Novel Small Molecule Inhibitors of Cancer Stem Cell Signaling Pathways
Published 2015 View Full Article
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Title
Novel Small Molecule Inhibitors of Cancer Stem Cell Signaling Pathways
Authors
Keywords
Cancer, Stem cells, Inhibitor, Wnt, Notch, Hedgehog, Signaling pathway
Journal
Stem Cell Reviews and Reports
Volume 11, Issue 6, Pages 909-918
Publisher
Springer Nature
Online
2015-07-25
DOI
10.1007/s12015-015-9612-x
References
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Note: Only part of the references are listed.- A first-in-human, first-in-class, phase (ph) I study of systemic Hedgehog (Hh) pathway antagonist, GDC-0449, in patients (pts) with advanced solid tumors
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- (2014) Noelle K. LoConte et al. INVESTIGATIONAL NEW DRUGS
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- (2014) Alexander Stein WORLD JOURNAL OF GASTROENTEROLOGY
- A phase I study of the combination of ro4929097 and cediranib in patients with advanced solid tumours (PJC-004/NCI 8503)
- (2013) S Sahebjam et al. BRITISH JOURNAL OF CANCER
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- (2013) Shinichi Yabuuchi et al. CANCER LETTERS
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- (2013) A. Gajjar et al. CLINICAL CANCER RESEARCH
- A phase I study of the oral gamma secretase inhibitor R04929097 in combination with gemcitabine in patients with advanced solid tumors (PHL-078/CTEP 8575)
- (2013) Suzanne Richter et al. INVESTIGATIONAL NEW DRUGS
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- (2013) Rebecca A. Burrell et al. NATURE
- Unraveling the therapeutic potential of the Hedgehog pathway in cancer
- (2013) Dereck Amakye et al. NATURE MEDICINE
- Molecular Pathways: Context-Dependent Approaches to Notch Targeting as Cancer Therapy
- (2012) A. M. Egloff et al. CLINICAL CANCER RESEARCH
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- (2010) M. Fischer et al. CANCER RESEARCH
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- (2010) E. M. F. de Sousa et al. CLINICAL CANCER RESEARCH
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- (2008) C. Odoux et al. CANCER RESEARCH
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