Platycodon grandiflorum Saponins Ameliorate Cisplatin-Induced Acute Nephrotoxicity through the NF-κB-Mediated Inflammation and PI3K/Akt/Apoptosis Signaling Pathways

Protective Effect of Safflower Seed on Cisplatin-Induced Renal Damage in Mice via Oxidative Stress and Apoptosis-Mediated Pathways

(2018) Chan Hum Park et al.   AMERICAN JOURNAL OF CHINESE MEDICINE

Zingerone ameliorates cisplatin‐induced ovarian and uterine toxicity via suppression of sex hormone imbalances, oxidative stress, inflammation and apoptosis in female wistar rats

(2018) Erdal kaygusuzoglu et al.   BIOMEDICINE & PHARMACOTHERAPY

Opposite Interplay Between the Canonical WNT/β-Catenin Pathway and PPAR Gamma: A Potential Therapeutic Target in Gliomas

(2018) Alexandre Vallée et al.   Neuroscience Bulletin

Cisplatin generates oxidative stress which is accompanied by rapid shifts in central carbon metabolism

(2018) Wangie Yu et al.   Scientific Reports

Phosphoinositide 3-Kinase Signaling Pathway in Pancreatic Ductal Adenocarcinoma Progression, Pathogenesis, and Therapeutics

(2018) Divya Murthy et al.   Frontiers in Physiology

Platycodin D suppressed LPS-induced inflammatory response by activating LXRα in LPS-stimulated primary bovine mammary epithelial cells

(2017) Yanan Wang et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Stevia and stevioside protect against cisplatin nephrotoxicity through inhibition of ERK1/2, STAT3, and NF-κB activation

(2017) Iva Potočnjak et al.   FOOD AND CHEMICAL TOXICOLOGY

Supplementation of American ginseng berry extract mitigated cisplatin-evoked nephrotoxicity by suppressing ROS-mediated activation of MAPK and NF-κB signaling pathways

(2017) Zhi-na Ma et al.   FOOD AND CHEMICAL TOXICOLOGY

Nephroprotective Effects of Saponins from Leaves of Panax quinquefolius against Cisplatin-Induced Acute Kidney Injury

(2017) Zhi-Na Ma et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Platycodon grandiflorum (PG) reverses angiotensin II-induced apoptosis by repressing IGF-IIR expression

(2017) Yuan-Chuan Lin et al.   JOURNAL OF ETHNOPHARMACOLOGY

Rapid characterization of chemical constituents of Platycodon grandiflorum and its adulterant Adenophora stricta by UPLC-QTOF-MS/MS

(2017) Cuizhu Wang et al.   JOURNAL OF MASS SPECTROMETRY

Nephroprotective Effects of Anthocyanin from the Fruits of Panax ginseng (GFA) on Cisplatin-Induced Acute Kidney Injury in Mice

(2017) Zhen-Lan Qi et al.   PHYTOTHERAPY RESEARCH

The protective effects of Zhen-Wu-Tang against cisplatin-induced acute kidney injury in rats

(2017) Qi Liu et al.   PLoS One

Effect of curcumin on glycerol-induced acute kidney injury in rats

(2017) Jindao Wu et al.   Scientific Reports

QiShenYiQi Pills, a Compound Chinese Medicine, Prevented Cisplatin Induced Acute Kidney Injury via Regulating Mitochondrial Function

(2017) Li Zhou et al.   Frontiers in Physiology

Curcumin inhibits apoptosis by modulating Bax/Bcl-2 expression and alleviates oxidative stress in testes of streptozotocin-induced diabetic rats

(2017) Lingling Zhao et al.   Therapeutics and Clinical Risk Management

Eriodictyol attenuates cisplatin-induced kidney injury by inhibiting oxidative stress and inflammation

(2016) Cheng-zhen Li et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Chemomics-Integrated Proteomics Analysis of Jie-Geng-Tang to Ameliorate Lipopolysaccharide-Induced Acute Lung Injury in Mice

(2016) Jin Tao et al.   Evidence-based Complementary and Alternative Medicine

Nephrotoxicity of anticancer treatment

(2016) Jolanta Małyszko et al.   NEPHROLOGY DIALYSIS TRANSPLANTATION

Effects of Delta-9-Tetrahydrocannabinol and Cannabidiol on Cisplatin-Induced Neuropathy in Mice

(2016) Hannah Harris et al.   PLANTA MEDICA

Ginsenoside Rg5 Ameliorates Cisplatin-Induced Nephrotoxicity in Mice through Inhibition of Inflammation, Oxidative Stress, and Apoptosis

(2016) Wei Li et al.   Nutrients

Beneficial effects of fermented black ginseng and its ginsenoside 20(S)-Rg3 against cisplatin-induced nephrotoxicity in LLC-PK1 cells

(2016) Myoung-Sik Han et al.   Journal of Ginseng Research

Saikosaponin-D reduces cisplatin-induced nephrotoxicity by repressing ROS-mediated activation of MAPK and NF-κB signalling pathways

(2015) Xiaobin Ma et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Platycodin D isolated from the aerial parts of Platycodon grandiflorum protects alcohol-induced liver injury in mice

(2015) Wei Li et al.   Food & Function

Effects of Olmesartan on Endothelial Progenitor Cell Mobilization and Function in Carotid Atherosclerosis

(2015) Yong Zou   MEDICAL SCIENCE MONITOR

Platycodon grandiflorum root-derived saponins attenuate atopic dermatitis-like skin lesions via suppression of NF-κB and STAT1 and activation of Nrf2/ARE-mediated heme oxygenase-1

(2014) Jae Ho Choi et al.   PHYTOMEDICINE

DAP5 Ameliorates Cisplatin-Induced Apoptosis of Renal Tubular Cells

(2012) Jian-jun Gao et al.   AMERICAN JOURNAL OF NEPHROLOGY

TNF-α-mediated NF-κB survival signaling impairment by cisplatin enhances JNK activation allowing synergistic apoptosis of renal proximal tubular cells

(2012) Giulia Benedetti et al.   BIOCHEMICAL PHARMACOLOGY

ISOLATION AND PURIFICATION OF SAPONINS FROMPLATYCODON GRANDIFLORUMBY SEMI-PREPARATIVE HIGH PERFORMANCE LIQUID CHROMATOGRAPHY AND LC/ESI-MS

(2012) Wei Li et al.   JOURNAL OF LIQUID CHROMATOGRAPHY & RELATED TECHNOLOGIES

Activity-screening-guided isolation and purification for vasodilative effects compounds fromRadix Astragaliby high-speed counter-current chromatography using gradient elution

(2012) Zu-fei Feng et al.   NATURAL PRODUCT RESEARCH

Toll-Like Receptor 4 and MYD88-Dependent Signaling Mechanisms of the Innate Immune System Are Essential for the Response to Lipopolysaccharide by Epithelial and Stromal Cells of the Bovine Endometrium1

(2011) James G. Cronin et al.   BIOLOGY OF REPRODUCTION

Evaluation of the total oxidant scavenging capacity of saponins isolated from Platycodon grandiflorum

(2011) Chang Seon Ryu et al.   FOOD CHEMISTRY

Posttranslational modifications of NF-κB: Another layer of regulation for NF-κB signaling pathway

(2010) Bo Huang et al.   CELLULAR SIGNALLING

Enzymatic transformation of platycosides and one-step separation of platycodin D by high-speed countercurrent chromatography

(2010) In Jin Ha et al.   JOURNAL OF SEPARATION SCIENCE

Epigallocatechin-3-gallate activates Nrf2/HO-1 signaling pathway in cisplatin-induced nephrotoxicity in rats

(2010) Kazim Sahin et al.   LIFE SCIENCES

Shared Principles in NF-κB Signaling

(2008) Matthew S. Hayden et al.   CELL

Role of oxidative and nitrosative stress in cisplatin-induced nephrotoxicity

(2008) Yolanda I. Chirino et al.   EXPERIMENTAL AND TOXICOLOGIC PATHOLOGY

The phosphoinositide-3 kinase γ–Akt pathway mediates renal tubular injury in cisplatin nephrotoxicity

(2007) H. Kuwana et al.   KIDNEY INTERNATIONAL