Article
Medicine, General & Internal
David Simmons, Jincy Immanuel, William M. Hague, Helena Teede, Christopher J. Nolan, Michael J. Peek, Jeff R. Flack, Mark McLean, Vincent Wong, Emily Hibbert, Alexandra Kautzky-Willer, Juergen Harreiter, Helena Backman, Emily Gianatti, Arianne Sweeting, Viswanathan Mohan, Joanne Enticott, N. Wah Cheung
Summary: The effectiveness of early treatment for gestational diabetes before 20 weeks' gestation on maternal and infant health is not clear. In this study, women at risk of hyperglycemia and diagnosed with gestational diabetes were randomly assigned to receive immediate treatment or deferred/no treatment based on the results of an oral glucose-tolerance test at 24 to 28 weeks' gestation. The results showed that immediate treatment led to a slightly lower incidence of adverse neonatal outcomes, but no significant differences were observed for pregnancy-related hypertension or neonatal lean body mass.
NEW ENGLAND JOURNAL OF MEDICINE
(2023)
Article
Biochemistry & Molecular Biology
Holger Steinbrenner, Leonidas H. H. Duntas, Margaret P. P. Rayman
Summary: This review discusses the role of selenium in T2DM and its metabolic co-morbidities, emphasizing the relevance of inflammation and oxidative stress. It describes the epidemiology of selenium studies in diabetes and explains the interaction between selenium status and glucose control. According to current research, dietary selenium supplementation does not appear to be a major causal factor for the development of T2DM.
Article
Plant Sciences
Jia-Shang Li, Tao Ji, Shu-Lan Su, Yue Zhu, Xing-Ling Chen, Er-Xin Shang, Sheng Guo, Da-Wei Qian, Jin-Ao Duan
Summary: Alkaloids, flavonoids, and polysaccharides from mulberry leaves have been shown to significantly lower blood glucose and lipid levels by regulating glucose, amino acid, and lipid metabolism, while compounds like 1-DNJ and QG exhibit strong antidiabetic effects through various mechanisms in different cell types.
JOURNAL OF ETHNOPHARMACOLOGY
(2022)
Article
Food Science & Technology
Jiangxiong Zhu, Meirong Wu, Hui Zhou, Lizeng Cheng, Xinlin Wei, Yuanfeng Wang
Summary: This study found that Liubao tea extract has a positive impact on metabolic disorders and intestinal flora dysbiosis in hyperglycemic mice, which can improve insulin resistance and activate related signaling pathways.
FOOD RESEARCH INTERNATIONAL
(2021)
Article
Nutrition & Dietetics
Madlen Ungersboeck, Xiaowen Tang, Vanessa Neeff, Dominic Steele, Pascal Grimm, Matthew Fenech
Summary: Personalized nutritional recommendations based on individual-level understanding of post-prandial glycaemic responses (PPGRs) may have a role in the non-pharmaceutical management of type 2 diabetes.
Article
Nutrition & Dietetics
Alessandro Mengozzi, Edoardo Biancalana, Federico Parolini, Simona Baldi, Francesco Raggi, Anna Solini
Summary: The study found that there was no significant difference in the post-prandial metabolic response of male healthy individuals to normally processed and slowly processed pasta in a single meal, despite the common belief of different impacts on glucose metabolism. Further research is needed to confirm these results, including validation in chronic, real-life settings and among metabolically impaired individuals.
Article
Chemistry, Multidisciplinary
Debasis Maity, Preetam Guha Ray, Peter Buchmann, Maysam Mansouri, Martin Fussenegger
Summary: Currently available bioelectronic devices consume too much power and are powered wirelessly, leading to issues of reliability and mobility. A new implantable blood-glucose-powered metabolic fuel cell is designed, which continuously monitors blood-glucose levels, converts excess glucose into electrical power, and drives regulation of insulin release. This integration enables the fuel cell to restore blood-glucose homeostasis in an experimental model of type-1 diabetes.
ADVANCED MATERIALS
(2023)
Article
Biochemistry & Molecular Biology
Gurprit Bhardwaj, Mitul Vakani, Abhay Srivastava, Dhaval Patel, Anju Pappachan, Prashant Murumkar, Hemal Shah, Rushabh Shah, Sarita Gupta
Summary: Swertisin effectively lowers blood glucose levels by inhibiting SGLT2 and reducing its expression, leading to improved glucose homeostasis in diabetic mice.
ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS
(2021)
Review
Health Care Sciences & Services
Enza Mozzillo, Roberto Franceschi, Francesca Di Candia, Alessia Ricci, Letizia Leonardi, Martina Girardi, Francesco Maria Rosanio, Maria Loredana Marcovecchio
Summary: The systematic review aimed to investigate the optimal timing of insulin bolus in youths with type 1 diabetes. The findings suggest that pre-meal administration of insulin is associated with lower postprandial blood glucose levels and reduced HbA1c without increasing the risk of hypoglycemia. Furthermore, postprandial administration of fast-acting analogues is superior to rapid-acting analogues in controlling postprandial glycemia. These results have important implications for improving blood glucose control and quality of life in patients.
JOURNAL OF PERSONALIZED MEDICINE
(2022)
Article
Endocrinology & Metabolism
Danielle K. Longmore, Jessica E. Miller, Siroon Bekkering, Christoph Saner, Edin Mifsud, Yanshan Zhu, Richard Saffery, Alistair Nichol, Graham Colditz, Kirsty R. Short, David P. Burgner
Summary: In adults hospitalized with COVID-19, overweight, obesity, and diabetes were associated with increased odds of requiring respiratory support but were not associated with death. In patients with diabetes, the odds of severe COVID-19 were not increased above the BMI-associated risk.
Article
Endocrinology & Metabolism
Jakob Kau Starup-Linde, Rikke Viggers, Bente Langdahl, Soeren Gregersen, Simon Lykkeboe, Aase Handberg, Peter Vestergaard
Summary: Osteoglycin levels were similar in patients with type 1 and type 2 diabetes, and were not correlated with glucose, HbA1c, or any other biochemical marker of bone turnover. This suggests that there is no evidence supporting the existence of an osteoglycin-bone-pancreas axis.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Article
Geriatrics & Gerontology
Oleg Zaslavsky, Onchee Yu, Rod L. Walker, Paul K. Crane, Shelly L. Gray, Tatiana Sadak, Soo Borson, Eric B. Larson
Summary: The study found that incident dementia is associated with an increased rate of potentially preventable hospitalizations (PPHs) in individuals with diabetes, especially PPHs due to diabetes, urinary tract infections (UTIs), and dehydration. Additionally, HbA1c levels above 8% are associated with higher rates of overall PPHs and PPHs related to UTIs and dehydration.
JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES
(2021)
Article
Nutrition & Dietetics
David J. Mela, Xiu-Zhen Cao, Santhosh Govindaiah, Harry Hiemstra, Ramitha Kalathil, Li Lin, Joshi Manoj, Tingyan Mi, Carole Verhoeven
Summary: The study shows that a dose as low as 0.37g of mulberry fruit extract can effectively reduce post-prandial glucose and insulin responses to a carbohydrate-rich meal, without any apparent adverse effects.
BRITISH JOURNAL OF NUTRITION
(2023)
Article
Endocrinology & Metabolism
Shihchen Kuo, Wen Ye, Mary de Groot, Chandan Saha, Jay H. Shubrook, W. Guyton Hornsby, Yegan Pillay, Kieren J. Mather, William H. Herman
Summary: From the healthcare sector perspective, the EXER intervention saved $313 per patient and produced 0.38 more QALY, the CBT intervention cost $596 more and gained 0.29 more QALY, and the EXER+CBT intervention cost $403 more and gained 0.69 more QALY compared with UC. From the societal perspective, the EXER intervention saved $126, the CBT intervention cost $2,838 per QALY gained, and the EXER+CBT intervention cost $1,167 per QALY gained. Both EXER and EXER+CBT interventions were more cost-effective compared to the CBT intervention.
Review
Nutrition & Dietetics
Ewa Olechno, Anna Puscion-Jakubik, Malgorzata Elzbieta Zujko
Summary: Chokeberry has positive effects on various metabolic parameters such as dyslipidemia and hypertension, increasing antioxidant defense mechanisms and potentially reducing the risk of metabolic disorders.
Editorial Material
Neurosciences
Abigail R. Bland, John C. Ashton, Mohammad Amjad Kamal, Amirhossein Sahebkar
CNS & NEUROLOGICAL DISORDERS-DRUG TARGETS
(2023)
Review
Neurosciences
Asim Azhar, Mohammad Akram Wali, Qudsia Rashid, Wajihul Hasan Khan, Khaled Al-hosaini, Mohammad Owais, Mohammad Amjad Kamal
Summary: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the causative agent of COVID-19, has become a global concern since March 2020. Initially thought to be limited to the respiratory system, the virus has been found to affect other organs, including the nervous system. Reports indicate that SARS-CoV-2 can penetrate the central nervous system (CNS) and cause neurological symptoms. This comprehensive review examines the entry routes of SARS-CoV-2 into the CNS, the molecular mechanisms involved, clinical symptoms, and associated nervous system diseases.
CNS & NEUROLOGICAL DISORDERS-DRUG TARGETS
(2023)
Review
Neurosciences
Harsh Goel, Keshav Goyal, Avanish Kumar Pandey, Mercilena Benjamin, Fahad Khan, Pratibha Pandey, Sandeep Mittan, Danish Iqbal, Mohammed Alsaweed, Wael Alturaiki, Yahya Madkhali, Mohammad Amjad Kamal, Pranay Tanwar, Tarun Kumar Upadhyay
Summary: Due to environmental contamination, humans are exposed to physical and chemical mutagens, which cause a variety of neurological disorders through neuroinflammation, genetic instability, oxidative stress, and mitochondrial damage. This review summarizes the molecular mechanisms and effects of mutagens in the environment on neurological disorders.
CNS & NEUROLOGICAL DISORDERS-DRUG TARGETS
(2023)
Article
Biochemistry & Molecular Biology
Akhtar Atiya, Shivani Batra, Taj Mohammad, Nasser M. Alorfi, Waleed Al Abdulmonem, Fahad A. Alhumaydhi, Ghulam Md Ashraf, Saleh S. Baeesa, Abdelbaset Mohamed Elasbali, Moyad Shahwan
Summary: This study identified two potential CDK5 inhibitors through virtual screening from a herbal library. These compounds showed significant binding to CDK5's ATP-binding pocket. These findings are important for treating complex diseases such as neurodegeneration and tumors.
JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS
(2023)
Article
Biochemistry & Molecular Biology
Ghulam Md Ashraf, Mohd Rehan, Alhuseen O. Alsayed, Pallavi Somvanshi, Shafiul Haque
Summary: This study examines the possibility of cardiovascular medications inhibiting Galectin-3-related biological activities using bioinformatics techniques. Through clustering, molecular docking, and molecular dynamics simulation, potential chemical compounds were screened and repurposed. The results show that certain compounds have the ability to inhibit Galectin-3. Further experimental validation and animal model-based studies are needed.
JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS
(2023)
Review
Endocrinology & Metabolism
Nobendu Mukerjee, Swastika Maitra, Subhradeep Roy, Shaswata Modak, Mohammad Mehedi Hasan, Biswajit Chakraborty, Arabinda Ghosh, Asmita Ghosh, Mohammad Amjad Kamal, Abhijit Dey, Ghulam Md Ashraf, Sumira Malik, Md Habibur Rahman, Badrah S. Alghamdi, Adel Mohammad Abuzenadah, Athanasios Alexiou
Summary: Glioblastoma is an aggressive tumor that hinders normal brain function, and the inability of the skull to expand results in increased pressure in the brain. Recent studies have found that SNPs play a significant role in the development and spread of glioblastoma, with many GB-related SNPs being highly abundant in the promoter region, creating genetic vulnerability to glioma.
METABOLIC BRAIN DISEASE
(2023)
Article
Biochemistry & Molecular Biology
Akhtar Atiya, Habiba Shahidi, Taj Mohammad, Sharaf E. Sharaf, Waleed Al Abdulmonem, Ghulam Md Ashraf, Abdelbaset Mohamed Elasbali, Salem Hussain Alharethi, Fahad A. Alhumaydhi, Saleh Salem Baeesa, Mohd Rehan, Anas Shamsi, Moyad Shahwan
Summary: CDK9 is a protein involved in controlling the cell cycle and is often deregulated in stress conditions. It is being studied as a druggable target for cancer and other diseases. In this study, structure-based virtual screening was used to discover potential inhibitors of CDK9. Two natural compounds, Glabrene and Guggulsterone, were identified as high affinity and specific CDK9 inhibitors. Molecular dynamic simulations confirmed the stability of the complexes. These findings may contribute to the development of novel CDK9 inhibitors for the treatment of life-threatening diseases, including cancer.
JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS
(2023)
Article
Biochemistry & Molecular Biology
Akhtar Atiya, Abdulrhman Alsayari, Abdullatif Bin Muhsinah, Dalia Almaghaslah, Anwar L. Bilgrami, Waleed Al Abdulmonem, Nasser M. Alorfi, Debarati DasGupta, Ghulam Md Ashraf, Anas Shamsi, Moyad Shahwan
Summary: Cardiovascular diseases are a leading cause of premature adult death. This study evaluates the inhibitory potential of lisinopril on MARK4, a protein involved in regulating cardiomyocyte contractility. Molecular docking and molecular dynamics simulations demonstrate the stable binding and therapeutic role of lisinopril in managing cardiovascular diseases.
JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS
(2023)
Correction
Biochemistry & Molecular Biology
Ghulam Md. Ashraf, Debarati DasGupta, Mohammad Zubair Alam, Saleh S. Baeesa, Badrah S. Alghamdi, Firoz Anwar, Thamer M. A. Alqurashi, Sharaf E. Sharaf, Waleed Al Abdulmonem, Mohammed A. Alyousef, Fahad A. Alhumaydhi, Anas Shamsi
Article
Behavioral Sciences
Rajeev K. Singla, Shikha Joon, Baivab Sinha, Mohammad Amjad Kamal, Jesus Simal-Gandara, Jianbo Xiao, Bairong Shen
Summary: The number of studies on natural product-based management of dementia has been increasing steadily, with a significant rise in 2020 and 2021. This article analyzed current trends from 2016 to 2021 to assess the potential growth of natural products in dementia treatment. Common targets and pathways included oxidative stress, NF-kappa B pathway, tau aggregation, AChE inhibition, and A-beta aggregation. The analysis of 33 natural compounds identified 125 sustainable resources distributed among various families, orders, and classes. Certain families and orders, such as Berberidaceae, Zingiberaceae, and Lamiales, were identified as important for further research. Natural products like quercetin, curcumin, icariside II, berberine, and resveratrol were found to have diverse applications. The importance of dietary supplements and natural products is supported by clinical studies and patents, which are also discussed. The article concludes with a discussion on the broad scope, future challenges, and opportunities for field researchers.
NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS
(2023)
Editorial Material
Behavioral Sciences
Rupesh K. Gautam, Aziz Unnisa, Nigel H. Greig, Mohammad Amjad Kamal
NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS
(2023)
Article
Infectious Diseases
Amr Selim Abu Lila, Tareq Nafea Alharby, Jowaher Alanazi, Muteb Alanazi, Marwa H. Abdallah, Syed Mohd Danish Rizvi, Afrasim Moin, El-Sayed Khafagy, Shams Tabrez, Abdullah Ali Al Balushi, Wael A. H. Hegazy
Summary: This study investigates the prevalence and genetic basis of antibiotic resistance to macrolides, lincosamides, and streptogramins (MLS) in Enterococci and the correlation between MLS resistance and biocide resistance. The results show high resistance rates to MLS antibiotics, with constitutive resistance being the most prevalent phenotype. The erythromycin ribosome methylase (erm) genes, particularly ermB, were the most detected MLS resistance-encoding genes. The study also reveals a significant correlation between MLS resistance and reduced susceptibility to biocides, with efflux genes playing a crucial role in developing cross-resistance to both MLS antibiotics and biocides.
Article
Multidisciplinary Sciences
Read F. Alserihi, Mohammed Razeeth Shait Mohammed, Mohammed Kaleem, Mohammad Imran Khan, Mario Sechi, Torki A. Zughaibi, Shams Tabrez
Summary: This study aimed to evaluate the anticancer potential of epigallocatechin gallate (EGCG) and EGCG-loaded nanoparticles (EGCG NP) in 3D spheroids of prostate cancer cell lines. The results showed that EGCG and EGCG NP significantly reduced the size of spheroids and increased the level of ROS in PCa cells to some extent. In addition, EGCG induced apoptosis in PCa cells, while EGCG NP did not significantly affect the number of apoptotic and live cells.
JOURNAL OF KING SAUD UNIVERSITY SCIENCE
(2023)
Review
Chemistry, Medicinal
Nazia Nazam, Nasimudeen R. Jabir, Iftikhar Ahmad, Saif A. Alharthy, Mohd Shahnawaz Khan, Rashid Ayub, Shams Tabrez
Summary: Cancer is a global health problem that is on the rise, and ovarian cancer is one of the leading causes of mortality worldwide. Current treatments for ovarian cancer have limited effectiveness and come with side effects, recurrence risk, and drug resistance. Therefore, there is a need for alternative, cost-effective, and safer therapeutic strategies.
Article
Gastroenterology & Hepatology
Saad Saleem, Faisal Inayat, Aleena A. Khan, Junaid Rasul Awan, Muhammad Hassan Naeem Goraya, Ali Hussain, Wissam Bleibel, Azhar Hussain, Shams S. M. Tabrez
Summary: This study found that the estimated prevalence of autoimmune hepatitis (AIH) in HIV-infected patients in the United States is 52.8/100,000. AIH primarily affects females, African Americans, and Hispanics, and shows a higher correlation with rheumatoid arthritis and ulcerative colitis.
GASTROENTEROLOGY REVIEW-PRZEGLAD GASTROENTEROLOGICZNY
(2023)