A system for the continuous directed evolution of proteases rapidly reveals drug-resistance mutations
Published 2014 View Full Article
- Home
- Publications
- Publication Search
- Publication Details
Title
A system for the continuous directed evolution of proteases rapidly reveals drug-resistance mutations
Authors
Keywords
-
Journal
Nature Communications
Volume 5, Issue 1, Pages -
Publisher
Springer Nature
Online
2014-10-30
DOI
10.1038/ncomms6352
References
Ask authors/readers for more resources
Related references
Note: Only part of the references are listed.- Resistance Mutations Against HCV Protease Inhibitors and Antiviral Drug Design
- (2014) Luqing Shang et al. CURRENT PHARMACEUTICAL DESIGN
- The Discovery of Asunaprevir (BMS-650032), An Orally Efficacious NS3 Protease Inhibitor for the Treatment of Hepatitis C Virus Infection
- (2014) Paul M. Scola et al. JOURNAL OF MEDICINAL CHEMISTRY
- Negative selection and stringency modulation in phage-assisted continuous evolution
- (2014) Jacob C Carlson et al. Nature Chemical Biology
- A Population-Based Experimental Model for Protein Evolution: Effects of Mutation Rate and Selection Stringency on Evolutionary Outcomes
- (2013) Aaron M. Leconte et al. BIOCHEMISTRY
- Resistance analysis of hepatitis C virus genotype 1 prior treatment null responders receiving daclatasvir and asunaprevir
- (2013) Fiona McPhee et al. HEPATOLOGY
- Discovery of Danoprevir (ITMN-191/R7227), a Highly Selective and Potent Inhibitor of Hepatitis C Virus (HCV) NS3/4A Protease
- (2013) Yutong Jiang et al. JOURNAL OF MEDICINAL CHEMISTRY
- New therapeutic strategies in HCV: second-generation protease inhibitors
- (2013) Virginia C. Clark et al. LIVER INTERNATIONAL
- Novel therapies for hepatitis C — one pill fits all?
- (2013) Michael P. Manns et al. NATURE REVIEWS DRUG DISCOVERY
- Experimental interrogation of the path dependence and stochasticity of protein evolution using phage-assisted continuous evolution
- (2013) B. C. Dickinson et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Engineering of TEV protease variants by yeast ER sequestration screening (YESS) of combinatorial libraries
- (2013) L. Yi et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Resistance Analysis of the Hepatitis C Virus NS3 Protease Inhibitor Asunaprevir
- (2012) Fiona McPhee et al. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
- The Molecular Basis of Drug Resistance against Hepatitis C Virus NS3/4A Protease Inhibitors
- (2012) Keith P. Romano et al. PLoS Pathogens
- Virologic Escape during Danoprevir (ITMN-191/RG7227) Monotherapy Is Hepatitis C Virus Subtype Dependent and Associated with R155K Substitution
- (2011) Sharlene R. Lim et al. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
- Proteases as therapeutics
- (2011) Charles S. Craik et al. BIOCHEMICAL JOURNAL
- Genotype differences in susceptibility and resistance development of hepatitis C virus to protease inhibitors telaprevir (VX-950) and danoprevir (ITMN-191)
- (2011) Ingrid Imhof et al. HEPATOLOGY
- A system for the continuous directed evolution of biomolecules
- (2011) Kevin M. Esvelt et al. NATURE
- Activation of Specific Apoptotic Caspases with an Engineered Small-Molecule-Activated Protease
- (2010) Daniel C. Gray et al. CELL
- Design of next-generation protein therapeutics
- (2010) Justin Caravella et al. CURRENT OPINION IN CHEMICAL BIOLOGY
- Tracking the Evolution of Multiple In Vitro Hepatitis C Virus Replicon Variants under Protease Inhibitor Selection Pressure by 454 Deep Sequencing
- (2010) T. Verbinnen et al. JOURNAL OF VIROLOGY
- Drug resistance against HCV NS3/4A inhibitors is defined by the balance of substrate recognition versus inhibitor binding
- (2010) K. P. Romano et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Rapid Emergence of Protease Inhibitor Resistance in Hepatitis C Virus
- (2010) L. Rong et al. Science Translational Medicine
- Engineering of protease variants exhibiting altered substrate specificity
- (2008) Saravanan Sellamuthu et al. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
- Proteome-derived, database-searchable peptide libraries for identifying protease cleavage sites
- (2008) Oliver Schilling et al. NATURE BIOTECHNOLOGY
- Highly active and selective endopeptidases with programmed substrate specificities
- (2008) Navin Varadarajan et al. Nature Chemical Biology
Publish scientific posters with Peeref
Peeref publishes scientific posters from all research disciplines. Our Diamond Open Access policy means free access to content and no publication fees for authors.
Learn MoreFind the ideal target journal for your manuscript
Explore over 38,000 international journals covering a vast array of academic fields.
Search