Article
Gastroenterology & Hepatology
Mauricio Lisker-Melman, Abdus S. Wahed, Marc G. Ghany, Raymond T. Chung, Wendy C. King, David E. Kleiner, Atul K. Bhan, Mandana Khalili, Mamta K. Jain, Mark Sulkowski, David K. Wong, Gavin Cloherty, Richard K. Sterling
Summary: In patients coinfected with HBV and HIV, HBV RNA and HBcrAg can still be detected despite viral suppression, and their levels are associated with the extent of HBsAg and HBcAg staining in liver cells. This suggests that residual transcription and translation may contribute to liver pathology even when viral replication is suppressed.
Article
Multidisciplinary Sciences
Nguyen Thi Cam Huong, Nguyen Quang Trung, Bac An Luong, Duong Bich Tram, Hoang Anh Vu, Hoang Huu Bui, Hoa Pham Thi Le
Summary: This study describes the characteristics of HBV PreS/S mutations in Vietnamese CHB-infected patients and their association with HCC. The results show that several amino acid replacements were detected in the PreS1/PreS2/S genes, and mutations such as W4P/R/Y on PreS1 and T47A/E/V/K, P120S/T, S174N, and P203R on S gene were associated with HCC.
Article
Immunology
Zhan Zeng, Ruyu Liu, Weihua Cao, Liu Yang, Yanjie Lin, Xiaoyue Bi, Tingting Jiang, Wen Deng, Shiyu Wang, Huihui Lu, Fangfang Sun, Ge Shen, Min Chang, Yao Lu, Shuling Wu, Hongxiao Hao, Mengjiao Xu, Xiaoxue Chen, Leiping Hu, Lu Zhang, Gang Wan, Yao Xie, Minghui Li
Summary: This study aimed to investigate the clinical characteristics of HBV DNA-negative, HBsAg-positive, HBeAg-negative patients based on liver histopathology. The findings showed that age, total bilirubin, cholinesterase, and platelet were significantly correlated with the presence of significant hepatic histopathology. Age was identified as an independent factor for significant hepatic histopathology.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Immunology
Zhan Zeng, Hongxiao Hao, Xiaoyue Bi, Yanjie Lin, Liu Yang, Shiyu Wang, Ge Shen, Min Chang, Tingting Jiang, Wen Deng, Huihui Lu, Fangfang Sun, Yao Lu, Yuanjiao Gao, Ruyu Liu, Mengjiao Xu, Xiaoxue Chen, Leiping Hu, Lu Zhang, Minghui Li, Yao Xie
Summary: This study aimed to compare liver histopathological findings in chronic hepatitis B (CHB) patients with different alanine aminotransferase (ALT) normal values to explore the occurrence of liver inflammation. A total of 1474 patients were enrolled, and ALT, HBsAg, and HBeAg status were found to be relevant factors in the occurrence of significant hepatic histopathology.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Infectious Diseases
Mohamed A. El-Mokhtar, Helal F. Hetta, Mohamed A. Mekky, Doaa M. Abd El-Kareem, Mohammed Ramadan, Mohammed Salah, Nahed A. Mohamed, Eman A. El-Masry, Sara Adel, Ibrahim M. Sayed
Summary: In Upper Egypt, genotype D was found to be the major circulating type among chronic HBV-infected patients, with mutations in the a determinant region only detected in genotype D isolates. This could pose a potential threat to HBV diagnosis, therapy success, and vaccination programs in Upper Egypt.
INFECTION AND DRUG RESISTANCE
(2021)
Article
Immunology
Xin Liu, Shu-xiang Chen, Hui Liu, Jin-li Lou
Summary: This study analyzed the differences in T-lymphocyte subsets, cytokine levels, and HBV S gene sequences between HBsAg-negative and HBsAg-positive patients. The results showed that HBsAg-negative patients had superior cellular immune function compared to HBsAg-positive patients, with possible mutations and amino acid replacement sites in the HBV S region.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Gastroenterology & Hepatology
Hui Xu, Stephen Locarnini, Darren Wong, Rachel Hammond, Danni Colledge, Sally Soppe, Thao Huynh, Tim Shaw, Alexander J. Thompson, Peter A. Revill, P. Mark Hogarth, Bruce D. Wines, Renae Walsh, Nadia Warner
Summary: This study identified key anti-HBs profiles associated with either functional cure or failure to achieve functional cure in patients with chronic hepatitis B, suggesting a role for anti-HBs responses in functional cure.
JOURNAL OF HEPATOLOGY
(2022)
Article
Pharmacology & Pharmacy
Yan Liu, Rongjuan Chen, Wenhui Liu, Lanlan Si, Le Li, Xiaodong Li, Zengtao Yao, Hao Liao, Jun Wang, Yuanhua Li, Jun Zhao, Dongping Xu
Summary: MDR HBV, with mutations resistant to both LAM/LdT/ETV and ADV, can be difficult to treat. The study identified a variety of MDR mutation patterns, with different responses to therapies, and found that TDF/TDF+ETV showed higher inhibitory rates on MDR HBV compared to ADV + ETV, especially for ETVr + ADVr strains. This has important clinical implications for resistance management.
ANTIVIRAL RESEARCH
(2021)
Article
Virology
Nokukhanya Msomi, Raveen Parboosing, Eduan Wilkinson, Jennifer Giandhari, Kerusha Govender, Benjamin Chimukangara, Koleka P. Mlisana
Summary: This study assessed the rate of HBV virological response in HIV/HBV co-infected patients on HBV-active ART in KwaZulu-Natal, South Africa, and analyzed factors associated with persistent HBV viraemia. The findings showed a high proportion of patients on HBV-active ART were unsuppressed, which will have an impact on global elimination goals. Better monitoring and early HBV drug-resistance testing should be implemented.
Article
Gastroenterology & Hepatology
Barbara Testoni, Caroline Scholtes, Marie-Laure Plissonnier, Alexia Paturel, Francoise Berby, Floriana Facchetti, Francois Villeret, Elisabetta Degasperi, Beth Scott, Aaron Hamilton, Marintha Heil, Pietro Lampertico, Massimo Levrero, Fabien Zoulim
Summary: This study investigated the correlation between circulating HBV RNA and intrahepatic viral markers and HBcrAg in untreated and NUC-treated CHB patients.
Article
Surgery
Chi-Ming Tai, Hung-Pin Tu, Jau-Chung Hwang, Ming-Lun Yeh, Chung-Feng Huang, Ming-Lung Yu
Summary: This study found that bariatric surgery can achieve significant weight loss and improve liver function, but there is a risk of HBV reactivation after bariatric surgery for patients with obesity.
Article
Oncology
Bei Jiang, Qinghai Dai, Yamin Liu, Guangxin Yu, Yuqiang Mi
Summary: The study investigated the dynamic pattern and clinical value of HBV RNA in chronic HBV infected patients receiving first-line nucleos(t)ide analogues (NAs) therapy. The results demonstrated a positive correlation between HBV RNA and HBV DNA, and indicated that HBV RNA could monitor virus activity in patients whose serum HBV DNA could not be detected.
INFECTIOUS AGENTS AND CANCER
(2022)
Article
Immunology
Muttiah Barathan, Behnaz Riazalhosseini, Thevambiga Iyadorai, Kumutha Malar Vellasamy, Jamuna Vadivelu, Li-Yen Chang, Ahmad Khusairy Zulpa, Marie Larsson, Esaki M. Shankar, Rosmawati Mohamed
Summary: In chronic HBV patients, those with liver cirrhosis showed higher levels of oxidative stress and cell apoptosis, as well as alterations in inflammatory mediators.
MICROBIAL PATHOGENESIS
(2021)
Article
Medicine, General & Internal
Muhammed Bekcibasi, Ozcan Deveci, Abdullah Oguz, Fatma Bozkurt, Saim Dayan, Mustafa Kemal celen
Summary: This study evaluated the serum levels of TNF-alpha, IL-1 beta, and IL-6 in chronic HBV-infected patients. The results showed that TNF-alpha and IL-6 levels were significantly higher in the CHB group compared to the control group, indicating potential inflammation and immune response in CHB patients.
INTERNATIONAL JOURNAL OF CLINICAL PRACTICE
(2021)
Article
Multidisciplinary Sciences
Yifei Shen, Shuaishuai Xu, Chanqi Ye, Qiong Li, Ruyin Chen, Wei Wu, Qi Jiang, Yunlu Jia, Xiaochen Zhang, Longjiang Fan, Wenguang Fu, Ming Jiang, Jinzhang Chen, Michael P. Timko, Peng Zhao, Jian Ruan
Summary: Through whole-exome sequencing, proteomic analysis, and single-cell RNA sequencing, this study revealed that HBV-infected ICC patients have decreased cell-cell junction levels and an increased epithelial-mesenchymal transition (EMT) program. The immune landscape analysis found more CD8 T cells and Th2 cells in HBV-ICC patients. Single-cell analysis showed increased transforming growth factor beta signaling-related EMT program changes in tumor cells of HBV-ICC patients. Additionally, ICAM1(+) tumor-associated macrophages were associated with a poor prognosis and contributed to EMT in HBV-ICC patients. These findings provide new insights into the mechanisms driving HBV-infected ICC.
Article
Public, Environmental & Occupational Health
Hamid Hakimi, Jafar Ahmadi, Alireza Vakilian, Ahmad Jamalizadeh, Zahra Kamyab, Mahya Mehran, Reza Malekzadeh, Hossein Poustchi, Sareh Eghtesad, Farimah Sardari, Mohammadreza Soleimani, Morteza Khademalhosseini, Mohammadreza Abolghasemi, Movahedeh Mohammadi, Tabandeh Sadeghi, Fatemeh Ayoobi, Mitra Abbasi, Maryam Mohamadi, Zahra Jalali, Ali Shamsizadeh, Ali Esmaeili-Nadimi
Summary: Rafsanjan is a unique city in Iran, known for its large human-made pistachio jungle and the second largest copper mine, as well as its location on the opium trade route. Concerns about health outcomes in this city led to the initiation of the Rafsanjan Cohort Study, which revealed a concerning prevalence of non-communicable disease risk factors. Further investigations and interventions are needed to address these health issues.
EUROPEAN JOURNAL OF EPIDEMIOLOGY
(2021)
Review
Immunology
Shokrollah Assar, Reza Nosratabadi, Hossein Khorramdel Azad, Javad Masoumi, Mahshad Mohamadi, Gholamhossein Hassanshahi
Summary: Past research highlights that some antibiotics have immunomodulatory effects in addition to their antimicrobial properties. Fluoroquinolones (FQs) are synthetic antibiotics that decompose DNA to prevent bacterial growth and indirectly modulate immune responses by suppressing pro-inflammatory cytokines and affecting lymphocyte activity and cytokine expression.
IMMUNOLOGICAL INVESTIGATIONS
(2021)
Article
Biochemistry & Molecular Biology
Majid Mollahosseini, Hadis Ahmadirad, Reza Goujani, Hossein Khorramdelazad
Summary: The study demonstrated that patients with a femoral fracture and TBI have significantly elevated serum levels of certain growth factors and cytokines, leading to accelerated healing compared to other groups.
JOURNAL OF MOLECULAR NEUROSCIENCE
(2021)
Article
Cardiac & Cardiovascular Systems
Parvin Khalili, Fatemeh Ayoobi, Maryam Mohamadi, Ahmad Jamalizadeh, Carlo La Vecchia, Ali Esmaeili-nadimi
Summary: The study found that opium consumption is associated with an increased risk of both ischemic heart diseases (IHD) and myocardial infarction (MI). The odds of suffering from IHD and MI were higher among individuals who consumed opium, particularly in the 4th quartile.
BMC CARDIOVASCULAR DISORDERS
(2021)
Correction
Cell Biology
Maryam Masoumi, Hamidreza Bashiri, Hossein Khorramdelazad, Khadijeh Barzaman, Nader Hashemi, Hale Abdoli Sereshki, Amirhossein Sahebkar, Jafar Karami
Article
Allergy
Mitra Abassifard, Hossein Khorramdelazad, Shayan Rezaee, Abdollah Jafarzadeh
Summary: The study found significantly higher serum IL-38 levels in OA patients compared to healthy controls, with the levels possibly influenced by WOMAC, VAS, and BMI indices. It suggests that IL-38 may serve as a valuable marker for OA and its expression in serum may be elevated in patients with more severe disease to modulate inflammatory responses.
IRANIAN JOURNAL OF ALLERGY ASTHMA AND IMMUNOLOGY
(2021)
Review
Medicine, Research & Experimental
Fatemeh Moadab, Hossein Khorramdelazad, Mitra Abbasifard
Summary: The CCL2/CCR2 axis plays a crucial role in the pathogenesis of rheumatoid arthritis, triggering various immunological events such as inflammation and being involved in multiple processes of RA development. Targeting the CCL2/CCR2 axis offers potential opportunities for immunotherapy in RA treatment.
Review
Oncology
Maryam Katoueezadeh, Niloofar Pilehvari, Ahmad Fatemi, Gholamhossein Hassanshahi, Seyedeh Atekeh Torabizadeh
Summary: In response to the alarming increase in acute lymphoblastic leukemia cases, researchers are investigating new therapeutic strategies targeting DNA damage response pathways to overcome resistance to chemotherapy and radiotherapy. This review aims to evaluate the synergistic effects of DNA damage response pathway inhibitors with radiation in the treatment of leukemia.
Article
Neurosciences
Elnaz Azizi, Fatemeh Ayoobi, Ali Shamsizadeh, Amir Moghadam-Ahmadi, Seyed Ali Shafiei, Ali Reza Khoshdel, Mohammad Reza Mirzaei
Summary: The present study demonstrates that exposure to local extremely low-frequency magnetic fields (ELF-MFs) can modulate sleep and anxiety levels in male rats, potentially affecting the metabolism of oxalate and inducing sleepiness.
BASIC AND CLINICAL NEUROSCIENCE
(2022)
Article
Endocrinology & Metabolism
Mojgan Noroozi Karimabad, Parvin Khalili, Fatemeh Ayoobi, Ali Esmaeili-Nadimi, Carlo La Vecchia, Zahra Jamali
Summary: Elevated levels of ALT, AST, GGT, and ALP are associated with a higher odds of diabetes. Additionally, increased levels of ALT, GGT, and ALP even within the normal range are independently associated with an increased odds of diabetes.
BMC ENDOCRINE DISORDERS
(2022)
Article
Cardiac & Cardiovascular Systems
Parvin Khalili, Saeedeh Abdollahpoor, Fatemeh Ayoobi, Alireza Vakilian, Hamid Hakimi, Zohreh Rajabi, Zahra Jamali
Summary: This study aimed to evaluate the relationship between liver enzymes (ALT, AST, GGT, and ALP) and hypertension. The results showed that increased serum ALP activity was positively associated with increased odds of hypertension in subjects with normal levels of liver enzymes.
INTERNATIONAL JOURNAL OF HYPERTENSION
(2022)
Article
Endocrinology & Metabolism
Mohammadreza Soleimani, Fateme Alipour, Yousef Taghavi, Marjan Fatemipour, Hamid Hakimi, Zahra Jamali, Parvin Khalili, Fatemeh Ayoobi, Maryam Sheikh, Roya Tavakoli, Amin Zand
Summary: We determined the prevalence and risk factors for diabetic retinopathy (DR) in Rafsanjan City, Iran using single-field fundus photographs. Duration of diabetes, positive family history for diabetes, fasting plasma glucose, and serum creatinine level may be associated with DR.
Article
Immunology
Pedram Basirjafar, Raziyeh Zandvakili, Javad Masoumi, Nahid Zainodini, Zahra Taghipour, Hossein Khorramdelazad, Soheila Yousefi, Tayyebeh Tavakoli, Mahboobeh Vatanparast, Sepehr Safdel, Mahsa Gheitasi, Fatemeh Ayoobi, Bahar Naseri, Abdollah Jafarzadeh
Summary: The study found that the Leptin/LPS-treated mDC vaccine was more effective in inhibiting breast cancer development and boosting immune responses, by increasing CTLs and TH1 cells frequency, promoting IFN-gamma and IL-12 production, as well as enhancing T-bet and Granzyme B expression.
IMMUNOPHARMACOLOGY AND IMMUNOTOXICOLOGY
(2023)
Article
Medicine, General & Internal
Akram Norouzi, Marzieh Motaghi, Gholamhossein Hassanshahi, Mahdieh Nazari-Robati
Summary: This study found that there was no significant difference in serum 25(OH) vitamin D levels between patients with acute lymphoblastic leukemia (ALL) and healthy subjects, but a significant reduction in the expression of VDR and H19 was observed in ALL patients.
REVISTA DA ASSOCIACAO MEDICA BRASILEIRA
(2021)
Article
Medicine, General & Internal
Fatemeh Ayoobi, Parvin Khalili, Maryam Mohamadi, Hamid Hakimi, Carlo La Vecchia, Narjes Soltani, Ali Esmaeili-nadimi
Summary: This study aimed to analyze the associations between occupational status and cardiovascular diseases in the Iranian population. The results indicated that there was no significant association between occupational status and the risk of ischemic heart disease and myocardial infarction in this population.
IRANIAN RED CRESCENT MEDICAL JOURNAL
(2021)
Review
Gastroenterology & Hepatology
Leonard Depotte, Juliette Palle, Cosimo Rasola, Chloe Broudin, Vlad-Adrian Afrasanie, Antoine Mariani, Aziz Zaanan
Summary: Advanced gastric adenocarcinoma is a disease with poor prognosis. In recent years, new drugs, such as trastuzumab for HER2-positive tumors, ramucirumab alone or in combination with paclitaxel, and trifluridine-tipiracil, have improved patient survival. Other drugs, including monoclonal antibodies and targeted therapies, are also being evaluated.
CLINICS AND RESEARCH IN HEPATOLOGY AND GASTROENTEROLOGY
(2024)
