Review
Infectious Diseases
Martha M. Grout, Kenneth B. Mitchell
Summary: Lyme disease, caused by multiple vector-borne organisms, can be treated successfully in its early stages. However, if diagnosis is delayed, it can lead to disseminated infection and affect multiple organ systems, causing life-altering symptoms. Conventional antibiotic therapy may not be effective, but recent literature suggests that disulfiram may be a potent drug in treating chronic Lyme disease.
Article
Multidisciplinary Sciences
Vicktoria Vishnevskia-Dai, Lihi Rozner, Raanan Berger, Ziv Jaron, Sivan Elyashiv, Gal Markel, Ofira Zloto
Summary: Biological anti-cancer therapies can lead to a wide range of ocular side effects, from dry eye symptoms to severe pathologies that may cause ocular morbidity and vision loss. Screening by ophthalmologists before treatment, re-screening every 4-6 months during treatment, and again at the end of treatment is recommended for all patients receiving biological treatments. Patients on biological treatment who have ocular complaints should be urgently referred to ocular consultation for early identification and early intervention.
SCIENTIFIC REPORTS
(2021)
Review
Immunology
Daniel B. Chastain, Megan Spradlin, Hiba Ahmad, Andres F. Henao-Martinez
Summary: This article evaluates the risks of opportunistic infections in patients requiring glucocorticoid therapy by considering the dose, duration, and potency of the medication, as well as other factors such as concomitant immunosuppressive therapy. It proposes strategies for preventing these infections through screening, antimicrobial prophylaxis, and immunizations. Clinicians should assess the benefit-harm ratios of glucocorticoid treatment and implement preventive efforts to reduce infection complications.
CLINICAL INFECTIOUS DISEASES
(2023)
Article
Green & Sustainable Science & Technology
Mariana Tolotti, Patrice Guillotreau, Fabien Forget, Manuela Capello, Laurent Dagorn
Summary: Ecosystem-based management is crucial for achieving sustainability of ecosystem services, but this study reveals the unintended consequences of management measures that focus solely on a single target species. The adoption of a plan to rebuild yellowfin tuna stock in the Indian Ocean led to increased silky shark bycatch and significant economic losses in the French fleet. This research highlights the socioeconomic trade-offs between FAD use in tuna purse seine fisheries and shark bycatch.
ENVIRONMENT DEVELOPMENT AND SUSTAINABILITY
(2023)
Editorial Material
Medicine, General & Internal
Zhijun Zhou, Min Li
Summary: Targeted therapy is crucial for improving overall survival and reducing side effects in cancer treatment, but each patient responds differently to treatment. The development of cutting-edge technologies, such as next-generation sequencing, has allowed for the identification of more actionable targets. This special issue of BMC Medicine presents a collection of studies on targeted therapies for various cancer types, aiming to bridge the gap between genomic testing and precision medicine and spark innovations in improving the efficacy of targeted therapies.
Article
Hospitality, Leisure, Sport & Tourism
Marissa Orlowski, Sarah Lefebvre, Laura Boman
Summary: The growth of third-party food delivery services has increased the opportunities for food tampering and contamination. To address these concerns, restaurants are implementing tamper-evident closures. However, our research shows that these closures have a negative effect on willingness to pay due to perceived contamination signals. This effect is attenuated for consumers with a high food safety risk perception.
INTERNATIONAL JOURNAL OF HOSPITALITY MANAGEMENT
(2022)
Review
Cell Biology
Yi Xiao, Tian-Jian Yu, Ying Xu, Rui Ding, Yi-Ping Wang, Yi-Zhou Jiang, Zhi-Ming Shao
Summary: Metabolic reprogramming in cancer has potential as a treatment target, but the complexity and adaptability of metabolic networks hinder the effectiveness of metabolic therapies. This review summarizes the current status of clinical trials targeting cancer metabolism and proposes future directions to improve the efficacy of metabolism-based therapies.
Review
Multidisciplinary Sciences
Candice R. Gurbatri, Nicholas Arpaia, Tal Danino
Summary: With the use of synthetic biology tools, researchers are repurposing bacteria as tumor-specific delivery systems, which can modulate the tumor microenvironment and enhance therapeutic efficacy and safety through their immunogenicity and local payload production.
Article
Public, Environmental & Occupational Health
Talbot M. Andrews, John Barry Ryan
Summary: This study reveals that people's preferences for prevention spending are influenced by cost conflation, causing them to deviate from equilibrium. Experimental results show that individuals often mistakenly believe the costs of disaster prevention are positively correlated with disaster damages, leading to biases in disaster prevention efforts.
Editorial Material
Biochemistry & Molecular Biology
Emilie Narni-Mancinelli, Eric Vivier
Summary: In this study, it was found that pro-apoptotic molecules like BH3-mimetics synergize with NK cells to induce mitochondria-driven apoptosis in tumor cells, thereby enhancing the efficacy of NK cell therapies.
Article
Computer Science, Artificial Intelligence
N. Ege Sarac, Omer Faruk Altun, Kamil Tolga Atam, Sertac Karahoda, Kamer Kaya, Husnu Yenigun
Summary: This research focuses on the importance of synchronization problem in automata and the limitations of existing heuristics. By improving the runtime of SYNCHROP, adapting it for many-core architectures, and proposing two SYNCHROP variants, the study achieves a more efficient approach to solving synchronization problems. The performance evaluation shows significant speedup on GPUs compared to naive sequential implementation.
EXPERT SYSTEMS WITH APPLICATIONS
(2021)
Article
Development Studies
Sebastian Eichhorn, David Pehlke
Summary: Regional planning plays a crucial role in managing regional and local land use in Germany, providing concrete guidelines for urban land use planning. However, the impact of regional planning regulations on housing market, migration, and prices is relatively small, and does not support important predictions of neoclassical urban theory.
Review
Biochemistry & Molecular Biology
Gazmend Temaj, Silvia Chichiarelli, Margherita Eufemi, Fabio Altieri, Rifat Hadziselimovic, Ammad Ahmad Farooqi, Ilhan Yaylim, Luciano Saso
Summary: Ribosomes play a crucial role in cancer transformation, with cancer diseases associated with an increase in ribosome biogenesis and mutation of ribosomal proteins. Therefore, studying anti-cancer therapy strategies targeting ribosomes is of great importance.
Review
Chemistry, Inorganic & Nuclear
Chunhui Wang, Xinda Yang, Chunyan Dong, Keke Chai, Juan Ruan, Shuo Shi
Summary: Copper is an essential micronutrient that plays a crucial role in promoting metabolism and maintaining basic biological functions. The imbalance of copper levels can have negative effects on cell function and metabolism. Therefore, copper-related agents have gained attention in the field of cancer therapy as a means to inhibit proliferation or induce cell death. This review provides a comprehensive summary of the recent developments in copper-related agents for cancer treatment, focusing on copper depletion and supplementation strategies. The challenges and future directions in the development of copper-related anticancer agents are also discussed.
COORDINATION CHEMISTRY REVIEWS
(2023)
Article
Green & Sustainable Science & Technology
Dirk-Jan Koch, Jolynde Vis, Maria van der Harst, Elric Tendron, Joost de Laat
Summary: Assessing unintended effects in international cooperation projects is currently inadequate, with only about one in six evaluations carefully considering this issue. Development of an operational typology incorporating 10 types of unintended effects in international cooperation, applied to evaluations of Dutch development cooperation, shows promise in systematically guiding assessments and consideration of unintended effects in international development cooperation.
