Article
Medicine, General & Internal
Fan Wu, Yi-Yun Yin, Wen-Hua Fan, You Zhai, Ming-Chen Yu, Di Wang, Chang-Qing Pan, Zheng Zhao, Guan-Zhang Li, Wei Zhanga
Summary: Through integrated analysis of transcriptome, genome, and methylome, two intrinsic molecular subtypes associated with distinct molecular characteristics and clinical outcomes were identified and validated. Oligo1 subtype was characterized by worse prognosis and enrichment of cell proliferation and Wnt signaling pathways, while Oligo2 subtype had a favorable outcome with increased activation of immune response and metabolic process. This classification serves as an independent prognostic factor in oligodendrogliomas, and its robustness was verified in validation cohorts.
Article
Oncology
Vittorio Stumpo, Lelio Guida, Jacopo Bellomo, Christiaan Hendrik Bas Van Niftrik, Martina Seboek, Moncef Berhouma, Andrea Bink, Michael Weller, Zsolt Kulcsar, Luca Regli, Jorn Fierstra
Summary: Neuroimaging techniques can be used to generate imaging biomarkers for molecular features of gliomas, helping to improve clinical diagnosis and treatment monitoring. Advanced hemodynamic imaging methods are valuable for evaluating treatment efficacy and predicting prognosis of gliomas.
Article
Oncology
Steven P. Rowe, Martin G. Pomper
Summary: Molecular imaging, defined as visualizing, characterizing, and measuring biological processes at the molecular and cellular levels, has rapidly developed in recent years, with a particular focus on oncology for early detection and optimal disease management. The expansion of molecular imaging is driven by new animal models, sensitive imaging devices, high-throughput methods, genetic manipulation techniques, and cloud computing. Researchers and clinicians are utilizing molecular imaging for a variety of physiological processes, with a focus on oncology for its potential in detecting diseases at an early stage.
CA-A CANCER JOURNAL FOR CLINICIANS
(2022)
Article
Cardiac & Cardiovascular Systems
Jessica Magid-Bernstein, Romuald Girard, Sean Polster, Abhinav Srinath, Sharbel Romanos, Issam A. Awad, Lauren H. Sansing
Summary: This review article provides an overview of the epidemiology, cause, mechanisms of injury, current treatment strategies, and future research directions of intracerebral hemorrhage (ICH). The incidence of hemorrhagic stroke has increased globally in the past 40 years, with changes in the cause over time due to improved hypertension management and increased use of anticoagulants. Preclinical and clinical trials have shed light on the underlying cause and mechanisms of injury from ICH, including the complex interaction between edema, inflammation, iron-induced injury, and oxidative stress. Although several trials have investigated the optimal medical and surgical management of ICH, there has been no clear improvement in survival and functional outcomes. Ongoing research into novel approaches for ICH management offers hope for reducing the devastating impact of this disease in the future.
CIRCULATION RESEARCH
(2022)
Review
Oncology
Athanasios Armakolas, Maria Kotsari, John Koskinas
Summary: Liquid biopsies have great potential in cancer diagnosis and prognosis, providing less invasive and more accurate solutions. They analyze circulating molecules in the blood and offer promising techniques for managing cancer patients. This study aims to discuss the clinical relevance of liquid biopsies, as well as the opportunities they bring for cancer prognosis, diagnosis, and monitoring. It also explains the isolation process and clinical use of the biological components of liquid biopsies, with a focus on novel procedures and future possibilities.
Review
Oncology
Hirokazu Takami
Summary: This review discusses the important advances in the research of central nervous system germ cell tumors in the past decade and future research directions. The characteristics of CNS GCTs and the treatment methods for germinoma and non-germinomatous GCTs have been discovered. Further research is needed in liquid biopsy, genomic structural variants, and treatment stratification.
CURRENT ONCOLOGY REPORTS
(2022)
Review
Medicine, Research & Experimental
Chenyue Zhang, Chenxing Zhang, Kai Wang, Haiyong Wang
Summary: Small cell lung cancer (SCLC) is a difficult-to-treat malignancy with poor prognosis. Recent advancements in targeted therapy and immune checkpoint inhibitors have shown promise in SCLC treatment. However, improving the efficacy and reducing the toxicity of immune checkpoint inhibitors, as well as identifying reliable biomarkers, remain challenging and require further investigation.
JOURNAL OF TRANSLATIONAL MEDICINE
(2023)
Article
Biochemistry & Molecular Biology
Shanshan Luo, Chuiyu Kong, Danyu Ye, Xingeng Liu, Yu Wang, Guoliang Meng, Yi Han, Liping Xie, Yong Ji
Summary: Hydrogen sulfide (H2S) is a gasotransmitter that regulates physiological and pathological activities. S-sulfhydration, involving the formation of protein persulfides, explains the multiple functions of H2S. Investigating protein persulfides can provide insights into the potential functions of H2S.
ANTIOXIDANTS & REDOX SIGNALING
(2023)
Review
Biochemistry & Molecular Biology
Wojciech Grodzicki, Katarzyna Dziendzikowska, Joanna Gromadzka-Ostrowska, Marcin Kruszewski
Summary: The widespread use of plastic has a significant impact on the environment and various species. Exposure to nanoplastic can accumulate in tissues and potentially affect the gut-brain axis, with reported outcomes including microbiota alterations, neurotoxicity, and behavioral disturbances, highlighting the need for further research to understand the potential threats.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Oncology
Jordina Rincon-Torroella, Maureen Rakovec, Josh Materi, Divyaansh Raj, Tito Vivas-Buitrago, Abel Ferres, William Reyes Serpa, Kristin J. Redmond, Matthias Holdhoff, Chetan Bettegowda, Jose Juan Gonzalez Sanchez
Summary: Oligodendrogliomas, a subtype of adult diffuse glioma, show better responsiveness to systemic chemotherapy. Key factors in diagnosis and treatment include 1p19q codeletion and IDH mutations. However, the optimal treatment paradigm for molecularly defined oligodendrogliomas is still not fully understood, and many questions remain unanswered.
FRONTIERS IN ONCOLOGY
(2022)
Review
Environmental Sciences
Seungmok Paik, Seung-Ki Min, Seok-Woo Son, Eun-Pa Lim, Shayne McGregor, Soon-Il An, Jong-Seong Kug, Sang-Wook Yeh
Summary: Understanding the impacts of volcanic eruptions on atmospheric circulations and surface climate is crucial for climate prediction. Previous studies have shown that volcanic eruptions can induce warming in the Northern Hemisphere through certain circulation patterns, but uncertainties and controversies remain. This paper reviews previous studies, updates our understanding using new observations and model simulations, and proposes new insights into the role of volcanic eruption latitude. It also discusses uncertainty factors and suggests future research directions to resolve these issues.
ENVIRONMENTAL RESEARCH LETTERS
(2023)
Review
Integrative & Complementary Medicine
Xue Gong, Min Yang, Chun-nian He, Ya-qiong Bi, Chun-hong Zhang, Min-hui Li, Pei-gen Xiao
Summary: Medicinal plants have been used for thousands of years and have provided many active ingredients for Chinese medicine and traditional pharmacologies. In recent years, there has been an increased focus on studying the chemical composition, molecular phylogeny, and pharmacological activity of medicinal plants. Pharmacophylogeny, which studies the correlation between plant phylogeny, chemical composition, and curative effects, provides important tools for research and development of traditional medicine resources.
CHINESE JOURNAL OF INTEGRATIVE MEDICINE
(2022)
Review
Oncology
Long Su, Yuan-Yuan Shi, Zeng-Yan Liu, Su-Jun Gao
Summary: This review summarizes the research progress and treatment methods of CEBPA gene mutations in AML, proposes a new treatment algorithm, and may be beneficial for further investigation and optimizing clinical management of AML patients with CEBPA mutations.
FRONTIERS IN ONCOLOGY
(2022)
Article
Oncology
Leila T. Tchelebi, Cathy Eng, Craig A. Messick, Theodore S. Hong, Ethan B. Ludmir, Lisa A. Kachnic, Nicholas G. Zaorsky
Summary: The treatment of squamous cell carcinoma of the anus has shifted from radical surgery to sphincter-preserving chemoradiation, with chemotherapy using mitomycin-C and 5-fluorouracil found to be essential for cure. Advanced radiation techniques are now considered standard of care, and further studies are exploring the addition of immune checkpoint inhibitors in locally advanced cancers.
CA-A CANCER JOURNAL FOR CLINICIANS
(2022)
Review
Endocrinology & Metabolism
Jose Miguel Hinojosa-Amaya, Cesar Ernesto Lam-Chung, Daniel Cuevas-Ramos
Summary: Corticotroph tumors are pituitary neoplasms arising from the Tpit lineage, with functioning CTs causing Cushing's disease and non-functioning or silent CTs and Crooke's cell subtypes more frequently manifesting as macroadenomas. Tumorigenesis involves disruption of cell-cycle regulators through genetic, epigenetic, and post-transcriptional mechanisms, potentially becoming therapeutic targets. Treatment options include targeted therapies like EGFR inhibitors and HSP90 inhibitors, as well as BRAF inhibitors for specific mutations.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Article
Oncology
Nimish A. Mohile, Jaishri O. Blakeley, Na Tosha N. Gatson, Andreas F. Hottinger, Andrew B. Lassman, Douglas E. Ney, Adriana Olar, David Schiff, Helen A. Shih, Roy Strowd, Martin J. van den Bent, Mateo Ziu
Article
Immunology
Ronak K. Kapadia, Douglas E. Ney, Markus Hannan, Morgan Farley, Daniel M. Pastula, Amanda L. Piquet
JOURNAL OF NEUROIMMUNOLOGY
(2020)
Article
Oncology
Nimish A. Mohile, Hans Messersmith, Na Tosha Gatson, Andreas F. Hottinger, Andrew Lassman, Jordan Morton, Douglas Ney, Phioanh Leia Nghiemphu, Adriana Olar, Jeffery Olson, James Perry, Jana Portnow, David Schiff, Anne Shannon, Helen A. Shih, Roy Strowd, Martin van den Bent, Mateo Ziu, Jaishri Blakeley
Summary: This article provides guidance on the therapy for diffuse astrocytic and oligodendroglial tumors in adults. The recommendations are based on a systematic literature review and offer specific treatment options for different tumor grades, with reasonable alternatives. The article also provides treatment suggestions for specific patient populations.
JOURNAL OF CLINICAL ONCOLOGY
(2022)
Article
Oncology
Nimish A. Mohile, Hans Messersmith, Na Tosha Gatson, Andreas F. Hottinger, Andrew Lassman, Jordan Morton, Douglas Ney, Phioanh Leia Nghiemphu, Adriana Olar, Jeffery Olson, James Perry, Jana Portnow, David Schiff, Anne Shannon, Helen A. Shih, Roy Strowd, Martin van den Bent, Mateo Ziu, Jaishri Blakeley
Summary: This article provides guidance for therapy of diffuse astrocytic and oligodendroglial tumors in adults. Based on a systematic review of literature, the article provides recommendations for different tumor types and grades, including radiation therapy, chemotherapy, and other treatment options.
Article
Oncology
Jay C. Shiao, Andrew B. Wolf, Rachel A. Rabinovitch, Clay Smith, B. K. Kleinschmidt-DeMasters, Douglas E. Ney
ADVANCES IN RADIATION ONCOLOGY
(2021)
Editorial Material
Clinical Neurology
Suzanne E. Schindler, Douglas E. Ney, Adeline L. Goss, Gil Rabinovici
ANNALS OF NEUROLOGY
(2022)
Article
Clinical Neurology
Xavier Boumaza, Baptiste Bonneau, Damien Roos-Weil, Carmela Pinnetti, Sebastian Rauer, Louisa Nitsch, Arnaud Del Bello, Ilijas Jelcic, Kurt-Wolfram Suehs, Jacques Gasnault, Yasemin Goreci, Oliver Grauer, Sharmilee Gnanapavan, Rebecca Wicklein, Nicolas Lambert, Thomas Perpoint, Martijn Beudel, David Clifford, Agnes Sommet, Irene Cortese, Guillaume Martin-Blondel
Summary: This study aimed to evaluate the real-world effectiveness of immune checkpoint inhibitors in the treatment of patients with progressive multifocal leukoencephalopathy (PML). Retrospective data from 79 PML patients who received immune checkpoint inhibitors were analyzed, and the results showed that mortality remained high and the development of inflammatory features or PML-IRIS was commonly observed. The study highlights the importance of personalized use of immune checkpoint inhibitors for PML patients.
ANNALS OF NEUROLOGY
(2023)
Article
Hematology
Kevin A. A. David, Suchitra Sundaram, Seo-Hyun Kim, Ryan Vaca, Yong Lin, Samuel Singer, Mary-Kate Malecek, Jordan Carter, Adam Zayac, Myung Sun Kim, Nishitha Reddy, Douglas Ney, Alma Habib, Christopher Strouse, Jerome Graber, Veronika Bachanova, Sidra Salman, Jean Alyxa Vendiola, Nasheed Hossain, Mazie Tsang, Ajay Major, David A. A. Bond, Prashasti Agrawal, Angel Mier-Hicks, Pallawi Torka, Priya Rajakumar, Parameswaran Venugopal, Stephanie Berg, Michael Glantz, Samuel A. A. Goldlust, Matthew Folstad, Pallavi Kumar, Thomas A. A. Ollila, Johnny Cai, Stephen Spurgeon, Alex Sieg, Joseph Cleveland, Julie Chang, Narendranath Epperla, Reem Karmali, Seema Naik, Peter Martin, Sonali M. M. Smith, James Rubenstein, Brad Kahl, Andrew M. M. Evens
Summary: This retrospective analysis examined the outcomes and prognostic factors of 539 newly-diagnosed PCNSL patients aged 60 years and older from 20 U.S. academic centers. The study found that induction regimens using high-dose methotrexate (HD-MTX) combined with rituximab, as well as maintenance therapy, optimized the outcomes for older PCNSL patients. Additionally, several factors including age, hypoalbuminemia, high CIRS-G score, and ECOG performance status were associated with inferior outcomes.
AMERICAN JOURNAL OF HEMATOLOGY
(2023)
Article
Oncology
Prashasti Agrawal, Kevin A. A. David, Zhengming Chen, Suchitra Sundaram, Seo-Hyun Kim, Ryan Vaca, Yong Lin, Samuel Singer, Mary-Kate Malecek, Jordan Carter, Adam Zayac, Myung Sun Kim, Nishitha Reddy, Douglas Ney, Alma Habib, Christopher Strouse, Jerome Graber, Veronika Bachanova, Sidra Salman, Jean A. A. Vendiola, Nasheed Hossain, Mazie Tsang, Ajay Major, Maher K. K. Gandhi, Colm Keane, David A. A. Bond, Matthew Folstad, Julie Chang, Angel Mier-Hicks, Pallawi Torka, Priya Rajakumar, Parameswaran Venugopal, Stephanie Berg, Michael Glantz, Samuel A. A. Goldlust, Rahul Matnani, Pallavi Kumar, Thomas A. A. Ollila, Johnny Cai, Stephen E. E. Spurgeon, Alex G. G. Sieg, Joseph Cleveland, Narendranath Epperla, Reem Karmali, Seema Naik, Sonali M. M. Smith, James L. L. Rubenstein, Brad S. S. Kahl, Amy Chadburn, Andrew M. M. Evens, Peter Martin
Summary: The objective of this multicenter retrospective study was to examine the incidence, patient characteristics, pathology, and outcomes associated with Epstein-Barr virus (EBV)-related CNS lymphoma (CNSL) in older patients. The study found that 11.7% of CNSL patients aged ≥ 60 had EBV + tumors, mainly solid organ transplant-related post-transplant lymphoproliferative disorders (PTLD). EBV positive tumors were associated with younger age, solid organ transplant or autoimmune disease, and immunosuppressive treatment. Furthermore, EBV + PTLD had a shorter median overall survival compared to EBV + non-PTLD and EBV-negative patients.
LEUKEMIA & LYMPHOMA
(2023)
Meeting Abstract
Oncology
Jiayi Huang, Feng Gao, Joshua Shimony, Tanner Michael Johanns, Megan Mantica, Timothy Robin Gershon, Douglas Edward Ney, Tolga Tuncer Joe Sammy Mendez, Howard Streicher, Jian Li Campian
JOURNAL OF CLINICAL ONCOLOGY
(2022)
Meeting Abstract
Clinical Neurology
B. K. Kleinschmidt-DeMasters, Douglas Ney
JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY
(2021)
Meeting Abstract
Hematology
Nancy D. Doolittle, Prakash Ambady, David M. Peereboom, Douglas E. Ney, Larry Junck, Yoshie Umemura, Roy Ervin Strowd, Glenn J. Lesser, David Schiff, Camilo E. Fadul, Michael Glantz, Erin M. Dunbar, Peter Barth, Edward Pan, Alissa A. Thomas, Rongwei Fu, Edward A. Neuwelt
Meeting Abstract
Clinical Neurology
Katherine Belanger, Timothy H. Ung, Douglas Ney, Kevin O. Lillehei, Chad Rusthoven, Denise M. Damek, David R. Ormond
Meeting Abstract
Clinical Neurology
B. K. Kleinschmidt-DeMasters, Douglas Ney
JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY
(2020)
Review
Oncology
Kareem R. Fakhoury, Douglas E. Ney, D. Ryan Ormond, Chad G. Rusthoven
Summary: The study investigates the use of immunotherapy in treating HGG, with a focus on how radiation can enhance immunogenicity and the feasibility of combination therapy. While some studies have not shown consistent improvements in clinical outcomes, there are still important lessons to be learned from completed research in this early-stage field.
TRANSLATIONAL CANCER RESEARCH
(2021)
