Article
Pharmacology & Pharmacy
Jung-Eun Kim, Hengmin Han, Yinzhu Xu, Min-Ho Lee, Hyo-Jeong Lee
Summary: This study evaluated the efficacy of FRO, a formula composed of fermented Rhus verniciflua Stokes and Orostachys japonicus, against acne pathogenesis. The results showed that FRO exhibited antimicrobial and anti-inflammatory effects, inhibiting the growth of Cutibacterium acnes (CA) and reducing inflammation and excess sebum production. Therefore, FRO could be used for functional cosmetics or acne treatments.
Article
Dermatology
Manisha Loss, Katherine G. Thompson, Alessandra Agostinho-Hunt, Garth A. James, Emmanuel F. Mongodin, Ian Rosenthal, Nancy Cheng, Sherry Leung, Anna L. Chien, Sewon Kang
Summary: Biofilm frequency was highest in comedones among acne lesions, with a significant increase in Staphylococcus abundance. The microenvironment of comedones differs from other lesions and unaffected skin, potentially contributing to the lack of host inflammatory response to these lesions.
INTERNATIONAL JOURNAL OF DERMATOLOGY
(2021)
Article
Cell Biology
Guang Zuo, Yidan Gao, Guangtong Lu, Ming Bu, Jun Liu, Juncha Zhang, Xisheng Fan, Hao Chen, Xuesong Wang, Yanfen She
Summary: In this study, the anti-inflammatory effects of auriculotherapy in the treatment of acne vulgaris were explored. The results showed that auricular bloodletting therapy, auricular point sticking, and a combination of both therapies could improve the inflammatory symptoms of acne and reduce inflammatory cytokines.
MEDIATORS OF INFLAMMATION
(2023)
Article
Dermatology
Celine Mias, Nathalie Chansard, Martine Maitre, Marie Florence Galliano, Lucile Garidou, Valerie Mengeaud, Sandrine Bessou-Touya, Helene Duplan
Summary: This study evaluated the pharmacological properties of the plant extracts Myrtus communis and Celastrol enriched plant cell culture (CEE) extracts on the C. acnes/Th17 pathway. The results showed that Myrtacine (R) and CEE can inhibit the virulence of C. acnes IA1 strain and alleviate the inflammatory response, especially the Th17 pathway. These findings suggest that these plant extracts may have beneficial effects in the treatment of acne.
JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY
(2023)
Article
Dermatology
Andrea M. Schneider, Zachary T. Nolan, Kalins Banerjee, Allison R. Paine, Zhaoyuan Cong, Samantha L. Gettle, Amy L. Longenecker, Xiang Zhan, George W. Agak, Amanda M. Nelson
Summary: The composition of the skin microbiome varies during puberty, with a distinct 'acne microbiome' emerging in those with acne. This study found a significant shift in microbial diversity between early and late stages of puberty, coinciding with increased sebum production on the face. The abundance of Cutibacterium acnes, a specific strain associated with acne, increased during puberty, and different strains of C. acnes were affected differently by pubertal stage and the presence of acne. A unique acne microbiome signature was identified in late puberty, characterized by specific C. acnes strain composition and metabolic activity.
JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY
(2023)
Article
Multidisciplinary Sciences
Amit Rimon, Chani Rakov, Vanda Lerer, Sivan Sheffer-Levi, Sivan Alkalay Oren, Tehila Shlomov, Lihi Shasha, Ruth Lubin, Khaled Zubeidat, Nora Jaber, Musa Mujahed, Asaf Wilensky, Shunit Coppenhagen-Glazer, Vered Molho-Pessach, Ronen Hazan
Summary: Acne vulgaris is a common inflammatory skin disorder caused by Cutibacterium acnes (C. acnes), which can be effectively treated with phage therapy. In this study, eight novel phages isolated in the laboratory and commonly used antibiotics were able to completely eradicate clinically isolated C. acnes strains. Topical phage therapy also demonstrated superior efficacy in a mouse model of C. acnes-induced acne-like lesions, reducing inflammation and improving clinical and histological scores.
NATURE COMMUNICATIONS
(2023)
Article
Multidisciplinary Sciences
Ilaria Cavallo, Francesca Sivori, Mauro Truglio, Flavio De Maio, Federica Lucantoni, Giorgia Cardinali, Martina Pontone, Thierry Bernardi, Maurizio Sanguinetti, Bruno Capitanio, Antonio Cristaudo, Fiorentina Ascenzioni, Aldo Morrone, Fulvia Pimpinelli, Enea Gino Di Domenico
Summary: This study explores the microbiome at different skin sites in adolescent acne and the role of biofilm production in promoting the growth and persistence of Cutibacterium acnes isolates. The findings show that there is lower microbiota diversity in inflammatory lesions compared to non-inflammatory lesions and healthy subjects, and there is an overabundance of C. acnes in inflammatory lesions. Additionally, specific Cutibacterium acnes phylotypes were found to be more represented in the skin of acne patients and were associated with early adhesion, biomass production, and increased antibiotic tolerance.
SCIENTIFIC REPORTS
(2022)
Article
Biotechnology & Applied Microbiology
Mengyuan Shan, Fanqiang Meng, Chao Tang, Libang Zhou, Zhaoxin Lu, Yingjian Lu
Summary: Accumulating evidence suggests that suppressing Propionibacterium acnes-induced inflammation is a promising strategy to alleviate acne vulgaris. This study evaluated the alleviating effect of surfactin-oleogel on P. acnes-induced inflammatory acne vulgaris in mice. The results demonstrated that surfactin-oleogel has antibacterial and anti-inflammation activities, making it a potential treatment for P. acnes-induced inflammatory acne vulgaris.
APPLIED MICROBIOLOGY AND BIOTECHNOLOGY
(2022)
Review
Dermatology
Rochelle Cheryl Monteiro, Merwyn Fernandes
Summary: Antibiotics have been widely used for acne treatment, but their indiscriminate usage has led to the problem of antimicrobial resistance. Cutibacterium acnes can develop resistance through mutation or genetic acquisition, and can transfer this resistance to other bacteria, complicating the management of skin and soft tissue infections. Recent studies have highlighted the role of C. acnes in maintaining the skin microbiome, and the role of Malassezia in causing acne has also drawn interest. The effectiveness of antibiotics in acne treatment is mainly attributed to their anti-inflammatory action rather than antimicrobial action, thus advocating for the use of low-dose antibiotics and alternative therapies.
INTERNATIONAL JOURNAL OF DERMATOLOGY
(2023)
Review
Dermatology
Andrea Bernales Salinas
Summary: Acne vulgaris is a widespread condition with a complex pathophysiology based on four classic principles of the pilosebaceous unit. The immune system plays a key role in the disease process, stimulated by other participants such as P. acnes, AMPs, SGs, MMPs, and other immune pathways.
INTERNATIONAL JOURNAL OF DERMATOLOGY
(2021)
Review
Dermatology
Celine Mias, Valerie Mengeaud, Sandrine Bessou-Touya, Helene Duplan
Summary: Acne vulgaris is a common skin disease characterized by inflammation in pilosebaceous units. Recent studies have shown that Cutibacterium acnes plays a crucial role in the pathogenesis of acne, especially through the formation of biofilms, loss of genetic diversity, and activation of the Th17 pathway. This understanding has opened up new possibilities for developing novel treatments and diagnostic biomarkers.
JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY
(2023)
Article
Pharmacology & Pharmacy
Aftab Alam, Gulam Mustafa, Gopal Prasad Agrawal, Sana Hashmi, Riyaz Ahmed Khan, Faris F. Aba Alkhayl, Zabih Ullah, Md Sajid Ali, Ahmed F. Elkirdasy, Shamshir Khan
Summary: A new microemulsion-based topical treatment containing hydrogen-loaded isotretinoin and erythromycin estolate has been developed for acne management, showing promising drug permeation and skin retention effects in experiments.
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
(2022)
Review
Multidisciplinary Sciences
Juan Farfan, John M. Gonzalez, Martha Vives
Summary: Acne, the most common skin disorder in the world, has an inflammatory pathogenesis, making control of inflammation a target for treatment. Traditional chemical or physical treatments have side effects and antibiotics have developed resistance. Phage therapy, a new immunomodulatory therapy, has been proposed to treat antibiotic-resistant acne.
Review
Multidisciplinary Sciences
Juan Farfan, John M. Gonzalez, Martha Vives
Summary: Acne is a common global skin disorder with a key inflammatory component, and phage therapy may be an alternative treatment for acne, helping to reduce inflammatory reactions caused by C. acnes.
Article
Dermatology
Celine Mias, Marie Dominique Thouvenin, Eleonore Gravier, Sandrine Dalmon, Karine Bouyer, Sandrine Alvarez, Valerie Mengeaud, Virginie Ribet, Sandrine Bessou-Touya, Helene Duplan
Summary: This study aimed to evaluate the efficacy of a new dermocosmetic product on Cutibacterium acnes phylotype abundance and clinical parameters in subjects with mild to moderate acne vulgaris. The results showed that the dermocosmetic cream could reduce inflammatory and comedonal acne lesions and improve the severity of acne according to the GEA score.
JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY
(2023)