Journal
CURRENT ONCOLOGY REPORTS
Volume 11, Issue 3, Pages 193-199Publisher
SPRINGER
DOI: 10.1007/s11912-009-0028-0
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Funding
- National Cancer Institute [P50 CA127003]
- Caring for Carcinoid Foundation
- Stephen and Caroline Kaufer fund for neuroendocrine tumor research
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Traditional treatments for patients with advanced neuroendocrine tumors include surgical debulking, hepatic embolization, somatostatin analogues, and interferon-alpha. Patients with pancreatic neuroendocrine tumors also may benefit from treatment with the alkylating agents streptozocin or temozolomide. In recent years, several promising new approaches have been investigated in patients with advanced neuroendocrine tumors. One such approach has been the use of radiopeptide therapy targeting somatostatin receptors. Additionally, agents targeting the vascular endothelial growth factor pathway and mammalian target of rapamycin have shown preliminary evidence of activity and are currently being evaluated in large randomized studies.
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