Regulation of pancreatic β-cell survival by nitric oxide

Hormesis, cell death and aging

(2016) Isabelle Martins et al.   Aging-US

S-nitrosylation in the regulation of gene transcription

(2011) Yonggang Sha et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

Mitochondrial calcium handling during ischemia-induced cell death in neurons

(2011) Yves Gouriou et al.   BIOCHIMIE

Nitric oxide: role in tumour biology and iNOS/NO-based anticancer therapies

(2011) Simendra Singh et al.   CANCER CHEMOTHERAPY AND PHARMACOLOGY

Guanylyl cyclase structure, function and regulation

(2011) Lincoln R. Potter   CELLULAR SIGNALLING

Differential effects of proinflammatory cytokines on cell death and ER stress in insulin-secreting INS1E cells and the involvement of nitric oxide

(2011) Stella Kacheva et al.   CYTOKINE

Peripheral and Islet Interleukin-17 Pathway Activation Characterizes Human Autoimmune Diabetes and Promotes Cytokine-Mediated  -Cell Death

(2011) S. Arif et al.   DIABETES

Interleukin-6 treatment induces beta-cell apoptosis via STAT-3-mediated nitric oxide production

(2011) Yoon Sin Oh et al.   DIABETES-METABOLISM RESEARCH AND REVIEWS

Differential regulation of adaptive and apoptotic unfolded protein response signalling by cytokine-induced nitric oxide production in mouse pancreatic beta cells

(2011) J. Y. Chan et al.   DIABETOLOGIA

Inducible Nitric-oxide Synthase and Nitric Oxide Donor Decrease Insulin Receptor Substrate-2 Protein Expression by Promoting Proteasome-dependent Degradation in Pancreatic β-Cells

(2011) Toshihiro Tanioka et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Glucagon-like Peptide 1 Stimulates Post-translational Activation of Glucokinase in Pancreatic β Cells

(2011) Shi-Ying Ding et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Cytokines Tumor Necrosis Factor-α and Interferon-γ Induce Pancreatic β-Cell Apoptosis through STAT1-mediated Bim Protein Activation

(2011) Jenny Barthson et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

FoxO1 and SIRT1 Regulate β-Cell Responses to Nitric Oxide

(2011) Katherine J. Hughes et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Stimulus-inducedS-Nitrosylation of Syntaxin 4 Impacts Insulin Granule Exocytosis

(2011) Dean A. Wiseman et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Nitric oxide and redox mechanisms in the immune response

(2011) David A. Wink et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Cytokine toxicity in insulin-producing cells is mediated by nitro-oxidative stress-induced hydroxyl radical formation in mitochondria

(2011) Ewa Gurgul-Convey et al.   JOURNAL OF MOLECULAR MEDICINE-JMM

Endogenous Nitric Oxide Generation Linked to Ryanodine Receptors Activates Cyclic GMP / Protein Kinase G Pathway for Cell Proliferation of Neural Stem/Progenitor Cells Derived From Embryonic Hippocampus

(2011) Masanori Yoneyama et al.   JOURNAL OF PHARMACOLOGICAL SCIENCES

ER stress is implicated in mitochondrial dysfunction-induced apoptosis of pancreatic beta cells

(2011) June Woo Lee et al.   MOLECULES AND CELLS

Nitric oxide activates Nrf2 through S-nitrosylation of Keap1 in PC12 cells

(2011) Han-Cheon Um et al.   NITRIC OXIDE-BIOLOGY AND CHEMISTRY

Role of the Mitochondria in Immune-Mediated Apoptotic Death of the Human Pancreatic β Cell Line βLox5

(2011) Yaíma L. Lightfoot et al.   PLoS One

Pancreatic β-Cell Death in Response to Pro-Inflammatory Cytokines Is Distinct from Genuine Apoptosis

(2011) J. Jason Collier et al.   PLoS One

Bcl-2 proteins in diabetes: mitochondrial pathways of β-cell death and dysfunction

(2011) Esteban N. Gurzov et al.   TRENDS IN CELL BIOLOGY

Protection of pancreatic INS-1 β-cells from glucose- and fructose-induced cell death by inhibiting mitochondrial permeability transition with cyclosporin A or metformin

(2011) S Lablanche et al.   Cell Death & Disease

Regulatory Effects of Nitric Oxide on Src Kinase, FAK, p130Cas, and Receptor Protein Tyrosine Phosphatase Alpha (PTP-α): A Role for the Cellular Redox Environment

(2010) Marli F. Curcio et al.   ANTIOXIDANTS & REDOX SIGNALING

Modulation of pro-survival proteins by S-nitrosylation: implications for neurodegeneration

(2010) Kenny K. K. Chung   APOPTOSIS

eNOS phosphorylation in health and disease

(2010) Gopi Krishna Kolluru et al.   BIOCHIMIE

Nitric oxide repression of Nanog promotes mouse embryonic stem cell differentiation

(2010) S Mora-Castilla et al.   CELL DEATH AND DIFFERENTIATION

Mcl-1 downregulation by pro-inflammatory cytokines and palmitate is an early event contributing to β-cell apoptosis

(2010) F Allagnat et al.   CELL DEATH AND DIFFERENTIATION

Glucose regulation of β-cell stress in type 2 diabetes

(2010) G. Leibowitz et al.   DIABETES OBESITY & METABOLISM

Silencing inducible nitric oxide synthase protects rat pancreatic islet

(2010) Li Bai-Feng et al.   DIABETES RESEARCH AND CLINICAL PRACTICE

Neuronal nitric oxide synthase protects the pancreatic beta cell from glucolipotoxicity-induced endoplasmic reticulum stress and apoptosis

(2010) E. Bachar et al.   DIABETOLOGIA

Chronic Ethanol Consumption-induced Pancreatic β-Cell Dysfunction and Apoptosis through Glucokinase Nitration and Its Down-regulation

(2010) Ji Yeon Kim et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

p53 Up-regulated Modulator of Apoptosis (PUMA) Activation Contributes to Pancreatic β-Cell Apoptosis Induced by Proinflammatory Cytokines and Endoplasmic Reticulum Stress

(2010) Esteban N. Gurzov et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

BH3 Domains other than Bim and Bid Can Directly Activate Bax/Bak

(2010) Han Du et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The BH3 α-Helical Mimic BH3-M6 Disrupts Bcl-XL, Bcl-2, and MCL-1 Protein-Protein Interactions with Bax, Bak, Bad, or Bim and Induces Apoptosis in a Bax- and Bim-dependent Manner

(2010) Aslamuzzaman Kazi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Essential roles of the nitric oxide (no)/cGMP/protein kinase G type-Iα (PKG-Iα) signaling pathway and the atrial natriuretic peptide (ANP)/cGMP/PKG-Iα autocrine loop in promoting proliferation and cell survival of OP9 bone marrow stromal cells

(2010) Janica C. Wong et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Loss of Nix in Pdx1-deficient mice prevents apoptotic and necrotic β cell death and diabetes

(2010) Kei Fujimoto et al.   JOURNAL OF CLINICAL INVESTIGATION

Modulation of Bcl-2-related protein expression in pancreatic beta cells by pro-inflammatory cytokines and its dependence on the antioxidative defense status

(2010) Ilir Mehmeti et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

GAPDH mediates nitrosylation of nuclear proteins

(2010) Michael D. Kornberg et al.   NATURE CELL BIOLOGY

Protein kinase G type-Iα phosphorylates the apoptosis-regulating protein Bad at serine 155 and protects against apoptosis in N1E-115 cells

(2010) Mary G. Johlfs et al.   NEUROCHEMISTRY INTERNATIONAL

Shear stress promotes nitric oxide production in endothelial cells by sub-cellular delocalization of eNOS: A basis for shear stress mediated angiogenesis

(2010) Gopi Krishna Kolluru et al.   NITRIC OXIDE-BIOLOGY AND CHEMISTRY

Regulation of the expression of inducible nitric oxide synthase

(2010) Andrea Pautz et al.   NITRIC OXIDE-BIOLOGY AND CHEMISTRY

Targeting cyclophilin D and the mitochondrial permeability transition enhances  -cell survival and prevents diabetes in Pdx1 deficiency

(2010) K. Fujimoto et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Paraquat Exposure Induces Nuclear Translocation of Glyceraldehyde-3-Phosphate Dehydrogenase (GAPDH) and the Activation of the Nitric Oxide-GAPDH-Siah Cell Death Cascade

(2010) Miguel A. Ortiz-Ortiz et al.   TOXICOLOGICAL SCIENCES

Low concentrations of nitric oxide delay the differentiation of embryonic stem cells and promote their survival

(2010) J R Tejedo et al.   Cell Death & Disease

Stress hypERactivation in the β-cell

(2010) Sonya G. Fonseca et al.   Islets

Zinc Fingers as Biologic Redox Switches?

(2009) Klaus-D. Kröncke et al.   ANTIOXIDANTS & REDOX SIGNALING

Glucose-modulated tyrosine nitration in beta cells: Targets and consequences

(2009) Thomas Koeck et al.   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

Comparing the chemical biology of NO and HNO

(2009) Wilmarie Flores-Santana et al.   ARCHIVES OF PHARMACAL RESEARCH

Signaling by IL-1β+IFN-γ and ER stress converge on DP5/Hrk activation: a novel mechanism for pancreatic β-cell apoptosis

(2009) E N Gurzov et al.   CELL DEATH AND DIFFERENTIATION

Proinflammatory Cytokines Activate the Intrinsic Apoptotic Pathway in  -Cells

(2009) L. G. Grunnet et al.   DIABETES

Glucose regulation of islet stress responses and β-cell failure in type 2 diabetes

(2009) J. C. Jonas et al.   DIABETES OBESITY & METABOLISM

Cytokine-mediated induction of anti-apoptotic genes that are linked to nuclear factor kappa-B (NF-κB) signalling in human islets and in a mouse beta cell line

(2009) S. A. Sarkar et al.   DIABETOLOGIA

Inhibition of Nuclear Factor-κB or Bax Prevents Endoplasmic Reticulum Stress- But Not Nitric Oxide-Mediated Apoptosis in INS-1E Cells

(2009) Morten F. Tonnesen et al.   ENDOCRINOLOGY

S-Nitrosylation at Cysteine 498 of c-Src Tyrosine Kinase Regulates Nitric Oxide-mediated Cell Invasion

(2009) Mohammad Aminur Rahman et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Molecular mechanisms underlying the activation of eNOS

(2009) Ingrid Fleming   PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY

NO sparks off chromatin: Tales of a multifaceted epigenetic regulator

(2009) Barbara Illi et al.   PHARMACOLOGY & THERAPEUTICS

Glucose Amplifies Fatty Acid-Induced Endoplasmic Reticulum Stress in Pancreatic β-Cells via Activation of mTORC1

(2009) Etti Bachar et al.   PLoS One

Nitric Oxide Induces Cell Death by Regulating Anti-Apoptotic BCL-2 Family Members

(2009) Colleen M. Snyder et al.   PLoS One

Cytokine signalling in the β-cell: a dual role for IFNγ: Figure 1

(2008) Conny Gysemans et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

Role of NF-κB in β-cell death: Figure 1

(2008) Danielle Melloul   BIOCHEMICAL SOCIETY TRANSACTIONS

SIRT1 Regulates Apoptosis and Nanog Expression in Mouse Embryonic Stem Cells by Controlling p53 Subcellular Localization

(2008) Myung-Kwan Han et al.   Cell Stem Cell

Induction of nuclear factor-κB and its downstream genes by TNF-α and IL-1β has a pro-apoptotic role in pancreatic beta cells

(2008) F. Ortis et al.   DIABETOLOGIA

The chemical biology of nitric oxide: Implications in cellular signaling

(2008) Douglas D. Thomas et al.   FREE RADICAL BIOLOGY AND MEDICINE

Diabetic eNOS knockout mice develop distinct macro- and microvascular complications

(2008) Sumathy Mohan et al.   LABORATORY INVESTIGATION

cGMP-independent anti-apoptotic effect of nitric oxide on thapsigargin-induced apoptosis in the pancreatic β-cell line INS-1

(2008) Akiko Noguchi et al.   LIFE SCIENCES

Nitric Oxide Donor, ( )-S-Nitroso-N-acetylpenicillamine, Stabilizes Transactive Hypoxia-Inducible Factor-1  by Inhibiting von Hippel-Lindau Recruitment and Asparagine Hydroxylation

(2008) Y.-K. Park et al.   MOLECULAR PHARMACOLOGY

S-nitrosylation of histone deacetylase 2 induces chromatin remodelling in neurons

(2008) Alexi Nott et al.   NATURE

Nitric oxide-induced nuclear GAPDH activates p300/CBP and mediates apoptosis

(2008) Nilkantha Sen et al.   NATURE CELL BIOLOGY

Palmitate-Induced β-Cell Dysfunction Is Associated with Excessive NO Production and Is Reversed by Thiazolidinedione-Mediated Inhibition of GPR40 Transduction Mechanisms

(2008) Sandra Meidute Abaraviciene et al.   PLoS One

Impaired glucose-stimulated insulin secretion in the GK rat is associated with abnormalities in islet nitric oxide production

(2008) Henrik Mosén et al.   REGULATORY PEPTIDES

Nitric oxide mediates the survival action of IGF-1 and insulin in pancreatic β cells

(2007) Gladys M. Cahuana et al.   CELLULAR SIGNALLING