Prediction of novel drug indications using network driven biological data prioritization and integration

Integrating gene expression and protein-protein interaction network to prioritize cancer-associated genes

(2012) Chao Wu et al.   BMC BIOINFORMATICS

Berberine, a genotoxic alkaloid, induces ATM-Chk1 mediated G2 arrest in prostate cancer cells

(2012) Yu Wang et al.   MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS

Low-dose paclitaxel enhances the anti-tumor efficacy of GM-CSF surface-modified whole-tumor-cell vaccine in mouse model of prostate cancer

(2011) Qiushan He et al.   CANCER IMMUNOLOGY IMMUNOTHERAPY

Paclitaxel Induces Apoptosis Through Activation of Nuclear Protein Kinase C-δ and Subsequent Activation of Golgi Associated Cdk1 in Human Hormone Refractory Prostate Cancer

(2011) Pin-Hsuan Lu et al.   JOURNAL OF UROLOGY

Berberine Suppresses Androgen Receptor Signaling in Prostate Cancer

(2011) J. Li et al.   MOLECULAR CANCER THERAPEUTICS

PREDICT: a method for inferring novel drug indications with application to personalized medicine

(2011) A. Gottlieb et al.   Molecular Systems Biology

PINTA: a web server for network-based gene prioritization from expression data

(2011) D. Nitsch et al.   NUCLEIC ACIDS RESEARCH

Discovery and Preclinical Validation of Drug Indications Using Compendia of Public Gene Expression Data

(2011) M. Sirota et al.   Science Translational Medicine

Regulatory impact factors: unraveling the transcriptional regulation of complex traits from expression data

(2010) Antonio Reverter et al.   BIOINFORMATICS

DrugBank 3.0: a comprehensive resource for 'Omics' research on drugs

(2010) C. Knox et al.   NUCLEIC ACIDS RESEARCH

The STRING database in 2011: functional interaction networks of proteins, globally integrated and scored

(2010) D. Szklarczyk et al.   NUCLEIC ACIDS RESEARCH

Discovery of drug mode of action and drug repositioning from transcriptional responses

(2010) F. Iorio et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Unveiling the role of network and systems biology in drug discovery

(2010) Albert Pujol et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

A human functional protein interaction network and its application to cancer data analysis

(2010) Guanming Wu et al.   GENOME BIOLOGY

Disease candidate gene identification and prioritization using protein interaction networks

(2009) Jing Chen et al.   BMC BIOINFORMATICS

Azacitidine improves antitumor effects of docetaxel and cisplatin in aggressive prostate cancer models

(2009) Claudio Festuccia et al.   ENDOCRINE-RELATED CANCER

Dynamic modularity in protein interaction networks predicts breast cancer outcome

(2009) Ian W Taylor et al.   NATURE BIOTECHNOLOGY

Human Disease-Drug Network Based on Genomic Expression Profiles

(2009) Guanghui Hu et al.   PLoS One

Building Disease-Specific Drug-Protein Connectivity Maps from Molecular Interaction Networks and PubMed Abstracts

(2009) Jiao Li et al.   PLoS Computational Biology

Identifying gene-disease associations using centrality on a literature mined gene-interaction network

(2008) A. Ozgur et al.   BIOINFORMATICS

ERCC5Is a Novel Biomarker of Ovarian Cancer Prognosis

(2008) Christine S. Walsh et al.   JOURNAL OF CLINICAL ONCOLOGY

Pathways to cancer therapy

(2008) Dan Jones   NATURE REVIEWS DRUG DISCOVERY

PolySearch: a web-based text mining system for extracting relationships between human diseases, genes, mutations, drugs and metabolites

(2008) D. Cheng et al.   NUCLEIC ACIDS RESEARCH

Comparative analysis of gene expression profiles between the normal human cartilage and the one with endemic osteoarthritis

(2008) W.Z. Wang et al.   OSTEOARTHRITIS AND CARTILAGE

Chronic azacitidine treatment results in differentiating effects, sensitizes against bicalutamide in androgen-independent prostate cancer cells

(2008) Giovanni Luca Gravina et al.   PROSTATE