Article
Biochemistry & Molecular Biology
Ching-Chung Ko, Yao-Yu Hsieh, Pei-Ming Yang
Summary: Epithelial-to-mesenchymal transition (EMT) is a biological process that promotes cancer cell dissemination and drug resistance. This study revealed that overexpression of MIR31HG in pancreatic ductal adenocarcinoma (PDAC) patients is associated with poorer disease-free survival, as well as upregulation of genes related to TGF beta signaling and EMT. In vitro experiments further demonstrated that TGF beta induces MIR31HG expression and knockdown of MIR31HG reverses TGF beta-induced EMT phenotypes and cancer cell migration.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Hwi Gon Kim, Ye Seon Lim, Seonyeong Hwang, Hye-Yoon Kim, Yuseok Moon, Yong Jung Song, Yong-Jin Na, Sik Yoon
Summary: DEHP, a commonly used plasticizer, may be linked to the development of endometriosis by inducing cell proliferation, migration, inflammation, and stemness through the TGF-β/Smad signaling pathway, providing novel insights into the pathogenesis of endometriosis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Gastroenterology & Hepatology
Tianhao Weng, Dong Yan, Danrong Shi, Miaojin Zhu, Yizhi Liu, Zhigang Wu, Taoming Tang, Linwei Zhu, Hong Zhang, Hangping Yao, Lanjuan Li
Summary: The study reveals that MSP is an important biomarker in the progression of liver cirrhosis and can be utilized for patient prognostication. The MSP-RON pathway promotes hepatocytes EMT and fibrosis progression via the TGF-beta related pathway. Potential therapeutic strategies for liver cirrhosis targetting the MSP/RON pathway have been identified.
LIVER INTERNATIONAL
(2021)
Article
Endocrinology & Metabolism
Xiaobo Ling
Summary: The study revealed that breviscapine suppressed proliferation, migration, invasion, epithelial-to-mesenchymal transition (EMT), and TGF-beta 1/Smad signaling in TGF-beta 1-induced pulmonary fibrotic cells in vitro by blocking the PI3K/AKT/GSK3 beta pathway. This suggests that breviscapine may be a potential candidate for the treatment of pulmonary fibrosis.
JOURNAL OF BIOLOGICAL REGULATORS AND HOMEOSTATIC AGENTS
(2022)
Review
Chemistry, Medicinal
Jianqing Yu, George G. Chen, Paul B. S. Lai
Summary: Hepatocellular carcinoma is a major cause of cancer mortality worldwide, with current treatments showing unsatisfactory outcomes. The HGF/c-Met axis is considered crucial in regulating liver diseases and promoting HCC, and inhibiting this pathway may lead to the development of new and effective treatments for HCC.
MEDICINAL RESEARCH REVIEWS
(2021)
Article
Medicine, Research & Experimental
Rui Yu, Yan Wu, Ping He, Yu Bai, Yongzhe Zhang, Xiaohui Bian, Guangping Sun, Beiru Zhang
Summary: Renal fibrosis is the main pathology of chronic kidney disease and LMCD1 is upregulated in patients with CKD and treated kidney cells. Knockdown of LMCD1 can improve renal fibrosis by blocking the activation of the extracellular signal-regulated kinase pathway. The study further investigates the effect of LMCD1 on TGF-01-induced epithelial-mesenchymal transition (EMT) and its potential role in the TGF-01/Smad signaling pathway.
LABORATORY INVESTIGATION
(2023)
Article
Biochemistry & Molecular Biology
Shuai Yang, Hui Li, Haipei Yao, Yao Zhang, Huiqian Bao, Liangjing Wu, Conghui Zhang, Min Li, Le Feng, Jingfa Zhang, Zhi Zheng, Guotong Xu, Fang Wang
Summary: The study revealed that lncRNA ERLR plays a role in TGF-beta 1-induced EMT in human RPE cells and is involved in the pathogenesis of PVR, providing new insights into the mechanism and treatment of the disease.
CELL DEATH AND DIFFERENTIATION
(2021)
Article
Medicine, General & Internal
Ritu Shrestha, Kim R. Bridle, Darrell H. G. Crawford, Aparna Jayachandran
Summary: Our study demonstrates a close association between TGF-beta 1-mediated EMT and regulation of immune checkpoints in HCC. Induction of EMT by TGF-beta 1 led to increased migratory potential of HCC cells and upregulation of immune checkpoint molecules PD-L1 and B7-H3, while reversal of EMT resulted in decreased expression of these immune checkpoint molecules.
INTERNATIONAL JOURNAL OF MEDICAL SCIENCES
(2021)
Review
Oncology
Meina Jiang, Shuai Fang, Xiaodong Zhao, Chengwei Zhou, Zhaohui Gong
Summary: EMT plays a crucial role in cancer development, especially in lung carcinoma. CircRNAs are involved in EMT-related cell invasion and metastasis, and may become promising biomarkers and therapeutic targets in cancer management.
CANCER BIOLOGY & MEDICINE
(2021)
Article
Immunology
Samuel James Brake, Wenying Lu, Collin Chia, Greg Haug, Josie Larby, Ashutosh Hardikar, Gurpreet K. Singhera, Tillie L. Hackett, Mathew Suji Eapen, Sukhwinder Singh Sohal
Summary: COPD is a common respiratory disease characterized by airflow obstruction, and the TGF-β1 and SMAD pathway is believed to be involved in its pathogenesis by inducing epithelial mesenchymal transition (EMT). Smoking and activation of the SMAD pathway were found to be correlated with the decline in lung function in mild to moderate COPD patients, independent of TGF-β1, suggesting the involvement of other factors in driving these pathways.
FRONTIERS IN IMMUNOLOGY
(2023)
Review
Cell Biology
Dorival Mendes Rodrigues-Junior, Chrysoula Tsirigoti, Sai Kiang Lim, Carl-Henrik Heldin, Aristidis Moustakas
Summary: This review summarizes the impact of extracellular vesicles (EVs) on the transforming growth factor beta (TGF-beta) signaling pathway in cancer. The cargo of EVs, including various molecules associated with TGF-beta pathway, can influence tumorigenesis, metastatic spread, immune evasion, and response to treatment. Additionally, TGF-beta-related molecules in circulating EVs show potential as useful biomarkers for prognosis, diagnosis, and treatment response in cancer patients.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Ke Li, Rong Zhou, Mingze Ma, Chaomei Jin, Linlin Jiao, Siyu Zhang, Mei Tian, Fang Zhou
Summary: This study demonstrates that TNF-alpha and TGF-beta 1 synergistically promote EMT and cell migration in BEAS-2B cells. In addition, inhibiting the NF-kappa B/NOX4 signaling pathway can suppress the expression of EMT-related markers and cell migration.
MOLECULAR BIOLOGY REPORTS
(2022)
Article
Plant Sciences
Hyunhee Kim, Pilju Choi, Taejung Kim, Youngseok Kim, Bong Geun Song, Young-Tae Park, Seon-Jun Choi, Cheol Hee Yoon, Won-Chul Lim, Hyeonseok Ko, Jungyeob Ham
Summary: The study found that Rk1 and Rg5 inhibited TGF-beta 1-induced EMT and the development of stem cell properties by regulating the Smad and NF-kB/ERK pathways.
JOURNAL OF GINSENG RESEARCH
(2021)
Article
Medicine, Research & Experimental
Yuki Miyake, Yoshiyuki Nagaoka, Kazuhiko Okamura, Yukimasa Takeishi, Sachio Tamaoki, Mitsutoki Hatta
Summary: The study revealed that SNAI2 does not play a vital role in the EMT process of HaCaT cells, and identified candidate transcription factors that may be involved in EMT-related gene expression induced by TGF-beta 1.
EXPERIMENTAL AND THERAPEUTIC MEDICINE
(2021)
Article
Biochemistry & Molecular Biology
Tsugumasa Toma, Hiroshi Tateishi, Kensaku Kawakami, Taha F. S. Ali, Masahiro Kamo, Kazuaki Monde, Yuta Nakashima, Mikako Fujita, Masami Otsuka
Summary: Metastasis is the main cause of mortality in solid tumors, but there are no available antimetastatic drugs on the market. This study focused on a synthetic compound called HPH-15, which showed anti-EMT and anti-cell migration activities in non-small-cell lung cancer cells. HPH-15 was found to inhibit downstream TGF-beta signaling and could potentially lead to the development of new antimetastatic drugs.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Laia Caja, Kalliopi Tzavlaki, Mahsa S. Dadras, E-Jean Tan, Gad Hatem, Naga P. Maturi, Anita Moren, Lotta Wik, Yukihide Watanabe, Katia Savary, Masood Kamali-Moghaddan, Lene Uhrbom, Carl-Henrik Heldin, Aristidis Moustakas
Article
Oncology
Athanassios Kotsinas, Vimla Aggarwal, E-Jean Tan, Brynn Levy, Vassilis G. Gorgoulis
Article
Biochemistry & Molecular Biology
Sylvie Thuault, E-Jean Tan, Hector Peinado, Amparo Cano, Carl-Henrik Heldin, Aristidis Moustakas
JOURNAL OF BIOLOGICAL CHEMISTRY
(2008)
Article
Biochemistry & Molecular Biology
E-Jean Tan, Sylvie Thuault, Laia Caja, Tea Carletti, Carl-Henrik Heldin, Aristidis Moustakas
JOURNAL OF BIOLOGICAL CHEMISTRY
(2012)
Article
Cell Biology
Yi Xie, E-Jean Tan, Shimei Wee, Edward Manser, Louis Lim, Cheng-Gee Koh
JOURNAL OF CELL SCIENCE
(2008)
Article
Cell Biology
Stefan Termen, E-Jean Tan, Carl-Henrik Heldin, Aristidis Moustakas
JOURNAL OF CELLULAR PHYSIOLOGY
(2013)
Article
Biochemistry & Molecular Biology
E-Jean Tan, Kaoru Kahata, Oskar Idas, Sylvie Thuault, Carl-Henrik Heldin, Aristidis Moustakas
NUCLEIC ACIDS RESEARCH
(2015)
Article
Oncology
Yuan Xie, Anders Sundstrom, Naga P. Maturi, E-Jean Tan, Voichita D. Marinescu, Malin Jarvius, Malin Tirfing, Chuan Fin, Lei Chen, Magnus Essand, Fredrik J. Swartling, Sven Nelander, Yiwen Jiang, Lene Uhrbom
JOURNAL OF PATHOLOGY
(2019)
Article
Biochemistry & Molecular Biology
CG Koh, EJ Tan, E Manser, L Lim