Article
Nutrition & Dietetics
Alfonso M. Duran, W. Lawrence Beeson, Anthony Firek, Zaida Cordero-MacIntyre, Marino De Leon
Summary: This study aims to identify the cellular pathways stimulated by dietary omega-3 polyunsaturated fatty acid (PUFA) supplementation in patients with type 2 diabetes mellitus (T2DM) affected by painful diabetic neuropathy (pDN). The results show that supplementation leads to a shift towards an anti-inflammatory state and improved membrane fluidity, which may be responsible for the reduction in adverse symptoms associated with neuroinflammatory diseases and painful neuropathy.
Review
Nutrition & Dietetics
Ivana Djuricic, Philip C. Calder
Summary: Oxidative stress and inflammation are important contributors to chronic non-communicable diseases. Different types of fatty acids have varying effects on chronic diseases, with moderate intake of Ω-6 fatty acids lowering the risk of cardiovascular diseases and Ω-3 fatty acids helping to reduce inflammation levels.
Article
Biochemistry & Molecular Biology
Sergio Davinelli, Alessandro Medoro, Mariano Intrieri, Luciano Saso, Giovanni Scapagnini, Jing X. Kang
Summary: The transcription factor NRF2 and its endogenous inhibitor KEAP1 are important for maintaining cellular redox homeostasis. Activation of NRF2 can provide cellular protection against age-related diseases. Recent studies have identified compounds, including omega-3 polyunsaturated fatty acids (PUFAs) and their electrophilic derivatives, that may restore NRF2 function in aging cells. These findings suggest that n-3 PUFAs could be potential agents for preventing chronic diseases and restoring age-related NRF2 impairment.
FREE RADICAL BIOLOGY AND MEDICINE
(2022)
Article
Obstetrics & Gynecology
J. Stanhiser, A. M. Z. Jukic, D. R. McConnaughey, A. Z. Steiner
Summary: The study found that self-reported use of omega-3 fatty acid supplements was associated with an increased probability of conceiving.
HUMAN REPRODUCTION
(2022)
Article
Endocrinology & Metabolism
Alexis Ceecee Britten-Jones, Jordan T. Kamel, Leslie J. Roberts, Sabine Braat, Jennifer P. Craig, Richard J. MacIsaac, Laura E. Downie
Summary: In this study, it was found that long-chain omega-3 fatty acid supplements have neuroregenerative effects on peripheral nerves in type 1 diabetes patients, indicating a potential role in modulating nerve health.
Article
Geriatrics & Gerontology
Roxana Coras, Brian Pedersen, Rekha Narasimhan, Anahy Brandy, Lourdes Mateo, Agueda Prior-Espanol, Arthur Kavanaugh, Aaron M. Armando, Mohit Jain, Oswald Quehenberger, Melania Martinez-Morillo, Monica Guma
Summary: The study revealed that arthritis symptoms in older adults were related to disturbances in serum oxylipins, suggesting that certain oxylipins may be key effectors in arthritis in this population.
JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES
(2021)
Review
Medicine, General & Internal
Halliru Zailani, Senthil Kumaran Satyanarayanan, Wei-Chih Liao, Hsien-Feng Liao, Shih-Yi Huang, Piotr Galecki, Kuan-Pin Su, Jane Pei-Chen Chang
Summary: Chronic obstructive pulmonary disease (COPD) is a leading cause of death globally, particularly in individuals over 40 years old. Mood disorders are frequently comorbid with COPD, but often overlooked or undiagnosed, leading to poor treatment outcomes and increased mortality. The exact link between COPD and mood disorders is still uncertain, but it is believed that inflammation in the lungs, blood, and brain may contribute to the development of mood disorders in COPD. Antidepressants are commonly used to manage mood disorders in COPD, but their efficacy is limited due to tolerability issues. Omega-3 polyunsaturated fatty acids (n-3 PUFAs), which regulate inflammatory responses, may offer promising alternatives for managing mood disorders in COPD.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Nutrition & Dietetics
Kathleen A. Lee-Sarwar, Kasper Fischer-Rasmussen, Klaus Bonnelykke, Hans Bisgaard, Bo Chawes, Rachel S. Kelly, Jessica Lasky-Su, Robert S. Zeiger, George T. O'Connor, Leonard B. Bacharier, Vincent J. Carey, Nancy Laranjo, Augusto A. Litonjua, Scott T. Weiss
Summary: The association between omega-3 fatty acids (n-3) and allergic diseases varies due to genetic variation. This study aimed to identify and validate genetic variants that modify the relationship between n-3 and childhood asthma or atopy. Results showed that certain SNPs in the DPP10 region interacted with n-3 levels in plasma or diet and were associated with atopy in early childhood and at age 6.
Review
Biochemistry & Molecular Biology
Roberta Cardim Lessa, Fabio de Abreu Alves, Erika Fortunati, Jun Lu
Summary: Oral mucositis (OM) is a painful condition caused by cancer treatments, impacting patients' quality of life and recovery. Current management strategies are insufficient, necessitating a search for new approaches. Utilizing ω-3 fatty acids to manage OM may be an effective strategy based on preliminary evidence.
Article
Agricultural Engineering
Anil Kumar Patel, Ajeet Singh Chauhan, Prashant Kumar, Philippe Michaud, Vijai Kumar Gupta, Jo-Shu Chang, Chiu-Wen Chen, Cheng-Di Dong, Reeta Rani Singhania
Summary: This article provides an update on the production of essential fatty acids from potential microbes and explores novel strategies to promote the accumulation of omega-3 and omega-6 through engineering and omics approaches.
BIORESOURCE TECHNOLOGY
(2022)
Article
Nutrition & Dietetics
Xuefei Li, Zhengjie Lu, Yongjian Qi, Biao Chen, Bin Li
Summary: This study used the Mendelian randomization approach to explore the potential causal relationships between polyunsaturated fatty acids (PUFAs) and osteoarthritis (OA), and found that higher levels of omega-6 fatty acids may reduce the risk of knee OA and hip OA. These results highlight the importance of maintaining optimal levels of PUFAs, especially omega-6 fatty acids, in individuals with a genetic predisposition to OA.
Article
Nutrition & Dietetics
Estefania Aparicio, Carla Martin-Grau, Cristina Bedmar, Nuria Serrat Orus, Josep Basora, Victoria Arija
Summary: This study found that factors such as high education levels, older age, consumption of fish and seafood, and non-smoking are significantly associated with serum fatty acid concentrations in pregnant women, leading to a better omega-3 fatty acid profile. Further research is needed to explore the health consequences of these findings.
Article
Biochemistry & Molecular Biology
Mosaab Salah El-din El-Agawy, Alaa Mohamed Mohamed Badawy, Mohammed R. Rabei, Mohamed Mahmoud Abdelraheem Elshaer, Eman Mohamad El Nashar, Mansour A. Alghamdi, Mohammed A. Alshehri, Hassan Reda Hassan Elsayed
Summary: LC-PUFA plays a beneficial role in preventing the adverse effects of MTX on the kidneys through its anti-apoptotic, antioxidant, and anti-inflammatory effects, as well as its role in restoring the expression of AQPs 1 and 2.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Gastroenterology & Hepatology
Julian Schwaerzler, Lisa Mayr, Arnau Vich Vila, Felix Grabherr, Lukas Niederreiter, Maureen Philipp, Christoph Grander, Moritz Meyer, Almina Jukic, Simone Troeger, Barbara Enrich, Nicole Przysiecki, Markus Tschurtschenthaler, Felix Sommer, Irmgard Kronberger, Jakob Koch, Richard Hilbe, Michael W. Hess, Georg Oberhuber, Susanne Sprung, Qitao Ran, Robert Koch, Maria Effenberger, Nicole C. Kaneider, Verena Wieser, Markus A. Keller, Rinse K. Weersma, Konrad Aden, Philip Rosenstiel, Richard S. Blumberg, Arthur Kaser, Herbert Tilg, Timon E. Adolph
Summary: This study provides evidence that excessive intake of polyunsaturated fatty acids (PUFAs) in a Western diet can induce gut inflammation and worsen the course of Crohn's disease (CD). The findings suggest a potential role for targeted nutritional therapy.
Review
Food Science & Technology
Yi Wang, Ke Liu, Tingting Long, Jieyi Long, Ying Li, Jiaoyuan Li, Liming Cheng
Summary: Through a meta-analysis of observational studies, we found that dietary fish and marine omega-3 PUFA consumption are associated with improved cancer prognosis and reduced mortality in patients.
CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION
(2023)
Article
Endocrinology & Metabolism
Yuka Shibata, Tatsuhito Himeno, Taeko Kamiya, Hiroya Tani, Takayuki Nakayama, Chika Kojima, Yukako Sugiura-Roth, Ena Naito, Masaki Kondo, Shin Tsunekawa, Yoshiro Kato, Jiro Nakamura, Hideki Kamiya
JOURNAL OF DIABETES INVESTIGATION
(2019)
Article
Endocrinology & Metabolism
Emiri Miura-Yura, Shin Tsunekawa, Keiko Naruse, Nobuhisa Nakamura, Mikio Motegi, Hiromi Nakai-Shimoda, Saeko Asano, Makoto Kato, Yuichiro Yamada, Takako Izumoto-Akita, Akihito Yamamoto, Tatsuhito Himeno, Masaki Kondo, Yoshiro Kato, Jiro Nakamura, Hideki Kamiya
JOURNAL OF DIABETES INVESTIGATION
(2020)
Review
Endocrinology & Metabolism
Tatsuhito Himeno, Hideki Kamiya, Jiro Nakamura
JOURNAL OF DIABETES INVESTIGATION
(2020)
Article
Endocrinology & Metabolism
Tatsuhito Himeno, Hideki Kamiya, Jiro Nakamura
JOURNAL OF DIABETES INVESTIGATION
(2020)
Article
Biochemistry & Molecular Biology
Mikio Motegi, Tatsuhito Himeno, Hiromi Nakai-Shimoda, Rieko Inoue, Norio Ozeki, Yusuke Hayashi, Sachiko Sasajima, Mohammad Sarif Mohiuddin, Emi Asano-Hayami, Makoto Kato, Saeko Asano, Emiri Miura-Yura, Yoshiaki Morishita, Masaki Kondo, Shin Tsunekawa, Yoshiro Kato, Koichi Kato, Keiko Naruse, Yusuke Seino, Yoshitaka Hayashi, Jiro Nakamura, Hideki Kamiya
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2020)
Article
Endocrinology & Metabolism
Hideki Kamiya, Yuka Shibata, Tatsuhito Himeno, Hiroya Tani, Takayuki Nakayama, Kenta Murotani, Nobuhiro Hirai, Miyuka Kawai, Yuriko Asada-Yamada, Emi Asano-Hayami, Hiromi Nakai-Shimoda, Yuichiro Yamada, Takahiro Ishikawa, Yoshiaki Morishita, Masaki Kondo, Shin Tsunekawa, Yoshiro Kato, Masayuki Baba, Jiro Nakamura
Summary: The study validated a new diagnostic method for diabetic polyneuropathy using a point-of-care nerve conduction device. By analyzing data from 375 participants with type 2 diabetes, it was found that the handheld device successfully predicted the severity of DPN.
JOURNAL OF DIABETES INVESTIGATION
(2021)
Review
Chemistry, Medicinal
Akiyoshi Takami, Yasuaki Tatsumi, Katsuhisa Sakai, Yasumichi Toki, Katsuya Ikuta, Yuka Oohigashi, Junko Takagi, Koichi Kato, Kazuhisa Takami
Article
Endocrinology & Metabolism
Yuichiro Yamada, Tatsuhito Himeno, Kotaro Tsuboi, Yuka Shibata, Miyuka Kawai, Yuriko Asada-Yamada, Yusuke Hayashi, Emi Asano-Hayami, Tomohide Hayami, Yuichiro Ishida, Yohei Ejima, Mikio Motegi, Saeko Asano, Makoto Kato, Eriko Nagao, Hiromi Nakai-Shimoda, Takahiro Ishikawa, Yoshiaki Morishita, Masaki Kondo, Shin Tsunekawa, Yoshiro Kato, Takayuki Nakayama, Motohiro Kamei, Jiro Nakamura, Hideki Kamiya
Summary: The study evaluated the correlation between the severity of diabetic polyneuropathy and changes in the thickness of neuroretinal layers. Results showed that as DPN progressed, the ganglion cell complex and retinal pigment epithelium became thinner, while the inner nuclear layer/outer plexiform layer thickened.
JOURNAL OF DIABETES INVESTIGATION
(2021)
Article
Endocrinology & Metabolism
Miyuka Kawai, Tatsuhito Himeno, Yuka Shibata, Nobuhiro Hirai, Yuriko Asada-Yamada, Emi Asano-Hayami, Yohei Ejima, Rina Kasagi, Eriko Nagao, Yukako Sugiura-Roth, Hiromi Nakai-Shimoda, Takayuki Nakayama, Yuichiro Yamada, Takahiro Ishikawa, Yoshiaki Morishita, Masaki Kondo, Shin Tsunekawa, Yoshiro Kato, Jiro Nakamura, Hideki Kamiya
Summary: Diabetic polyneuropathy (DPN) develops in the early stage of diabetes, and a study found that electroretinogram parameters obtained by a hand-held device can successfully predict the severity of DPN. This suggests the potential use of the device in evaluating DPN.
JOURNAL OF DIABETES INVESTIGATION
(2021)
Article
Biochemistry & Molecular Biology
Mohammad Sarif Mohiuddin, Tatsuhito Himeno, Yuichiro Yamada, Yoshiaki Morishita, Masaki Kondo, Shin Tsunekawa, Yoshiro Kato, Jiro Nakamura, Hideki Kamiya
Summary: This study hypothesized that glucagon might have a neuroprotective function in the peripheral nervous system (PNS) and experimentally validated this hypothesis. Glucagon was found to have neuroprotective effects on cells mimicking diabetic polyneuropathy (DPN), increasing cell survival and reducing apoptosis, as well as accelerating neurite outgrowth.
Article
Multidisciplinary Sciences
Hiromi Nakai-Shimoda, Tatsuhito Himeno, Tetsuji Okawa, Emiri Miura-Yura, Sachiko Sasajima, Makoto Kato, Yuichiro Yamada, Yoshiaki Morishita, Shin Tsunekawa, Yoshiro Kato, Yusuke Seino, Rieko Inoue, Masaki Kondo, Susumu Seino, Keiko Naruse, Koichi Kato, Hiroki Mizukami, Jiro Nakamura, Hideki Kamiya
Summary: Glucose-responsive ATP-sensitive potassium channels (K-ATP) play important roles in the peripheral nervous system, affecting neurite outgrowth and nerve conduction velocity.
Article
Biochemistry & Molecular Biology
Yasuaki Tatsumi, Ayako Kato, Naoko Niimi, Hideji Yako, Tatsuhito Himeno, Masaki Kondo, Shin Tsunekawa, Yoshiro Kato, Hideki Kamiya, Jiro Nakamura, Koji Higai, Kazunori Sango, Koichi Kato
Summary: This study reveals the potential application value of docosahexaenoic acid (DHA) in diabetic neuropathy. The experimental results suggest that DHA can inhibit oxidative stress-induced cell death, attenuate excessive autophagy, and has the potential to protect Schwann cells from oxidative stress.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Editorial Material
Endocrinology & Metabolism
Tatsuhito Himeno, Hideki Kamiya, Jiro Nakamura
Summary: Diabetic neuropathy, the most frequent complication of diabetes, lacks accessible objective assessments. Rethinking the concept and definition of diabetic neuropathy is essential for successful development of diagnostic and therapeutic methods.
JOURNAL OF DIABETES INVESTIGATION
(2022)
Article
Endocrinology & Metabolism
Emi Asano-Hayami, Yoshiaki Morishita, Tomohide Hayami, Yuka Shibata, Toshiki Kiyose, Sachiko Sasajima, Yusuke Hayashi, Mikio Motegi, Makoto Kato, Saeko Asano, Hiromi Nakai-Shimoda, Yuichiro Yamada, Emiri Miura-Yura, Tatsuhito Himeno, Masaki Kondo, Shin Tsunekawa, Yoshiro Kato, Jiro Nakamura, Hideki Kamiya
Summary: This study aimed to examine the relationship between clinical parameters and psoas muscle mass index (PMI) and found that thyroid-stimulating hormone (TSH) concentrations and the free triiodothyronine/free thyroxine (FT3/FT4) ratio are correlated with PMI, and their thresholds may help prevent muscle mass loss in individuals with type 2 diabetes mellitus (T2DM).
DIABETOLOGY INTERNATIONAL
(2023)
Article
Cell Biology
Makoto Kato, Shin Tsunekawa, Nobuhisa Nakamura, Emiri Miura-Yura, Yuichiro Yamada, Yusuke Hayashi, Hiromi Nakai-Shimoda, Saeko Asano, Tomohide Hayami, Mikio Motegi, Emi Asano-Hayami, Sachiko Sasajima, Yoshiaki Morishita, Tatsuhito Himeno, Masaki Kondo, Yoshiro Kato, Takako Izumoto-Akita, Akihito Yamamoto, Keiko Naruse, Jiro Nakamura, Hideki Kamiya