil extracellular trap release in patients with systemic mastocytosis.
SCANDINAVIAN JOURNAL OF IMMUNOLOGY
(2024)
Article
Allergy
Hanna Bonnekoh, Jannis Jelden-Thurm, Anastasiia Allenova, Yudi Chen, Ivan Cherrez-Ojeda, Inna Danilycheva, Irina Dorofeeva, Roberta Fachini Jardim Criado, Paulo Ricardo Criado, Asli Gelincik Akkor, Tomasz Hawro, Emek Kocaturk, Maryam Khoshkhui, Martin Metz, Iman Nasr, Michal Stec, Zuotao Zhao, Felix Aulenbacher, Pascale Salameh, Sabine Altrichter, Margarida Goncalo, Ana Gimenez-Arnau, Marcus Maurer, Karoline Krause, Pavel Kolkhir
Summary: Chronic spontaneous urticaria (CSU) and urticarial vasculitis (UV) have some clinical features in common. This study aimed to identify the differences, similarities, and specific clinical features between these two disorders.
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY-IN PRACTICE
(2023)
Article
Allergy
Ozge Sevil Karstarli Bakay, Betul Demir, Demet Cicek, Deniz Erol, Zulal Asci Toraman, Yunus Gural, Marcus Maurer
Summary: Chronic spontaneous urticaria (CSU) is a common and disabling disease. Assessments of IgE and CRP are recommended in the diagnostic work-up, but the role and clinical relevance of these biomarkers are not well characterized. It remains unknown if elevated levels of IgE or CRP are linked to CSU miRNA signatures or IL-31.
CLINICAL AND TRANSLATIONAL ALLERGY
(2023)
Review
Medicine, Research & Experimental
Man Hu, Joerg Scheffel, Daniel Elieh-Ali-Komi, Marcus Maurer, Tomasz Hawro, Martin Metz
Summary: Primary cutaneous T-cell lymphomas (CTCL) are characterized by the accumulation of malignant T-lymphocytes in the skin, leading to severe pruritus that significantly impacts patients' quality of life. Understanding the underlying mechanisms of CTCL pruritus is challenging, but studies suggest that proteases (such as tryptase) and neuropeptides (particularly Substance P) may play a significant role, alongside cytokine receptors, MRGPRs, and TRP channels. Targeting these mediators and receptors could lead to effective treatment options for CTCL pruritus.
CLINICAL AND EXPERIMENTAL MEDICINE
(2023)
Letter
Allergy
Rabia Oztas Kara, Semra Demir, Esra Sarac, Bahar Sevimli Dikicier, Derya Unal, Asli Gelincik, Simon Francis Thomsen, Marcus Maurer, Emek Kocaturk
INTERNATIONAL ARCHIVES OF ALLERGY AND IMMUNOLOGY
(2023)
Meeting Abstract
Allergy
Maureen Watt, Marcus Maurer, William Lumry, H. Henry Li, Emel Aygoeren-Puersuen, Paula Busse, Joshua Jacobs, Christina Nurse, Ming Yu, Dorothy Romanus, Giovanna Devercelli
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
(2023)
Meeting Abstract
Dermatology
C. E. Vera Ayala, M. Maurer, J. Scheffel
EXPERIMENTAL DERMATOLOGY
(2023)
Meeting Abstract
Dermatology
H. Bonnekoh, N. Mahnke, J. Scheffel, H. Wai, D. Baralle, S. Ennis, M. Maurer, K. Krause
EXPERIMENTAL DERMATOLOGY
(2023)
Meeting Abstract
Dermatology
M. Darvin, M. Kroeger, J. Scheffel, V. Nikolaev, E. Shirshin, F. Siebenhaar, J. Schleusener, M. Maurer, J. Lademann
EXPERIMENTAL DERMATOLOGY
(2023)
Meeting Abstract
Clinical Neurology
Mitzi Williams, Laura Airas, Tanuja Chitnis, Sarbjit Saini, Michihiro Hide, Gordon Sussman, Jin Nakahara, Robert Bermel, Thomas Doerner, Brett Loop, Marina Ziehn, Roman Willi, Bernd C. Kieseier, Ivan Nikolaev, Sibylle Haemmerle, Artem Zharkov, Richard Siegel, Bruno Cenni, Heinz Wiendl, Marcus Maurer, Ana Gimenez-Arnau, Xavier Montalban