Review
Biochemistry & Molecular Biology
Mohammad Mahmoudi Gomari, Shadi Abkhiz, Taha Ghantab Pour, Ehsan Lotfi, Neda Rostami, Fatemeh Nafe Monfared, Babak Ghobari, Mona Mosavi, Behruz Alipour, Nikolay V. Dokholyan
Summary: The low efficiency of cancer treatment strategies is a major obstacle in developing cancer inhibitors. Peptidomimetics, a new class of agents, have been introduced to overcome the limitations of peptides and have shown effectiveness in inhibiting metastasis, angiogenesis, and cancerous cell growth.
MOLECULAR MEDICINE
(2022)
Review
Pharmacology & Pharmacy
Xuan Liu, Yiqian Zhang, Xuyi Wu, Fuyan Xu, Hongbo Ma, Mengling Wu, Yong Xia
Summary: Ferroptosis is an iron-dependent form of cell death that is closely related to cancer progression, treatment response, and metastasis. Cancer cells can decrease their susceptibility to ferroptosis to resist anticancer therapy. Inducing ferroptosis can restore the sensitivity of drug-resistant cancer cells to standard treatments. Understanding the regulatory mechanisms and signaling pathways of ferroptosis can provide new insights to enhance the efficacy of anticancer drugs, overcome drug resistance, and inhibit cancer metastasis.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Chemistry, Multidisciplinary
Lulu Ren, Peirong Xu, Jie Yao, Zihan Wang, Kewei Shi, Weidong Han, Hangxiang Wang
Summary: Mitochondria-targeted drugs provide an alternative approach to treating aggressive cancers by enhancing drug efficacy and reducing toxicity.
Review
Medicine, Research & Experimental
Changpeng Chai, Pengfei Ji, Hao Xu, Huan Tang, Zhengfeng Wang, Hui Zhang, Wence Zhou
Summary: Cancer organoids generated from 3D in vitro cell cultures have provided valuable insights into drug resistance mechanisms. These organoids accurately predict drug resistance due to their genomic and transcriptomic similarity to parental cancer cells. Methods for establishing therapy-sensitive and therapy-resistant organoids involve either direct culture from patient samples or induction with anti-cancer drugs. Genomic and transcriptomic analyses and gene editing have identified key targets in drug resistance, including FGFR3, KHDRBS3, lncRP11-536 K7.3, and FBN1. Mechanisms contributing to resistance include metabolic adaptation, DNA damage response activation, apoptosis defects, reduced cellular senescence, cellular plasticity, subpopulation interactions, and gene fusions. Cancer stem cells (CSCs) have also been implicated in drug resistance using organoid technology. Targeting key genes and CSCs in cancer organoids can reverse drug resistance. This review summarizes the applications of organoids in cancer drug resistance research, highlighting their prospects and limitations.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Review
Oncology
Aliye Tabatabaee, Behjat Nafari, Armin Farhang, Amirali Hariri, Arezoo Khosravi, Ali Zarrabi, Mina Mirian
Summary: This comprehensive review explores vimentin as a pivotal therapeutic target in cancer treatment, primarily focusing on mitigating metastasis and overcoming drug resistance. It discusses diverse vimentin inhibition strategies, including antibodies, nanobodies, DNA and RNA aptamers, vaccines, and miRNAs. These multifaceted approaches hold substantial promise for enhanced cancer therapy.
CANCER AND METASTASIS REVIEWS
(2023)
Review
Biochemistry & Molecular Biology
Samantha M. Zeiders, Jean Chmielewski
Summary: The failure to treat bacterial infections is a current threat due to resistance mechanisms, but using cell-penetrating peptides (CPPs) to enhance antibiotics has shown increased permeation and selectivity against both sensitive and drug-resistant pathogens. This strategy has the potential to improve antibiotic effectiveness and repurpose existing drugs for broader use against various bacterial strains.
CHEMICAL BIOLOGY & DRUG DESIGN
(2021)
Article
Multidisciplinary Sciences
Jing Liu, Ying Xie, Jing Guo, Xin Li, Jingjing Wang, Hongmei Jiang, Ziyi Peng, Jingya Wang, Sheng Wang, Qian Li, Linquan Ye, Yuping Zhong, Qiguo Zhang, Xiaozhi Liu, David M. Lonard, Jin Wang, Bert W. O'Malley, Zhiqiang Liu
Summary: High expression of steroid receptor coactivator-3 (SRC-3) is correlated with relapse/refractory and poor outcomes in multiple myeloma (MM) patients treated with bortezomib (BTZ)-based regimens, and overexpression of histone methyltransferase NSD2 may contribute to acquired drug resistance by coordinating and enhancing SRC-3 in MM cells. Targeting SRC-3 or interfering with its interactions with NSD2 using a newly developed inhibitor, SI-2, can sensitize BTZ treatment and overcome drug resistance in MM patients.
NATURE COMMUNICATIONS
(2021)
Review
Pharmacology & Pharmacy
Xue Wei, Ming Yang
Summary: Breast cancer is the most common malignant tumor in women, with drug resistance, metastasis, and immune escape posing significant challenges in its treatment. Nanoparticles that target specific cell and subcellular organelles offer a potential solution for immune evasion, metastasis, and drug resistance. This study provides a detailed summary and critical analysis of the latest subcellular targeted therapies using organic nanoparticles, including chemotherapy, gene therapy, immunotherapy, and combination therapy, and discusses the challenges and opportunities of nanoparticle therapy.
FRONTIERS IN PHARMACOLOGY
(2023)
Article
Oncology
Joana B. Loureiro, Liliana Raimundo, Juliana Calheiros, Carla Carvalho, Valentina Barcherini, Nuno R. Lima, Celia Gomes, Maria Ines Almeida, Marco G. Alves, Jose Luis Costa, Maria M. M. Santos, Lucilia Saraiva
Summary: Melanoma, a deadly form of skin cancer, is highly metastatic and therapy-resistant. The p53-activating agent SLMP53-2 shows promising antitumor activity by inducing cell cycle arrest and apoptosis, inhibiting invasion and migration, and increasing sensitivity to chemotherapy. It also has the potential to improve outcomes in advanced melanoma, either alone or in combination therapy.
Article
Medicine, Research & Experimental
Raman Devarajan, Valerio Izzi, Hellevi Peltoketo, Gunilla Rask, Saila Kauppila, Marja-Riitta Vaisanen, Heli Ruotsalainen, Guillermo Martinez-Nieto, Sanna-Maria Karppinen, Timo Vaisanen, Inderjeet Kaur, Jussi Koivunen, Takako Sasaki, Robert Winqvist, Aki Manninen, Fredrik Warnberg, Malin Sund, Taina Pihlajaniemi, Ritva Heljasvaara
Summary: This study discovered the upregulation of ColXVIII in breast cancer and its association with poor prognosis. ColXVIII was found to promote cancer cell proliferation through its interaction with ErbB receptors and α6 integrin. The study also revealed the importance of ColXVIII in maintaining breast cancer stem cells and tumor progression and metastasis.
JOURNAL OF CLINICAL INVESTIGATION
(2023)
Article
Chemistry, Multidisciplinary
Sujan Kumar Mondal, Sudhakar Jinka, Gajji Shankar, Ragampeta Srinivas, Rajkumar Banerjee
Summary: To overcome the limitations of paclitaxel (PTX) as a chemotherapeutic agent, a tumor-targeting peptide conjugate of alpha-tocopheryl succinate (alpha-TOS) was synthesized and modified on PTX-loaded lipid aggregate (TL-PTX). This conjugate showed increased PTX entrapment efficiency, specific cellular uptake, enhanced apoptotic and cell killing activity, and inhibition of multidrug resistance (MDR) in melanoma. The conjugate resulted in a significant increase in overall survival of melanoma tumor-bearing mice. In conclusion, this study provides a unique NRP-1 targeted, drug-resistant reversing anticancer regimen for aggressive melanoma.
CHEMISTRY-AN ASIAN JOURNAL
(2023)
Review
Biochemistry & Molecular Biology
Mahshid Deldar Abad Paskeh, Shafagh Asadi, Amirhossein Zabolian, Hossein Saleki, Mohammad Amin Khoshbakht, Sina Sabet, Mohamad Javad Naghdi, Mehrdad Hashemi, Kiavash Hushmandi, Milad Ashrafizadeh, Sepideh Mirzaei, Ali Zarrabi, Gautam Sethi
Summary: The key to cancer treatment lies in understanding the unique mechanisms of cancer development, particularly in targeting cancer stem cells. Dietary agents play a crucial role in suppressing cancer stemness and enhancing treatment sensitivity.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Jehoshaphat Oppong Mensah, Aaron Boakye, Michael Laryea, Edward Ntim Gasu, Lawrence Sheringham Borquaye
Summary: This study used molecular dynamics simulation to investigate the membrane selectivity of antimicrobial peptide Maximin 1. The results showed that Maximin 1 interacts more strongly with the bacterial membrane due to electrostatic attraction and certain residues and structural characteristics play a crucial role in the adsorption and penetration of the bacterial membrane.
JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS
(2023)
Review
Biochemistry & Molecular Biology
Reid Loveless, Yong Teng
Summary: WASF3 is a crucial regulator in promoting cancer cell invasion and metastasis, and targeting it at the transcription, protein stability, and phosphorylation levels holds promise for metastasis suppression regardless of the diverse genetic backgrounds associated with tumor development.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Infectious Diseases
Leticia Matilla-Cuenca, Alejandro Toledo-Arana, Jaione Valle
Summary: Amyloids play a significant role in bacterial biofilms, serving as potential targets for drug development to enhance therapeutic strategies against biofilm-related infections.
Article
Cell Biology
Yi-Shyun Lai, Ya-Han Chang, Yong-Yi Chen, Jixuan Xu, Chi-Sian Yu, Su-Jing Chang, Pai-Sheng Chen, Shaw-Jenq Tsai, Wen-Tai Chiu
Summary: This study demonstrates the integral role of Ca2+ signals in cell biology, and optogenetic technology can be used to modulate Ca2+ waves and activate specific signaling pathways to explore the regulation of cell migration.
JOURNAL OF CELLULAR PHYSIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Jie-Ning Li, Pai-Sheng Chen, Ching-Feng Chiu, Yu-Jhen Lyu, Chiao Lo, Li-Wei Tsai, Ming-Yang Wang
Summary: This study reveals the regulatory role of TARBP2 in the ubiquitination-proteasomal degradation of HIF-1 alpha protein in breast cancer, showing its significance in cancer progression.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Surgery
Po-Jen Yang, Yen-Hao Su, Shih-Chiang Shen, Po-Chu Lee, Ming-Tsan Lin, Wei-Jei Lee, Weu Wang
Summary: Limited studies have focused on diabetes relapse after metabolic surgery in Asians. This study aimed to identify predictors of diabetes relapse after initial postoperative remission. The results showed that older age, lower BMI, insulin use, higher 1-year A1C, and weight regain were independent predictors of relapse. The ABCD score successfully predicted mid-term remission and relapse in Asians.
SURGERY FOR OBESITY AND RELATED DISEASES
(2022)
Article
Multidisciplinary Sciences
Ji Min Park, Chen-Zou Mau, Yang-Ching Chen, Yen-Hao Su, Hsin-An Chen, Shih-Yi Huang, Jung-Su Chang, Ching-Feng Chiu
Summary: High levels of serum ferritin (SF) may indicate risk of pancreatic cancer as a new tumor marker for diagnosis, while genes related to iron homeostasis and ferroptosis could contribute to pancreatic cancer risk and prognosis.
SCIENTIFIC REPORTS
(2021)
Article
Medicine, General & Internal
Yu-Ming Wu, Yen-Hao Su, Shih-Yu Huang, Po-Han Lo, Jui-Tai Chen, Hung-Chi Chang, Yun-Ling Yang, Yih-Giun Cherng, Hsiang-Ling Wu, Ying-Hsuan Tai
Summary: This trial investigated the effects of sevoflurane and desflurane on emergence time from anesthesia in obese patients, and found that desflurane can accelerate awakening and reduce agitation during emergence, with further improvement when using M-Entropy guidance.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Oncology
Yu-Yun Shao, Pai-Sheng Chen, Liang-In Lin, Bin-Shyun Lee, Andrew Ling, Ann-Lii Cheng, Chiun Hsu, Da-Liang Ou
Summary: This study identified miR-10b-3p as a potential biomarker for predicting sorafenib efficacy in advanced HCC patients and confirmed its mechanism of action.
BRITISH JOURNAL OF CANCER
(2022)
Article
Medicine, General & Internal
Yu-Ming Wu, Yen-Hao Su, Shih-Yu Huang, Chien-Wun Wang, Shih-Chiang Shen, Jui-Tai Chen, Po-Han Lo, Yih-Giun Cherng, Hsiang-Ling Wu, Ying-Hsuan Tai
Summary: This study found that greater neck circumference is an independent risk factor for difficult laryngoscopy in obese patients.
JOURNAL OF THE CHINESE MEDICAL ASSOCIATION
(2022)
Article
Medicine, General & Internal
Yu-Ming Wu, Chun-Cheng Li, Shih-Yu Huang, Yen-Hao Su, Chien-Wun Wang, Jui-Tai Chen, Shih-Chiang Shen, Po-Han Lo, Yun-Ling Yang, Yih-Giun Cherng, Hsiang-Ling Wu, Ying-Hsuan Tai
Summary: This study aimed to compare the risk of oxygen desaturation between high-flow nasal oxygenation (HFNO) and classical facemask oxygenation (FMO) during rapid sequence intubation for obese patients. The results showed that HFNO reduced the risk of arterial desaturation and increased arterial oxygen pressure compared to FMO.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Medicine, Research & Experimental
Ching-Feng Chiu, Ji Min Park, Hsin-Hua Chen, Chen-Zou Mau, Pai-Sheng Chen, Yen-Hao Su, Hsin-An Chen, Yun-Ru Liu, Tsung-Han Hsieh, Chien-Chao Chiu, Shao-Wen Hung, Cheng-Yi Kuo, Young-Mao Chen, Chi-Fen Chang
Summary: This study found that the expression of OCT2 is positively correlated with the sensitivity of PDAC cells to oxaliplatin. Inhibiting or silencing OCT2 expression significantly decreased the sensitivity to oxaliplatin. Moreover, the methylation frequency of OCT2 repressed its expression in gemcitabine-resistant cells, and DNMT inhibitors could recover OCT2 expression and oxaliplatin sensitivity.
BIOMEDICINE & PHARMACOTHERAPY
(2022)
Article
Cell Biology
Yu-Ying Chao, Bu-Miin Huang, I-Chen Peng, Pei-Rong Lee, Yi-Shyun Lai, Wen-Tai Chiu, Yi-Syuan Lin, Shih-Chieh Lin, Jung-Hsuan Chang, Pai-Sheng Chen, Shaw-Jenq Tsai, Chia-Yih Wang
Summary: Loss of primary cilia is associated with chemoresistance in pancreatic ductal adenocarcinoma (PDAC). Disruption of primary ciliogenesis sensitizes PDAC cells to cisplatin treatment, indicating a potential therapeutic strategy.
JOURNAL OF CELLULAR PHYSIOLOGY
(2022)
Article
Oncology
Yi-Ling Chen, Kuo-Ting Lee, Chih-Yang Wang, Che-Hung Shen, Sheau-Chiann Chen, Wei-Pang Chung, Ya-Ting Hsu, Yao-Lung Kuo, Pai-Sheng Chen, Chun Hei Antonio Cheung, Chih-Peng Chang, Meng-Ru Shen, Hui-Ping Hsu
Summary: The study investigated the expression of NOTCH1 gene in breast cancer through bioinformatics analysis and immunohistochemistry staining. The results showed that the correlation between NOTCH1 mRNA expression and survival of patients was inconsistent, while lower cytoplasmic staining of NOTCH1 protein was associated with poor prognosis, including cancer recurrence and bone metastasis. Additionally, the study found a correlation between NOTCH1 expression and cell cycle-related genes.
AMERICAN JOURNAL OF CANCER RESEARCH
(2022)
Article
Cell Biology
Jie-Ning Li, Hui-Lung Sun, Ming-Yang Wang, Pai-Sheng Chen
Summary: MicroRNAs (miRNAs) are small non-coding RNAs that play a role in regulating pathophysiological processes by suppressing target gene expression post-transcriptionally. The function of miRNAs is regulated by a conserved biogenesis machinery involving processing steps and the formation of a miRNA-induced silencing complex (miRISC). This study discovered a novel regulatory mechanism involving the post-translational modification of AGO2 by E-cadherin, leading to enhanced miRISC activity on gene silencing.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Cell Biology
Hsin-An Chen, Chi-Cheng Li, Yu-Jung Lin, Tso-Fu Wang, Ming-Cheng Chen, Yen-Hao Su, Yu-Lan Yeh, V. Vijaya Padma, Po-Hsiang Liao, Chih-Yang Huang
Summary: This study investigated the mechanism of resistance of hepatocellular carcinoma cells to histone deacetylase inhibitors, and found that downregulation of miR-107 leads to resistance in hepatocellular carcinoma cells.
Article
Cell Biology
Yen-Hao Su, Tung-Wei Hsu, Hsin-An Chen, Chih-Ming Su, Ming-Te Huang, Ta-Hsien Chuang, J. Leo Su, Chia-Ling Hsieh, Ching-Feng Chiu
Summary: Research has found that increased Dicer levels may be associated with gemcitabine resistance in pancreatic cancer, with Dicer suppression reducing resistance and overexpression increasing it. The ERK/Sp1 signaling pathway may regulate Dicer expression, correlating positively with pancreatic cancer progression and suggesting therapeutic potential for gemcitabine-resistant cases.
JOURNAL OF CELLULAR PHYSIOLOGY
(2021)
Review
Surgery
Yi-Shyue Chen, El-Wui Loh, Shih-Chiang Shen, Yen-Hao Su, Ka-Wai Tam
Summary: This meta-analysis assessed the effectiveness of fibrin sealant in reducing complications after bariatric surgery, finding that it significantly reduced bleeding incidence but did not have a significant impact on leakage, gastric stricture, reoperation rate, or length of hospital stay. The study suggests that while fibrin sealants may provide favorable results in bariatric surgery, further research is needed to determine their efficacy in reducing postoperative complications.
