Editorial Material
Biotechnology & Applied Microbiology
Song Ih Ahn, YongTae Kim
Summary: Advancements in stem cell engineering have facilitated the development of human BBB-on-a-chip technologies, enabling more accurate modeling of the human blood-brain barrier. The use of human brain cells is crucial for better modeling human brain pathophysiology.
TRENDS IN BIOTECHNOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Hana Konvickova, Lukas Spitzer, Zdenek Faltynek Fric, Pavel Kepka, Dan Lestina, David Novotny, Michal Zapletal, Kamil Zimmermann, Jana Papp Maresova, Jiri Benes, Martin Konvicka
Summary: In the pastoral landscape of the Czech Republic, specialist butterflies and generalist butterflies have different genetic characteristics. The conservation of species with intermediate features requires further study.
Article
Biochemical Research Methods
Min Jae Song, Kapil Bharti
Summary: We created a 3D outer-blood-retina-barrier (3D-oBRB) that consists of a polarized retinal pigment epithelium (RPE) monolayer, a Bruch's membrane, and a fenestrated choriocapillaris network. This 3D-oBRB model faithfully replicates RPE-choriocapillaris interactions, dry age-related macular degeneration (AMD) phenotypes such as sub-RPE drusen deposits and choriocapillaris degeneration, as well as the wet AMD phenotype of choriocapillaris neovascularization.
Article
Multidisciplinary Sciences
Kota Washimi, Rika Kasajima, Eigo Shimizu, Shinya Sato, Yoichiro Okubo, Emi Yoshioka, Hiroto Narimatsu, Toru Hiruma, Kotoe Katayama, Rui Yamaguchi, Kiyoshi Yamaguchi, Yoichi Furukawa, Satoru Miyano, Seiya Imoto, Tomoyuki Yokose, Yohei Miyagi
Summary: Based on a study of 85 patients with MFS/US, it was found that tumors with infiltrative growth patterns tended to have more myxoid areas and higher local recurrence rates, but fewer distant metastases and better overall survival. Sickle-shaped blood vessels were observed in these tumors, which were characterized by fewer alpha SMA-positive cells compared with normal vessels. By classifying conventionally diagnosed US tumors based on the incidence of these sickle-shaped blood vessels, a significant correlation was found with metastasis and prognosis. RNA sequencing revealed differential regulation of the proteasome, NF-kB, and VEGF pathways in MFS/US tumors, providing potential targets for therapeutic strategies.
SCIENTIFIC REPORTS
(2023)
Article
Multidisciplinary Sciences
Ava P. Amini, Jesse D. Kirkpatrick, Cathy S. Wang, Alex M. Jaeger, Susan Su, Santiago Naranjo, Qian Zhong, Christina M. Cabana, Tyler Jacks, Sangeeta N. Bhatia
Summary: This study develops methods to measure protease activity in cancer and identifies protease dysregulation in lung cancer. By analyzing protease activity dynamics using multiplexed nanosensors and machine learning, the researchers discover significant dysregulation associated with lung cancer. They also localize the dysregulated activity to tumor vasculature and uncover a pro-angiogenic phenotype in cells with specific protease activity.
NATURE COMMUNICATIONS
(2022)
Article
Cell Biology
Shichao Huang, Fei Huang, Huiying Zhang, Yongfeng Yang, Juan Lu, Jiadong Chen, Li Shen, Gang Pei
Summary: This study presents an innovative method to generate human brain organoids in vivo by injecting premature organoids into the corpus striatum of mice. These in vivo developed organoids contain more supporting cells and show lower levels of cellular stress and apoptosis compared to in vitro cultured organoids. This method has potential applications in disease models and therapies.
CELL PROLIFERATION
(2022)
Review
Biochemistry & Molecular Biology
Gaku Yamanaka, Shinichiro Morichi, Tomoko Takamatsu, Yusuke Watanabe, Shinji Suzuki, Yu Ishida, Shingo Oana, Takashi Yamazaki, Fuyuko Takata, Hisashi Kawashima
Summary: The pathogenesis of epilepsy is associated with neuroinflammation and cerebrovascular dysfunction, with evidence suggesting that peripheral immune cells may play a role in seizure development.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemical Research Methods
Qian Chen, Tian Jin, Weizhi Qi, Lei Xi
Summary: Observing microscale neurovascular dynamics under different physiological conditions is important for understanding brain functions. A dual-model wearable device integrating high-resolution photoacoustic microscopy and EEG allowed observation of capillary-level hemodynamics and neural activities in rats. Anesthesia had a dominant impact on seizure onset and affected the neurovascular coupling correlation.
BIOMEDICAL OPTICS EXPRESS
(2021)
Editorial Material
Oncology
Amanda R. Moore, Shiva Malek
Summary: The study found that sotorasib provides clinical benefit for KRAS p.G12C-mutated non-small-cell lung cancer (NSCLC) and provides mechanistic insights into acquired resistance to KRAS(G12C)-specific inhibition.
Article
Biology
Andrew T. Francis, Bryce Manifold, Elena C. Carlson, Ruoqian Hu, Andrew H. Hill, Shuaiqian Men, Dan Fu
Summary: This study presents the construction of a microscope that allows simultaneous nonlinear absorption, Raman, and fluorescence imaging. Machine learning is used to predict the identity of cells lining capillaries, which has significant implications for multiple research fields.
COMMUNICATIONS BIOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Yanqiao Lu, Huanhuan Huo, Feng Liang, Jieyuan Xue, Liang Fang, Yutong Miao, Lan Shen, Ben He
Summary: This study reveals the potential function of pericytes in cardiomyopathy-associated myocardial infarction, highlighting their importance in the microvascular function of the heart. Specifically, pericytes play an important role in regulating collagen synthesis and purine metabolism pathways, and they may serve as potential therapeutic targets.
Article
Biochemistry & Molecular Biology
Dipali Goyal, Sean W. Limesand, Ravi Goyal
Summary: A stem cell-like population is found in fetal carotid arteries, and the survival of these cells depends on the B-Raf kinase.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Business
Petra A. Nylund, Alexander Brem
Summary: Digital platforms are changing economies and societies, challenging democratic institutions, and requiring an understanding of their development. Our research focuses on the impact of dominant platforms on standardization in innovation ecosystems at various levels. We found that ecosystem-based standardization accelerates innovation and enhances synergies, but also creates power asymmetry with implications for regulations and institutions.
TECHNOLOGICAL FORECASTING AND SOCIAL CHANGE
(2023)
Article
Biochemistry & Molecular Biology
Lu Wang, David Sievert, Alex E. Clark, Sangmoon Lee, Hannah Federman, Benjamin D. Gastfriend, Eric V. Shusta, Sean P. Palecek, Aaron F. Carlin, Joseph G. Gleeson
Summary: Research findings suggest that pericytes may serve as important portals for SARS-CoV-2 infection in the nervous system. Introducing pericyte-like cells (PLCs) into cortical organoids can provide an experimental model that supports virus entry and replication.
Article
Ecology
Kumar Manish
Summary: This study examines the ecological response of medicinal plant species to climate change in the Sikkim Himalaya and proposes conservation strategies based on the predicted shifts in their distributions. The results show that most species are likely to move upward and northward in future climates. Species with restricted and narrow elevational distribution are the most vulnerable. This study suggests expanding the boundaries of existing protected areas and focusing on conserving suitable habitats.
ECOLOGICAL INFORMATICS
(2022)