Targeting epigenetic mechanisms and microRNAs by aspirin and other non steroidal anti-inflammatory agents - implications for cancer treatment and chemoprevention

Anacardic acid (6-pentadecylsalicylic acid) induces apoptosis of prostate cancer cells through inhibition of androgen receptor and activation of p53 signaling

(2013) Jing Tan et al.   Chinese Journal of Cancer Research

Targeting miR-21 for the Therapy of Pancreatic Cancer

(2013) Flavie Sicard et al.   MOLECULAR THERAPY

Epigenetic drug combination induces genome-wide demethylation and altered gene expression in neuro-ectodermal tumor-derived cell lines

(2013) Floor A.M. Duijkers et al.   CELLULAR ONCOLOGY

miRNAs in head and neck cancer revisited

(2013) Rahul Nagadia et al.   CELLULAR ONCOLOGY

Astemizole: an Old Anti-histamine as a New Promising Anti-cancer Drug

(2012) Janice Garcia-Quiroz et al.   Anti-Cancer Agents in Medicinal Chemistry

Loss of methylation in CpG sites in the NF-κB enhancer elements of inducible nitric oxide synthase is responsible for gene induction in human articular chondrocytes

(2012) María C. de Andrés et al.   ARTHRITIS AND RHEUMATISM

Aspirin may promote mitochondrial biogenesis via the production of hydrogen peroxide and the induction of Sirtuin1/PGC-1α genes

(2012) Pratibha Kamble et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

The tumor suppressormicroRNA-29cis downregulated and restored by celecoxib in human gastric cancer cells

(2012) Yoshimasa Saito et al.   INTERNATIONAL JOURNAL OF CANCER

Restoration of miR-34a in p53 deficient cells unexpectedly promotes the cell survival by increasing NFκB activity

(2012) Jiali Tan et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

DNA methyl transferase I acts as a negative regulator of allergic skin inflammation

(2012) Youngmi Kim et al.   MOLECULAR IMMUNOLOGY

Sulindac inhibits tumor cell invasion by suppressing NF-κB-mediated transcription of microRNAs

(2012) X Li et al.   ONCOGENE

Widespread dynamic DNA methylation in response to biotic stress

(2012) R. H. Dowen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Aberrant microRNA expression and its implications in the pathogenesis of leukemias

(2012) Sadegh Babashah et al.   CELLULAR ONCOLOGY

Hypomethylation of LINE-1, and not centromeric SAT-α, is associated with centromeric instability in head and neck squamous cell carcinoma

(2012) Jorge García Martínez et al.   CELLULAR ONCOLOGY

Pharmacology and cellular/molecular mechanisms of action of aspirin and Non-aspirin NSAIDs in colorectal cancer

(2011) Karsten Schrör   BEST PRACTICE & RESEARCH IN CLINICAL GASTROENTEROLOGY

Dimethylcelecoxib induces an inhibitory complex consisting of HDAC1/NF-κB(p65)RelA leading to transcriptional downregulation of mPGES-1 and EGR1

(2011) Klaus Deckmann et al.   CELLULAR SIGNALLING

Advances in the computational development of DNA methyltransferase inhibitors

(2011) José L. Medina-Franco et al.   DRUG DISCOVERY TODAY

Modulation of Lymphangiogenesis: A New Target for Aspirin and Other Nonsteroidal Anti-inflammatory Agents? A Systematic Review

(2011) Eugenia Yiannakopoulou   JOURNAL OF CLINICAL PHARMACOLOGY

Trimethylaurintricarboxylic acid inhibits human DNA methyltransferase 1: insights from enzymatic and molecular modeling studies

(2011) Jakyung Yoo et al.   JOURNAL OF MOLECULAR MODELING

The Redox Basis of Epigenetic Modifications: From Mechanisms to Functional Consequences

(2010) Anthony R. Cyr et al.   ANTIOXIDANTS & REDOX SIGNALING

Development of curcumin as an epigenetic agent

(2010) Siqing Fu et al.   CANCER

Non-steroidal anti-inflammatory drug (NSAID) use and breast cancer risk in the Western New York Exposures and Breast Cancer (WEB) Study

(2010) Theodore M. Brasky et al.   CANCER CAUSES & CONTROL

Association between Folate Levels and CpG Island Hypermethylation in Normal Colorectal Mucosa

(2010) K. Wallace et al.   Cancer Prevention Research

MiRSNPs or MiR-polymorphisms, new players in microRNA mediated regulation of the cell: Introducing microRNA pharmacogenomics

(2010) Prasun J. Mishra et al.   CELL CYCLE

Histone Deacetylase 3 Antagonizes Aspirin-Stimulated Endothelial Nitric Oxide Production by Reversing Aspirin-Induced Lysine Acetylation of Endothelial Nitric Oxide Synthase

(2010) Saet-Byel Jung et al.   CIRCULATION RESEARCH

MicroRNAs and their implications in toxicological research

(2010) Carolina Lema et al.   TOXICOLOGY LETTERS

Epigenetic architecture and miRNA: reciprocal regulators

(2010) Erik D Wiklund et al.   Epigenomics

MicroRNA-21 promotes cell proliferation and down-regulates the expression of programmed cell death 4 (PDCD4) in HeLa cervical carcinoma cells

(2009) Qing Yao et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Novel and selective DNA methyltransferase inhibitors: Docking-based virtual screening and experimental evaluation

(2009) Dirk Kuck et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Global DNA Hypomethylation (LINE-1) in the Normal Colon and Lifestyle Characteristics and Dietary and Genetic Factors

(2009) J. C. Figueiredo et al.   CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION

Chronic nonsteroidal anti-inflammatory drug (NSAID) use suppresses multiple CpG islands hyper methylation (CIHM) of tumor suppressor genes in the human gastric mucosa

(2009) Tomomitsu Tahara et al.   CANCER SCIENCE

Targeting DNA Methylation

(2009) J.-P. J. Issa et al.   CLINICAL CANCER RESEARCH

Chronic Aspirin Use Suppresses CDH1 Methylation in Human Gastric Mucosa

(2009) Tomomitsu Tahara et al.   DIGESTIVE DISEASES AND SCIENCES

Tumor markers and rectal cancer: Support for an inflammation-related pathway

(2009) Martha L. Slattery et al.   INTERNATIONAL JOURNAL OF CANCER

Protective effect of salicylates against hydrogen peroxide stress in yeast

(2009) E.Ch. Yiannakopoulou et al.   JOURNAL OF APPLIED MICROBIOLOGY

MicroRNA polymorphisms: the future of pharmacogenomics, molecular epidemiology and individualized medicine

(2009) Prasun J Mishra et al.   PHARMACOGENOMICS

The effect of dietary polyphenols on the epigenetic regulation of gene expression in MCF7 breast cancer cells

(2009) Jarosław Paluszczak et al.   TOXICOLOGY LETTERS

Anacardic acid (6-nonadecyl salicylic acid), an inhibitor of histone acetyltransferase, suppresses expression of nuclear factor- B-regulated gene products involved in cell survival, proliferation, invasion, and inflammation through inhibition of the inhibitory subunit of nuclear factor- B  kinase, leading to potentiation of apoptosis

(2008) B. Sung et al.   BLOOD

MicroRNA-21 down-regulates the expression of tumor suppressor PDCD4 in human glioblastoma cell T98G

(2008) Yang Chen et al.   CANCER LETTERS

From Human Genetics and Genomics to Pharmacogenetics and Pharmacogenomics: Past Lessons, Future Directions

(2008) Daniel W. Nebert et al.   DRUG METABOLISM REVIEWS

The Nonsteroidal Anti-Inflammatory Drug NS398 Reactivates SPARC Expression via Promoter Demethylation to Attenuate Invasiveness of Lung Cancer Cells

(2008) Mei-Ren Pan et al.   EXPERIMENTAL BIOLOGY AND MEDICINE

Epi-drugs to fight cancer: From chemistry to cancer treatment, the road ahead

(2008) Antonello Mai et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Nonsteroidal Anti-inflammatory Drug-activated Gene (NAG-1/GDF15) Expression Is Increased by the Histone Deacetylase Inhibitor Trichostatin A

(2008) Hiroki Yoshioka et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Epigenomics and breast cancer

(2008) Pang-Kuo Lo et al.   PHARMACOGENOMICS

The Inhibition of Embryonic Histone Deacetylases as the Possible Mechanism Accounting for Axial Skeletal Malformations Induced by Sodium Salicylate

(2008) Francesca Di Renzo et al.   TOXICOLOGICAL SCIENCES