Cisplatin generates oxidative stress which is accompanied by rapid shifts in central carbon metabolism

Metabolic interrogation as a tool to optimize chemotherapeutic regimens

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Kinetic Modeling and Constrained Reconstruction of Hyperpolarized [1-13C]-Pyruvate Offers Improved Metabolic Imaging of Tumors

(2015) J. A. Bankson et al.   CANCER RESEARCH

Acute Tumor Lactate Perturbations as a Biomarker of Genotoxic Stress: Development of a Biochemical Model

(2015) V. C. Sandulache et al.   MOLECULAR CANCER THERAPEUTICS

Combined inhibition of glycolysis, the pentose cycle, and thioredoxin metabolism selectively increases cytotoxicity and oxidative stress in human breast and prostate cancer

(2015) Ling Li et al.   Redox Biology

The myImageAnalysis Project: A Web-Based Application for High-Content Screening

(2014) Adam T. Szafran et al.   ASSAY AND DRUG DEVELOPMENT TECHNOLOGIES

A prospective clinical study of 18 F-FAZA PET-CT hypoxia imaging in head and neck squamous cell carcinoma before and during radiation therapy

(2014) Stéphanie Servagi-Vernat et al.   EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING

Dynamics of tumor hypoxia assessed by 18F-FAZA PET/CT in head and neck and lung cancer patients during chemoradiation: Possible implications for radiotherapy treatment planning strategies

(2014) Vikram R. Bollineni et al.   RADIOTHERAPY AND ONCOLOGY

Systems biology of cisplatin resistance: past, present and future

(2014) L Galluzzi et al.   Cell Death & Disease

Targeting lactate metabolism for cancer therapeutics

(2013) Joanne R. Doherty et al.   JOURNAL OF CLINICAL INVESTIGATION

In vivo1HMR spectroscopic imaging of aggressive prostate cancer: Can we detect lactate?

(2013) Thiele Kobus et al.   MAGNETIC RESONANCE IN MEDICINE

Chk1/2 Inhibition Overcomes the Cisplatin Resistance of Head and Neck Cancer Cells Secondary to the Loss of Functional p53

(2013) M. A. Gadhikar et al.   MOLECULAR CANCER THERAPEUTICS

Complex Cisplatin-Double Strand Break (DSB) Lesions Directly Impair Cellular Non-Homologous End-Joining (NHEJ) Independent of Downstream Damage Response (DDR) Pathways

(2012) Catherine R. Sears et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

EPR oxygen imaging and hyperpolarized13C MRI of pyruvate metabolism as noninvasive biomarkers of tumor treatment response to a glycolysis inhibitor 3-bromopyruvate

(2012) Shingo Matsumoto et al.   MAGNETIC RESONANCE IN MEDICINE

Glucose, not glutamine, is the dominant energy source required for proliferation and survival of head and neck squamous carcinoma cells

(2011) Vlad C. Sandulache et al.   CANCER

Individualizing antimetabolic treatment strategies for head and neck squamous cell carcinoma based on TP53 mutational status

(2011) Vlad C. Sandulache et al.   CANCER

TP53 Disruptive Mutations Lead to Head and Neck Cancer Treatment Failure through Inhibition of Radiation-Induced Senescence

(2011) H. D. Skinner et al.   CLINICAL CANCER RESEARCH

Assembly and Initial Characterization of a Panel of 85 Genomically Validated Cell Lines from Diverse Head and Neck Tumor Sites

(2011) M. Zhao et al.   CLINICAL CANCER RESEARCH

Altered metabolism in head and neck squamous cell carcinoma: an opportunity for identification of novel biomarkers and drug targets

(2011) Vlad C. Sandulache et al.   HEAD AND NECK-JOURNAL FOR THE SCIENCES AND SPECIALTIES OF THE HEAD AND NECK

Exome Sequencing of Head and Neck Squamous Cell Carcinoma Reveals Inactivating Mutations in NOTCH1

(2011) N. Agrawal et al.   SCIENCE

Platinum-DNA Interactions and Subsequent Cellular Processes Controlling Sensitivity to Anticancer Platinum Complexes

(2010) Saeed Ahmad   CHEMISTRY & BIODIVERSITY

Inhibition of lactate dehydrogenase A induces oxidative stress and inhibits tumor progression

(2010) A. Le et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Prospective Trial Incorporating Pre-/Mid-Treatment [18F]-Misonidazole Positron Emission Tomography for Head-and-Neck Cancer Patients Undergoing Concurrent Chemoradiotherapy

(2009) Nancy Lee et al.   INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS

Increased levels of superoxide and H2O2mediate the differential susceptibility of cancer cells versus normal cells to glucose deprivation

(2008) Nùkhet Aykin-Burns et al.   BIOCHEMICAL JOURNAL

Cisplatin sensitivity of oral squamous carcinoma cells is regulated by Na+,K+-ATPase activity rather than copper-transporting P-type ATPases, ATP7A and ATP7B

(2008) Zunaid Ahmed et al.   CANCER CHEMOTHERAPY AND PHARMACOLOGY

2-Deoxyglucose combined with wild-type p53 overexpression enhances cytotoxicity in human prostate cancer cells via oxidative stress

(2007) Iman M. Ahmad et al.   FREE RADICAL BIOLOGY AND MEDICINE