Recent advances in organocatalytic asymmetric Michael reactions

Highly Diastereo- and Enantioselective Synthesis of 5-Substituted 3-Pyrrolidin-2-ones: Vinylogous Michael Addition under Multifunctional Catalysis

(2011) Huicai Huang et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Asymmetric Synthesis of Bioactive Hydrodibenzofuran Alkaloids: (−)-Lycoramine, (−)-Galanthamine, and (+)-Lunarine

(2011) Peng Chen et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

The Vinylogous Aldol and Related Addition Reactions: Ten Years of Progress†

(2011) Giovanni Casiraghi et al.   CHEMICAL REVIEWS

Facile Creation of 2-Substituted Indolin-3-ones by Using Primary-Secondary Diamine Catalysts

(2011) Wangsheng Sun et al.   CHEMISTRY-A EUROPEAN JOURNAL

Oxazolones in Organocatalysis, New Tricks for an Old Reagent

(2011) Andrea-Nekane R. Alba et al.   Chemistry-An Asian Journal

Amino-Indanol-Catalyzed Asymmetric Michael Additions of Oxindoles to Protected 2-Amino-1-nitroethenes for the Synthesis of 3,3′-Disubstituted Oxindoles Bearing α,β-Diamino Functionality

(2011) Xiong-Li Liu et al.   JOURNAL OF ORGANIC CHEMISTRY

Asymmetric Michael Addition of 1-Acetylindolin-3-ones to β-Nitrostyrenes Catalyzed by Bifunctional Thioureas: A Simple Access to 2-Functionalized Indoles

(2011) Yao-Zong Liu et al.   JOURNAL OF ORGANIC CHEMISTRY

Organocatalytic Direct Asymmetric Vinylogous Michael Reaction of an α,β-Unsaturated γ-Butyrolactam with Enones

(2011) Yong Zhang et al.   JOURNAL OF ORGANIC CHEMISTRY

Enantioselective Direct Vinylogous Michael Addition of Functionalized Furanones to Nitroalkenes Catalyzed by an Axially Chiral Guanidine Base

(2011) Masahiro Terada et al.   ORGANIC LETTERS

Highly Enantioselective Direct Vinylogous Michael Addition of γ-Butenolide to Enals

(2011) Adrien Quintard et al.   ORGANIC LETTERS

Enantioselective Michael Addition Reactions

(2011) Muniappan Thirumalaikumar   ORGANIC PREPARATIONS AND PROCEDURES INTERNATIONAL

Highly Enantioselective Michael Addition Reactions of 3-Substituted Benzofuran-2(3H)-ones to Chalcones Catalyzed by a Chiral Alkyl-Substituted Thiourea

(2010) Xin Li et al.   ADVANCED SYNTHESIS & CATALYSIS

Catalytic Asymmetric Synthesis of Oxindoles Bearing a Tetrasubstituted Stereocenter at the C-3 Position

(2010) Feng Zhou et al.   ADVANCED SYNTHESIS & CATALYSIS

Asymmetric Michael Addition Reaction of 3-Substituted Oxindoles to Nitroolefins Catalyzed by a Chiral Alkyl- Substituted Thiourea Catalyst

(2010) Xin Li et al.   ADVANCED SYNTHESIS & CATALYSIS

Organocatalytic Michael Addition of Aldehydes to Protected 2-Amino-1-Nitroethenes: The Practical Syntheses of Oseltamivir (Tamiflu) and Substituted 3-Aminopyrrolidines

(2010) Shaolin Zhu et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Efficient direct asymmetric vinylogous Michael addition reactions of γ-butenolides to chalcones catalyzed by vicinal primary-diamine salts

(2010) Junfeng Wang et al.   CHEMICAL COMMUNICATIONS

Asymmetric vinylogous Michael reaction of α,β-unsaturated ketones with γ-butenolide under multifunctional catalysis

(2010) Huicai Huang et al.   CHEMICAL COMMUNICATIONS

An Unexpected Michael-Aldol-Smiles Rearrangement Sequence for the Synthesis of Versatile Optically Active Bicyclic Structures by Using Asymmetric Organocatalysis

(2010) Nicole Holub et al.   CHEMISTRY-A EUROPEAN JOURNAL

Enantioselective Organocatalytic Addition of Azlactones to Maleimides: A Highly Stereocontrolled Entry to 2,2-Disubstituted-2H-oxazol-5-ones

(2010) Andrea-Nekane R. Alba et al.   CHEMISTRY-A EUROPEAN JOURNAL

Organocatalytic Direct Vinylogous Michael Addition of α,β-Unsaturated γ-Butyrolactam to α,β-Unsaturated Aldehydes and an Illustration to Scaffold Diversity Synthesis

(2010) Xin Feng et al.   CHEMISTRY-A EUROPEAN JOURNAL

Asymmetric Conjugate Addition of Oxindoles to 2-Chloroacrylonitrile: A Highly Effective Organocatalytic Strategy for Simultaneous Construction of 1,3-Nonadjacent Stereocenters Leading to Chiral Pyrroloindolines

(2010) Xin Li et al.   CHEMISTRY-A EUROPEAN JOURNAL

Enantioselective Organocatalytic Addition of Oxazolones to 1,1-Bis(phenylsulfonyl)ethylene: A Convenient Asymmetric Synthesis of Quaternary α-Amino Acids

(2010) Andrea-Nekane R. Alba et al.   CHEMISTRY-A EUROPEAN JOURNAL

Chiral Amine Thiourea-Promoted Enantioselective Michael Addition Reactions of 3-Substituted Benzofuran-2(3H)-ones to Maleimides

(2010) Xin Li et al.   JOURNAL OF ORGANIC CHEMISTRY

Direct Catalytic Asymmetric Vinylogous Mannich-Type and Michael Reactions of an α,β-Unsaturated γ-Butyrolactam under Dinuclear Nickel Catalysis

(2010) Nicholas E. Shepherd et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Acyl Phosphonates: Good Hydrogen Bond Acceptors and Ester/Amide Equivalents in Asymmetric Organocatalysis

(2010) Hao Jiang et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Asymmetric organocatalysis in total synthesis – a trial by fire

(2010) Eugenia Marqués-López et al.   NATURAL PRODUCT REPORTS

Organocatalytic cascade reactions as a new tool in total synthesis

(2010) Christoph Grondal et al.   Nature Chemistry

Nitrophenylacetonitriles as Versatile Nucleophiles in Enantioselective Organocatalytic Conjugate Additions

(2010) M. Belén Cid et al.   ORGANIC LETTERS

Highly Diastereo- and Enantioselective Michael Additions of 3-Substituted Oxindoles to Maleimides Catalyzed by Chiral Bifunctional Thiourea−Tertiary Amine

(2010) Yu-Hua Liao et al.   ORGANIC LETTERS

Direct asymmetric vinylogous Michael addition of cyclic enones to nitroalkenes via dienamine catalysis

(2010) G. Bencivenni et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Organocatalyst-mediated enantioselective intramolecular Michael addition of aldehydes to vinyl sulfones

(2010) Chloée Bournaud et al.   TETRAHEDRON-ASYMMETRY

Diversity-oriented synthesis as a tool for the discovery of novel biologically active small molecules

(2010) Warren R.J.D. Galloway et al.   Nature Communications

Trends in Organocatalytic Conjugate Addition to Enones: An Efficient Approach to Optically Active Alkynyl, Alkenyl, and Ketone Products

(2009) Márcio Weber Paixão et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Catalytic Asymmetric Conjugate Addition of Nitroalkanes to 4-Nitro-5-styrylisoxazoles

(2009) Andrea Baschieri et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Phosphonium Salts as Chiral Phase-Transfer Catalysts: Asymmetric Michael and Mannich Reactions of 3-Aryloxindoles

(2009) Rongjun He et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

High-Yielding Synthesis of the Anti-Influenza Neuramidase Inhibitor (−)-Oseltamivir by Three “One-Pot” Operations

(2009) Hayato Ishikawa et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

α,α-Dicyanoalkenes: versatile vinylogous nucleophiles for organic synthesis

(2009) Hai-Lei Cui et al.   CHEMICAL COMMUNICATIONS

Chiral Brønsted acid catalyzed Friedel–Crafts alkylation reactions

(2009) Shu-Li You et al.   CHEMICAL SOCIETY REVIEWS

Asymmetric Iminium Ion Catalysis with a Novel Bifunctional Primary Amine Thiourea: Controlling Adjacent Quaternary and Tertiary Stereocenters

(2009) Patrizia Galzerano et al.   CHEMISTRY-A EUROPEAN JOURNAL

Organocatalytic Asymmetric Aza-Michael Additions

(2009) Dieter Enders et al.   CHEMISTRY-A EUROPEAN JOURNAL

Asymmetric Organocatalytic Formal Alkynylation and Alkenylation of α,β-Unsaturated Aldehydes

(2009) Martin Nielsen et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Direct Asymmetric Michael Addition to Nitroalkenes: Vinylogous Nucleophilicity under Dinuclear Zinc Catalysis

(2009) Barry M. Trost et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Enantioselective Intramolecular Michael Addition of Nitronates onto Conjugated Esters: Access to Cyclic γ-Amino Acids with up to Three Stereocenters

(2009) William J. Nodes et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Enantioselective Base-Free Phase-Transfer Reaction in Water-Rich Solvent

(2009) Rongjun He et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Thiourea-Catalyzed Highly Enantio- and Diastereoselective Additions of Oxindoles to Nitroolefins: Application to the Formal Synthesis of (+)-Physostigmine

(2009) Tommy Bui et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Molecular diversity by design

(2009) Stuart L. Schreiber   NATURE

Asymmetric Michael addition reaction of 3-substituted-N-Boc oxindoles to activated terminal alkenes catalyzed by a bifunctional tertiary-amine thiourea catalyst

(2009) Xin Li et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Crossed Intramolecular Rauhut−Currier-Type Reactions via Dienamine Activation

(2009) Eugenia Marqués-López et al.   ORGANIC LETTERS

Chiral Organic Ion Pair Catalysts Assembled Through a Hydrogen-Bonding Network

(2009) D. Uraguchi et al.   SCIENCE

The oxa-Michael reaction: from recent developments to applications in natural product synthesis

(2008) Carl F. Nising et al.   CHEMICAL SOCIETY REVIEWS

Asymmetric 1,4-Addition of Oxazolones to Nitroalkenes by Bifunctional Cinchona Alkaloid Thiourea Organocatalysts: Synthesis of α,α-Disubstituted α-Amino Acids

(2008) José Alemán et al.   CHEMISTRY-A EUROPEAN JOURNAL

Diphenylprolinol Silyl Ether as a Catalyst in an Enantioselective, Catalytic Michael Reaction for the Formation of α,α-Disubstituted α-Amino Acid Derivatives

(2008) Yujiro Hayashi et al.   Chemistry-An Asian Journal

Organocatalytic Asymmetric Synthesis of α,α-Disubstituted α-Amino Acids and Derivatives

(2008) Silvia Cabrera et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

The advent and development of organocatalysis

(2008) David W. C. MacMillan   NATURE

Natural products as inspiration for the development of asymmetric catalysis

(2008) Justin T. Mohr et al.   NATURE

Organocatalysis: asymmetric cascade reactions catalysed by chiral secondary amines

(2008) Xinhong Yu et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Towards the Optimal Screening Collection: A Synthesis Strategy

(2007) Thomas E. Nielsen et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION