Deregulation of brain insulin signaling in Alzheimer’s disease

2013 Alzheimer's disease facts and figures

(2013)   Alzheimers & Dementia

Intracerebroventricular Streptozotocin Exacerbates Alzheimer-Like Changes of 3xTg-AD Mice

(2013) Yanxing Chen et al.   MOLECULAR NEUROBIOLOGY

Human hippocampal energy metabolism is impaired during cognitive activity in a lipid infusion model of insulin resistance

(2013) Yaso Emmanuel et al.   Brain and Behavior

Metabolic Dysfunction in Alzheimers Disease and Related Neurodegenerative Disorders

(2012) Huan Cai et al.   Current Alzheimer Research

Brain Insulin Resistance and Deficiency as Therapeutic Targets in Alzheimers Disease

(2012) Suzanne M. de la Monte   Current Alzheimer Research

An anti-diabetes agent protects the mouse brain from defective insulin signaling caused by Alzheimer’s disease–associated Aβ oligomers

(2012) Theresa R. Bomfim et al.   JOURNAL OF CLINICAL INVESTIGATION

Demonstrated brain insulin resistance in Alzheimer’s disease patients is associated with IGF-1 resistance, IRS-1 dysregulation, and cognitive decline

(2012) Konrad Talbot et al.   JOURNAL OF CLINICAL INVESTIGATION

A Non-transgenic Mouse Model (icv-STZ Mouse) of Alzheimer’s Disease: Similarities to and Differences from the Transgenic Model (3xTg-AD Mouse)

(2012) Yanxing Chen et al.   MOLECULAR NEUROBIOLOGY

Brain Gene Expression of a Sporadic (icv-STZ Mouse) and a Familial Mouse Model (3xTg-AD Mouse) of Alzheimer’s Disease

(2012) Yanxing Chen et al.   PLoS One

O-GlcNAc cycling modulates neurodegeneration

(2012) C.-X. Gong et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Posterior Cingulate Glucose Metabolism, Hippocampal Glucose Metabolism, and Hippocampal Volume in Cognitively Normal, Late-Middle-Aged Persons at 3 Levels of Genetic Risk for Alzheimer Disease

(2012) Hillary D. Protas et al.   JAMA Neurology

Intranasal delivery of biologics to the central nervous system

(2011) Jeffrey J. Lochhead et al.   ADVANCED DRUG DELIVERY REVIEWS

Intranasal Insulin Therapy for Alzheimer Disease and Amnestic Mild Cognitive Impairment

(2011) Suzanne Craft   ARCHIVES OF NEUROLOGY

Rosiglitazone Does Not Improve Cognition or Global Function when Used as Adjunctive Therapy to AChE Inhibitors in Mild-to-Moderate Alzheimers Disease: Two Phase 3 Studies

(2011) C. Harrington et al.   Current Alzheimer Research

Effect of Intranasal Insulin on Cognitive Function: A Systematic Review

(2011) Elad Shemesh et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Deficient brain insulin signalling pathway in Alzheimer's disease and diabetes

(2011) Ying Liu et al.   JOURNAL OF PATHOLOGY

Insulin-induced neurite-like process outgrowth: Acceleration of tau protein synthesis via a phosphoinositide 3-kinase∼mammalian target of rapamycin pathway

(2011) Takayuki Nemoto et al.   NEUROCHEMISTRY INTERNATIONAL

Metabolic syndrome and cognitive decline in French elders: The Three-City Study

(2011) C. Raffaitin et al.   NEUROLOGY

Insulin Promotes Glycogen Storage and Cell Proliferation in Primary Human Astrocytes

(2011) Martin Heni et al.   PLoS One

Insulin Resistance and Alzheimer-like Reductions in Regional Cerebral Glucose Metabolism for Cognitively Normal Adults With Prediabetes or Early Type 2 Diabetes

(2010) Laura D. Baker et al.   ARCHIVES OF NEUROLOGY

Tau in Alzheimer Disease and Related Tauopathies

(2010) K. Iqbal et al.   Current Alzheimer Research

Rosiglitazone Monotherapy in Mild-to-Moderate Alzheimer’s Disease: Results from a Randomized, Double-Blind, Placebo-Controlled Phase III Study

(2010) Michael Gold et al.   DEMENTIA AND GERIATRIC COGNITIVE DISORDERS

Intranasal insulin as a therapeutic option in the treatment of cognitive impairments

(2010) Christian Benedict et al.   EXPERIMENTAL GERONTOLOGY

Comparable Sensitivity of Postmenopausal and Young Women to the Effects of Intranasal Insulin on Food Intake and Working Memory

(2010) Rosemarie Krug et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Hippocampal memory processes are modulated by insulin and high-fat-induced insulin resistance

(2010) Ewan C. McNay et al.   NEUROBIOLOGY OF LEARNING AND MEMORY

Dysregulation of Insulin Signaling, Glucose Transporters, O -GlcNAcylation, and Phosphorylation of Tau and Neurofilaments in the Brain

(2009) Yanqiu Deng et al.   AMERICAN JOURNAL OF PATHOLOGY

Intracerebroventricular insulin improves spatial learning and memory in male Wistar rats.

(2009) V. Haj-ali et al.   BEHAVIORAL NEUROSCIENCE

Reduced O-GlcNAcylation links lower brain glucose metabolism and tau pathology in Alzheimer's disease

(2009) F. Liu et al.   BRAIN

Insulin-stimulated translocation of GLUT4 to the plasma membrane in rat hippocampus is PI3-kinase dependent

(2009) C.A. Grillo et al.   BRAIN RESEARCH

Brain glucose transporters,O-GlcNAcylation and phosphorylation of tau in diabetes and Alzheimer’s disease

(2009) Ying Liu et al.   JOURNAL OF NEUROCHEMISTRY

Awake Intranasal Insulin Delivery Modifies Protein Complexes and Alters Memory, Anxiety, and Olfactory Behaviors

(2009) D. R. Marks et al.   JOURNAL OF NEUROSCIENCE

Protection of synapses against Alzheimer's-linked toxins: Insulin signaling prevents the pathogenic binding of Aβ oligomers

(2009) Fernanda G. De Felice et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Genome-Wide Association Studies in Alzheimer Disease

(2008) Stephen C. Waring et al.   ARCHIVES OF NEUROLOGY

Insulin neuroprotection against oxidative stress is mediated by Akt and GSK-3β signaling pathways and changes in protein expression

(2008) Ana I. Duarte et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

RETRACTED: Intranasal insulin prevents cognitive decline, cerebral atrophy and white matter changes in murine type I diabetic encephalopathy

(2008)   BRAIN

Evaluation of Insulin and Ascorbic Acid Effects on Expression of Bcl-2 Family Proteins and Caspase-3 Activity in Hippocampus of STZ-Induced Diabetic Rats

(2008) Iraj Jafari Anarkooli et al.   CELLULAR AND MOLECULAR NEUROBIOLOGY

Decreased glucose transporters correlate to abnormal hyperphosphorylation of tau in Alzheimer disease

(2008) Ying Liu et al.   FEBS LETTERS

Insulin Receptor Substrate-2 Regulates Aerobic Glycolysis in Mouse Mammary Tumor Cells via Glucose Transporter 1

(2008) Shannon L. Pankratz et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Differential Sensitivity of Men and Women to Anorexigenic and Memory-Improving Effects of Intranasal Insulin

(2008) Christian Benedict et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Defects in IGF-1 receptor, insulin receptor and IRS-1/2 in Alzheimer's disease indicate possible resistance to IGF-1 and insulin signalling

(2008) Aileen M. Moloney et al.   NEUROBIOLOGY OF AGING

Central obesity and increased risk of dementia more than three decades later

(2008) R. A. Whitmer et al.   NEUROLOGY

Amyloid beta oligomers induce impairment of neuronal insulin receptors

(2007) Wei-Qin Zhao et al.   FASEB JOURNAL

Insulin rescues amyloid β-induced impairment of hippocampal long-term potentiation

(2007) Cheng-Che Lee et al.   NEUROBIOLOGY OF AGING